Animal Sciences Commons^™

Utilization Of Alpha-1-Acid Glycoprotein Levels In The Serum As A Parameter For In Vivoassay Of Influenza Virus Inhibitors. Antivir Chem Chemother, R. W. Sidwell, M. H. Wong, K. W. Bailey, Dale L. Barnard, M. K. Jackson, Donald F. Smee

Animal, Dairy, and Veterinary Science Faculty Publications

Alpha-1-acid glycoprotein (AGP), an acute phase protein in serum assayed by single radial immunodiffusion using a commercially available kit, was found to significantly increase in mice infected with influenza A and B viruses. Experiments were run to determine the rate of increase of serum AGP and its relation to other influenza disease parameters, including lung consolidation, development of lung virus titres, decline in arterial oxygen saturation (SaO2), histopathological changes in the lung, and death of the animal. Maximal AGP levels occurred by day 3 in the animals, at about the same time lung virus titres reached their peak and inflammatory …