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Full-Text Articles in Entire DC Network
Mutagenetic Analysis Of The Minor Capsid Protein Vp3 Of The Archaeal Fusellovirus Ssv1, Laura Costal Lagarde
Mutagenetic Analysis Of The Minor Capsid Protein Vp3 Of The Archaeal Fusellovirus Ssv1, Laura Costal Lagarde
Student Research Symposium
Viruses, while often associated with disease, are integral to life and play an important role in the microbiome. Despite their importance in medical research, archaeal viruses, particularly those found in extreme environments, are not widely understood. The Sulfolobus Spindle-Shaped Viruses (SSVs) of the Fuselloviridae family are unique among viruses in that they do not kill their host, the archaeon Sulfolobus Solfataricus in volcanic hot springs, but rather slow its growth, allowing for halo assay assessments.The study focuses on the type virus SSV1, which is predominantly composed of the Major and Minor capsid proteins vp1 and vp3, respectively. Previous study has …
Histone Changes As A Response To Lactic Acid Selection In Cells Of Austrofundulus Limnaeus, Lori Tran, Jason Podrabsky, Chelsea Hughes
Histone Changes As A Response To Lactic Acid Selection In Cells Of Austrofundulus Limnaeus, Lori Tran, Jason Podrabsky, Chelsea Hughes
Student Research Symposium
The killifish Austrofundulus limnaeus is an extremophile native to small temporary ponds of Venezuela. Normal embryonic development of A. limnaeus is segmented into up to three stages of metabolic depression (diapause), and both developing and diapausing embryos can survive long bouts of the complete absence of oxygen (anoxia) by using anaerobic metabolic pathways. While there has been much focus on how mutations in DNA drive evolution, environmental stress can cause heritable changes to histone post-translational modifications (hPTMs) in multiple species. However, this evolutionary role of hPTMs has never been studied in A. limnaeus. Additionally, the possible evolutionary role of extracellular …
Annual Killifish: Eye Development And Retinal Cell Regeneration, Carmen Z. Rodriguez
Annual Killifish: Eye Development And Retinal Cell Regeneration, Carmen Z. Rodriguez
Student Research Symposium
Vertebrate eye development is highly conserved. Current models have allowed the understanding of gene expression patterns that support eye development, but lack the context of extreme environmental conditions that challenge these fundamental programs. Typical vertebrate life spans can be years, but annual killifish, Austrofundulus limnaeus, are able to complete their entire adult lifespan in only weeks. Thus, A. limnaeus is a strong model for age-related macular degeneration. A. limnaeus also experiences embryonic diapause; a period of developmental dormancy. Developing/diapausing embryos of A. limnaeus are resistant to environmental stresses such as hypoxia/anoxia that would cause irreparable damage to vital organs, such …
Examining The Role Of Rgs2 In The Maintenance Of Diapause After Anoxic Stress In Embryos Of The Annual Killifish Austrofundulus Limnaeus, Patrick Clouser
Examining The Role Of Rgs2 In The Maintenance Of Diapause After Anoxic Stress In Embryos Of The Annual Killifish Austrofundulus Limnaeus, Patrick Clouser
Student Research Symposium
Austrofundulus limnaeus live in ephemeral ponds of Venezuela. They have evolved a unique life history that includes embryonic diapause, a period of developmental dormancy, metabolic arrest, and reduced protein synthesis. Diapausing embryos are resistant to environmental stress and survive months without oxygen (anoxia). A. limnaeus’ anoxia tolerance is an important survival mechanism as they can be buried in anoxic soil during development. Analysis of RNAseq data from diapausing A. limnaeus embryos show significant down-regulation of RGS2 transcripts in anoxic embryos. RGS2 regulates G-protein receptor signaling by inhibiting associated Ga-proteins and can inhibit protein synthesis. I hypothesis that …
Locating Vitamin D Receptors (Vdrs) In Annual Killifish, Austrofundulus Limnaeus, Rosalia N. Tanori, Amie L. Romney, Jason E. Podrabsky
Locating Vitamin D Receptors (Vdrs) In Annual Killifish, Austrofundulus Limnaeus, Rosalia N. Tanori, Amie L. Romney, Jason E. Podrabsky
Student Research Symposium
Austrofundulus limnaeus, a species of annual killifish found in unpredictable temporary habitats in South America, has a profound ability to survive long periods without water and oxygen. This tolerance is associated with the ability to enter metabolic dormancy associated with diapause. Entrance into diapause and tolerance of environmental stress is governed by an interplay of genetic and environmental factors. The vitamin D receptor (VDR) is among these factors and plays a crucial role in determining if an embryo will enter diapause or actively develop. My work aims to identify the genomic locations of VDR proteins in the A. limnaeus genome …
