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Brigham Young University

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Articles 361 - 390 of 3027

Full-Text Articles in Life Sciences

Weekly One-Day Water-Only Fasting Interventional Trial For Low-Density Lipoprotein Cholesterol Reduction (Wonderful), Ciera Lynn Bartholomew Mar 2021

Weekly One-Day Water-Only Fasting Interventional Trial For Low-Density Lipoprotein Cholesterol Reduction (Wonderful), Ciera Lynn Bartholomew

Theses and Dissertations

Purpose: Fasting has been promoted as a method of preventing disease and aging for thousands of years. With heart disease being a leading cause of death in the U.S., researchers have explored the effects of fasting on variables that influence cardiovascular disease (CVD), like LDL cholesterol. Therefore, the purpose of this study was to assess the effects of weekly water-only fasting on LDL cholesterol (LDL-C) in men and women with metabolic risk factors for CVD. Methods: This study was a randomized control trial in adult men and women. Participants were randomized to fasting (treatment) or normal diet (control). The fasting …

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Improving Perennial Bunchgrass Seeding Success In Annual Grass Invaded Areas Using Pre-Emergent Herbicide And Furrowing Techniques, Spencer Chad Camp Mar 2021

Improving Perennial Bunchgrass Seeding Success In Annual Grass Invaded Areas Using Pre-Emergent Herbicide And Furrowing Techniques, Spencer Chad Camp

Theses and Dissertations

Exotic annual weeds have transformed western North America, particularly in sagebrush-steppe systems. Restoration of these invaded sites has been met with low levels of success. Pre-emergent herbicide provides a means to control annual weeds, but typically, this treatment does not allow for the concurrent seeding of desired species. Seeding within a deep, U-shaped furrow following herbicide application may be a method to reduce pre-emergent herbicide effects by transferring the herbicide away from the seed at the time of planting. We tested this potential planting technique by spraying plots with or without the pre-emergent herbicide imazapic, and planting bunchgrass seeds either …

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The Relationship Between Hip Mobility And Performance On The Functional Movement Screen In Apparently Healthy Older Adults: A Preliminary Study, Kimberly Jaye Lindstrom Mar 2021

The Relationship Between Hip Mobility And Performance On The Functional Movement Screen In Apparently Healthy Older Adults: A Preliminary Study, Kimberly Jaye Lindstrom

Theses and Dissertations

Limited or asymmetrical hip mobility can affect movement patterns common to everyday living. The aim of this study was to evaluate the relationship between hip mobility and performance on the Functional Movement Screen (FMS) in apparently healthy older adults. This relationship was evaluated in both males and females. In this observational study, 20 older adults (10 male, 10 female, mean age = 65.65 ± 10.18 years old) completed the Functional Movement Screen and measurements of passive hip range of motion. Separate regression analyses and Pearson Product-Moment Correlations were used to evaluate the relationship between hip mobility measures and FMS composite …

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Telsam-Target Protein Fusions Can Form Diffraction-Quality Crystals Without Direct Inter-Polymer Contacts, Moriah Longhurst Mar 2021

Telsam-Target Protein Fusions Can Form Diffraction-Quality Crystals Without Direct Inter-Polymer Contacts, Moriah Longhurst

Undergraduate Honors Theses

X-ray diffraction is a robust method for determining the detailed 3D structures of specific proteins. However, this requires the formation of well-ordered protein crystals, a process that is time-consuming, expensive, and only has about a 10-30% success rate. New methods are needed to enable the efficient crystallization of challenging proteins. One such technique is explored here, which utilizes a protein polymer (the sterile alpha motif domain of the human protein translocation Ets leukemia, or TELSAM) as a crystallization chaperone to form a more ordered crystal lattice of target proteins and drive crystallization. This method was successfully used to crystallize, collect …

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Milk-Fat Intake And Differences In Abdominal Adiposity And Bmi: Evidence Based On 13,544 Randomly Selected Adults, Klarissa Rae Wilkinson Mar 2021

Milk-Fat Intake And Differences In Abdominal Adiposity And Bmi: Evidence Based On 13,544 Randomly Selected Adults, Klarissa Rae Wilkinson

