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Articles 1 - 14 of 14
Full-Text Articles in Biomaterials
An Investigation Of Process Parameters To Optimize The Fiber Diameter Of Electrospun Vascular Scaffolds Through Experimental Design, Steffi Wong
Biomedical Engineering
No abstract provided.
Synthesis And Characterization Of Diamond-Like Carbon Thin Films For Biomedical Applications, Russell Lee Leonard
Synthesis And Characterization Of Diamond-Like Carbon Thin Films For Biomedical Applications, Russell Lee Leonard
Masters Theses
Diamond-like carbon (DLC) thin films were produced by pulsed laser deposition (PLD) on silicon, fused silica, and silicon nitride substrates. The films produced were either undoped, made using a pure graphite target, or doped, using multi-component targets made from a combination of graphite and silicon, silicon nitride, titanium dioxide, or silicon monoxide. These films were evaluated for their potential use in biomedical applications, including coatings for artificial joints, heart stents, and bronchoscopes. The films were characterized by Raman spectroscopy, atomic force microscopy, ball-on-flat tribometry, contact angle measurements, and spectrophotometry. Film thickness was determined by optical profilometry. Film adhesion was checked …
Controlled Delivery Of Serp-1 Protein From Poly(Vinyl Alcohol) Hydrogel, Karen L. Kennedy
Controlled Delivery Of Serp-1 Protein From Poly(Vinyl Alcohol) Hydrogel, Karen L. Kennedy
Electronic Thesis and Dissertation Repository
Poly(vinyl alcohol) (PVA) was selected and evaluated as a controlled drug delivery matrix for Serp-1, a potential new therapeutic with anti-inflammatory properties for control of restenosis. PVA hydrogels, containing a high water content, can be formed by physical crosslinking via a process involving freezing and thawing the material in multiple cycles. PVA, being a well known biomaterial, is suited for biomedical applications and the high water content and hydrophilicity provides a friendly environment for the delivery of large protein based drugs. Using bovine serum albumin (BSA) as a model protein, the controlled release properties of PVA were investigated. Release profiles …
Rapid Cell Extraction In Aqueous Two-Phase Microdroplet Systems, Kalpana Vijayakumar, Shelly Gulati, Andrew J. De Mello, Joshua B. Edel
Rapid Cell Extraction In Aqueous Two-Phase Microdroplet Systems, Kalpana Vijayakumar, Shelly Gulati, Andrew J. De Mello, Joshua B. Edel
All Faculty Articles - School of Engineering and Computer Science
Distinguishing specific cells is an essential technique in cell research and clinical diagnostics. We report a novel method to passively isolate and extract cells in a microfluidic device. We utilise a droplet-based microfluidic system to generate an aqueous two phase system in which aqueous droplets consist of two phases in the form of a double emulsion. Specifically, we generate PEG droplets that completely encapsulate DEX droplets within a microfluidic channel. Target cells can be introduced directly into the droplets and driven to partition to the more favourable phase, whilst still being contained within the aqueous droplet. Human T lymphoma cells, …
A New Multilayer Composite With Functionally Graded Design For Endodontic Application., Ahmed A. Madfa
A New Multilayer Composite With Functionally Graded Design For Endodontic Application., Ahmed A. Madfa
Ahmed A. Madfa
Multilayer composite with FG structure were fabricated using zirconia (ZrO), alumina (AI2O3), Hydroxyapatite (HA) and titanium (Ti) micropowders. Powder selection and their combination in each layer were according to the results of finite element analysis.
The Gel Documentation System: A Cornerstone To The Implementation Of The Introduction To Biotechnology And Introduction To Bioinformatics Cross-Disciplinary Course Series, Marcy Kelly, Gregory Lampard, Constance Knapp
The Gel Documentation System: A Cornerstone To The Implementation Of The Introduction To Biotechnology And Introduction To Bioinformatics Cross-Disciplinary Course Series, Marcy Kelly, Gregory Lampard, Constance Knapp
Cornerstone 3 Reports : Interdisciplinary Informatics
No abstract provided.
