Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Molecular Biology
Role Of Microrna Let-7 In Pancreatic Beta Cells, Shungang Zhang
Role Of Microrna Let-7 In Pancreatic Beta Cells, Shungang Zhang
Dissertations, Master's Theses and Master's Reports - Open
MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression at transcriptional or post-transcriptional level. Let-7 family is among the first identified human miRNAs and regulates multiple cellular processes including glucose metabolism in multiple organs. It has been reported that overexpression of let-7 resulted in insulin resistance and impaired glucose tolerance through repressing insulin signaling pathway in both muscle and liver. However, the role and mechanism underlying let-7 function in pancreatic beta-cells have yet to be elucidated.
Let-7 family contains nine members, which poses a significant challenge in complete deletion of this miRNA family. To study the function of let-7 …