Biomedical Engineering and Bioengineering Commons^™

Computer-Based Skeletal Age Assessment Using Hand/Wrist Radiographs In Children 8-18 Years Old, Zhihong Ni

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Children's skeletons mature at different rates, and they can be affected by a variety of factors including disease, hormone imbalance or genetics. The assessment of skeletal maturity is a frequently performed procedure that allows the detection of hormonal, growth or genetic disorders. Several methods have been developed to estimate skeletal maturity. Most methods evaluate hand/wrist radiographs using indicators such as the ratios of various bone widths, the onset of the ossification of epiphysis and epiphyseal-diaphyseal fusion. Among those methods, the FELS method differs from others in the application of different grades to each indicator and the provision of a confidence …

Characterization And Improvement Of A Cone-Beam Ct Scanner For Quantitative Imaging, Jimish Dilip Joshi

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Computed tomography (CT) has various applications in different fields. In our case, the cone-beam CT scanner is used in the industrial field for qualitative and quantitative assessment of Procter and Gamble products. The Flash CT scanner, on which we do our research, has a microfocus x-ray tube, a detector size of 30 cm x 40 cm and a rotating stage for the object to be imaged. The x-ray tube can be operated up to 225 kV. Non-linearities in the response of the detector, scatter and beam hardening may cause false interpretations of the image values. To allow appropriate assessment of …

Timing-Pulse Measurement And Detector Calibration Of The Osteoquant, Binu Eapen Enchakalody

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The OsteoQuant is a second-generation pQCT scanner, which can provide precisedensity assessment of bone. The scanner is being upgraded with an x-ray tube radiation source and a semiconductor CZT detector. This thesis provides solutions for two issues: motion-detector timing and dead-time/beam-hardening corrections. During translation, the motion-control system of the scanner repositions the source and detector by small intervals. However, the detector collects photon counts asynchronously with respect to the motor-timing pulses and reads photon counts (frames) at regular intervals based on its own clock. Since there needs to be correspondence between source/detector location and detector readout, the first part of …

Graphical User Interface (Gui) To Study Different Reconstruction Algorithms In Computed Tomography, Shital K. Abhange

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Computed tomography (CT) imaging relies on computational algorithms to reconstruct images from projections gathered from the CT scan. Depending on the scanner geometry, different types of reconstruction algorithms can be used. To study these different types of reconstruction algorithms in a user-friendly way, a software tool was built. The aim of the thesis was to provide a software platform to access a number of previously implemented reconstruction algorithms with ease and minimal knowledge of the reconstruction code. The goal was accomplished by building a Graphical User Interface (GUI) using MATLAB 7.7.0 (R2008b). In addition to creating mathematical objects and invoking …

Biomechanical Evaluation Of Locked And Non-Locked Constructs Under Axial And Torsion Loading, Vinit A. Patel

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Locking compression plates are proven to be safe for use in open reduction and internal fixation (ORIF). The ORIF is a procedure performed to treat fractures. It has various combination of holes, the system provides more options for clinicians to use either locking screw or non-locking screws. This thesis investigates and determines the best construct with special locking and non-locking screws under both axial and torsion loading. Twenty femur constructs were assembled with 2 cm osteotomy gap between femur shaft and condyle, bridged with 4.5 mm - 10 holes condyle plates. Femurs were divided in to 4 groups according to …

Histogram-Based Template Matching Object Detection In Images With Varying Brightness And Contrast, Christina Da-Wann Schrider

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Our challenge was to develop a semi-automatic target detection algorithm to aid human operators in locating potential targets within images. In contrast to currently available methods, our approach is relatively insensitive to image brightness, image contrast and object orientation. Working on overlapping image blocks, we used a sliding difference method of histogram matching. Incrementally sliding the histograms of the known object template and the image region of interest (ROI) together, the sum of absolute histogram differences was calculated. The minimum of the resultant array was stored in the corresponding spatial position of a response surface matrix. Local minima of the …

Finite Element Optimization Of Hip Implant Geometrical Parameters To Determine Safe Zones And Resist Dislocation, Himanshu K. Bhatt

