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Full-Text Articles in Engineering

Understanding The Relationship Between Urban Areas And The Boundary Layer Using Remote Sensing Methods, Gabriel A. Rios Jan 2022

Understanding The Relationship Between Urban Areas And The Boundary Layer Using Remote Sensing Methods, Gabriel A. Rios

Dissertations and Theses

The atmospheric boundary layer is crucial to the exchange in energy between the Earth's surface and the atmosphere. Within this layer, the majority of human activities are carried out, which makes understanding the boundary layer especially important for many of our interests. A key component of this energy exchange is found at the surface, was surface properties are the interface through which momentum, heat, moisture, and other fluxes are transferred between media. Not only does the surface act as an interface, but as an actor that influences the exchange efficiency and rates. This concept is the crux of atmospheric boundary …


Exosome- And Microrna-Based Therapeutic Approach For Tendinopathy, Angela Wang Ilaltdinov Jan 2022

Exosome- And Microrna-Based Therapeutic Approach For Tendinopathy, Angela Wang Ilaltdinov

Dissertations and Theses

Tendinopathy, characterized by degeneration and chronic inflammation, is a significant clinical burden. Current treatments focus on symptom management but do not sufficiently address its underlying pathology; however, stem cell-based approaches aimed at repairing diseased tissues may overcome this limitation. Therapeutic effects of stem cells may be due in part to paracrine actions, including some mediated by exosomes – extracellular vesicles secreted by cells that play a role in cell communication. MicroRNA (miRNA), small non-coding RNA carried by exosomes, are likely responsible for many exosome effects. Exosomes and miRNA therapies show promise in treating diseases such as cancer and arthritis, but …


Crop Water Deficits And Their Season-Ahead Climate Determinants Across The United States, Siena W. Dante Jan 2022

Crop Water Deficits And Their Season-Ahead Climate Determinants Across The United States, Siena W. Dante

Dissertations and Theses

The agricultural sector in the United States provides an essential food and revenue source and it faces severe challenges due to increasing climate variability, which reduces reliable access to water needed for the crops. Unreliable access to water and the potential for drought result in major economic losses to the sector as well as potentially significant environmental damage. It is thus necessary to mitigate the effects of drought as well as to develop agricultural practices that include preparedness strategies for droughts. To develop these strategies, comprehensive information about droughts must be available early enough to consider before the growing season. …


Use Of Battery Systems For Var Support In Con Edison’S Distribution Network/Substation, Elihu Nyemah Jan 2022

Use Of Battery Systems For Var Support In Con Edison’S Distribution Network/Substation, Elihu Nyemah

Dissertations and Theses

Battery Energy Storage System (BESS) can facilitate the integration of Distributed Energy Resources (DER) and help create a more reliable grid by providing multiple services including reactive power (VAR) support. This research will investigate the use of smart inverters to provide VAR support, assess the impact it has on the lifetime of a BESS and determine how the adverse effects (if any) can be mitigated/eliminated. To achieved this, a 7.5MW/30MWh grid connected BESS located at Con Edison substations have been modeled in MATLAB/Simulink. Preliminary assessment of the system showed that DC current to/from the battery is oscillating (non-zero) during reactive …


Fundamentals Of Microgel Flooding And Nanoparticles-Stabilized Foams In Enhanced Oil Recovery, Shuaijun Li Jan 2022

Fundamentals Of Microgel Flooding And Nanoparticles-Stabilized Foams In Enhanced Oil Recovery, Shuaijun Li

Dissertations and Theses

For centuries oil has remained a critical energy source for human civilization. After years of extraction, many oil fields have reached or are reaching a decline stage of production, even though up to a half of the total crude oil reserves in these fields has not been recovered yet. One reason is due to the structural heterogeneity of the oil reservoirs—reservoirs may consist of regions of higher permeability with larger pore size and regions of lower permeability with smaller pore size. Displacing fluids tend to flow through large permeability zones only without reaching the oil trapped in low permeability region; …


Osseointegration Of A Cementless Total Knee Arthroplasty In A Murine Model Of Glucocorticoid Induced Osteoporosis, Elexis C. Baral Jan 2022

Osseointegration Of A Cementless Total Knee Arthroplasty In A Murine Model Of Glucocorticoid Induced Osteoporosis, Elexis C. Baral

