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Dissecting The Interaction Between P53 And Trim24, Aundrietta D. Duncan
Dissecting The Interaction Between P53 And Trim24, Aundrietta D. Duncan
Dissertations & Theses (Open Access)
Dissecting the Interaction of p53 and TRIM24
Aundrietta DeVan Duncan
Supervisory Professor, Michelle Barton, Ph.D.
p53, the “guardian of the genome”, plays an important role in multiple biological processes including cell cycle, angiogenesis, DNA repair and apoptosis. Because it is mutated in over 50% of cancers, p53 has been widely studied in established cancer cell lines. However, little is known about the function of p53 in a normal cell. We focused on characterizing p53 in normal cells and during differentiation. Our lab recently identified a novel binding partner of p53, Tripartite Motif 24 protein (TRIM24). TRIM24 is a member of …