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Full-Text Articles in Molecular Biology
The Role Of Formins In Human Disease, Aaron D. Deward, Kathryn M. Eisenmann, Stephen F. Matheson, Arthur S. Alberts
The Role Of Formins In Human Disease, Aaron D. Deward, Kathryn M. Eisenmann, Stephen F. Matheson, Arthur S. Alberts
University Faculty Publications and Creative Works
Formins are a conserved family of proteins that play key roles in cytoskeletal remodeling. They nucleate and processively elongate non-branched actin filaments and also modulate microtubule dynamics. Despite their significant contributions to cell biology and development, few studies have directly implicated formins in disease pathogenesis. This review highlights the roles of formins in cell division, migration, immunity, and microvesicle formation in the context of human disease. In addition, we discuss the importance of controlling formin activity and protein expression to maintain cell homeostasis. © 2009 Elsevier B.V. All rights reserved.
Dynamics Of Galectin-3 In The Nucleus And Cytoplasm, Kevin C. Haudek, Kimberly J. Spronk, Patricia G. Voss, Ronald J. Patterson
Dynamics Of Galectin-3 In The Nucleus And Cytoplasm, Kevin C. Haudek, Kimberly J. Spronk, Patricia G. Voss, Ronald J. Patterson
University Faculty Publications and Creative Works
This review summarizes selected studies on galectin-3 (Gal3) as an example of the dynamic behavior of a carbohydrate-binding protein in the cytoplasm and nucleus of cells. Within the 15-member galectin family of proteins, Gal3 (Mr ∼ 30,000) is the sole representative of the chimera subclass in which a proline- and glycine-rich NH2-terminal domain is fused onto a COOH-terminal carbohydrate recognition domain responsible for binding galactose-containing glycoconjugates. The protein shuttles between the cytoplasm and nucleus on the basis of targeting signals that are recognized by importin(s) for nuclear localization and exportin-1 (CRM1) for nuclear export. Depending on the cell type, specific …