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Articles 1 - 30 of 81

Full-Text Articles in Biomedical Engineering and Bioengineering

Advancements And Challenges In Additively Manufactured Functionally Graded Materials: A Comprehensive Review, Suhas Alkunte, Ismail Fidan, Vivekanand Naikwadi, Shamil Gudavasov, Mohammad Alshaikh Ali, Mushfig Mahmudov, Seymur Hasanov, Muralimohan Cheepu Jan 2024

Advancements And Challenges In Additively Manufactured Functionally Graded Materials: A Comprehensive Review, Suhas Alkunte, Ismail Fidan, Vivekanand Naikwadi, Shamil Gudavasov, Mohammad Alshaikh Ali, Mushfig Mahmudov, Seymur Hasanov, Muralimohan Cheepu

Engineering Technology Faculty Publications

This paper thoroughly examines the advancements and challenges in the field of additively manufactured Functionally Graded Materials (FGMs). It delves into conceptual approaches for FGM design, various manufacturing techniques, and the materials employed in their fabrication using additive manufacturing (AM) technologies. This paper explores the applications of FGMs in diverse fields, including structural engineering, automotive, biomedical engineering, soft robotics, electronics, 4D printing, and metamaterials. Critical issues and challenges associated with FGMs are meticulously analyzed, addressing concerns related to production and performance. Moreover, this paper forecasts future trends in FGM development, highlighting potential impacts on diverse industries. The concluding section summarizes …

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Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen Dec 2023

Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen

Purdue Journal of Service-Learning and International Engagement

Engineering Projects in Community Service (EPICS) is a service-learning design program run by the College of Engineering at Purdue University. EPICS teaches students design skills by providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. Biomedical Engineering is a team within EPICS that strives to serve community partners through biomedical applications. HR is a patient who suffers from severe lymphedema. This condition results in her foot swelling three times its original size and requires her to utilize weekly leg compression therapy. Prescription shoes are slightly adequate. However, they lead to sores and pain …

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Effects Of Noise Electrical Stimulation On Proprioception, Force Control, And Corticomuscular Functional Connectivity, Li-Wei Chou, Shiang-Lin Hou, Hui-Min Lee, Felipe Fregni, Alice Yen, Vincent Chiun-Fan Chen, Shun-Hwa Wei, Chung-Lan Kao May 2023

Effects Of Noise Electrical Stimulation On Proprioception, Force Control, And Corticomuscular Functional Connectivity, Li-Wei Chou, Shiang-Lin Hou, Hui-Min Lee, Felipe Fregni, Alice Yen, Vincent Chiun-Fan Chen, Shun-Hwa Wei, Chung-Lan Kao

Engineering Science Faculty Publications

Sensory afferent inputs play an important role in neuromuscular functions. Subsensory level noise electrical stimulation enhances the sensitivity of peripheral sensory system and improves lower extremity motor function. The current study aimed to investigate the immediate effects of noise electrical stimulation on proprioceptive senses and grip force control, and whether there are associated neural activities in the central nervous system. Fourteen healthy adults participated in 2 experiments on 2 different days. In day 1, participants performed grip force and joint proprioceptive tasks with and without (sham) noise electrical stimulation. In day 2, participants performed grip force steady hold task before …

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Finite Element Modeling Of Meniscal Tears Using Continuum Damage Mechanics And Digital Image Correlation, Derek Q. Nesbitt, Dylan E. Burruel, Bradley S. Henderson, Trevor J. Lujan Mar 2023

Finite Element Modeling Of Meniscal Tears Using Continuum Damage Mechanics And Digital Image Correlation, Derek Q. Nesbitt, Dylan E. Burruel, Bradley S. Henderson, Trevor J. Lujan

