Nanoscience and Nanotechnology Commons^™

Nano-Biophysical Approaches For Assessing Nanoparticle Interactions With Biological Systems, Zachary Untracht

Electronic Theses and Dissertations

Understanding interactions between nanoparticles and biological systems is fundamental for the development of emerging nano-biotechnology applications. In this thesis, I present an investigation of zinc oxide (ZnO) nanoparticles interactions with biomolecules in two separate studies. The first section of my thesis covers tracking and detection of ZnO nanoparticles using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). ZinkicideTM is a bactericidal ZnO nanoparticle which has been developed for agriculture. The characterization of Zinkicide in biological media and in solution has been difficult due to its high dispersibility and ultra-small size. SDS-PAGE is considered a golden standard for protein qualitative interpretations. In …

Femtosecond Photon-Mediated Plasma Enhances Photosynthesis Of Plasmonic Nanostructures And Their Sers Applications, Peng Ran, Lan Jiang, Xin Li, Bo Li, Pei Zuo, Yongfeng Lu

Department of Electrical and Computer Engineering: Faculty Publications

Laser ablation in liquid has proven to be a universal and green method to synthesize nanocrystals and fabricate functional nanostructures. This study demonstrates the superiority of femtosecond laser-mediated plasma in enhancing photoredox of metal cations for controllable fabrication of plasmonic nanostructures in liquid. Through employing upstream high energetic plasma during laser-induced microexplosions, single/three-electron photoreduction of metallic cations can readily occur without chemical reductants or capping agents. Experimental evidences demonstrate that this process exhibits higher photon utilization efficiency in yield of colloidal metal nanoparticles than direct irradiation of metallic precursors. Photogenerated hydrated electrons derived from strong ionization of silicon and water …

Titanium Nitride Nanotube Electrode, Gui Chen, Marcella Gatti

Research Opportunities for Engineering Undergraduates (ROEU) Program 2018-19

This project presents a corrosion-resistant and high capacity implantable TiN nanotube electrode to work as a neural probe. Smaller electrode size allows for reduced tissue damage while the nanopore morphology of the TiN gives a larger surface area and stability to the electrode. The electrode offers improved biocompatibility, reduced tissue damage, reduced cost, and increased usability over time.

Fast Growth Of Thin Mapbi3 Crystal Wafers On Aqueous Solution Surface For Efficient Lateral-Structure Perovskite Solar Cells, Ye Liu, Qingfeng Dong, Yanjun Fang, Yuze Lin, Yehao Deng, Jinsong Huang

Department of Mechanical and Materials Engineering: Faculty Publications

Solar-grade single or multiple crystalline wafers are needed in large quantities in the solar cell industry, and are generally formed by a top-down process from crystal ingots, which causes a significant waste of materials and energy during slicing, polishing, and other processing. Here, a bottom-up technique that allows the growth of wafer-size hybrid perovskite multiple crystals directly from aqueous solution is reported. Single-crystalline hybrid perovskite wafers with centimeter size are grown at the top surface of a perovskite precursor solution. As well as saving raw materials, this method provides unprecedented advantages such as easily tunable thickness and rapid growth of …

The Role Of Low-Level Image Features In The Affective Categorization Of Rapidly Presented Scenes, L. Jack Rhodes, Matthew Rios, Jacob M. Williams, Gonzalo Quinones, Prahalada K. Rao, Vladimir Miskovic

