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Full-Text Articles in Animal Sciences
Genvir, Dale L. Barnard
Genvir, Dale L. Barnard
Animal, Dairy, and Veterinary Science Faculty Publications
Flamel Technologies is developing Genvir (formerly known as Viropump), a twice-daily controlled-release formulation of aciclovir, for potential use in the treatment of herpes simplex virus and varicella zoster virus infections. Genvir utilizes Flamel's proprietary Micropump technology, a microparticle-based drug delivery system designed to extend the time of absorption of drugs in the small intestine. The drug shows a comparable therapeutic efficacy to valaciclovir and famciclovir (both GlaxoSmithKline) [313393]. Phase III trials have been completed [302829]. In August 2000, Flamel filed for regulatory approval for the treatment of herpes in France, as a prelude to a pan-European approval [378641] and is …
Utilization Of Alpha-1-Acid Glycoprotein Levels In The Serum As A Parameter For In Vivoassay Of Influenza Virus Inhibitors. Antivir Chem Chemother, R. W. Sidwell, M. H. Wong, K. W. Bailey, Dale L. Barnard, M. K. Jackson, Donald F. Smee
Utilization Of Alpha-1-Acid Glycoprotein Levels In The Serum As A Parameter For In Vivoassay Of Influenza Virus Inhibitors. Antivir Chem Chemother, R. W. Sidwell, M. H. Wong, K. W. Bailey, Dale L. Barnard, M. K. Jackson, Donald F. Smee
Animal, Dairy, and Veterinary Science Faculty Publications
Alpha-1-acid glycoprotein (AGP), an acute phase protein in serum assayed by single radial immunodiffusion using a commercially available kit, was found to significantly increase in mice infected with influenza A and B viruses. Experiments were run to determine the rate of increase of serum AGP and its relation to other influenza disease parameters, including lung consolidation, development of lung virus titres, decline in arterial oxygen saturation (SaO2), histopathological changes in the lung, and death of the animal. Maximal AGP levels occurred by day 3 in the animals, at about the same time lung virus titres reached their peak and inflammatory …
Inhibition Of Measles Virus Replication By 5'-Norcarbocyclic Nucleoside Analogs, Dale L. Barnard, V. Stowell, K. L. Seley, V. R. Hegde, R. Subha, P. Rajappan, S. W. Schneller, Donald F. Smee, R. W. Sidwell
Inhibition Of Measles Virus Replication By 5'-Norcarbocyclic Nucleoside Analogs, Dale L. Barnard, V. Stowell, K. L. Seley, V. R. Hegde, R. Subha, P. Rajappan, S. W. Schneller, Donald F. Smee, R. W. Sidwell
Animal, Dairy, and Veterinary Science Faculty Publications
Despite intense efforts to increase vaccine coverage, measles virus (MV) still causes significant morbidity and mortality in the world, sometimes as the result of severe, chronic, lethal disease. In an effort to develop therapies to supplement immunization strategies, a number of 5′-nor carbocyclic adenosine analogues were evaluated for anti-MV activity in CV-1 monkey kidney cells. Of those compounds tested, those either unsubstituted at C4 or possessing a hydroxyl, azido or amino substituent at that position were the most active, with particularly significant inhibition of MV, strain Chicago-1. The EC50 values against this strain ranged from100 mg/ml in actively growing and …
Prevention Of Viral Drug Resistance By Novel Combination Therapy, W. F. Mangel, M. T. Brown, M. L. Baniecki, Dale L. Barnard, W. J. Mcgrath
Prevention Of Viral Drug Resistance By Novel Combination Therapy, W. F. Mangel, M. T. Brown, M. L. Baniecki, Dale L. Barnard, W. J. Mcgrath
Animal, Dairy, and Veterinary Science Faculty Publications
A new form of antiviral clinical therapy is proposed in which three different drugs are administered against three different targets on the same virus-coded protein. If the physiological functions of the three different target sites are not independent of each other, then a mutation conferring drug resistance at one site may alter the physiological functions at the other sites and further drug resistance may not arise. The adenovirus proteinase, with its two cofactors that act synergistically on enzyme activity, may be a good model system within which to test the efficacy of this form of combination therapy.
Antioxidants Protect Turkeys Against Toxicity Of Aflatoxin, Roger A. Coulombe Jr.
Antioxidants Protect Turkeys Against Toxicity Of Aflatoxin, Roger A. Coulombe Jr.
Animal, Dairy, and Veterinary Science Faculty Publications
Toxins stemming from mold in feed grains are unavoidable in poultry production. "Mycotoxins" such as aflatoxin B (AFB1) are among the most potent liver-damaging toxins known. AFB1 is also a probable human carcinogen. Poultry are the most sensitive of all farm animals to the toxic effects of even small amounts of AFB1. Although poultry don’t generally live long enough to develop cancers, AFB1-related diseases adversely affect their health. This aflatoxin can cause slowing of growth and decreased resistance to microbial pathogens that make poultry ill. Because these toxins are so pervasive in feed grains, eliminating them has proved either impractical …