Theses and Dissertations

The primary objective of this study was to evaluate the relationship between milk-fat intake and obesity, particularly abdominal obesity, in 13,544 U.S. adults. A secondary objective was to determine the extent to which the association was influenced by multiple potential confounding variables. This cross-sectional study used data from the 2011–2016 National Health and Nutrition Examination Survey (NHANES). Level of milk-fat content regularly consumed was the exposure variable. Body mass index (BMI) and sagittal abdominal diameter (SAD), a measure of abdominal obesity, were the outcome variables. SAD correlates strongly with visceral fat, when measured by computed tomography, and has been shown …

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Lymphocyte Proteomics For Monitoring Long Term Immune System Dynamics, Michaela Mccown Mar 2021

Lymphocyte Proteomics For Monitoring Long Term Immune System Dynamics, Michaela Mccown

Undergraduate Honors Theses

Time dependent change in lymphocytes provides a necessary background for monitoring the development of Chronic Lymphocytic Leukemia from asymptomatic to malignant. Several bulk proteomics studies characterize differences between tumor cells and healthy B cells, yet the transition to symptomatic disease is not well understood. This could be shown by a longitudinal study beginning with asymptomatic patients if the rare tumor cells in early stages can be isolated from small volume blood draws and effectively characterized with few cells, such as was done here using healthy B cells to provide a baseline for such studies to discriminate routine fluctuation from pathogenic …

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Spatiotemporal Analysis Of Variability In Soil Volumetric Water Content And Spatial Statistical Methods For Management Zone Delineation For Variable Rate Irrigation, Isak Lars Larsen Mar 2021

Spatiotemporal Analysis Of Variability In Soil Volumetric Water Content And Spatial Statistical Methods For Management Zone Delineation For Variable Rate Irrigation, Isak Lars Larsen

Theses and Dissertations

Irrigated agriculture is the largest user of freshwater in a world experiencing increased water scarcity and water demands. Variable rate irrigation (VRI) aims to use water efficiently in crop production, resulting in good yields and water conservation. With VRI, the grower is able to employ custom irrigation rates for different parts of a field. Adoption of VRI has been limited due to the complexity of matching irrigation to spatiotemporal crop water needs and the cost/benefit economics of VRI equipment. The goal of this study was to quantify spatiotemporal variability of VWC in a field that has uniform soil type and …

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Mutations In Hiv-1 Vpr Affect Pathogenesis In T-Lymphocytes And Novel Strategies To Contain The Current Covid-19 Pandemic, Antonio Solis Leal Feb 2021

Mutations In Hiv-1 Vpr Affect Pathogenesis In T-Lymphocytes And Novel Strategies To Contain The Current Covid-19 Pandemic, Antonio Solis Leal

Theses and Dissertations

Background SARS-CoV-2 is the virus responsible for the current global pandemic, COVID-19. Because this virus is novel, little is known about its sensitivity to disinfection. Methods We performed suspension tests against SARS-CoV-2 using three commercially available quaternary ammonium compound (Quat) disinfectants and one laboratory-made 0.2% benzalkonium chloride solution. Findings Three of the four formulations completely inactivated the virus within 15 s of contact, even in the presence of a soil load or when diluted in hard water. Conclusion Quats rapidly inactivate SARS-CoV-2, making them potentially useful for controlling SARS-CoV-2 spread in hospitals and the community.

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Supplemental Material (Metabolomics Of Acid Whey Derived From Greek Yogurt), Muriel Allen Feb 2021

Supplemental Material (Metabolomics Of Acid Whey Derived From Greek Yogurt), Muriel Allen

ScholarsArchive Data

Supplemental material from the study Metabolomics of Acid Whey Derived from Greek Yogurt.

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Cystic Fibrosis: An Ecological Review, Christopher Bozer Jan 2021

Cystic Fibrosis: An Ecological Review, Christopher Bozer

Student Works

This article focuses on the mechanisms of cystic fibrosis and the resulting microbial dysbiosis created through this disease. Through mutations in the CFTR gene, chloride ion proteins become dysfunctional, and mucus secreted in the lungs become thick and heavy, allowing infectious and pathogenic bacteria to thrive. 16s rRNA has been the primary method of sequencing the lung microbiome. Researchers have relied on bronchoscopies to collect proper samples. It can be concluded through current research that chloride ion dysfunction allows for an abnormal lung environment to develop. This abnormal environment allows for chronic infection of the lungs, and the formation of …

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Testing The Effect Of Aquarium-Based Learning On Patron Acceptance Of Evolutionary Theory, Jamie Jensen, Ethan R. Tolman, Spencer G. Shumway, Liam S. Williams Jan 2021

Testing The Effect Of Aquarium-Based Learning On Patron Acceptance Of Evolutionary Theory, Jamie Jensen, Ethan R. Tolman, Spencer G. Shumway, Liam S. Williams

ScholarsArchive Data

This is data collected prior to and directly following an intervention at a public aquarium in Idaho surrounding the reconciliation of evolution with religious audiences.