Describing Shen & Shen Ming Via A Hybrid Quantum Computational Model, Alex M. Cullen, Johnny Lemau
Describing Shen & Shen Ming Via A Hybrid Quantum Computational Model, Alex M. Cullen, Johnny Lemau
Student Research Symposium
Definitions for Traditional Chinese Medicine (TCM) terminology within the context of quantum biology (QB) have recently been proposed. These definitions aim to elucidate concepts such as qi meridians in TCM. Our study presents a hypothesis that seeks to provide an operational definition for Spirit (Shen) and Bright Spirit (Shen Ming) in TCM via a scoping review. We propose that Shen represents physical, phenomenological proto-consciousness/consciousness in the forms of computation, such as singular particles/bits/qubits, computers, organisms, or computational strategies, whereas Shen Ming may refer to emergent, quasi-physical meta-proto-consciousness/consciousness formed by coherent relationships of multiple orchestrated/integrated units of computation; manifesting itself as …
Qibc Analysis On Killifish Cells Under Anoxic Conditions, Jaina Canlas
Qibc Analysis On Killifish Cells Under Anoxic Conditions, Jaina Canlas
Student Research Symposium
Faithful DNA replication is vital for all living organisms. Environmental stressors can cause a multitude of mutations and DNA lesions during replication leading to cell death if not accurately repaired. The annual killifish, Austrofundulus limnaeus, has a heightened tolerance to many known genotoxic stressors, including anoxia. Embryos of the annual killifish can survive months of anoxia during the dry season when the ephemeral ponds they inhabit, completely dry. During these exposures, they have shown they are capable of repairing substantial amounts of damaged DNA. This resilience has led us to hypothesize that A. limnaeus have enhanced DNA repair capabilities. …
Role Of Integrase-Pp2a Interaction In Human T-Cell Leukemia Virus Type-1 Replication And Pathogenesis, Shayna Turbin
Role Of Integrase-Pp2a Interaction In Human T-Cell Leukemia Virus Type-1 Replication And Pathogenesis, Shayna Turbin
Senior Honors Papers / Undergraduate Theses
Human T-cell leukemia virus type-1 (HTLV-1) is an oncogenic retrovirus that causes multiple disorders, including adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 retroviral integrase binds to the regulatory B’56γ subunit of the host cell Protein Phosphatase 2A (PP2A). Integrase contains a highly conserved LxxIxE motif that is essential for binding, which increases integration efficiency and facilitates HTLV-1 hijack of host cell machinery. We aim to understand how mutations introduced in the highly conserved binding site can affect viral particle production and infectivity. We transfected 729B human lymphoblastoid cells and 293T cells with mutant and wildtype virus. Mutations L213A, …
Autism Risk Gene Cul3 Alters Neuronal Morphology Via Caspase-3 Activity In Mouse Hippocampal Neurons, Qiang-Qiang Xia, Anju Singh, Jing Wang, Zhong Xin Xuan, Jeffrey D. Singer, Craig M. Powell
Autism Risk Gene Cul3 Alters Neuronal Morphology Via Caspase-3 Activity In Mouse Hippocampal Neurons, Qiang-Qiang Xia, Anju Singh, Jing Wang, Zhong Xin Xuan, Jeffrey D. Singer, Craig M. Powell
Biology Faculty Publications and Presentations
Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders (NDDs) in which children display differences in social interaction/communication and repetitive stereotyped behaviors along with variable associated features. Cul3, a gene linked to ASD, encodes CUL3 (CULLIN-3), a protein that serves as a key component of a ubiquitin ligase complex with unclear function in neurons. Cul3 homozygous deletion in mice is embryonic lethal; thus, we examine the role of Cul3 deletion in early synapse development and neuronal morphology in hippocampal primary neuronal cultures. Homozygous deletion of Cul3 significantly decreased dendritic complexity and dendritic length, as well as axon formation. Synaptic spine density significantly …
Measuring The Effects Of Selenium Exposure On Batrachochytrium Dendrobatidis (Bd) Growth In Vivo In Larval American Bullfrogs (Rana Catesbeiana)., Taylor Morrison
Measuring The Effects Of Selenium Exposure On Batrachochytrium Dendrobatidis (Bd) Growth In Vivo In Larval American Bullfrogs (Rana Catesbeiana)., Taylor Morrison