Dissertations and Theses

Glucocorticoid-Induced Osteoporosis (GIOP) is the second largest cause of osteoporosis worldwide. Glucocorticoid-Induced osteoporosis is rapidly, driven principally by deficient osteoblast activity (i.e., decreased bone formation) rather than increased osteoclastic activity. Glucocorticoid-type steroids (GC) are used long-term typically for inflammatory diseases such as rheumatoid arthritis, lupus, multiple sclerosis, and other autoimmune disorders. Inflammatory arthritis often leads to joint replacement at relatively young ages. However, patients who are on GC treatment appear to have poorer outcomes for total joint arthroplasty compared to healthy patients. This is thought to be due to the anti-anabolic effects of GCs and impaired bone healing and osseous …


Nonlinear Light - Matter Interactions Of Ultrafast High Intensity Laser Pulses, Henry Meyer Jan 2022

Nonlinear Light - Matter Interactions Of Ultrafast High Intensity Laser Pulses, Henry Meyer

Dissertations and Theses

This thesis focuses on the key nonlinear optical effects that arise from the interactions of intense ultrafast laser pulses with various states of matter. These interactions involve electronic and molecular states and yield new information on the underlying fundamental processes that govern the molecular world. Modern day lasers offer ultrashort pulses, high intensities, and complex polarizations and wavefronts. These extreme conditions have profound effect on the optical properties and behaviors of electronic and molecular states within a material. The changes in these mechanisms effect generation of nonlinear optics, such supercontinuum (SC), stimulated Raman (SRS), self-focusing and filamentation, conical emission (CE), …


Helium-Air Mixing In Simulated Reactor Cavities Of Very High Temperature Reactors, Abdullah Abubakar Jan 2022

Helium-Air Mixing In Simulated Reactor Cavities Of Very High Temperature Reactors, Abdullah Abubakar

Dissertations and Theses

Abstract

Very High Temperature Reactors (VHTRs) and High Temperature Gas Reactors (HTGRs) are Generation IV gas reactors that promise to deliver high temperature process heat and efficient electricity for both industrial and commercial purposes. They have a high level of inherent passive safety making them a viable alternative to traditional water-cooled reactors. These helium gas-cooled reactors use graphite containing U-235 TRISO fuel particles in their core, as a moderator to slow down neutrons for fission chain reactions and for general core support. In the event of a primary circuit pipe break, the coolant gas escapes into the surrounding reactor cavity …


Computational Model Of Electroconvulsive Therapy Considering Electric Field Dependent Skin Conductivity, Gozde Unal Jan 2022

Computational Model Of Electroconvulsive Therapy Considering Electric Field Dependent Skin Conductivity, Gozde Unal

Dissertations and Theses

Improvements in electroconvulsive therapy (ECT) outcomes have followed refinement in device electrical output and electrode montage. The physical properties of the ECT stimulus, together with those of the patient’s head, determine the impedances measured by the device and govern current delivery to the brain and ECT outcomes. However, the precise relations among physical properties of the stimulus, patient head anatomy, and patient-specific impedance to the passage of current are long-standing questions in ECT research and practice. In this thesis, we develop a computational framework based on diverse clinical data sets. We developed anatomical MRI-derived models of transcranial electrical stimulation (tES) …


Droplets In An Electric Field: Surface Rheology, Coalescence And Rebound, Yu Han Jan 2022

Droplets In An Electric Field: Surface Rheology, Coalescence And Rebound, Yu Han

Dissertations and Theses

Electrocoalescence is the process in which pairs of conducting droplets suspended in a continuous dielectric (nonconducting) liquid phase are drawn together and merge upon the application of an electric field. The electric field polarizes each of the droplets in the field direction. The polarization causes the drops to deform and drives a dipolar attraction which forces them to approach each other and coalesce. Many technologies use electric fields to manipulate fluid dispersions. Electrocoalescence is an essential unit operation for separating water droplets in a crude oil. This water in oil emulsion is stabilized by surfactants, such as asphaltenes, resins and …


A Citizen-Science Approach For Urban Flood Risk Analysis Using Data Science And Machine Learning, Candace Agonafir Jan 2022

A Citizen-Science Approach For Urban Flood Risk Analysis Using Data Science And Machine Learning, Candace Agonafir

Dissertations and Theses

Street flooding is problematic in urban areas, where impervious surfaces, such as concrete, brick, and asphalt prevail, impeding the infiltration of water into the ground. During rain events, water ponds and rise to levels that cause considerable economic damage and physical harm. The main goal of this dissertation is to develop novel approaches toward the comprehension of urban flood risk using data science techniques on crowd-sourced data. This is accomplished by developing a series of data-driven models to identify flood factors of significance and localized areas of flood vulnerability in New York City (NYC). First, the infrastructural (catch basin clogs, …