Department of Mechanical and Materials Engineering: Faculty Publications

It remains unclear how the visual system is able to extract affective content from complex scenes even with extremely brief (< 100 millisecond) exposures. One possibility, suggested by findings in machine vision, is that low-level features such as unlocalized, two-dimensional (2-D) Fourier spectra can be diagnostic of scene content. To determine whether Fourier image amplitude carries any information about the affective quality of scenes, we first validated the existence of image category differences through a support vector machine (SVM) model that was able to discriminate our intact aversive and neutral images with ~ 70% accuracy using amplitude-only features as inputs. This model allowed us to confirm that scenes belonging to different affective categories could be mathematically distinguished on the basis of amplitude spectra alone. The next question is whether these same features are also exploited by the human visual system. Subsequently, we tested observers’ rapid classification of affective and neutral naturalistic scenes, presented briefly (~33.3 ms) and backward masked with synthetic textures. We tested categorization accuracy across three distinct experimental conditions, using: (i) original images, (ii) images having their amplitude spectra swapped within a single affective image category (e.g., an aversive image whose amplitude spectrum has been swapped with another aversive image) or (iii) images having their amplitude spectra swapped between affective categories (e.g., an aversive image containing the amplitude spectrum of a neutral image). Despite its discriminative potential, the human visual system does not seem to use Fourier amplitude differences as the chief strategy for affectively categorizing scenes at a glance. The contribution of image amplitude to affective categorization is largely dependent on interactions with the phase spectrum, although it is impossible to completely rule out a residual role for unlocalized 2-D amplitude measures.

Segregation Of Mo Atoms Into Stacking Faults In Crfeconimo Alloy, Kaisheng Ming, Xiaofang Bi, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

Solute segregation at dislocations can impede the motion of dislocations, strengthening materials. Here, we study the formation and role of solute segregation at dislocations in CrFeCoNiMo high-entropy alloys (HEAs) by high-angle annular dark-field scanning transmission electron microscopy imaging and mechanical testing both deformed and annealed samples. Mo atoms exhibit pronounced segregation into the planar-extended core of dislocations, i.e. stacking faults, causing the increase in the yield strength while the loss of the ductility. This work suggests that mechanical properties of HEAs can be tailored by alloying additional elements that are in favor of segregation into dislocations.

Disposable Fluidic Self-Propelling Robot For Traversing A Tubular Passage, Carl Nelson, Benjamin Terry, Abolfazl Pourghodrat, Hossein Dehghani, Dmitry Oleynikov, Prithviraj Dasgupta

Department of Mechanical and Materials Engineering: Faculty Publications

A probe for traversing a tubular passage includes an introducer to be supported at an entrance to the tubular passage. The probe also includes a probe tip to traverse the tubular passage, and a tube with an inflatable tube segment. In some embodiments, the inflatable tube segment is storable in the probe tip. The inflatable tube segment is configured to be inflated to push the probe tip away from the introducer toward an end on the tubular passage. In some embodiments, the probe includes a sealing mechanism, whre the sealing mechanism can be positioned between the inflatable tube segment of …

Robotic Devicewith Compact Joint Design And Related Systems And Methods, Tom Frederick, Eric Markvicka, Shane Michael Farritor, Dmitry Oleynikov

Department of Mechanical and Materials Engineering: Faculty Publications

The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices.

Gentamicin-Modified Nanocarriers For Placental Targeted Drug Delivery To Treat Pregnancy-Related Complications, Ali Alfaifi

Wayne State University Dissertations

Diseases of pregnancy are the leading cause of maternal and neonatal morbidity and mortality affecting more than 20% (26 million) of all pregnancies annually. Those diseases include preeclampsia, preterm labor, intrauterine growth restriction and gestational diabetes, many of which are caused by compromised functions of the placenta. Placenta is a specialized organ that is only present during pregnancy where it creates a maternal-fetal interface that is responsible for many functions that contribute to the development of the fetus. Unfortunately, there is currently no treatment for any of those diseases. Our work focuses on the development of a novel nanoplatform that …

Developments Towards High-Flux Silica Nanosphere Substrates To Support Conforming Self-Assembled Gold Nanoparticle Monolayers For Applications In Size-Selective Filtration, Ryan Baker Vincent

Theses, Dissertations and Capstones

Hydrophobic thiol coated gold nanoparticles have recently been investigated for their ability to self-assemble into robust, ultra-thin, porous membranes at a liquid-vapor interface. Due to the well-ordered, hexagonal close-packed nanoparticle arrays formed during the self-assembly process, these 2-dimensional sheets have very well-defined pore structures and have been shown to span gaps of several microns under ideal conditions. While these self-assembled nanoparticle monolayers have very promising applications in the field of size-selective filtration due to their well-defined pore structure, they need to be supported by a rigid substrate with a large amount of open area. Here, tightly packed arrays of silica …