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A computational study was performed using finite element analysis (FEA) of three dimensional solid hip implant models. Twelve different hip implant models were designed to investigate the performance of geometrical parameters affecting hip stability. The parameters examined were head diameter, neck diameter, head-to-neck ratio, neck angle and acetabular liner thickness. Component orientations included cup anatomical inclination and cup anteversion, which should be accounted for during total hip implant design as well as in the practice of arthroplasties. A static analysis was performed for all 12 hip designs using stainless steel 316L. von Mises stress, contact stress, contact penetration, and sliding …

Motion-Control System Of Bench-Top Ct Scanner, Tarpit Kaushikbhai Patel

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Computed Tomography (CT) imaging has found applications in many areas such as diagnostic visualization, quantitative estimation, and therapeutic verification. In this wide range of applications, a CT scanner that can provide the data collection schemes of both second- and third-generation data-collection geometries will be an asset for laboratory research. In this thesis project, we developed a mechanical design and constructed a dual-generation CT scanner that provides flexibility in accommodating a wide range of object sizes with minimum scan time. Using 3-D graphical design software, models of the current second-generation CT scanner and possible solutions for modification were simulated. Based on …

Performance Analysis Of Quantitative Bone Measurement With Spiral, Multi-Detector Ct Scanners, Shruti Gupta

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The measure of bone strength and fracture risk assessment is based primarily on bone mineral density (BMD). Computed tomography (CT), a frequently used radiographic technique that provides cross-sectional images, can be used for BMD quantification. Called quantitative computed tomography (QCT), it determines true volumetric density and also differentiates between trabecular and cortical bone. As a result, QCT improves the ability to detect early changes in trabecular BMD accurately and precisely.

The introduction of helical CT for quantitative analysis introduces new complexities. Even though using multi-detector helical CT for BMD assessment is being suggested, a detailed analysis of its validity is …

Automated Analysis Of Metacarpal Cortical Thickness In Serial Hand Radiographs, Aarti Raheja

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To understand the roles of various genes that influence skeletal bone accumulation and loss, accurate measurement of bone mineralization is needed. However, it is a challenging task to accurately assess bone growth over a person's lifetime. Traditionally, manual analysis of hand radiographs has been used to quantify bone growth, but these measurements are tedious and may be impractical for a large-scale growth study. The aim of this project was to develop a tool to automate the measurement of metacarpal cortical bone thickness in standard hand-wrist radiographs of humans aged 3 months to 70+ years that would be more accurate, precise …

Optimal Eeg Channels And Rhythm Selection For Task Classification, Vikramvarun Kannan Adikarapatti

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The Primary Objective of this research is to implement an automatic method for selecting the most optimal EEG channels for task classification purposes. The secondary objective of this research is to choose the most optimal EEG rhythm from which the optimal EEG channels would be selected automatically. The automatic selection of the optimal channels is enabled by implementing the Common Spatial Patterns algorithm (CSP). Common spatial analysis is performed on the data recorded. By choosing the channels with high spatial pattern values the optimal channels are chosen. The optimal frequency bands are chosen by splitting the data from a single …

Fabrication And Testing Of Scaffolds For Cell Growth From Ionic Liquid Solubilized Fibroin, Maneesh Kumar Gupta

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The advent of tissue engineering has spurred research into developing materials to act as scaffolds for tissue growth. These scaffolds require materials capable of mimicking the in vivo conditions so that tissues can be grown effectively in vitro. Silk is an attractive biomaterial for use in tissue engineering applications because of its slow degradation, excellent mechanical properties, and biocompatibility. The major objective of the research in this thesis is to demonstrate a simple method to cast films directly from silk fibroin dissolved in an ionic liquid. The films cast from the silk ionic liquid solution were found to support normal …

Methodology For Quantifying Biomechanical Bone Movement Of Transtibial Amputations, Johanna C. Bell

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A controversy has long existed about an alternate below knee amputation procedure that may be more beneficial than the traditional transtibial amputation. The proponents of this alternate procedure that stabilizes the distal tibia and fibula claim it reduces excessive movement of the fibula relative to the tibia that occurs with common movements, such as walking. The purpose of this study is to develop a methodology for quantifying excessive movement of the fibula bone relative to the tibia bone in traditional below the knee amputations. The methodology will measure the movement and rotation of the fibula relative to the tibia. These …