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Meniscal tears are a common, painful, and debilitating knee injury with limited treatment options. Computational models that predict meniscal tears may help advance injury prevention and repair, but first these models must be validated using experimental data. Here we simulated meniscal tears with finite element analysis using continuum damage mechanics (CDM) in a transversely isotropic hyperelastic material. Finite element models were built to recreate the coupon geometry and loading conditions of forty uniaxial tensile experiments of human meniscus that were pulled to failure either parallel or perpendicular to the preferred fiber orientation. Two damage criteria were evaluated for all experiments: …

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Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole Nov 2022

Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole

Purdue Journal of Service-Learning and International Engagement

EPICS (Engineering Projects in Community Service) is a service-learning design program run through Purdue University. It strives to teach students design skills through providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Bio-medical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. Members of a health care team often spend valuable time organizing cables associated with machines used to take patients’ vital signs. Due to time constraints and the fast-paced work environment, these cables may be mismanaged and damaged. The BME team is working on a …

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An Introductory Module In Medical Image Segmentation For Bme Students, Christine Buffinton, Donna Ebenstein, James W. Baish Sep 2022

An Introductory Module In Medical Image Segmentation For Bme Students, Christine Buffinton, Donna Ebenstein, James W. Baish

Faculty Journal Articles

To support recent trends toward the use of patient-specific anatomical models from medical imaging data, we present a learning module for use in the undergraduate BME curriculum that introduces image segmentation, the process of partitioning digital images to isolate specific anatomical features. Five commercially available software packages were evaluated based on their perceived learning curve, ease of use, tools for segmentation and rendering, special tools, and cost: ITK-SNAP, 3D Slicer, OsiriX, Mimics, and Amira. After selecting the package best suited for a stand-alone course module on medical image segmentation, instructional materials were developed that included a general introduction to imaging, …

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Flexible Battery-Less Wireless Glucose Monitoring System, Saikat Banerjee, Gymama Slaughter Jan 2022

Flexible Battery-Less Wireless Glucose Monitoring System, Saikat Banerjee, Gymama Slaughter

Bioelectrics Publications

In this work, a low power microcontroller-based near field communication (NFC) interfaced with a flexible abiotic glucose hybrid fuel cell is designed to function as a battery-less glucose sensor. The abiotic glucose fuel cell is fabricated by depositing colloidal platinum (co–Pt) on the anodic region and silver oxide nanoparticles-multiwalled carbon nanotubes (Ag2O-MWCNTs) composite on the cathodic region. The electrochemical behavior is characterized using cyclic voltammetry and chronoamperometry. This glucose hybrid fuel cell generated an open circuit voltage of 0.46 V, short circuit current density of 0.444 mA/cm2, and maximum power density of 0.062 mW/cm2 at 0.26 V …

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Integration Of Neural Architecture Within A Finite Element Framework For Improved Neuromusculoskeletal Modeling, Victoria L. Volk, Landon D. Hamilton, Donald R. Hume, Kevin B. Shelburne, Clare K. Fitzpatrick Nov 2021

Integration Of Neural Architecture Within A Finite Element Framework For Improved Neuromusculoskeletal Modeling, Victoria L. Volk, Landon D. Hamilton, Donald R. Hume, Kevin B. Shelburne, Clare K. Fitzpatrick

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Neuromusculoskeletal (NMS) models can aid in studying the impacts of the nervous and musculoskeletal systems on one another. These computational models facilitate studies investigating mechanisms and treatment of musculoskeletal and neurodegenerative conditions. In this study, we present a predictive NMS model that uses an embedded neural architecture within a finite element (FE) framework to simulate muscle activation. A previously developed neuromuscular model of a motor neuron was embedded into a simple FE musculoskeletal model. Input stimulation profiles from literature were simulated in the FE NMS model to verify effective integration of the software platforms. Motor unit recruitment and rate coding …

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Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi Oct 2021

Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi

Purdue Journal of Service-Learning and International Engagement

Because of its extreme rarity, the genetic disease arthrogryposis multiplex congenita (AMC) and the needs of individuals with the diagnosis are often overlooked. AMC refers to the development of nonprogressive contractures in disparate areas of the body and is characterized by decreased flexibility in joints, muscle atrophy, and developmental delays. Colton Darst, a seven-year-old boy from Indianapolis, Indiana, was born with the disorder, and since then, he has undergone numerous surgical interventions and continues to receive orthopedic therapy to reduce his physical limitations. His parents, Michael and Amber Darst, have hopes for him to regain his limbic motion and are …

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Novel Insights Into Negative Pressure Wound Healing From An In Situ Porcine Perspective, Jacob G. Hodge, Ashley L. Pistorio, Christopher A. Neal, Hongyan Dai, Jennifer G. Nelson-Brantley, Molly E. Steed, Richard A. Korentager, David S. Zamierowski, Adam J. Mellott Oct 2021

Novel Insights Into Negative Pressure Wound Healing From An In Situ Porcine Perspective, Jacob G. Hodge, Ashley L. Pistorio, Christopher A. Neal, Hongyan Dai, Jennifer G. Nelson-Brantley, Molly E. Steed, Richard A. Korentager, David S. Zamierowski, Adam J. Mellott

School of Medicine Faculty Publications

Negative pressure wound therapy (NPWT) is used clinically to promote tissue formation and wound closure. In this study, a porcine wound model was used to further investigate the mechanisms as to how NPWT modulates wound healing via utilization of a form of NPWT called the vacuum-assisted closure. To observe the effect of NPWT more accurately, non-NPWT control wounds containing GranuFoam™ dressings, without vacuum exposure, were utilized. In situ histological analysis revealed that NPWT enhanced plasma protein adsorption throughout the GranuFoam™, resulting in increased cellular colonization and tissue ingrowth. Gram staining revealed that NPWT decreased bacterial dissemination to adjacent tissue with …

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Somatic Inhibition By Microscopic Magnetic Stimulation, Hui Ye Jun 2021

Somatic Inhibition By Microscopic Magnetic Stimulation, Hui Ye

Biology: Faculty Publications and Other Works

Electric currents can produce quick, reversible control of neural activity. Externally applied electric currents have been used in inhibiting certain ganglion cells in clinical practices. Via electromagnetic induction, a miniature-sized magnetic coil could provide focal stimulation to the ganglion neurons. Here we report that high-frequency stimulation with the miniature coil could reversibly block ganglion cell activity in marine mollusk Aplysia californica, regardless the firing frequency of the neurons, or concentration of potassium ions around the ganglion neurons. Presence of the ganglion sheath has minimal impact on the inhibitory effects of the coil. The inhibitory effect was local to the …

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The Hate Within, Kora Kukk May 2021

The Hate Within, Kora Kukk

Honors College

A novel in its beginning stages, The Hate Within (May 2021) is the product of discovering a way to be able to eloquently combine biomedical engineering with creative writing which will intrigue young adult readers. This thesis contains the first few chapters of the story along with an additional journal entry, the story’s outline with a list of plot events, and a disquisition exploring the motivation and methodology behind creating this thesis.The novel is about a junior in high school named Alaita. She is a super sweet, kind, and popular girl in school until one day she is diagnosed with …

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Neurovascular Catheter Measurement System Development For Process And Design Effect Evaluation, Cathal Tadhg Merz Jan 2021

Neurovascular Catheter Measurement System Development For Process And Design Effect Evaluation, Cathal Tadhg Merz

Theses

Neurovascular guide catheters are used to treat problems affecting blood vessels within the brain through minimally invasive procedures. Catheters are inserted into the patient via their femoral or brachial arteries and manually navigated to the brain to deliver treatment. This procedure replaces the requirement to cut into the patient’s skull and brain tissue but is limited by reduction of blood vessel lumen diameter and increase in tortuosity of blood vessels deep in the brain. During these procedures, catheters can sometimes fail by kinking or fracturing into two pieces. The rate of failure by fracture of a particular neurovascular catheter device …