Au@Tio2 Nanocomposites Synthesized By X-Ray Radiolysis As Potential Radiosensitizers, Maria C. Molina Higgins

Theses and Dissertations

Radiosensitization is a novel targeted therapy strategy where chemical compounds are being explored to enhance the sensitivity of the tissue to the effects of ionizing radiation. Among the different radiosensitizers alternatives, nanomaterials have shown promising results by enhancing tumor injury through the production of free radicals and reactive oxygen species (ROS). In this work, Gold-supported titania (Au@TiO₂) nanocomposites were synthesized through an innovative strategy using X-ray irradiation, and their potential as radiosensitizers was investigated. Radiosensitization of Au@TiO₂ nanocomposites was assessed by monitoring the decomposition of Methylene Blue (MB) under X-ray irradiation in the presence of the nanomaterial. …

Resonant Acoustic Wave Assisted Spin-Transfer-Torque Switching Of Nanomagnets, Austin R. Roe

Theses and Dissertations

We studied the possibility of achieving an order of magnitude reduction in the energy dissipation needed to write bits in perpendicular magnetic tunnel junctions (p-MTJs) by simulating the magnetization dynamics under a combination of resonant surface acoustic waves (r-SAW) and spin-transfer-torque (STT). The magnetization dynamics were simulated using the Landau-Lifshitz-Gilbert equation under macrospin assumption with the inclusion of thermal noise. We studied such r-SAW assisted STT switching of nanomagnets for both in-plane elliptical and circular perpendicular magnetic anisotropy (PMA) nanomagnets and show that while thermal noise affects switching probability in in-plane nanomagnets, the PMA nanomagnets are relatively robust to the …

Potential Of Nanoscale Elements To Control Fusarium Wilt Disease In Tomato (Solanum Lycopersicum), Enhance Macronutrient Use Efficiency, And Increase Its Yield, Ishaq Olarewaju Adisa

Open Access Theses & Dissertations

Nanotechnology has a great potential in ensuring food production, security and safety globally. Over the past decade, research on the use of nanomaterials to supply nutrient elements and protect plants from pest and diseases has significantly increased. Tomato (Solanum lycopersicum) is one of the most consumed vegetables in the world and United State is one of its largest producers globally generating billions of dollars annually in revenue.. Tomato plants are affected worldwide by Fusarium wilt caused by Fusarium oxysporum f. sp. Lycopersici. There is growing concern about excessive use of conventional pesticides in controlling Fusarium and other diseases in tomato …

Magnetic Nanoparticles For Hyperthermia For Cancer Treatment, Bianca Paola Meneses Brassea

Open Access Theses & Dissertations

Fe3O4 and NixCu4-x magnetic nanoparticles were synthesized using supercritical conditions of liquids and wet chemistry, respectively. Characterization methods (VSM, SEM, TEM, and magnetic hyperthermia) yielded results that prove feasibility for magnetic hyperthermia for cancer treatment.

Numerical Study On The Dynamic Process Of Single Plume Flow In Thermal Convection With Polymers, Jian-Ping Cheng, Wei-Hua Cai, Hong-Na Zhang, Feng-Chen Li, Lian Shen, Shi-Zhi Qian

Mechanical & Aerospace Engineering Faculty Publications

A direct numerical simulation of single plume flow in thermal convection with polymers was carried out in a domain with 1:3 as the width to height ratio. The heat transport ability is weakened by adding polymers within the here-investigated governing parameter range. However, it is promoted when the maximum polymer extension L is increased. The distribution of vertical velocity and temperature indicates that the plume in the polymer solution case is speeded up and widens bigger as compared to that in the Newtonian fluid case. Inside the plume, polymer chains tend to release energy at the position where the …

Nitrogen-Vacancy Centers In Diamond For Nanoscale Magnetic Resonance Imaging Applications, Alberto Boretti, Lorenzo Rosa, Jonathan Blackledge, Stefania Castelletto

