Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- MicroRNAs (2)
- RNA, Messenger (2)
- *Alternative Splicing (1)
- *Nucleic Acid Conformation (1)
- *Phenotype (1)
-
- Alternative splicing (1)
- Animals (1)
- Binding Sites (1)
- Caenorhabditis elegans (1)
- Caenorhabditis elegans Proteins (1)
- Carrier Proteins (1)
- Cell Line, Tumor (1)
- Exons (1)
- Gene Deletion (1)
- Gene Expression Profiling (1)
- Gene Regulatory Networks (1)
- Heterogeneous-Nuclear Ribonucleoprotein Group A-B (1)
- HnRNP A1 (1)
- Inverted Repeat Sequences (1)
- Mag (1)
- Mice (1)
- Models, Genetic (1)
- Mutation (1)
- Myelin (1)
- Myelin-Associated Glycoprotein (1)
- Myelin-associated glycoprotein (1)
- Protein Binding (1)
- Protein Interaction Mapping (1)
- RNA Isoforms (1)
- RNA Splice Sites (1)
Articles 1 - 4 of 4
Full-Text Articles in Molecular Biology
Systematic Analysis Of Dynamic Mirna-Target Interactions During C. Elegans Development, Liang Zhang, Molly Hammell, Brian Kudlow, Victor Ambros, Min Han
Systematic Analysis Of Dynamic Mirna-Target Interactions During C. Elegans Development, Liang Zhang, Molly Hammell, Brian Kudlow, Victor Ambros, Min Han
Victor R. Ambros
Although microRNA (miRNA)-mediated functions have been implicated in many aspects of animal development, the majority of miRNA::mRNA regulatory interactions remain to be characterized experimentally. We used an AIN/GW182 protein immunoprecipitation approach to systematically analyze miRNA::mRNA interactions during C. elegans development. We characterized the composition of miRNAs in functional miRNA-induced silencing complexes (miRISCs) at each developmental stage and identified three sets of miRNAs with distinct stage-specificity of function. We then identified thousands of miRNA targets in each developmental stage, including a significant portion that is subject to differential miRNA regulation during development. By identifying thousands of miRNA family-mRNA pairs with temporally …
Micrornas: Genetically Sensitized Worms Reveal New Secrets, Victor Ambros
Micrornas: Genetically Sensitized Worms Reveal New Secrets, Victor Ambros
Victor R. Ambros
Why do many microRNA gene mutants display no evident phenotype? Multiply mutant worms that are selectively impaired in genetic regulatory network activities have been used to uncover previously unknown functions for numerous Caenorhabditis elegans microRNAs.
Three-Dimensional Confocal Microscopy Indentation Method For Hydrogel Elasticity Measurement, Donghee Lee, Md Mahmudur Rahman, You Zhou, Sangjin Ryu
Three-Dimensional Confocal Microscopy Indentation Method For Hydrogel Elasticity Measurement, Donghee Lee, Md Mahmudur Rahman, You Zhou, Sangjin Ryu
Md Mahmudur Rahman
No abstract provided.
Hnrnp A1 And Secondary Structure Coordinate Alternative Splicing Of Mag, Nancy Zearfoss, Emily Johnson, Sean Ryder
Hnrnp A1 And Secondary Structure Coordinate Alternative Splicing Of Mag, Nancy Zearfoss, Emily Johnson, Sean Ryder
Sean P. Ryder
Myelin-associated glycoprotein (MAG) is a major component of myelin in the vertebrate central nervous system. MAG is present in the periaxonal region of the myelin structure, where it interacts with neuronal proteins to inhibit axon outgrowth and protect neurons from degeneration. Two alternatively spliced isoforms of Mag mRNA have been identified. The mRNA encoding the shorter isoform, known as S-MAG, contains a termination codon in exon 12, while the mRNA encoding the longer isoform, known as L-MAG, skips exon 12 and produces a protein with a longer C-terminal region. L-MAG is required in the central nervous system. How inclusion of …