Development Of Cellulose-Based, Semi-Interpenetrating Network Hydrogels As Tissue-Adhesive, Thermoresponsive, Injectable Implants, Jesse Martin Jan 2022

Development Of Cellulose-Based, Semi-Interpenetrating Network Hydrogels As Tissue-Adhesive, Thermoresponsive, Injectable Implants, Jesse Martin

Dissertations and Theses

Abstract Development of Cellulose-Based, Semi-Interpenetrating Network Hydrogels as Tissue-Adhesive, Thermoresponsive, Injectable Implants

Hydrogels are three-dimensional polymer networks with high water content and tunable mechanical properties, which have been widely investigated as replacements for soft tissues, such as the intervertebral disc (IVD). Various derivatives of the plant polysaccharide, cellulose, have been explored for use as injectable hydrogel implants. Methylcellulose (MC), which exhibits thermogelation at temperatures above 32°C, and relatively hydrophilic carboxymethyl-cellulose (CMC), are versatile cellulosic polymers that have shown promise as base materials for such applications. In prior work, functionalization with methacrylate groups allowed for the formation of stable, covalently crosslinked …


Low-Intensity Ultrasonic Neuromodulation Of The Rat Hippocampus, Duc Nguyen Jan 2022

Low-Intensity Ultrasonic Neuromodulation Of The Rat Hippocampus, Duc Nguyen

Dissertations and Theses

Techniques to non-invasively modulate brain activity are important for mapping human brain circuits, and also for the treatment of a host of neurological and psychiatric disorders marked by aberrant brain activity. Though a wide range of techniques for non-invasive neuromodulation have been proposed, the conventional approaches suffer from significant limitations. Most notably, focal stimulation of deep brain regions is presently only possible with invasive optogenetic and chemogenetic approaches that require craniotomies and genetic access to the brain.

Transcranial focused ultrasound stimulation (tFUS) possesses many of the characteristics desirable from a neuromodulation approach: non-invasiveness, a spatial resolution in the order of …


A Study Of Greenhouse Gas Emissions And Performance Of An Internal Combustion Engine Operating On Landfill Gas Blends As Fuel, Lauren T. Creadore Jan 2022

A Study Of Greenhouse Gas Emissions And Performance Of An Internal Combustion Engine Operating On Landfill Gas Blends As Fuel, Lauren T. Creadore

Dissertations and Theses

Landfill gas (LFG) is an abundant resource naturally occurring from the decomposition of municipal solid waste. It can be generated in U.S. landfills at a rate of 24.2 to 59.1 GNm3 per year.1 LFG presents both a problem and solution with respect to global warming. Composed of carbon dioxide (CO2, 30-40%) and methane (CH4, 45-55%), as well as nitrogen (N2, 10-15%), oxygen (O2, 0-5%), and other trace gasses1, LFG that is permitted release into the atmosphere will contribute to the greenhouse gas effect due to the presence of …


Inter-Subject Correlation While Listening To Minimalist Music: A Study Of Electrophysiological And Behavioral Responses To Steve Reich’S Piano Phase, Tysen Dauer, Duc T. Nguyen, Nick Gang, Jacek P. Dmochowski, Jonathan Berger, Blair Kaneshiro Dec 2021

Inter-Subject Correlation While Listening To Minimalist Music: A Study Of Electrophysiological And Behavioral Responses To Steve Reich’S Piano Phase, Tysen Dauer, Duc T. Nguyen, Nick Gang, Jacek P. Dmochowski, Jonathan Berger, Blair Kaneshiro

Publications and Research

Musical minimalism utilizes the temporal manipulation of restricted collections of rhythmic, melodic, and/or harmonic materials. One example, Steve Reich’s Piano Phase, offers listeners readily audible formal structure with unpredictable events at the local level. For example, pattern recurrences may generate strong expectations which are violated by small temporal and pitch deviations. A hyper-detailed listening strategy prompted by these minute deviations stands in contrast to the type of listening engagement typically cultivated around functional tonal Western music. Recent research has suggested that the inter-subject correlation (ISC) of electroencephalographic (EEG) responses to natural audio-visual stimuli objectively indexes a state of “engagement,” demonstrating …


Messiness: Automating Iot Data Streaming Spatial Analysis, Christopher White, Atilio Barreda Ii Dec 2021

Messiness: Automating Iot Data Streaming Spatial Analysis, Christopher White, Atilio Barreda Ii

Publications and Research

The spaces we live in go through many transformations over the course of a year, a month, or a day; My room has seen tremendous clutter and pristine order within the span of a few hours. My goal is to discover patterns within my space and formulate an understanding of the changes that occur. This insight will provide actionable direction for maintaining a cleaner environment, as well as provide some information about the optimal times for productivity and energy preservation.