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In Vitro Screening Of Tp5801 Against Kinases For Nature Communications Publication, Joshua Andersen Jan 2021

In Vitro Screening Of Tp5801 Against Kinases For Nature Communications Publication, Joshua Andersen

ScholarsArchive Data

Data from screen of TP-5801 against in vitro kinases

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Improvement In 14-3-3 Binding Site Prediction, Katherine K. Mccormack Jan 2021

Improvement In 14-3-3 Binding Site Prediction, Katherine K. Mccormack

ScholarsArchive Data

The 14-3-3 family of phospho-binding proteins regulate a variety of major cellular processes through interaction with a network of dynamic proteins. Deregulation of the 14-3-3 interaction network contributes to a variety of degenerative disorders and cancers. Our lab focuses on identifying novel 14-3-3 interactions and understanding how 14-3-3 binding regulates protein function. A major gap in this process is that identifying the phospho-site where 14-3-3 docks on a given protein is time- and resource-consuming. Prediction algorithms have been developed to predict canonical 14-3-3 binding sites, however, there are many non-canonical sites that existing software is unable to predict. To fill …

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Kinase Screen Data For Nature Communications Publication, Joshua Andersen Jan 2021

Kinase Screen Data For Nature Communications Publication, Joshua Andersen

ScholarsArchive Data

A TNK1 peptide encompassing S502 was screened against 245 Ser/Thr kinases. This file contains kinase activity values (against S502) from an n=1 experiment. These data support a manuscript to be published in Nature Communications (Chan and Egbert et al.)

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Biological Pretreatment Of Biomass For Enhanced Biogas Production, Skylar F. Van Horne Dec 2020

Biological Pretreatment Of Biomass For Enhanced Biogas Production, Skylar F. Van Horne

Undergraduate Honors Theses

The biogas output efficiency of controlled anaerobic digestion (AD) can be enhanced by several different pretreatment methods to produce renewable energy. According to the literature, there are pros and cons to each pretreatment method. Biological pretreatment provides environmentally safe and renewable means for enhancing biodegradability and net energy output. Current research has yet to reliably demonstrate the ability of bacterial strains, such as Caldicellulosiruptor bescii (C. bescii), to digest common waste substrates in efficient ways. Novel methods in key intermediate molecular quantification and alkalinity tracking are used here to explore C. bescii’s ability to digest lignocellulosic material in …

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Identification Of Genes That Determine Fitness, Virulence, And Disease Outcomes In Mastitis Associated Eschericia Coli, Michael Andrew Olson Dec 2020

Identification Of Genes That Determine Fitness, Virulence, And Disease Outcomes In Mastitis Associated Eschericia Coli, Michael Andrew Olson

Theses and Dissertations

Escherichia coli is an incredibly diverse group of bacteria that consist of both commensal and pathogenic strains that cause disease in a wide variety of tissues in many different animals. The current dogma, based on years of extensive molecular and genetic studies, is that individual strains have adapted to specific environments through acquisition of specific genes or come from lineages that are particularly suited to a unique tissue or host. However, mastitis-associated E. coli (MAEC) have thus far resisted such descriptions. The fitness and virulence factors of MAEC are poorly understood and molecular tools are rarely applied. This dissertation reports …

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Antimicrobial Peptide Development: From Massively Parallel Peptide Sequencing To Bioinformatic Motif Identification, Alexander K. Erikson Dec 2020

Antimicrobial Peptide Development: From Massively Parallel Peptide Sequencing To Bioinformatic Motif Identification, Alexander K. Erikson

Theses and Dissertations

The isolation, purification, and clinical deployment of antibiotics is one of the major drivers of decrease in morbidity and mortality from infectious bacteria in the 20th century. The rapid, ubiquitous deployment of antibiotics encouraged swift development and distribution of antibiotic resistance. New, novel techniques, technologies, and ultimately therapeutic antimicrobial compounds will be required to counter the rise of antibiotic resistant microbes. Historically, mimicking naturally occurring compounds has been the most fruitful method for discovering new antibiotics; unsurprisingly, many recent efforts have focused on expanding the cultivation and detection of previously unknown microbes and compounds, respectively. Other techniques explore developing compounds …

