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Full-Text Articles in Biomedical Engineering and Bioengineering

Grant Funding Needs Parallel The Start-Up Venture: An Analogy For Translational Research Success, Brian W. Pogue Aug 2018

Grant Funding Needs Parallel The Start-Up Venture: An Analogy For Translational Research Success, Brian W. Pogue

Dartmouth Scholarship

This editorial offers some ways to think about how best to position a research group for funding, by examining the parallels between what is needed for translational grants versus industry start-ups.


Foot Stress And Blood Flow Sensing Under High-Loading During Hip Surgery, Chris Cardenas, Esther Chen, Claire Kingston, Katie Paswaters, Brianna Rodebaugh Jun 2018

Foot Stress And Blood Flow Sensing Under High-Loading During Hip Surgery, Chris Cardenas, Esther Chen, Claire Kingston, Katie Paswaters, Brianna Rodebaugh

Mechanical Engineering

The PolyHIPS team was tasked with integrating sensors into Stryker’s hip arthroscopy boot that monitor blood flow and heel slip during hip surgery. During hip arthroscopy, the femur head is distracted from the acetabulum to create space in the joint for the surgeon to operate. This requires the use of up to 200 lbf. In order to maintain this space, the foot is held tightly in the boot. Complications can result from the foot being held too tightly in the boot during the procedure. The most common complication is neuropraxia, or temporary nerve damage. PolyHIPS proposes a solution that utilizes …


3d Printed Force Transducers For In-Vitro Mitral Valve Chordae Tendineae Force Measurements, Hayley Chandler May 2018

3d Printed Force Transducers For In-Vitro Mitral Valve Chordae Tendineae Force Measurements, Hayley Chandler

Biomedical Engineering Undergraduate Honors Theses

Mitral valve surgery is incredibly prevalent in the United States with more than 40,000 mitral valve surgical procedures annually. Improving the imaging techniques used to diagnose these cases requires validation of 3D models through experimental data such as mechanical properties of the tissue. An essential part of this process for the mitral valve is measuring the force experienced by chordae tendineae. This has been achieved with brass force transducers but using a 3D printed design can have many benefits. In this study, 3D printed miniature c-shaped force transducers comparable to previous metal models were designed and created using Solidworks 2016. …


Increasing Drug Delivery Efficacy Of Drug-Coated Balloons, Alexander Galan, Eric Bidinger, Franco Godoy, Shrusti Patel Apr 2018

Increasing Drug Delivery Efficacy Of Drug-Coated Balloons, Alexander Galan, Eric Bidinger, Franco Godoy, Shrusti Patel

Senior Theses

Peripheral artery disease (PAD), the narrowing of peripheral arteries located in areas such as the arms and legs, is a common disease that affects 12% to 20% of people over 65. Numerous therapies have been developed to treat PAD, the most recent technology being drug-coated balloons. Drug-coated balloons release drugs, such as Paclitaxel (PTX), into the arterial wall during balloon angioplasty to locally treat PAD. Current levels of drug transfer from the balloon to the vascular endothelium are at a low 10%-18%. Our Biomedical Engineering Senior Design project aims to increase drug delivery of drug-coated balloons by manipulating the clinically-controllable …