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Full-Text Articles in Biomedical Engineering and Bioengineering

Organ Printing: Computer Aided Jet Based 3d Tissue Engineering, Vladimir Mironov, Thomas Boland, Thomas Trusk, Gabor Forgacs, Roger Markwald Dec 2002

Organ Printing: Computer Aided Jet Based 3d Tissue Engineering, Vladimir Mironov, Thomas Boland, Thomas Trusk, Gabor Forgacs, Roger Markwald

Thomas Boland

Tissue engineering technology promises to solve the organ transplantation crisis. However, assembly of vascularized 3D soft organs remains a big challenge. Organ printing, which we define as computer-aided, jet-based 3D tissue-engineering of living human organs, offers a possible solution. Organ printing involves three sequential steps: pre-processing or development of "blueprints" for organs; processing or actual organ printing; and postprocessing or organ conditioning and accelerated organ maturation. A cell printer that can print gels, single cells and cell aggregates has been developed. Layer-by-layer sequentially placed and solidified thin layers of a thermo-reversible gel could serve as "printing paper". Combination of an …


A Quantitative Approach To Studying Structures And Orientation At Self- Assembled Monolayer/Fluid Interfaces", Laura Pardo, Thomas Boland Dec 2002

A Quantitative Approach To Studying Structures And Orientation At Self- Assembled Monolayer/Fluid Interfaces", Laura Pardo, Thomas Boland

Thomas Boland

Self-assembled monolayers (SAMs) have become a standard tool for exploring surface interactions. Although well characterized, SAMs are known to undergo structural and conformational changes in the presence of solution, yet the ability to quantify these changes remains an obstacle due to limited analytical techniques. In this study, we determine changes in structure and conformation of CH3, OH, and COOH terminated hexadecanethiols on gold in water by means of a new technique known as evanescence reflection spectroscopy. This FTIR application, in conjunction with a semiempirical formalism, is capable of providing both qualitative and quantitative understanding of the molecular structure and orientation …


Stiffness Of Measurement System And Significant Figures Of Displacement Which Are Required To Interpret Adhesional Force Curves, Nancy Burnham, Kunio Takahashi, Hubert Pollock, Tadao Onzawa Feb 1997

Stiffness Of Measurement System And Significant Figures Of Displacement Which Are Required To Interpret Adhesional Force Curves, Nancy Burnham, Kunio Takahashi, Hubert Pollock, Tadao Onzawa

Nancy A. Burnham

Force curves obtained from an elastic contact theory are shown and compared with experimental results. In the elastic contact theory, a pin-on-disk contact is assumed and the following interaction are taken into consideration; (i) elastic deformation, (ii) the specific energy of adhesion in the area of the contact, which is expressed as the difference between the surface energies and the interface energy, (iii) the long-range interaction outside the area of contact, assuming the additivity of the Lennard-Jones type potential, and (iv) another elastic term for the measurement system such as the cantilever stiffness of an atomic force microscope (AFM). In …


Phase Transitions In Polymers: Towards Dynamic Mechanical Analysis With Submicron Spatial Resolution, Nancy Burnham, F Oulevey, A Hammiche, H Pollock, M Song, D Hourston, M Reading Dec 1996

Phase Transitions In Polymers: Towards Dynamic Mechanical Analysis With Submicron Spatial Resolution, Nancy Burnham, F Oulevey, A Hammiche, H Pollock, M Song, D Hourston, M Reading

Nancy A. Burnham

No abstract provided.


The Treatment Of Depression With Group Behavioural-Cognitive Therapy And Imipramine., Glenn Gaudette, A Stravynski, R Verreault, R Langlois, S Gagnier, M Larose Aug 1994

The Treatment Of Depression With Group Behavioural-Cognitive Therapy And Imipramine., Glenn Gaudette, A Stravynski, R Verreault, R Langlois, S Gagnier, M Larose

Glenn R. Gaudette

Twenty-four outpatients meeting DSM-III-R criteria for major depression were assigned to group behavioral-cognitive therapy either with or without antidepressant medication (imipramine). Eighteen patients completed 15 weekly sessions of treatment. Equivalent improvement was observed in both regimens after treatment. The results essentially maintained at six months follow-up. This suggests that a group format of behavioural-cognitive therapy is a viable therapeutic intervention for outpatients diagnosed as suffering from major depression. However, the addition of imipramine to group behavioural-cognitive therapy did not enhance the outcome.