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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Green Manufacturing Of Nanoparticles For Biomedical Applications, Sijia Yi
Green Manufacturing Of Nanoparticles For Biomedical Applications, Sijia Yi
Doctoral Dissertations
The vast majority of nanomaterials are chemically synthesized, a costly process, that is environmentally risky, and the produced nanoparticles are potentially toxic to patients. Nature-based nanomaterials, however, are proving to be much more biocompatible with lower environmental toxicity. Even though a variety of natural nanomaterials have been designed, fabrication technologies for the desired natural nanoparticles with reproducible quality, high productivity and low cost remain a challenge. My objective has been to establish strategies for the isolation, purification and characterization of nanoparticles using a production system based on green tea and fungus (Arthrobotrys oligospora) and also to develop new …
Semi-Interpenetrating Network Gelatin Fiber Sca Old For Oral Mucosal Delivery Of Insulin, Leyuan Xu
Semi-Interpenetrating Network Gelatin Fiber Sca Old For Oral Mucosal Delivery Of Insulin, Leyuan Xu
Theses and Dissertations
Common therapy for diabetes mellitus is subcutaneous administration of insulin that is subject to serious disadvantages, such as patient noncompliance and occasional hypoglycemia. Hence, oral administration of insulin could be more convenient and serve as a desired route. However, oral administration of insulin is severely limited by the low bioavailability of insulin through the gastrointestinal tract. In this study, a semi-interpenetrating network gelatin fiber scaffold (sIPN GF) was fabricated for oral mucosal delivery of insulin as an alternative route. This sIPN GF was engineered from an electrospun gelatin fiber scaffold (GF), which was further crosslinked with polyethylene glycol diacrylate (PEG-DA) …