Using a Raspberry Pi, I will set up automated image capture in a room in my home. These images will …


3d Bionic Arm, Anny Baez Silfa Dec 2021

3d Bionic Arm, Anny Baez Silfa

Publications and Research

Previous work had been done on what was an adaptation of a robotic arm for Roboqueen, which is a persistent research project of the Department of Computer Engineering Technology. This robotic arm consisted of removing the cardboard hands from the Roboqueen and being replaced by 3D printed fingers and wrists to add functionality that did not exist before. Servo motors connected to Arduinos hidden in the forearm will be used to move the fingers and pick up and hold objects in the hand. Currently, the Finger Myoware is an update of the robotic arm in order to understand how prosthetic …


Child Detection System For Preventing Hot-Car Death, Touheda Khanom, Fahmeda Khanom Dec 2021

Child Detection System For Preventing Hot-Car Death, Touheda Khanom, Fahmeda Khanom

Publications and Research

According to the Safety Organization Kids and Cars, an average of 38 children die each year from hot cars due to lack of attention from parents. Existing alert system uses sensors that detect child presence and care less about detecting temperature inside the car. In order to save children from heatstroke, our research focuses on providing information about the temperature inside the car using very effective sensors with high precision. In our research, we have tested different sensors and figured out three sensors that can provide precise information about the presence of a child without an adult. Our child detection …


Comparative Analysis Of 3d Printed Denture Resins With Traditional Denture Materials At The Micro Level, Aneeza Hussain, Caleb Beckwith, Gaffar Gailani Dec 2021

Comparative Analysis Of 3d Printed Denture Resins With Traditional Denture Materials At The Micro Level, Aneeza Hussain, Caleb Beckwith, Gaffar Gailani

Publications and Research

The aim of this experiment was to evaluate and identify compression strength between traditionally manufactured acrylic dentures and additive manufacturing resin dentures. Specifically, the dentures produced by Uhler Dental, its Reveal line were compared against samples produced on the Formlabs Form 2 SLA, Stereolithography, 3D printer using their Denture Teeth A2 resin to test compression strength to assure they are compatible with the occlusal forces in the oral cavity. Using the ZwickRoell tensile testing machine, it appeared that the acrylic dentures were half as strong as the resin dentures. Then we went ahead to and did a comparative analysis under …


Force-Feedback Design For Robotics: Bio-Based Design And Simulation, Husnain Khan, Zhou Zhang Dec 2021

Force-Feedback Design For Robotics: Bio-Based Design And Simulation, Husnain Khan, Zhou Zhang

Publications and Research

The great challenge for the Virtual Assembly Platform is how to make the users have the in-person feeling with the augmented tools. Hands are the most important organs that are used to provide touch feeling. In a real assembly scenario, the force from the components and tools will be feedback to the brain via the hands. Unfortunately, the virtual assembly failed to mimic the in-person scenarios since it will not provide such kind of feedback. As a result, the users’ real identities are lost. Then, the users’ slower-progressing wrong habits will prevent them from success in the future. Therefore, it …


Plasmonic Field-Effect Transistors (Terafets) For 6g Communications, Michael Shur, Gregory Aizin, Taiichi Otsuji, Victor Ryzhii Nov 2021

Plasmonic Field-Effect Transistors (Terafets) For 6g Communications, Michael Shur, Gregory Aizin, Taiichi Otsuji, Victor Ryzhii

Publications and Research

Ever increasing demands of data traffic makes the transition to 6G communications in the 300 GHz band inevitable. Short-channel field-effect transistors (FETs) have demonstrated excellent potential for detection and generation of terahertz (THz) and sub-THz radiation. Such transistors (often referred to as TeraFETs) include short-channel silicon complementary metal oxide (CMOS). The ballistic and quasi-ballistic electron transport in the TeraFET channels determine the TeraFET response at the sub-THz and THz frequencies. TeraFET arrays could form plasmonic crystals with nanoscale unit cells smaller or comparable to the electron mean free path but with the overall dimensions comparable with the radiation wavelength. Such …


