Arts and Humanities Commons^™

Charles Birch: Synthesis And Hope, Rowan Cahill

Rowan Cahill

A Comprehensive Genetic Linkage Map Of The Human Genome, Nih/Ceph Collaborators Mapping Group, Helen Donis-Keller

Helen Donis-Keller

A genetic linkage map of the human genome was constructed that consists of 1416 loci, including 279 genes and expressed sequences. The loci are represented by 1676 polymorphic systems genotyped with the CEPH reference pedigree resource. A total of 339 microsatellite repeat markers assayed by PCR are contained within the map, and of the 351 markers with heterozygosities of at least 70%, 205 are microsatellites. Seven telomere loci define physical and genetic endpoints for 2q, 4p, 7q, 8p, 14q, 16p, and 16q, and in other cases distal markers on the maps have been localized to terminal cytogenetic bands. Therefore, at …

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Review Essay Of Two Books On The History Of Science, Charles Kay Smith

Charles Kay Smith

Contrary to what I was taught in high school in the mid-1940s, science is no longer defined as an inductive methodology for immaculately conceiving culture-free truth after sifting through a huge data base of objective facts. For without some prior hypothesis to guide her, a scientist would not be able to decide which facts were relevant. Nowadays hypotheses can come from anywhere in the imagination or culture within which the scientist is working. The importance of a scientific hypothesis is that it be framed in such a way that it can be falsified when tested. Science now has a history …

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Entropy, Information, And Evolution: New Perspectives On Physical And Biological Evolution, David Depew, Bruce Weber

David J Depew

Can recent developments in thermodynamics and information theory offer a way out of the current crisis in evolutionary theory? One of the most exciting and controversial areas of scientific research in recent years has been the application of the principles of nonequilibrium thermodynamics to the problems of the physical evolution of the universe, the origins of life, the structure and succession of ecological systems, and biological evolution. These sixteen original essays by evolutionists, ecologists, molecular biologists, physical chemists, physicists, and philosophers of science provide the best current summary of this developing research program.Chapters in the book's first part - by …

Evolution At A Crossroads: The New Biology And The New Philosophy Of Science, David Depew, Bruce Weber

David J Depew

No abstract provided.

Justice And The Treatment Of Animals, Michael Pritchard

Michael Pritchard

Rna Sequencing Provides Evidence For Allelism Of Determinants Of The N-, B-, Or Nb- Tropism Of Murine Leukemia Viruses, Jean Rommelaere, Helen Donis-Keller, Nancy Hopkins

Helen Donis-Keller

Previous genetic and biochemical studies identified three large RNAase T1-resistant oligonucleotides, each associated with either the N-, B- or NB-tropism of murine C-type viruses of BALB/c origin. These oligonucleotides were shown to lie in the 5′ third of the oligonucleotide maps of their respective viruses. We sequenced the three oligonucleotides and found that they share a 10 base sequence. Together these observations provide good evidence that the determinants of N-, B- or NB-tropism monitored by the three oligonucleotides are allelic.The oligonucleotides associated with N- and B-tropism differ in sequence at four of sixteen nucleotides, while the B- and NB-tropism-associated oligonucleotides …

Mapping Adenines, Guanines, And Pyrimidines In Rna, Helen Donis-Keller, Allan Maxam, Walter Gilbert

Helen Donis-Keller

The positions of adenines, guanines, and pyrimidines can be determined by partial nuclease digestion of a terminally labeled RNA molecule. In urea, at elevated temperatures, RNase T1 generates a pattern reflecting cleavage at guanines while RNase U2 cleaves only at adenine. A limited alkaline hydrolysis provides a continuum of fragments derived from breaks at every phosphodiester bond. The reaction products are electrophoretically fractionated by size in adjacent lanes of a polyacrylamide gel. An autoradiograph of the gel displays the sequence up to 100 nucleotides from the end of the molecule, although uracil cannot as yet be distinguished from cytosine. These …

Logical And Persuasive Structures In Charles Darwin's Prose Style, Charles Kay Smith

Charles Kay Smith

This paper analyzes Charles Darwin's characteristic writing behavior. Darwin was a more interesting and dedicated writer than he is commonly credited for being. This essay will reassess the importance of his writing. The surface characteristics of Darwin's prose (conventionally referred to as his "style") seem at first glance so plain and ordinary that Darwin's writing rarely interests students of style. Exceptions such as Theodore Baird in an essay entitled "Darwin and the Tangled Bank"1 and Stanley Edgar Hyman in a longer study of Darwin's writing, The Tangled Bank,2 both make a point of the current general disregard of Darwin as …