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A Morphological Phylogeny Of Odonatoptera: Examining Missing Data In A Group With A Lot Of "Naturally" Missing Data, Robert James Erickson Dec 2020

A Morphological Phylogeny Of Odonatoptera: Examining Missing Data In A Group With A Lot Of "Naturally" Missing Data, Robert James Erickson

Theses and Dissertations

Odonatopera exhibit a wide diversity of morphologies for an ancient group of winged insects. A morphological matrix of 463 characters is compiled for 347 extant and fossil representatives used in parsimony analyses, implemented in TNT, to document arrangements of taxonomic groups above the family level. Missing data and other challenges approaches implemented and interpretation of the results. We employ a novel approach to testing monophyly relative to quantities of missing data for each taxon. Phylogenetic reconstructions recover patterns of monophyly and trends based on missing data. We discuss the implications of our findings on missing data as well as limitations …

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A Rapid Spectrophotometric Assay For Quantifying Seed Coat Saponins In Quinoa, Sydney Diver Szabo Dec 2020

A Rapid Spectrophotometric Assay For Quantifying Seed Coat Saponins In Quinoa, Sydney Diver Szabo

Theses and Dissertations

Background and objectives: The commonly used afrosimetric foam-height method for quantifying saponins in quinoa is rapid but imprecise. A rapid UV/Vis method, utilizing the Liebermann-Burchard (LB) color reaction, was compared to the foam method across a range of saponin levels in washed and unwashed seed. Findings: A 6 min UV/Vis method provided greater precision and accuracy than the afrosimetric method at the lower saponin levels found in washed quinoa. The afrosimetric method did not differentiate saponin levels below 0.6 mg/mL but allows for useful relative comparisons of saponin content in unwashed quinoa where the foam height is large. Conclusions: The …

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Climate Change, Increased Wildfire Frequency, And Rodent-Exclusion Create Opportunities For Exotic Grass Invasion And Alter The Timing And Availability Of Soil Water, Joshua Clark Gilman Dec 2020

Climate Change, Increased Wildfire Frequency, And Rodent-Exclusion Create Opportunities For Exotic Grass Invasion And Alter The Timing And Availability Of Soil Water, Joshua Clark Gilman

Theses and Dissertations

In deserts, global environmental changes, plant community structure, and soil water availability form a complex relationship characterized by direct and indirect relationships and feedbacks. Plant community structure is affected by the establishment and spread of invasive grasses, which form a positive feedback with wildfire. Plant community structure is also controlled by top-down trophic interactions by small-mammals and climate change, which alters the timing and amount of soil water. In deserts, soil water availability mediates the effects of global environmental changes and trophic interactions on plant community structure because it is the limiting resource for plant growth. In order to predict …

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Using Structural Equation Modeling To Model Compliance With Covid-19 Related Non-Pharmaceutical Interventions Amongst University Students In The United States, Spencer G. Shumway, Jonas D. Hopper, Ethan R. Tolman, Daniel G. Ferguson, Gabriella Hubble, David Patterson, Jamie Jensen Dec 2020

Using Structural Equation Modeling To Model Compliance With Covid-19 Related Non-Pharmaceutical Interventions Amongst University Students In The United States, Spencer G. Shumway, Jonas D. Hopper, Ethan R. Tolman, Daniel G. Ferguson, Gabriella Hubble, David Patterson, Jamie Jensen

ScholarsArchive Data

There are two data files. The "General Data" comes from a nationwide poll using Qualtrics polling software. The "Utah Data" comes from undergraduate biology students at UVU and BYU. The survey gathered demographic data and attitudes toward the COVID pandemic.