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Low-Intensity Vibration Restores Nuclear Yap Levels And Acute Yap Nuclear Shuttling In Mesenchymal Stem Cells Subjected To Simulated Microgravity, Matthew Thompson, Kali Woods, Joshua Newberg, Julia Thom Oxford, Gunes Uzer Dec 2020

Low-Intensity Vibration Restores Nuclear Yap Levels And Acute Yap Nuclear Shuttling In Mesenchymal Stem Cells Subjected To Simulated Microgravity, Matthew Thompson, Kali Woods, Joshua Newberg, Julia Thom Oxford, Gunes Uzer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Reducing the musculoskeletal deterioration that astronauts experience in microgravity requires countermeasures that can improve the effectiveness of otherwise rigorous and time-expensive exercise regimens in space. The ability of low-intensity vibrations (LIV) to activate force-responsive signaling pathways in cells suggests LIV as a potential countermeasure to improve cell responsiveness to subsequent mechanical challenge. Mechanoresponse of mesenchymal stem cells (MSC), which maintain bone-making osteoblasts, is in part controlled by the “mechanotransducer” protein YAP (Yes-associated protein), which is shuttled into the nucleus in response to cyto-mechanical forces. Here, using YAP nuclear shuttling as a measurement outcome, we tested the effect of 72 h …

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Axonal Blockage With Microscopic Magnetic Stimulation, Hui Ye Oct 2020

Axonal Blockage With Microscopic Magnetic Stimulation, Hui Ye

Biology: Faculty Publications and Other Works

Numerous neurological dysfunctions are characterized by undesirable nerve activity. By providing reversible nerve blockage, electric stimulation with an implanted electrode holds promise in the treatment of these conditions. However, there are several limitations to its application, including poor bio-compatibility and decreased efficacy during chronic implantation. A magnetic coil of miniature size can mitigate some of these problems, by coating it with biocompatible material for chronic implantation. However, it is unknown if miniature coils could be effective in axonal blockage and, if so, what the underlying mechanisms are. Here we demonstrate that a submillimeter magnetic coil can reversibly block action potentials …

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Effect Of Bout Length On Gait Measures In People With And Without Parkinson’S Disease During Daily Life, Vrutangkumar Shah, James Mcnames, Graham Harker, Martina Mancini, Patricia Carlson-Kuhta, John G. Nutt, Mahmoud El-Gohary, Carolin Curtze, Fay Horak Oct 2020

Effect Of Bout Length On Gait Measures In People With And Without Parkinson’S Disease During Daily Life, Vrutangkumar Shah, James Mcnames, Graham Harker, Martina Mancini, Patricia Carlson-Kuhta, John G. Nutt, Mahmoud El-Gohary, Carolin Curtze, Fay Horak

Electrical and Computer Engineering Faculty Publications and Presentations

Although the use of wearable technology to characterize gait disorders in daily life is increasing, there is no consensus on which specific gait bout length should be used to characterize gait. Clinical trialists using daily life gait quality as study outcomes need to understand how gait bout length affects the sensitivity and specificity of measures to discriminate pathological gait as well as the reliability of gait measures across gait bout lengths. We investigated whether Parkinson’s disease (PD) affects how gait characteristics change as bout length changes, and how gait bout length affects the reliability and discriminative ability of gait measures …

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Fabrication And Characterization Of Flexible Three-Phase Zno-Graphene-Epoxy Electro-Active Thin-Film Nanocomposites: Towards Applications In Wearable Biomedical Devices, Mandeep Singh, Sanjeev Kumar, Shervin Zoghi, Debaki Sarcar, Saquib Ahmed, Shaestagir Chowdhury, Sankha Banerjee Jul 2020