Articles

The nitrogen-vacancy (NV) center is a point defect in diamond with unique properties for use in ultra-sensitive, high-resolution magnetometry. One of the most interesting and challenging applications is nanoscale magnetic resonance imaging (nano-MRI). While many review papers have covered other NV centers in diamond applications, there is no survey targeting the specific development of nano-MRI devices based on NV centers in diamond. Several different nano-MRI methods based on NV centers have been proposed with the goal of improving the spatial and temporal resolution, but without any coordinated effort. After summarizing the main NV magnetic imaging methods, this review presents a …

High Strength, Deformable Nanotwinned Al–Co Alloys, S. Xue, Qiang Li, D. Y. Xie, Y. F. Zhang, Han Wang, Haiyan Wong, J. Wang, Xinghang Zhang

Department of Mechanical and Materials Engineering: Faculty Publications

Aluminum (Al) alloys have been widely used in the transportation industry. However, most highstrength Al alloys to date have limited mechanical strength, on the order of a few hundred MPa, which is much lower than the flow stress of high-strength steels. In this study, we show the fabrication of nanocrystalline Al alloys with high-density growth twins enabled by a few atomic percent of Co solute. In situ uniaxial compression tests show that the flow stress of Al–Co solid solution alloys exceeds 1.5 GPa, while good work hardening capability is maintained. This study provides a new perspective on the design of …

Mass Spectrometry Analysis Of Contaminants Of Emerging Concern: Nanoparticles, Algal Toxins, And Cyanotoxins In Natural Waters And Their Potential Health Impacts, Ariel R. Donovan

Doctoral Dissertations

“The analysis of contaminants of emerging concern is critical to protecting environmental health. In the presented dissertation, two groups of contaminants of emerging concern were assessed using mass spectrometry methods: nanoparticles and algal and cyanotoxins.

Analysis of metal oxide nanoparticles in environmental matrices has been a challenging issue, as most traditional methods require complicated sample preparation methods or that can alter or destroy the nanoparticles in the system. Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) methods were used to detect metal oxide nanoparticles in surface waters and their removal through drinking water treatment simulations while retaining all information regarding …

Surface Modification Of Silver Nanoparticle (Agnp) By Liposomal Encapsulation Mitigates Agnp-Induced Inflammation, Azeez O. Yusef, Alan Casey

Articles

Silver nanoparticles (AgNP) are widely used in a variety of consumable products as antibacterial to prevent or treat infection. Unfortunately, evidence exits that AgNP induces inflammation which can worsen with repeated human exposure. However, there is little or no research on how to mitigate these adverse effects due to AgNP induced-toxicity. Here, we investigated if surface modification of AgNP by liposomal encapsulation suppresses AgNP-mediated inflammatory responses in THP1 monocytes and THP1 differentiated macrophages (TDM). AgNP was encapsulated in a dipalmitoyl phosphatidyl choline- (DPPC)/cholesterol-based liposome by extrusion through a 100-nm polycarbonate membrane to form Lipo-AgNP. It was found as expected that …

Evaluation Of Silver Nanoparticle Encapsulation In Dppc-Based Liposome By Different Methods For Enhanced Cytotoxicity, Azeez O. Yusef, Alan Casey

Articles

Here we carried out a comparative study on two cost and time effective methods of encapsulating silver nanoparticles (AgNP) in dipalmitoyl-phosphatidyl choline (DPPC)/cholesterol-based liposome to enhance nanoparticle cytotoxicity, and evaluated the effect of this on a blood cell line (THP1 monocytes) often involved in uptake of nanoparticles during human exposure. DLS and Zeta potential analyses over a 6-months period showed the extruded Lipo-AgNP (Ex-Lipo-AgNP) exhibited more stable characteristics when compared with the probe-sonicated Lipo-AgNP (PB-Lipo-AgNP). SEM microscopy indicated agglomeration of the PB-Lipo-AgNP which was not observed in Ex-Lipo-AgNP. Ex-Lipo-AgNP also exhibited higher temperature-dependent stability with 35.3% reduction in size from …