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A Lake Divided: Regional Shifts In Trophic Niche Structure Of Lake Powell Fishes Corresponding To The Invasion Of Quagga Mussels, Nathan Richard St Andre Dec 2020

A Lake Divided: Regional Shifts In Trophic Niche Structure Of Lake Powell Fishes Corresponding To The Invasion Of Quagga Mussels, Nathan Richard St Andre

Theses and Dissertations

Introduced species can become invasive and cause catastrophic alterations to the system they invade. Both zebra mussels (Dreissena polymorpha) and quagga mussels (Dreissena bugensis) have caused significant ecosystem alterations wherever they have invaded. These Dreissena species have caused changes in water quality and biodiversity and have disrupted energy pathways which can have cascading effects on other trophic levels. Recently quagga mussels invaded Lake Powell, a reservoir located in the southwestern USA, creating the possibility of a trophic cascade that could alter energy flow in the reservoir and change the trophic niche structure of the fishes in the lake. However, due …

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Improving Rangeland Seedling Recruitment Using Fungicide Seed Coatings And Golden Eagle Reproductive Success In Relation To Explosive Military Tests And Trainings, Benjamin William Hoose Nov 2020

Improving Rangeland Seedling Recruitment Using Fungicide Seed Coatings And Golden Eagle Reproductive Success In Relation To Explosive Military Tests And Trainings, Benjamin William Hoose

Theses and Dissertations

The objective of the first chapter of this thesis was to determine whether fungicide seed coatings constitute an effective strategy for increasing seedling recruitment in restoration scenarios in the Intermountain West. We tested a mixture of four fungicides that address potential fungal pathogens to bluebunch wheatgrass, a dominant bunchgrass that is commonly used in restoration. Across two sites and three years, we found that the fungicide seed coating increased emergence in five of the six sites and years, with an average increase of 59.1% over the control. There was a strong interaction (P < 0.001) between the effects of fungicide treatment, the year and the site on emergence. This interaction was likely related to the effects of the hydrothermal microsite environment on disease severity. Further research is necessary to fully understand the conditions under which fungicide seed coatings are most likely to be effective. The objectives the second chapter of this thesis were to 1) estimate the effects of golden eagle nest proximity to explosive disturbances on reproductive success given other relevant habitat variables (e.g. indices of topography and vegetation), and 2) determine the relative importance of nest proximity to explosive disturbances as a predictor of golden eagle reproductive success compared to other relevant habitat variables. Reproductive success data were collected from nesting territories within and surrounding land controlled and managed by the US Department of Defense. We fit the reproductive survey data using generalized linear mixed-effects models comprised of unique, hypothesis-based sets of habitat variables. We compared the models using AICc-based model selection processes. Given the best approximating model, we found no evidence that the likelihood of reproductive success was affected by nest proximity to explosive disturbances (P = 0.460). We further found nest proximity to explosive disturbances consistently ranked in the bottom 50% of relative variable importance. These results may indicate golden eagle tolerance or habituation to explosive military tests and trainings. Although the two chapters of this thesis are disjointed, they are loosely unified by the ecological importance of disturbance, invasive species, and restoration within the Great Basin ecoregion.

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Soil Water Dynamics Within Variable Rate Irrigation Zones Of Winter Wheat, Elisa Anne Woolley Nov 2020

Soil Water Dynamics Within Variable Rate Irrigation Zones Of Winter Wheat, Elisa Anne Woolley

Theses and Dissertations

Understanding the spatial and temporal dynamics of soil water and crop water stress within a field is critical for effective Variable Rate Irrigation (VRI) management. Proper VRI can result in improved protection of the crop from early onset of crop water stress while minimizing runoff and drainage losses. The objectives of this study are (1) to examine zone delineation for informing irrigation recommendations from volumetric water content (VWC) and field capacity (FC) to grow similar or greater wheat yields with less water, (2) evaluate the ability to model soil and crop water dynamics within a season and within a field …

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Movements And Space-Use Of Female Greater Sage-Grouse (Centrocercus Urophasianus) During Nesting And Breeding Seasons, Drew W. Retherford Nov 2020

Movements And Space-Use Of Female Greater Sage-Grouse (Centrocercus Urophasianus) During Nesting And Breeding Seasons, Drew W. Retherford

Theses and Dissertations

Greater sage-grouse (Centrocercus urophasianus) are a species of conservation concern throughout their range including the state of Idaho. Little is known about the size of areas used by female sage-grouse during the breeding and nesting seasons, fidelity of females to those areas, or fidelity of female sage-grouse to specific leks or nest sites. The recent miniaturization of global positioning system (GPS) transmitting devices allows for a more thorough analysis of this behavior. We placed GPS transmitters on 234 female sage-grouse in Idaho, USA, from 2015 to 2019. We monitored 145 nest attempts, 15 of which occurred in consecutive years, from …

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The Effects Of Passive Hallux Adduction On Posterior Tibial Artery Blood Flow Compared To The Lateral Plantar Artery, Jaysen Alani Hatch Nov 2020

