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Neuroscience and Neurobiology

2017

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Articles 571 - 576 of 576

Full-Text Articles in Life Sciences

Comparing Caenorhabditis Elegans Gentle And Harsh Touch Response Behavior Using A Multiplexed Hydraulic Microfluidic Device, Patrick D. Mcclanahan, Joyce Xu, Christopher Fang-Yen Dec 2016

Comparing Caenorhabditis Elegans Gentle And Harsh Touch Response Behavior Using A Multiplexed Hydraulic Microfluidic Device, Patrick D. Mcclanahan, Joyce Xu, Christopher Fang-Yen

Christopher Fang-Yen

The roundworm Caenorhabditis elegans is an important model system for understanding the genetics and physiology of touch. Classical assays for C. elegans touch, which involve manually touching the animal with a probe and observing its response, are limited by their low throughput and qualitative nature. We developed a microfluidic device in which several dozen animals are subject to spatially localized mechanical stimuli with variable amplitude. The device contains 64 sinusoidal channels through which worms crawl, and hydraulic valves that deliver touch stimuli to the worms. We used this assay to characterize the behavioral responses to gentle touch stimuli and the …

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Food Responsiveness Regulates Episodic Behavioral States In Caenorhabditis Elegans, Richard J. Mccloskey, Anthony D. Fouad, Matthew A. Churgin, Christopher Fang-Yen Dec 2016

Food Responsiveness Regulates Episodic Behavioral States In Caenorhabditis Elegans, Richard J. Mccloskey, Anthony D. Fouad, Matthew A. Churgin, Christopher Fang-Yen

Christopher Fang-Yen

Animals optimize sur- vival and reproduction in part through control of behavioral states, which depend on an organism’s internal and external environments. In the nematode Caenorhabditis elegans a variety of behavioral states have been described, including roaming, dwelling, quiescence, and episodic swimming. These states have been considered in isolation under varied experimental conditions, making it difficult to establish a unified picture of how they are regulated. Using long-term imaging, we examined C. elegans episodic behavioral states under varied mechanical and nutritional environments. We found that animals alternate between high-activity (active) and low-activity (sedentary) episodes in any mechanical environment, while the …

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Sensory Neurons Co-Opt Classical Immune Signaling Pathways To Mediate Chronic Itch.Pdf, Sisi Chen Dec 2016

Sensory Neurons Co-Opt Classical Immune Signaling Pathways To Mediate Chronic Itch.Pdf, Sisi Chen

SISI CHEN

No abstract provided.

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Sciatic Endometriosis Induces Mechanical Hypersensitivity,.Pdf, Sisi Chen Dec 2016

Sciatic Endometriosis Induces Mechanical Hypersensitivity,.Pdf, Sisi Chen

SISI CHEN

No abstract provided.

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Neurobiology Of The Premonitory Urge In Tourette's Syndrome: Pathophysiology And Treatment Implications, Andrea E. Cavanna, Kevin J. Black, Mark Hallett, Valerie Voon Dec 2016

Neurobiology Of The Premonitory Urge In Tourette's Syndrome: Pathophysiology And Treatment Implications, Andrea E. Cavanna, Kevin J. Black, Mark Hallett, Valerie Voon

Kevin J. Black, MD

Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette's syndrome (TS). Although traditional descriptions have focused on objective phenomenological observations, such as anatomical location, number and frequency of tics, patients' first-person accounts have consistently reported characteristic subjective correlates. These sensory phenomena are often described as a feeling of mounting inner tension or urge to move ("premonitory urge"), which is transiently relieved by tic expression. This article reviews the existing literature on the clinical and neurobiological aspects of the premonitory urge in patients with TS, with focus on its pathophysiology and possible treatment implications.

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Whole Genome Dna Methylation Sequencing Of The Chicken Retina, Cornea And Brain, Isac Lee, Bejan A. Rasoul, Ashton S. Holub, Alannah Lejeune, Raymond A. Enke, Winston Timp Dec 2016

Whole Genome Dna Methylation Sequencing Of The Chicken Retina, Cornea And Brain, Isac Lee, Bejan A. Rasoul, Ashton S. Holub, Alannah Lejeune, Raymond A. Enke, Winston Timp

Ray Enke Ph.D.

No abstract provided.

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