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Full-Text Articles in Molecular Biology
Staufen Negatively Modulates Microrna Activity In Caenorhabditis Elegans, Zhiji Ren, Isana Veksler-Lublinsky, David Morrissey, Victor Ambros
Staufen Negatively Modulates Microrna Activity In Caenorhabditis Elegans, Zhiji Ren, Isana Veksler-Lublinsky, David Morrissey, Victor Ambros
Victor R. Ambros
The double-stranded RNA-binding protein Staufen has been implicated in various post-transcriptional gene regulatory processes. Here we demonstrate that the Caenorhabditis elegans homolog of Staufen, STAU-1, functionally interacts with microRNAs. Loss-of-function mutations of stau-1 significantly suppress phenotypes of let-7 family microRNA mutants, a hypomorphic allele of dicer and a lsy-6 microRNA partial loss-of-function mutant. Furthermore, STAU-1 modulates the activity of lin-14, a target of lin-4 and let-7 family microRNAs, and this modulation is abolished when the 3' untranslated region of lin-14 is removed. Deep sequencing of small RNA cDNA libraries reveals no dramatic change in the levels of microRNAs, or other …
Mapping Transcriptome Profiles Of In Vitro Ipsc-Derived Cardiac Differentiation To In Utero Heart Development, Xing Li, Katherine A. Campbell, Sherri M. Biendarra, Andre Terzic, Timothy J. Nelson
Mapping Transcriptome Profiles Of In Vitro Ipsc-Derived Cardiac Differentiation To In Utero Heart Development, Xing Li, Katherine A. Campbell, Sherri M. Biendarra, Andre Terzic, Timothy J. Nelson
Katherine Campbell, PhD
No abstract provided.