The Effects Of Passive Hallux Adduction On Posterior Tibial Artery Blood Flow Compared To The Lateral Plantar Artery, Jaysen Alani Hatch

Theses and Dissertations

Passive hallux adduction has been shown to decrease blood flow in the lateral plantar artery (LPA) in a non-weight-bearing condition. Further research in weight-bearing and shod conditions is necessary to explore relationships between altered blood flow and injury or tissue healing. However, measuring blood flow in a shod foot would require an alternate measurement location to accommodate footwear, such as the more proximal posterior tibial artery (PTA). PURPOSE: To determine changes in blood flow in the PTA and LPA subsequent to passive hallux adduction and to compare the observed changes between the two arteries. Second, to determine if measurement at …

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Classification Of Planetary Craters Using Outline-Based Morphometrics, Thomas J. Slezak, Jani Radebaugh, Eric H. Christiansen, Mark C. Belk Nov 2020

Classification Of Planetary Craters Using Outline-Based Morphometrics, Thomas J. Slezak, Jani Radebaugh, Eric H. Christiansen, Mark C. Belk

Faculty Publications

The morphologies of craters on planetary surfaces reveal clues about the geologic mechanisms by which they originate and subsequently evolve, as well as the materials and physical variables inherent to the environment in which they formed. We carried out a quantitative multivariate analysis of shape descriptors derived from the outlines of craters formed by volcanic processes on Mars, Io, and Earth and by impact cratering on the Moon using elliptic Fourier analysis (EFA) and the Zahn-Roskies (Z-R) shape function. Canonical variate analysis (CVA) was used to construct a statistical model of differences between the crater groups to classify …

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Predators As Agents Of Selection And Diversification, Jerald B. Johnson, Mark C. Belk Oct 2020

Predators As Agents Of Selection And Diversification, Jerald B. Johnson, Mark C. Belk

Faculty Publications

Predation is ubiquitous in nature and can be an important component of both ecological and evolutionary interactions. One of the most striking features of predators is how often they cause evolutionary diversification in natural systems. Here, we review several ways that this can occur, exploring empirical evidence and suggesting promising areas for future work. We also introduce several papers recently accepted in Diversity that demonstrate just how important and varied predation can be as an agent of natural selection. We conclude that there is still much to be done in this field, especially in areas where multiple predator species prey …

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Comparative Efficacies Of Calmare Therapy And Transcutaneous Electrical Nerve Stimulation In Randomized Peripheral Neuropathy Subjects With Resting State Fmri Monitoring, Ty A. Bodily, Logan Edvalson, Jordan B. Peacock, Zack M. Bradshaw, Carson Hart, Cameron Ernst, Samuel Biggs, David D. Busath Oct 2020

Comparative Efficacies Of Calmare Therapy And Transcutaneous Electrical Nerve Stimulation In Randomized Peripheral Neuropathy Subjects With Resting State Fmri Monitoring, Ty A. Bodily, Logan Edvalson, Jordan B. Peacock, Zack M. Bradshaw, Carson Hart, Cameron Ernst, Samuel Biggs, David D. Busath

Faculty Publications

Clinical reports of Calmare protocol efficacy suggest enhanced durability compared to TENS and the possibility changes in resting fMRI connectivity. The objective was to compare peripheral neuropathy pain relief and resting fMRI changes with Calmare and TENS treatments. Randomized double-blind trials performed in August 2015 and between August 2016 and November 2017, with 18 and 20 human peripheral neuropathy subjects, respectively. The initial trial examined effects of a single session while the latter trial examined the effects of a course of ten treatment sessions on consecutive weekdays. fMRI scans were examined for changes in blood flow correlations and connectivity. Subjective …

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Hydroxychloroquine Prophylaxis For Covid-19, David D. Busath Oct 2020

Hydroxychloroquine Prophylaxis For Covid-19, David D. Busath

Faculty Publications

It is common in medicine that simple, inexpensive remedies are held hostage to medical prejudice, financial or political interest, and legal precedent. The purpose of this review is to take the point of view of the victims of COVID-19 and address whether scientific information, including randomized-control trials, can answer whether the hydroxychloroquine should be dispensed for those testing positive and their immediate recent contacts at the point of testing. Although the FDA in the United States is yet to be convinced, the demonstration of positive effects in clinical trials cannot be ignored and there is a large amount of information …

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