Flaw Detection With Ultrasonic Backscatter Signal Envelopes, Yongfeng Song, Christopher M. Kube, Zuoxiang Peng, Joseph A. Turner, Xiongbing Li

Department of Mechanical and Materials Engineering: Faculty Publications

Ultrasound is a prominent nondestructive testing modality for the detection, localization, and sizing of defects in engineering materials. Often, inspectors analyze ultrasonic waveforms to determine if echoes, which stem from the scattering of ultrasound from a defect, exceed a threshold value. In turn, the initial selection of the threshold value is critical. In this letter, a time-dependent threshold or upper bound for the signal envelope is developed based on the statistics governing the scattering of ultrasound from microstructure. The utility of the time-dependent threshold is demonstrated using experiments conducted on sub-wavelength artificial defects. The results are shown to enhance current …

Hemodynamics And Wall Mechanics After Surgical Repair Of Aortic Arch: Implication For Better Clinical Decisions, Siyeong Ju, Ibrahim Abdullah, Shengmao Lin, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

Graft repair of aortic coarctation is commonly used to mimic the physiological aortic arch shape and function. Various graft materials and shapes have been adopted for the surgery. The goal of this work is to quantitatively assess the impact of graft materials and shapes in the hemodynamics and wall mechanics of the restored aortic arch and its correlation with clinical outcomes. A three-dimensional aortic arch model was reconstructed from magnetic resonance images. The fluid–structure interaction (FSI) analysis was performed to characterize the hemodynamics and solid wall mechanics of the repaired aortic arch. Two graft shapes (i.e., a half-moon shape and …

Interface Facilitated Reorientation Of Mg Nanolayers In Mg-Nb Nanolaminates, Y. Chen, Mingyu Gong, N. A. Mara, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

Mg/Nb nanolaminates synthesized through vapor deposition techniques exhibit high flow strength without conventional twinning in Mg. In this work, we investigated the influence of laminated microstructures on deformation mechanisms of Mg nanolayers. Using molecular dynamics simulations, we explored that (0001)-oriented Mg layers transform or re-orient to {10¯10}-oriented Mg layers through nucleation and growth of {10¯12} twins by atomic shuffling, instead of conventional {10¯12} twinning shear. Such a reorientation accommodates in-plane compressive strain and out-of-plane tensile strain when Mg/Nb laminates are subjected to compression parallel to the Mg/Nb interfaces. The nucleation of {10¯12} twins is promoted at the Mg/Nb interface due …

Monolithic Heat-Transfer Device, Sidy Ndao, George Gogos, Dennis Alexander, Troy Anderson, Craig Zuhlke

Department of Mechanical and Materials Engineering: Faculty Publications

A monolithic heat-transfer device can include a container wall configured to retain a working fluid, where the container wall is formed of a single material. The container wall also includes an interior surface configured to be in fluid communication with the working fluid. The monolithic heat-transfer device also includes a channel disposed in the interior surface of the container wall, where the channel comprises a microstructure and a nanostructure. The microstructure and the nanostructure are materially contiguous with the single material forming the container wall. In some embodiments, the nanostructure comprises one or more layers of nanoparticles. The monolithic heat-transfer …

Higher-Order Overtone Thickness-Shear Vibrations Of Multilayered Thin-Film Acoustic Wave Resonators And Angular Rate Sensing, Hui Chen, Ji Wang, Jianke Du, Jiashi Yang

Department of Mechanical and Materials Engineering: Faculty Publications

We propose a new structure for piezoelectric gyroscopes. It is made from multilayered thin films of AlN or ZnO with alternating c-axes along the film thickness. It is shown theoretically that when such a film is electrically driven into higher-order overtone thickness-shear vibration in one of the two in-plane directions of the film and is rotating about the film normal, the Coriolis force due to the rotation causes a higher-order overtone thicknessshear vibration in a perpendicular direction with an electrical output that can be used to measure the angular rate of the rotation. Different from existing thickness-shear mode piezoelectric gyroscopes …

