Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biochemistry (20)
- Structural Biology (13)
- Chemistry (11)
- Medicinal-Pharmaceutical Chemistry (11)
- Physical Sciences and Mathematics (11)
-
- Medicinal Chemistry and Pharmaceutics (10)
- Pharmacology, Toxicology and Environmental Health (10)
- Microbiology (8)
- Virology (7)
- Cell and Developmental Biology (5)
- Immunity (5)
- Immunology and Infectious Disease (5)
- Bioinformatics (4)
- Diseases (4)
- Genetics and Genomics (4)
- Medicine and Health Sciences (4)
- Cellular and Molecular Physiology (2)
- Developmental Biology (2)
- Eye Diseases (2)
- Genetics (2)
- Genomics (2)
- Immunology of Infectious Disease (2)
- Medical Biochemistry (2)
- Medical Molecular Biology (2)
- Medical Sciences (2)
- Medical Specialties (2)
- Ophthalmology (2)
- Keyword
-
- RNA-seq (5)
- Active learning (4)
- Gene expression analysis protocol (3)
- QPCR (3)
- Apoptosis (2)
-
- Biochemistry (2)
- Chicken embryo (2)
- Cupin (2)
- Endoplasmic reticulum stress (ER stress) (2)
- Enzyme kinetics (2)
- Fibrosis (2)
- Interferon regulatory factor (IRF) (2)
- Isothermal titration calorimetry (2)
- Liver injury (2)
- Molecular biology (2)
- Oxalate oxidase (2)
- 1st strand synthesis (1)
- 3’UTR (1)
- APOBEC3G (1)
- Activation (1)
- Adaptive (1)
- Allosteric binding site (1)
- Amyotrophic lateral sclerosis (1)
- Automated structure solution (1)
- Borrelia burgdorferi (1)
- Cell envelope (1)
- DNA binding (1)
- DNA repair (1)
- Development (1)
- Domain (1)
- Publication
Articles 31 - 32 of 32
Full-Text Articles in Molecular Biology
Structural And Thermodynamic Effects Of Macrocyclization In Hcv Ns3/4a Inhibitor Mk-5172, Djade Soumana, Nese Yilmaz, Kristina Prachanronarong, Cihan Aydin, Akbar Ali, Celia Schiffer
Structural And Thermodynamic Effects Of Macrocyclization In Hcv Ns3/4a Inhibitor Mk-5172, Djade Soumana, Nese Yilmaz, Kristina Prachanronarong, Cihan Aydin, Akbar Ali, Celia Schiffer
Celia A. Schiffer
Recent advances in direct-acting antivirals against Hepatitis C Virus (HCV) have led to the development of potent inhibitors, including MK-5172, that target the viral NS3/4A protease with relatively low susceptibility to resistance. MK-5172 has a P2-P4 macrocycle and a unique binding mode among current protease inhibitors where the P2 quinoxaline packs against the catalytic residues H57 and D81. However, the effect of macrocyclization on this binding mode is not clear, as is the relation between macrocyclization, thermodynamic stabilization, and susceptibility to the resistance mutation A156T. We have determined high-resolution crystal structures of linear and P1-P3 macrocyclic analogs of MK-5172 bound …
Testing The Metabolic Theory Of Ecology., Andrew Kerkhoff
Testing The Metabolic Theory Of Ecology., Andrew Kerkhoff
Andrew J Kerkhoff
The metabolic theory of ecology (MTE) predicts the effects of body size and temperature on metabolism through considerations of vascular distribution networks and biochemical kinetics. MTE has also been extended to characterise processes from cellular to global levels. MTE has generated both enthusiasm and controversy across a broad range of research areas. However, most efforts that claim to validate or invalidate MTE have focused on testing predictions. We argue that critical evaluation of MTE also requires strong tests of both its theoretical foundations and simplifying assumptions. To this end, we synthesise available information and find that MTE's original derivations require …