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Full-Text Articles in Aerodynamics and Fluid Mechanics
Microfluidics Design Considering Hyperuniformity And Cell Transport In Flow For Improved Circulating Tumor Cell Capture Efficiency, Michael Clarence Hood
Microfluidics Design Considering Hyperuniformity And Cell Transport In Flow For Improved Circulating Tumor Cell Capture Efficiency, Michael Clarence Hood
Graduate Research Theses & Dissertations
Isolation of circulating tumor cells (CTCs) from patient derived blood samples for cancerdiagnostics and monitoring is challenging due to the extremely low CTC concentration. This thesis work evaluates the performance of passive microfluidics devices with different designs based on computational modeling. A new cell separation method is proposed based on velocity differentiation of varying cell sizes. All numerical studies were conducted in 2D based on a fluid structure interaction code where the fluid flow was solved based on the lattice Boltzmann method (LBM) implemented in Palabos, and the cell dynamics were simulated based on the molecular dynamics package LAMMPS, with …
Blood Flow Simulation In A Microvascular Network, Kacper Ostalowski
Blood Flow Simulation In A Microvascular Network, Kacper Ostalowski
Graduate Research Theses & Dissertations
Cardiovascular disease such as heart attack or stroke has been the leading cause of death in the US for over 100 years. Understanding the blood cell transport physics in a vascular network is important in both fundamental research and clinical practices. In this study, 3Dnumerical simulations on blood flow in a complex retina vascular network were performed considering deformable red blood cells (RBCs), white blood cells (WBCs), and obstructed vessels. The blood was modeled as a mixture of RBCs and WBCs suspended in fluid. The fluid was solved using the lattice Boltzmann method (LBM), and blood cells were modeled by …