Glocal Integrity In 420 Stainless Steel By Asynchronous Laser Processing, Michael P. Sealy, Haitham Hadidi, Cody Kanger, X. L. Yan, Bai Cui, J. A. Mcgeough

Department of Mechanical and Materials Engineering: Faculty Publications

Cold working individual layers during additive manufacturing (AM) by mechanical surface treatments, such as peening, effectively “prints” an aggregate surface integrity that is referred to as a glocal (i.e., local with global implications) integrity. Printing a complex, pre-designed glocal integrity throughout the build volume is a feasible approach to improve functional performance while mitigating distortion. However, coupling peening with AM introduces new manufacturing challenges, namely thermal cancellation, whereby heat relaxes favorable residual stresses and work hardening when printing on a peened layer. Thus, this work investigates glocal integrity formation from cyclically coupling LENS® with laser peening on 420 stainless steel.

9r Phase Enabled Superior Radiation Stability Of Nanotwinned Cu Alloys Via In Situ Radiation At Elevated Temperature, Cuncai Fan, Dongyue Xie, Jin Li, Zhongxia Shang, Youxing Chen, Sichuang Xue, Jian Wang, Meimei Li, Anter El-Azab, Haiyan Wang, Xinghang Zhang

Department of Mechanical and Materials Engineering: Faculty Publications

Nanotwinned metals exhibit outstanding radiation tolerance as twin boundaries effectively engage, transport and eliminate radiation-induced defects. However, radiation-induced detwinning may reduce the radiation tolerance associated with twin boundaries, especially at elevated temperatures. Here we show, via in-situ Kr ion irradiation inside a transmission electron microscope, that 3 at. % Fe in epitaxial nanotwinned Cu (Cu₉₇Fe₃) significantly improves the thermal and radiation stability of nanotwins during radiation up to 5 displacements-per-atom at 200 °C. Such enhanced stability of nanotwins is attributed to a diffuse 9R phase resulted from the dissociation of incoherent twin boundaries in nanotwinned Cu …

Three-Dimensional Character Of The Deformation Twin In Magnesium, Y. Liu, P.Z. Tang, M.Y. Gong, R.J. Mccabe, J. Wang, C.N. Tome

Department of Mechanical and Materials Engineering: Faculty Publications

Deformation twins are three-dimensional domains, traditionally viewed as ellipsoids because of their two-dimensional lenticular sections. In this work, we performed statistical analysis of twin shapes viewing along three orthogonal directions: the ‘dark side’ (DS) view along the twin shear direction (η1), the twinning plane normal (TPN) view (k1) and the ‘bright side’ (BS) view along the direction λ(=k1 × η1). Our electron back-scatter diffraction results show that twins in the DS and BS views normally exhibit a lenticular shape, whereas they show an irregular shape in the TPN view. Moreover, the findings in the TPN view revealed that twins grow …

Spatiotemporal Characterizations Of Spontaneously Beating Cardiomyocytes With Adaptive Reference Digital Image Correlation, Akankshya Shradhanjali, Brandon D. Riehl, Bin Duan, Ruiguo Yang, Jung Yul Lim

Department of Mechanical and Materials Engineering: Faculty Publications

We developed an Adaptive Reference-Digital Image Correlation (AR-DIC) method that enables unbiased and accurate mechanics measurements of moving biological tissue samples. We applied the AR-DIC analysis to a spontaneously beating cardiomyocyte (CM) tissue, and could provide correct quantifications of tissue displacement and strain for the beating CMs utilizing physiologically-relevant, sarcomere displacement length-based contraction criteria. The data were further synthesized into novel spatiotemporal parameters of CM contraction to account for the CM beating homogeneity, synchronicity, and propagation as holistic measures of functional myocardial tissue development. Our AR-DIC analyses may thus provide advanced non-invasive characterization tools for assessing the development of spontaneously …

Compliant Surgical Graspers And Methods Of Making And Using, Carl Nelson, Alan Goyzueta

Department of Mechanical and Materials Engineering: Faculty Publications

This disclosure describes compliant graspers for use in endoscopic surgeries.