Fabrication And Characterization Of Flexible Three-Phase Zno-Graphene-Epoxy Electro-Active Thin-Film Nanocomposites: Towards Applications In Wearable Biomedical Devices, Mandeep Singh, Sanjeev Kumar, Shervin Zoghi, Debaki Sarcar, Saquib Ahmed, Shaestagir Chowdhury, Sankha Banerjee

Mechanical and Materials Engineering Faculty Publications and Presentations

Perovskite oxides have been used as sensors, actuators, transducers, for sound generation and detection, and also in optical instruments and microscopes. Perovskite halides are currently considered as optoelectronic devices such as solar cells, photodetectors, and radiation detection, but there are major issues with stability, interfacial recombination, and electron/hole mobility. The following work looks into the fabrication of non-toxic ZnO-based lead-free alternatives to perovskite oxides for use as secondary sensors or electron transport layers along with perovskite halides for application in stacked biomedical wearable devices. Three-phase, lead-free, Zinc Oxide-Graphene-Epoxy electroactive nanocomposite thin films were fabricated. The volume fraction of the Graphene …

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An Improved Method For Hospital Acquired Pressure Ulcer (Hapu) Prevention, Julia Beekman, Jillian Yeager, Megan Morrissey Jun 2020

An Improved Method For Hospital Acquired Pressure Ulcer (Hapu) Prevention, Julia Beekman, Jillian Yeager, Megan Morrissey

Honors Theses

Hospital acquired pressure ulcers (HAPUs), also called bedsores, are damage to the skin and/or underlying tissue caused by prolonged pressure on the bony areas of the body, with around 20% of pressure ulcers occurring in the heel region. Currently, the most common practice for HAPU prevention is arbitrary manual repositioning of patients by nurses every 1-2 hours. The goal of our project was to address HAPUs in the heel region of low mobility patients through an ulceration risk sensing system. Our team has created a wearable ulceration risk assessment system that combines individual patient risk data with real time pressure …

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Modified Stent Design For A Coronary Bifurcation Lesion, Abigail Nowell May 2020

Modified Stent Design For A Coronary Bifurcation Lesion, Abigail Nowell

Biological Sciences Undergraduate Honors Theses

Currently, 18.2 million adults aged 20 and older are diagnosed with Coronary Artery Disease (CAD) (Benjamin et al., 2019). Stenosis is the most common intervention. However, when a patient has a bifurcated artery, treatment becomes more difficult and is often unsuccessful. This project created a new stent and balloon complex that was tested in vitro using a gel phantom artery model. Two separate prototypes have been created and tested so far, with improvements made upon each. Testing is still underway with Prototype 2.

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Enhancement Of The Syncardia Total Artificial Heart For Pediatric Use, Margaret Clark, Madison Marks Jan 2020

Enhancement Of The Syncardia Total Artificial Heart For Pediatric Use, Margaret Clark, Madison Marks

Williams Honors College, Honors Research Projects

Pediatric patients with disorders and diseases of the heart have limited options with regards to implantable devices. Many of these implants are ventricular assist devices, which is not always suitable for a patient. Total artificial hearts (TAHs) have supported many adult patients until transplantation, and we believe that they could do the same for pediatric patients. SynCardia has the only Food and Drug Administration (FDA) approved TAH devices. Since SynCardia is the only company with FDA approved TAHs, we decided to modify the design of the SynCardia TAH for use in pediatric patients without compromising the function of the current …

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A Multi-Scale Approach To Study Biochemical And Biophysical Aspects Of Resveratrol On Diesel Exhaust Particle-Human Primary Lung Cell Interaction, Wei Zhang, Qifei Li, Mingjie Tang, Han Zhang, Xiaoping Sun, Sige Zou, Judy L. Jensen, Theodore G. Liou, Anhong Zhou Dec 2019

A Multi-Scale Approach To Study Biochemical And Biophysical Aspects Of Resveratrol On Diesel Exhaust Particle-Human Primary Lung Cell Interaction, Wei Zhang, Qifei Li, Mingjie Tang, Han Zhang, Xiaoping Sun, Sige Zou, Judy L. Jensen, Theodore G. Liou, Anhong Zhou