Needle In A Haystack: Detecting Subtle Malicious Edits To Additive Manufacturing G-Code Files, Caleb Beckwith, Harsh Sankar Naicker, Svara Mehta, Viba R. Udupa, Nghia Tri Nim, Varun Gadre, Hammond Pearce, Gary Mac Nov 2021

Needle In A Haystack: Detecting Subtle Malicious Edits To Additive Manufacturing G-Code Files, Caleb Beckwith, Harsh Sankar Naicker, Svara Mehta, Viba R. Udupa, Nghia Tri Nim, Varun Gadre, Hammond Pearce, Gary Mac

Publications and Research

Increasing usage of Digital Manufacturing (DM) in safety-critical domains is increasing attention on the cybersecurity of the manufacturing process, as malicious third parties might aim to introduce defects in digital designs. In general, the DM process involves creating a digital object (as CAD files) before using a slicer program to convert the models into printing instructions (e.g. g-code) suitable for the target printer. As the g-code is an intermediate machine format, malicious edits may be difficult to detect, especially when the golden (original) models are not available to the manufacturer. In this work we aim to quantify this hypothesis through …


Inverse Kinematics Of The 6dof C12xl, Carl Liu, Lili Ma Nov 2021

Inverse Kinematics Of The 6dof C12xl, Carl Liu, Lili Ma

Publications and Research

Industrial robotic manipulators are widely used in applications such as pick & place, welding, and assembly to perform repeated tasks in replace of human labor. Such tasks typically require fully autonomous mechanical arms that are capable of identifying the parts to operate, path planning, and trajectory generation & tracking. A robotic arm consists of a sequence of rigid links connected by movable components (the joints). Proper control of the arm’s motion requires the knowledge of inverse kinematics, which computes/outputs the joint variables, i.e., angles for revolute joints and displacement for prismatic joints, causing the robotic arm’s end effector (e.g., gripper, …


Dataset Of Concurrent Eeg, Ecg, And Behavior With Multiple Doses Of Transcranial Electrical Stimulation, Nigel Gebodh, Zeinab Esmaeilpour, Abhishek Datta, Marom Bikson Oct 2021

Dataset Of Concurrent Eeg, Ecg, And Behavior With Multiple Doses Of Transcranial Electrical Stimulation, Nigel Gebodh, Zeinab Esmaeilpour, Abhishek Datta, Marom Bikson

Publications and Research

We present a dataset combining human-participant high-density electroencephalography (EEG) with physiological and continuous behavioral metrics during transcranial electrical stimulation (tES). Data include within participant application of nine High-Definition tES (HD-tES) types, targeting three cortical regions (frontal, motor, parietal) with three stimulation waveforms (DC, 5 Hz, 30 Hz); more than 783 total stimulation trials over 62 sessions with EEG, physiological (ECG, EOG), and continuous behavioral vigilance/alertness metrics. Experiment 1 and 2 consisted of participants performing a continuous vigilance/alertness task over three 70-minute and two 70.5-minute sessions, respectively. Demographic data were collected, as well as self-reported wellness questionnaires before and after each …


Tailoring Plasmon Excitations In Alpha − T 3 Armchair Nanoribbons, Andrii Iurov, Liubov Zhemchuzhna, Godfrey Gumbs, Danhong Huang, Paula Fekete, Farhana Anwar, Dipendra Dahal, Nicholas Weekes Oct 2021

Tailoring Plasmon Excitations In Alpha − T 3 Armchair Nanoribbons, Andrii Iurov, Liubov Zhemchuzhna, Godfrey Gumbs, Danhong Huang, Paula Fekete, Farhana Anwar, Dipendra Dahal, Nicholas Weekes

Publications and Research

We have calculated and investigated the electronic states, dynamical polarization function and the plasmon excitations for α − T 3 nanoribbons with armchair-edge termination. The obtained plasmon dispersions are found to depend significantly on the number of atomic rows across the ribbon and the energy gap which is also determined by the nanoribbon geometry. The bandgap appears to have the strongest effect on both the plasmon dispersions and their Landau damping. We have determined the conditions when relative hopping parameter α of an α − T 3 lattice has a strong effect on the plasmons which makes our material distinguished …


Physiological Processes, Chirag B. Raval Oct 2021

Physiological Processes, Chirag B. Raval

Open Educational Resources

Physiological Processes is designed to introduce fundamental concepts of physiology to biomedical engineering learners. Areas covered include: neural, muscular, cardiovascular, respiratory and renal system function; bioelectrical signals, capillary-level transport, organ-level exchange. Whenever possible, analysis will be quantitative in order to fulfill the course goals and to build the foundation for the subsequent biomedical engineering curriculum. This course is for Biomedical Engineering majors only.