Honors Thesis
Most amphibians in today’s world are exposed to a variety of environmental stressors. This project’s main objective was to determine any effects of selenium on Batrachochytrium dendrobatidis (Bd) and infection levels in South Dakota amphibians. I selected American bullfrogs (Rana catesbeiana) as they are susceptible to Bd and are found throughout eastern South Dakota. The secondary objective of this project was to measure any impact of Bd and selenium, combined, on growth measures of the frogs. The third objective was to see if survival rates were reduced when amphibians were exposed to Bd and selenium. Tadpoles were collected (n=225) from …
The Effect Of Temperature On The Invasive Asian Needle Ant, Kaylee Mulligan '25
The Effect Of Temperature On The Invasive Asian Needle Ant, Kaylee Mulligan '25
Biology Student Scholarship
The Asian Needle Ant (Brachyponera chinensis) is an invasive species currently spreading on the Eastern Coast of the United States. They were first reported around the 1930s in Florida and have since migrated to Massachusetts. As an invasive species, this pest originating from Asia has a negative impact on environment ecosystems and other species of ants. Asian Needle Ants displace resident ant colonies, taking over nesting sites by consuming food sources and decreasing the amount of space other ant colonies can use. They are also known to have a sting that contains venom more likely to result in …
Sea Surface Temperature Influence On Tropical Storms And Hurricanes, Elise Leroux '26
Sea Surface Temperature Influence On Tropical Storms And Hurricanes, Elise Leroux '26
Biology Student Scholarship
Hurricanes are both dangerous and difficult to predict because of the various factors that influence the size and intensity of storms, where sea surface temperature (SST) is one of the most relevant variables. As temperatures are increasingly rising due to climate change, the effect on storm size, intensity, and frequency is going to be greater. There have been many studies how individual storms are affected, but less so on the overall frequency of hurricanes. This study assesses the number of hurricanes each year in comparison to the SST and the average wind speed of each hurricane. I predict that years …
Gdp Effects On Bottlenose Dolphins Within The Gulf Of Mexico, Kathleen Kelly '24
Gdp Effects On Bottlenose Dolphins Within The Gulf Of Mexico, Kathleen Kelly '24
Biology Student Scholarship
Bottlenose dolphins (Tursiops truncatus) are highly sensitive to environmental changes and anthropogenic stressors. Making them important indicators of marine ecosystem health. The Gulf of Mexico sustains diverse marine ecosystems and coastal communities. However, rapid industrialization, urbanization, and coastal development have altered marine habitats and increased anthropogenic pressures on marine wildlife. While various factors contribute to these strandings, the potential influence of socio-economic factors, particularly Gross Domestic Product (GDP) disparities among Gulf Coast counties, remains underexplored. This number (GDP) is influenced by human activities such as fisheries, shipping, and tourism, all of which directly or indirectly could affect marine …
Michigan Water Supply: Analysis Of Health Violations, Gabriela Guzman Reyes '24
Michigan Water Supply: Analysis Of Health Violations, Gabriela Guzman Reyes '24
Biology Student Scholarship
The presence of toxins in water sources poses a significant public health challenge. In Michigan, this issue has garnered widespread attention due to its adverse effects on human health and well-being. The contaminants found in water, including but not limited to lead, industrial pollutants, and agricultural runoff, stem from a variety of sources such as aging infrastructure, industrial activities, and agricultural practices. News articles and Government officials have reported the adverse affects and impact toxin exposure has on Michigan residents. However, there is little research examining the relationship between water quality violations and socioeconomic factors like poverty levels. I predict …
The Effect Sea Temperature Has On Coral Reef Health In The Great Barrier Reef, Elizabeth Glasspool '26
The Effect Sea Temperature Has On Coral Reef Health In The Great Barrier Reef, Elizabeth Glasspool '26
Biology Student Scholarship