Biological Engineering Faculty Publications

Diesel exhaust particles (DEPs) are major air pollutants that lead to numerous human disorders, especially pulmonary diseases, partly through the induction of oxidative stress. Resveratrol is a polyphenol that ameliorates the production of reactive oxygen species (ROS) and delays aging-related processes. Herein we studied the cytoprotective effect of resveratrol on DEP-exposed human lung cells in a factorial experimental design. This work investigates biophysical features including cellular compositions and biomechanical properties, which were measured at the single-cell level using confocal Raman microspectroscopy (RM) and atomic force microscopy (AFM), respectively. Principal component analysis (PCA), hierarchical cluster analysis (HCA) and partial least square …

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Improving 3d Printed Prosthetics With Sensors And Motors, Rachel Zarin Jul 2019

Improving 3d Printed Prosthetics With Sensors And Motors, Rachel Zarin

Honors Projects

A 3D printed hand and arm prosthetic was created from the idea of adding bionic elements while keeping the cost low. It was designed based on existing models, desired functions, and materials available. A tilt sensor keeps the hand level, two motors move the wrist in two different directions, a limit switch signals the fingers to open and close, and another motor helps open and close the fingers. All sensors and motors were built on a circuit board, programmed using an Arduino, and powered by a battery. Other supporting materials include metal brackets, screws, guitar strings, elastic bands, small clamps, …

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Seeing Eye To Eye: A Machine Learning Approach To Automated Saccade Analysis, Maigh Attre May 2019

Seeing Eye To Eye: A Machine Learning Approach To Automated Saccade Analysis, Maigh Attre

Honors Scholar Theses

Abnormal ocular motility is a common manifestation of many underlying pathologies particularly those that are neurological. Dynamics of saccades, when the eye rapidly changes its point of fixation, have been characterized for many neurological disorders including concussions, traumatic brain injuries (TBI), and Parkinson’s disease. However, widespread saccade analysis for diagnostic and research purposes requires the recognition of certain eye movement parameters. Key information such as velocity and duration must be determined from data based on a wide set of patients’ characteristics that may range in eye shapes and iris, hair and skin pigmentation [36]. Previous work on saccade analysis has …

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Biomedical Engineering Or Biomedical Optics: Will The Real Discipline Please Stand Up?, Brian W. Pogue Apr 2019

Biomedical Engineering Or Biomedical Optics: Will The Real Discipline Please Stand Up?, Brian W. Pogue

Dartmouth Scholarship

This editorial reflects on the shape of biomedical engineering as a discipline, and its relation to biomedical optics.

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Development Of An Astrocyte/Glioma Co-Culture System For Measuring Cellular Dynamics, Urna Kansakar Feb 2019

Development Of An Astrocyte/Glioma Co-Culture System For Measuring Cellular Dynamics, Urna Kansakar

Doctoral Dissertations

Gliomas are brain tumors that primarily arise from glial cells. Gliomas account for 70% of the brain tumors and they are more prevalent in older adults. About 60% of the people with gliomas experience at least one seizure. Brain tumors can grow and metastasize to neighboring areas, thereby destroying normal brain cells. In a brain tumor microenvironment, both malignant cancer cells and healthy brain cells are present. Studies have shown that astrocytes may have a role in tumor growth in the brain. Monocultures cannot evaluate interactions between two cell types and does not accurately represent in vivo conditions. Thus, a …

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Recovery Of Stem Cell Proliferation By Low Intensity Vibration Under Simulated Microgravity Requires Linc Complex, H. Touchstone, R. Bryd, S. Loisate, M. Thompson, X. Pu, R. Beard, J. T. Oxford, G. Uzer Jan 2019