During Natural Viewing, Neural Processing Of Visual Targets Continues Throughout Saccades, Atanas D. Stankov, Jonathan Touryan, Stephen Gordon, Anthony J. Ries, Jason Ki, Lucas C. Parra Sep 2021

During Natural Viewing, Neural Processing Of Visual Targets Continues Throughout Saccades, Atanas D. Stankov, Jonathan Touryan, Stephen Gordon, Anthony J. Ries, Jason Ki, Lucas C. Parra

Publications and Research

Relatively little is known about visual processing during free-viewing visual search in realistic dynamic environments. Free-viewing is characterized by frequent saccades. During saccades, visual processing is thought to be suppressed, yet we know that the presaccadic visual content can modulate postsaccadic processing. To better understand these processes in a realistic setting, we study here saccades and neural responses elicited by the appearance of visual targets in a realistic virtual environment. While subjects were being driven through a 3D virtual town, they were asked to discriminate between targets that appear on the road. Using a system identification approach, we separated overlapping …


Tools And Strategies For The Patterning Of Bioactive Molecules And Macromolecules, Daniel J. Valles Sep 2021

Tools And Strategies For The Patterning Of Bioactive Molecules And Macromolecules, Daniel J. Valles

Dissertations, Theses, and Capstone Projects

Hypersurface Photolithography (HP) is a printing method for fabricating structures and patterns composed of soft materials bound to solid surfaces and with ~1 micrometer resolution in the x, y, and z dimensions. This platform leverages benign, low intensity light to perform photochemical surface reactions with spatial and temporal control of irradiation, and, as a result, is particularly useful for patterning delicate organic and biological material. In particular, surface- initiated controlled radical polymerizations can be leveraged to create arbitrary polymer and block- copolymer brush patterns. Chapter 1 will review the advances in instrumentation architectures from our group that have made these …


Molecular Dynamics Simulations Of Self-Assemblies In Nature And Nanotechnology, Phu Khanh Tang Sep 2021

Molecular Dynamics Simulations Of Self-Assemblies In Nature And Nanotechnology, Phu Khanh Tang

Dissertations, Theses, and Capstone Projects

Nature usually divides complex systems into smaller building blocks specializing in a few tasks since one entity cannot achieve everything. Therefore, self-assembly is a robust tool exploited by Nature to build hierarchical systems that accomplish unique functions. The cell membrane distinguishes itself as an example of Nature’s self-assembly, defining and protecting the cell. By mimicking Nature’s designs using synthetically designed self-assemblies, researchers with advanced nanotechnological comprehension can manipulate these synthetic self-assemblies to improve many aspects of modern medicine and materials science. Understanding the competing underlying molecular interactions in self-assembly is always of interest to the academic scientific community and industry. …


No Ordinary Proteins: Adsorption And Molecular Orientation Of Monoclonal Antibodies, Ankit D. Kanthe, Andrew Ilott, Mary Krause, Songyan Zheng, Jinjiang Li, Wei Bu, Mrinal K. Bera, Binhua Lin, Charles Maldarelli, Raymond S. Tu Aug 2021

No Ordinary Proteins: Adsorption And Molecular Orientation Of Monoclonal Antibodies, Ankit D. Kanthe, Andrew Ilott, Mary Krause, Songyan Zheng, Jinjiang Li, Wei Bu, Mrinal K. Bera, Binhua Lin, Charles Maldarelli, Raymond S. Tu

Publications and Research

The interaction of monoclonal antibodies (mAbs) with air/water interfaces plays a crucial role in their overall stability in solution. We aim to understand this behavior using pendant bubble measurements to track the dynamic tension reduction and x-ray reflectivity to obtain the electron density profiles (EDPs) at the surface. Native immunoglobulin G mAb is a rigid molecule with a flat, “Y” shape, and simulated EDPs are obtained by rotating a homology construct at the surface. Comparing simulations with experimental EDPs, we obtain surface orientation probability maps showing mAbs transition from flat-on Y-shape configurations to side-on or end-on configurations with increasing concentration. …