Coral reef bleaching can happen for many different reasons including storms, disease, sediment and salinity changes, and of change in climate. Mass bleaching is typically a cause of increasing sea temperature in a certain area. Mass bleaching typically kills off many different species of coral. This is detrimental to a large portion of biodiversity, especially in a marine atmosphere. In 2016, records show that it is a record high ocean temperature which led to widespread coral bleaching on Australian reefs. This was part of the third global bleaching event declared by the National Oceanic and Atmospheric Administration (NOAA). At the …
The Effect Of Integrated Pest Management On Nutrition Of Bee Collected Pollen, Kaitlyn Bresnahan '25
The Effect Of Integrated Pest Management On Nutrition Of Bee Collected Pollen, Kaitlyn Bresnahan '25
Biology Student Scholarship
Honey bees are the world’s most commercially valuable pollinators, and they face many threats. The greatest challenge facing honey bees is Varroa mites, parasitic mites that feed on bees’ fat bodies, killing bees and spreading diseases. While chemical treatments are available to stop the spread of mites, these treatments are insecticides, which are not ideal to put in a hive of insects. A popular organic method of mite management is using drone comb. Drone brood is preferentially chosen by mites for ovipositing and development because of its larger size and longer development time, so removing drone brood can drastically reduce …
The Effect Of Population Density On Harmful Algal Blooms In Southwest Florida, Emma Barry '25
The Effect Of Population Density On Harmful Algal Blooms In Southwest Florida, Emma Barry '25
Biology Student Scholarship
Karenia brevis is a species of algae native to the Gulf of Mexico. Times when its growth becomes uncontrollable are called harmful algal blooms (formerly called “red tide events”), and they are often caused by increased nutrients in the water. These excessive nutrients come from watersheds and runoff that contain anthropogenic materials like fertilizer, and the phosphate and nitrogen in fertilizers catalyze the growth of algae. As population density in Florida increases, fertilizer runoff increases as well. Harmful algal bloom events are dangerous to both humans and the environment. Thick layers of algal growth on the water’s surface create “dead …
Whale Harvest Through Time: Unveiling The Hemispheric Contrasts In Whaling, Laura Mooney '24
Whale Harvest Through Time: Unveiling The Hemispheric Contrasts In Whaling, Laura Mooney '24
Biology Student Scholarship
Whales have been long known for their oils and rich blubber which has been a dish in many countries in both the Northern and Southern hemispheres. Some species were being hunted to near extinction. The earliest whaling began in 3000BC by Native American but commercial whaling began by the Basques in the 17th century with a huge increase in the 18th,19th and 20th centuries. This study examines how whale harvest has changed over time in years between 1900 and 1999 in both the Northern and Southern hemispheres. I analyzed the data collected by Jr. Robert(2015) and looked to see if …
Isolation Of Aged Mouse Primary Microglia As A Model System For Alzheimer’S Disease Research, Michael Landis
Isolation Of Aged Mouse Primary Microglia As A Model System For Alzheimer’S Disease Research, Michael Landis
Biology Honors Papers
Microglia and their role as the immune cells of the central nervous system are an emerging area of interest within Alzheimer’s research, particularly as they have shown in a benevolent and malevolent cellular context. Models of Alzheimer’s disease are very light in studying microglia, so in this study a model of microglia isolated from aged mice is established in order to study the phagocytic activity and protein expression of microglia in response to Amyloid Beta. The cells were isolated from aged mice and cultured before being used to confirm cellular identity, as well as to measure phagocytic activity. This study …
Clonal Plants' Traits And Responses Following Fire Disturbance In Ponderosa Pine Ecosystems In The Colorado Front Range, Raymond Erskine
Clonal Plants' Traits And Responses Following Fire Disturbance In Ponderosa Pine Ecosystems In The Colorado Front Range, Raymond Erskine
Master's Theses
Mountain ecosystems are currently experiencing increasing impacts of disturbances (e.g., wildfire) due to global changes in climate and land use, leading to significant changes in vegetation composition and landscape dynamics. Clonal plants, characterized by their vegetative reproduction strategies, offer a range of ecologically important traits to cope with disturbances. However, clonality is often excluded in studies of post-fire vegetation dynamics in mountain ecosystems, and our knowledge of the ability of clonal plants to respond to differing disturbance regimes is limited. Therefore, I examined the response of understory vegetation following fire disturbance in burned and unburned ponderosa pine stands of the …
