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Biomedical Engineering and Bioengineering Commons™
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Articles 31 - 32 of 32
Full-Text Articles in Biomedical Engineering and Bioengineering
A Simulation Of The Neural Action Potential Under The Influence Of Acetylcholinesterase Inhibitors Modeled In The Neuromuscular Junction, Frank Jenkins
Doctoral Dissertations
The rise of terrorism has created an interest in better ways to detect when humans are exposed to neurotoxins, especially nerve gases developed for military use, most of which are acetylcholinesterase inhibitors. Many current methods of detection are based on mass spectrometry, a method that is cumbersome and not particularly robust when used as an early warning method. The detection of acetylcholinesterase inhibitors would benefit from a combined model of the processes occurring in the neuromuscular junction between the presynaptic action potential and the motor end-plate action potential that includes the kinetics of acetylcholine and acetylcholinesterase in the synaptic cleft. …
Biomimetic Synthesis Within Polyelectrolyte Microcapsules: Characterization Of Enzyme Catalyzed Polyphenols And Polypeptides, Rohit C. Ghan
Biomimetic Synthesis Within Polyelectrolyte Microcapsules: Characterization Of Enzyme Catalyzed Polyphenols And Polypeptides, Rohit C. Ghan
Doctoral Dissertations
An enzyme-catalyzed synthesis of novel polymers within layer-by-layer (LbL) constructed polyelectrolyte microcapsules has been developed. This approach is based on the selective permeability of polyelectrolyte-capsule walls to monomer molecules. Conversely biocatalysts and forming polymeric chains cannot exit the micro-capsule interior because of their characteristic high molecular weight. Horseradish Peroxidase (HRP) was encapsulated into four bilayer PSS (poly-styrenesulfonate)/PAH (poly-allylamine hydrochloride) capsules with an average diameter of 5 μm using pH-driven pore opening. The polymerization of 4-(2-Aminoethyl) phenol hydrochloride (tyramine) catalyzed by HRP produces easily detectable fluorescent polymeric products after the addition of hydrogen peroxide to the system. It is known that …