Biomedical Engineering and Bioengineering Commons^™

Neuro-Silicon Interface Of A Hirudo Medicinalis Retzius Cell Integrated With Field Effect Transistor, Kurt Christian Sjoberg

Master's Theses

The focus of this thesis was to measure the intracellular voltage of a living neural cell using a silicon transistor. The coupling of neurological tissues with silicon devices is of interest to the fields of neurology, neuroscience, electrophysiology and cellular biology. In previous work by Peter Fromherz, single neurons were successfully coupled to transistors [1]. This thesis aims to show proof of concept of the fabrication of a simple neuro-silicon interface using wafer processing methods currently available at Cal Poly. The types of transistors and cells used, the methods for dissecting and preparing the cells, the electrophysiology methods for validating …