Mate Guarding Against Strong Men Displaying Affiliative And Aggressive Humor, Jacob Pauley
Mate Guarding Against Strong Men Displaying Affiliative And Aggressive Humor, Jacob Pauley
Biological Sciences Undergraduate Honors Theses
Mate retention behaviors serve to discourage partner defection from a current pairbond. Such behaviors are oftentimes more prevalent toward intrasexual rivals exhibiting physical and behavioral cues implicating that rival as an optimal mate. Among these features in men are their upper body strength, a feature diagnostic of heritable fitness, and men's ability to produce humor, a cue to their social competence. This study considered the intersection of these desirable features in shaping men's mate retention behavior toward an intrasexual rival. After learning of a hypothetical interloper exhibiting high or low upper body strength while similarly using humor in an affiliative …
Towards Understanding The Function Of An Ets-Like Gene In Nematostella Vectensis: Generation Of A Knockout Mutant Line And A Transgenic Reporter Line, Emily Bullock
Biological Sciences Undergraduate Honors Theses
Due to their unique phylogenic position as sister to Bilateria, Cnidaria are often credited with the utility of allowing for reconstruction of ancestral biology based on characteristics shared with bilaterians and other animals. This factor makes investigation into the nervous systems of cnidarians critical in understanding early neural evolution. Wamides, a class of neuropeptides, have been shown to play a regulatory role in life cycle transitions across many different species. The cnidarian specific Wamide neuropeptide, GLWamide, has previously been identified to play an accelerator role in the metamorphic timing of a specific species of sea anemone, Nematostella vectensis. However, …
Effect Of Progesterone On Cognition Among College Aged Women, Katelyn Helberg
Effect Of Progesterone On Cognition Among College Aged Women, Katelyn Helberg
Biological Sciences Undergraduate Honors Theses
Women who have a reoccurring menstrual cycle and do not take hormonal birth control naturally experience changes in the amount of sex hormones that their body produces. These sex hormones help promote sexual development, fertility, and mood regulation, but can be hard to study due to their conflicting effects on each other. One such hormone, progesterone, is produced in different concentrations throughout the menstrual cycle to prepare the uterus for a potential pregnancy. However, it also may have secondhand effects on how well women can complete everyday tasks involving memory, attention, processing speed, and more which is what we measured …
Biophysical Model Of Retraction Motor Neurons And Their Modification By Operant Conditioning, Maria Rasheed
Biophysical Model Of Retraction Motor Neurons And Their Modification By Operant Conditioning, Maria Rasheed
Dissertations & Theses (Open Access)
Operant conditioning (OC) is a form of associative learning in which an animal modifies its behavior based on the consequences that follow that behavior. Despite its ubiquity, the underlying mechanisms of OC are poorly understood. Insights into the mechanisms of OC can be obtained by studying Aplysia feeding behavior as it can be modified by OC. This behavior is mediated by a central pattern generator (CPG) network in the buccal ganglia that contains a relatively small number of neurons. This CPG generates rhythmic motor patterns (BMPs) that move food into the gut by closing a tongue-like structure (i.e., radula) during …
Spatial Ecology Of Mule Deer Migrations From Grand Teton National Park And The Teton Range, Justin K. Schwabedissen
Spatial Ecology Of Mule Deer Migrations From Grand Teton National Park And The Teton Range, Justin K. Schwabedissen
All Graduate Theses and Dissertations, Fall 2023 to Present
The Greater Yellowstone Ecosystem hosts several of the longest, fully intact ungulate migrations remaining in the continental United States. However, expanding development and an increasing human footprint continue to truncate migratory routes. While the endpoints are often a seasonal range on protected lands, these migration corridors frequently cross other jurisdictional boundaries, including large tracts of private or multiple-use lands, with varying levels of protection. Thus, it is critical resource managers understand the dynamics of migratory movements to define population-level corridors and prioritize appropriate conservation strategies. Mule deer in Wyoming have been documented traveling long distances between summer and winter ranges; …