Recovery Of Stem Cell Proliferation By Low Intensity Vibration Under Simulated Microgravity Requires Linc Complex, H. Touchstone, R. Bryd, S. Loisate, M. Thompson, X. Pu, R. Beard, J. T. Oxford, G. Uzer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Mesenchymal stem cells (MSC) rely on their ability to integrate physical and spatial signals at load bearing sites to replace and renew musculoskeletal tissues. Designed to mimic unloading experienced during spaceflight, preclinical unloading and simulated microgravity models show that alteration of gravitational loading limits proliferative activity of stem cells. Emerging evidence indicates that this loss of proliferation may be linked to loss of cellular cytoskeleton and contractility. Low intensity vibration (LIV) is an exercise mimetic that promotes proliferation and differentiation of MSCs by enhancing cell structure. Here, we asked whether application of LIV could restore the reduced proliferative capacity seen …

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Grant Funding Needs Parallel The Start-Up Venture: An Analogy For Translational Research Success, Brian W. Pogue Aug 2018

Grant Funding Needs Parallel The Start-Up Venture: An Analogy For Translational Research Success, Brian W. Pogue

Dartmouth Scholarship

This editorial offers some ways to think about how best to position a research group for funding, by examining the parallels between what is needed for translational grants versus industry start-ups.

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Foot Stress And Blood Flow Sensing Under High-Loading During Hip Surgery, Chris Cardenas, Esther Chen, Claire Kingston, Katie Paswaters, Brianna Rodebaugh Jun 2018

Foot Stress And Blood Flow Sensing Under High-Loading During Hip Surgery, Chris Cardenas, Esther Chen, Claire Kingston, Katie Paswaters, Brianna Rodebaugh

Mechanical Engineering

The PolyHIPS team was tasked with integrating sensors into Stryker’s hip arthroscopy boot that monitor blood flow and heel slip during hip surgery. During hip arthroscopy, the femur head is distracted from the acetabulum to create space in the joint for the surgeon to operate. This requires the use of up to 200 lbf. In order to maintain this space, the foot is held tightly in the boot. Complications can result from the foot being held too tightly in the boot during the procedure. The most common complication is neuropraxia, or temporary nerve damage. PolyHIPS proposes a solution that utilizes …

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3d Printed Force Transducers For In-Vitro Mitral Valve Chordae Tendineae Force Measurements, Hayley Chandler May 2018

3d Printed Force Transducers For In-Vitro Mitral Valve Chordae Tendineae Force Measurements, Hayley Chandler

Biomedical Engineering Undergraduate Honors Theses

Mitral valve surgery is incredibly prevalent in the United States with more than 40,000 mitral valve surgical procedures annually. Improving the imaging techniques used to diagnose these cases requires validation of 3D models through experimental data such as mechanical properties of the tissue. An essential part of this process for the mitral valve is measuring the force experienced by chordae tendineae. This has been achieved with brass force transducers but using a 3D printed design can have many benefits. In this study, 3D printed miniature c-shaped force transducers comparable to previous metal models were designed and created using Solidworks 2016. …

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Increasing Drug Delivery Efficacy Of Drug-Coated Balloons, Alexander Galan, Eric Bidinger, Franco Godoy, Shrusti Patel Apr 2018

Increasing Drug Delivery Efficacy Of Drug-Coated Balloons, Alexander Galan, Eric Bidinger, Franco Godoy, Shrusti Patel

Senior Theses

Peripheral artery disease (PAD), the narrowing of peripheral arteries located in areas such as the arms and legs, is a common disease that affects 12% to 20% of people over 65. Numerous therapies have been developed to treat PAD, the most recent technology being drug-coated balloons. Drug-coated balloons release drugs, such as Paclitaxel (PTX), into the arterial wall during balloon angioplasty to locally treat PAD. Current levels of drug transfer from the balloon to the vascular endothelium are at a low 10%-18%. Our Biomedical Engineering Senior Design project aims to increase drug delivery of drug-coated balloons by manipulating the clinically-controllable …

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