Developing Chitosan-Based Biomaterials For Brain Repair And Neuroprosthetics, Zheng Cao
Developing Chitosan-Based Biomaterials For Brain Repair And Neuroprosthetics, Zheng Cao
Masters Theses
Chitosan is widely investigated for biomedical applications due to its excellent properties, such as biocompatibility, biodegradability, bioadhesivity, antibacterial, etc. In the field of neural engineering, it has been extensively studied in forms of film and hydrogel, and has been used as scaffolds for nerve regeneration in the peripheral nervous system and spinal cord. One of the main issues in neural engineering is the incapability of neuron to attach on biomaterials. The present study, from a new aspect, aims to take advantage of the bio-adhesive property of chitosan to develop chitosan-based materials for neural engineering, specifically in the fields of brain …
Synthesis Of An Endothelial Cell Mimicking Surface Containing Thrombomodulin And Endothelial Protein C Receptor, Karl E. Kador
Synthesis Of An Endothelial Cell Mimicking Surface Containing Thrombomodulin And Endothelial Protein C Receptor, Karl E. Kador
Department of Chemical and Biomolecular Engineering: Theses and Student Research
Synthetic materials for use in blood contacting applications have been studied for many years with limited success. One of the main areas of need for these materials is the design of synthetic vascular grafts for use in the hundreds of thousands of patients who have coronary artery bypass grafting, many without suitable veins for autologous grafts. The design of these grafts is constrained by two common modes of failure, the formation of intimal hyperplasia (IH) and thrombosis. IH formation has been previously linked to a mismatching of the mechanical properties of the graft and has been overcome by creating grafts …
Microstructural Characteristics Of Functionally Graded Materials Designed As Dental Post, Ahmed A. Madfa
Microstructural Characteristics Of Functionally Graded Materials Designed As Dental Post, Ahmed A. Madfa
Ahmed A. Madfa
To study the interfaces and microstructure of multilayered materials fabricated based on functionally graded concept for use as dental posts.
, Geun-Cheol Gil, William H. Velander, Kevin E. Van Cott
, Geun-Cheol Gil, William H. Velander, Kevin E. Van Cott
Kevin Van Cott Publications
Human protein C (hPC) is glycosylated at three Asn-X-Ser/Thr and one atypical Asn-X-Cys sequons. We have characterized the micro- and macro-heterogeneity of plasma-derived hPC and compared the glycosylation features with recombinant protein C (tg-PC) produced in a transgenic pig bioreactor from two animals having approximately tenfold different expression levels. The N-glycans of hPC are complex di- and tri-sialylated structures, and we measured 78% site occupancy at Asn-329 (the Asn-X-Cys sequon). The N-glycans of tg-PC are complex sialylated structures, but less branched and partially sialylated. The porcine mammary epithelial cells glycosylate the Asn-X-Cys sequon with a similar efficiency as human hepatocytes …
New Generation Of The Dental Posts For Endodontic Application., Ahmed A. Madfa
New Generation Of The Dental Posts For Endodontic Application., Ahmed A. Madfa
Ahmed A. Madfa
Fabricated multilayer dental post with the functionally graded design is a novel product that exhibits graded properties varied from coronal to apical parts of the tooth. The new dental post definitely performs better than posts available in the market and improves the quality of human life
Influence Of Compressible Aerogel Electrodes On The Properties Of An Electrochemical Cell, Chris Sponheimer
Influence Of Compressible Aerogel Electrodes On The Properties Of An Electrochemical Cell, Chris Sponheimer
Electronic Theses and Dissertations
In the biomedical field the need for intra organ pressure measurement can only be facilitated by adapting existing pressure sensing technology to the specific tissues under test. The customization of these sensors has only driven up cost and the need to explore new technologies has become increasingly more important. For this dissertation, we explore the use of a new technology, particularly electrochemical pressure sensing to provide a low-cost pressure sensor to fill this need. Preliminary testing showed that electrically conductive polymers exhibited a change in voltage when pressurized if bubbles were first electrolyzed in the gel creating an aerogel, and …
Destruction Of Α -Synuclein Based Amyloid Fibrils By A Low Temperature Plasma Jet, Erdinc Karakas, Agatha Munyanyi, Lesley Greene, Mounir Laroussi
Destruction Of Α -Synuclein Based Amyloid Fibrils By A Low Temperature Plasma Jet, Erdinc Karakas, Agatha Munyanyi, Lesley Greene, Mounir Laroussi
Electrical & Computer Engineering Faculty Publications
Amyloid fibrils are ordered beta-sheet aggregates that are associated with a number of neurodegenerative diseases such as Alzheimer and Parkinson. At present, there is no cure for these progressive and debilitating diseases. Here we report initial studies that indicate that low temperature atmospheric pressure plasma can break amyloid fibrils into smaller units in vitro. The plasma was generated by the plasma pencil, a device capable of emitting a long, low temperature plasma plume/jet. This avenue of research may facilitate the development of a plasma-based medical treatment.
Retrofit Of Distillation Columns In Biodiesel Production Plants, Nghi Nguyen, Yaşar Demirel
Retrofit Of Distillation Columns In Biodiesel Production Plants, Nghi Nguyen, Yaşar Demirel
Yaşar Demirel Publications
Column grand composite curves and the exergy loss profiles produced by the Column-Targeting Tool of the Aspen Plus simulator are used to assess the performance of the existing distillation columns, and reduce the costs of operation by appropriate retrofits in a biodiesel production plant. Effectiveness of the retrofits is assessed by means of thermodynamics and economic improvements. We have considered a biodiesel plant utilizing three distillation columns to purify biodiesel (fatty acid methyl ester) and byproduct glycerol as well as reduce the waste. The assessments of the base case simulation have indicated the need for modifications for the distillation columns. …