The Effect Of Hormonal Contraceptive Use On Dominance And Prestige Tactics, Carson Chappell
The Effect Of Hormonal Contraceptive Use On Dominance And Prestige Tactics, Carson Chappell
Biological Sciences Undergraduate Honors Theses
This study was designed to investigate the relationship between hormonal contraceptives and prestige and dominance status-seeking tactics. Existing literature has examined how the hormones estrogen and progesterone, especially in relation to the fertile window of the menstrual cycle, are associated with prestige and dominance but has yet to look in depth at how hormonal contraceptives might alter this impact. The current study asked participants to complete a 22- item questionnaire assessing dominance and prestige. I hypothesized that women on hormonal contraceptives would have lower scores for prestige and dominance compared to women who are naturally cycling. The results did not …
The Optimal Timing Of Abscisic Acid Treatment In Arabidopsis Under Drought And Salt Stress, Khelia Gihozo
The Optimal Timing Of Abscisic Acid Treatment In Arabidopsis Under Drought And Salt Stress, Khelia Gihozo
Graduate Student Dissertations, Theses, Capstones, and Portfolios
As climate change intensifies, harsh environmental conditions, such as increased drought and salt levels, will pose significant challenges to agricultural productivity globally. It is important to develop strategies for plants to tolerate these adverse conditions. This study aims to investigate how well the timing of abscisic acid (ABA) treatment can promote resistance to salt and drought in Arabidopsis thaliana grown on Murashige and Skoog agar medium. The study evaluates both wild-type and transgenic lines overexpressing the DREB2A gene, a transcriptional activator involved in the stress response of plants. Plants were exposed to drought and salt stress as they matured. Followed …
Utilizing Biomimicry To Design Sustainable Architecture, Virginia Hammond
Utilizing Biomimicry To Design Sustainable Architecture, Virginia Hammond
Architecture Undergraduate Honors Theses
Nature has an integral relationship with architecture and serves as a sustainable role model and inspiration for designers. The process of biomimicry in architecture has the potential to produce more sustainable design solutions and foster a connection between humans and nature. Existing biomimetic design projects have varying strengths and weaknesses as examples of the process. Utilizing guidelines and references from key leaders in biomimetic design consultancy (Biomimicry 3.8), selected case studies are assessed for their ability to demonstrate the benefits of this design strategy. Using these evaluations, the case studies are diagrammed and critiqued to determine how new projects could …
Qualitative Assessment Of Human Embryonic- And Induced Pluripotent Stem Cell Derived Neural Stem Cells Under Cgmp Methods, Michelle Hernandez
Qualitative Assessment Of Human Embryonic- And Induced Pluripotent Stem Cell Derived Neural Stem Cells Under Cgmp Methods, Michelle Hernandez
Electronic Theses, Projects, and Dissertations
Neural stem cell therapies represent a promising tool for the development of regenerative medicine and are being tested in clinical trials for several neurological disorders. However, the clinical applicability of stem cell therapies is dependent on the implementation of current good manufacturing practices (cGMPs) to ensure the quality, safety, and consistency that stem cell products need to meet FDA regulatory requirements. As such, there is a need for a shift to xeno-free methodologies so experimental conditions are cGMP compliant. The purpose of this study is to test a GMP compatible production method to generate multipotent neural stem cells (NSCs) from …
College Of Natural Sciences Newsletter, Spring 2024, College Of Natural Sciences
College Of Natural Sciences Newsletter, Spring 2024, College Of Natural Sciences
College of Natural Sciences Newsletters and Reports
Page 1 Dean's Message
Page 2 New Faculty and New Club on Campus
Page 3 2024 URSCAD Awards
Page 4 Day of Scholars 2024
Page 5 SDSU's First Representation at the Association for Anatomy's 2024
Annual Conference
Page 6-7 2024 Honor's College Convocation
Page 8 Other Student Activities
Page 9 Faculty Awards
Page 10-11 Other News
Page 12 2024 Drone Day and American Association of Geographers Convention - Hawaii
Page 13 55th Annual Geography Convention
Page 14 2024 Stethoscope Ceremony
Page 15 Open PRAIRIE Data