Rehabilitation and Therapy Commons^™

P38 Mapk Is Involved In Epigenetic Regulation Of Fibrotic Genes In Replication Induced Senescence In Lung Fibroblasts, Shan Zhu, Jennifer Q. Zhou, Kan Wang, Ming-Lei Guo, Yan Sanders

Department of Biomedical and Translational Sciences Faculty Publications

Fibroblast activation is essential for tissue repair following injury; however, prolonged activation drives pathological fibrosis. Idiopathic pulmonary fibrosis (IPF), a progressive and age-associated lung disease, is characterized by aberrant fibroblast activation, with increasing evidence implicating senescent and near-senescent fibroblasts in its pathogenesis. However, the underlying mechanisms remain poorly defined. In this study, we investigated whether histone modification is involved in TGF-β1 treated lung fibroblasts and contributes to the fibrotic phenotype. Human IMR90 lung fibroblasts at low and high population doubling levels (LPDL and HPDL), as well as primary IPF fibroblasts, were used in this study. In response to TGF-β1, both …

Regulation Creations: A Trauma-Informed Resource Addressing Sensory And Socio-Emotional Childhood Challenges, Meagan Noel Barnes Pearson

Occupational Therapy Capstones

Introduction: Trauma is ubiquitous and can negatively impact many life outcomes. Though trauma can occur across the lifespan, particular emphasis has been placed on the outcomes of experiences that occur in childhood. Adverse childhood experiences (ACEs), as coined by Felitti et al. (1998), pertain to traumatic events that occur before the age of 18, and the correlation between the number of ACEs and poor health outcomes is significant. Children can begin demonstrating unfavorable symptoms upon becoming exposed to trauma. Current literature has illustrated particular differences in sensory systems and social skills for young children. These challenges can lead to hardship …

Effect Of Active Music-Based Intervention Conducted By Music Therapists Or Medical Professionals On Reducing Agitation In Patients With Dementia: A Systematic Review And Meta-Analysis, Jian-Jia Huang, Yu-Hsuan Chen, Yun-Chen Chung, Yu-Peng Huang, Yu-Cheng Pei

Rehabilitation Practice and Science

Music-based interventions (MI), including music therapy and music medicine, have been proposed to reduce agitation in patients with dementia, yet evidence from randomized controlled trials (RCTs) and systematic reviews remains inconsistent. Moreover, the efficacy of MI may vary by method and professional involvement, which has not been fully examined. This study aimed to evaluate the effects of active MI conducted by music therapists or medical professionals on agitation in patients with dementia compared with those of general therapy (GT). RCTs published between January 1, 2010, and July 31, 2021, were identified from MEDLINE, PubMed, and the Cochrane Library. Study quality …

The Role Of Occupational Therapy In Supporting Neurodiverse Individuals In The Workplace, M'Kenna J. Henson

Occupational Therapy Doctorate Capstone Posters

My doctoral capstone was completed in partnership with the American Occupational Therapy Association (AOTA) and focused on the Accreditation Council for Occupational Therapy Education (ACOTE) areas of education and program development. The project involved developing a nationally-accessible asynchronous continuing education e-course, The Role of Occupational Therapy in Supporting Neurodiverse Individuals in the Workplace, to increase occupational therapy (OT) practitioners' and students' knowledge of neurodiversity, workplace inclusion, and evidence-based employment supports.

Current literature highlights significant barriers to employment for neurodivergent individuals. Approximately 20% of people are neurodivergent, yet nearly 80% of neurodiverse adults are unemployed, demonstrating the need for greater …

Acute Changes In Muscle Thickness And Perceptual Responses Following Different Applications Of Blood Flow Restriction, Anuj J. Prajapati

Honors Undergraduate Theses

The use of blood flow restriction (BFR) allows for reductions in exercise intensity without compromising muscular adaptations that are typically only manifested during high-load non-BFR exercise. There exist, however, several ways to implement BFR and there is a lack of information regarding which application may be beneficial over another. The purpose of this investigation was to examine acute changes in muscle size and perceptual responses following different pressure applications of BFR (i.e., continuous BFR [cBFR], intermittent during sets BFR [iBFR_sets], and intermittent during rest BFR [iBFR_rest]) relative to an unrestricted condition (i.e., nBFR). Participants completed cBFR, …

Relationships Between Quadriceps Neuromuscular Function And Time From Surgery Following Acl Reconstruction Are Sex-Specific, Tatiana Restrepo

Honors Undergraduate Theses

Anterior cruciate ligament reconstruction (ACLR) is associated with persistent quadriceps dysfunction, including muscular weakness and altered spinal and cortical excitability. While recovery has been widely studied, most investigations focus on isolated domains and fixed postoperative time points. Emerging evidence suggests females often experience slower or less complete quadriceps recovery compared to males, yet the time-dependent nature of these sex-specific outcomes remains unclear. The purpose of this study is to examine whether relationships between time since ACLR and quadriceps neuromuscular outcomes differ by sex across muscular, spinal, and cortical domains. Adults aged 18–35 with a history of primary, unilateral ACLR were …

Empowering Staff And Caregiver Through Occupational Therapy Education And Leadership At Hope Therapy Center, Natalie K. Antle

Occupational Therapy Doctorate Capstone Posters

My doctoral capstone was completed with Hope Therapy Center (HTC), a pediatric clinic in Da Nang, Vietnam that is part of a Christian-based nonprofit organization providing free therapy services to children with disabilities and their families. This project focused on the ACOTE areas of education and leadership. It was informed by a previous experience at HTC where I observed a need for additional staff education, caregiver support, and sustainable occupational therapy resources. Those observations guided the development of my capstone and helped ensure the project addressed the clinic's greatest needs.The purpose of this capstone was to strengthen staff knowledge of …

The Effect Of In-Game Cervical Exercises On Shoulder Internal Rotation Range Of Motion And External Rotator Strength In Baseball Pitchers, Vincent Ceasrine, Christine Ferraro, Jason K. Grimes

Physical Therapy Faculty Publications

Background

Consensus is lacking regarding the underlying cause of two prevalent risk factors for shoulder and elbow pain in overhead throwing athletes: loss of shoulder internal rotation (IR) range of motion (ROM) and strength of the external rotators (ER). Consideration of cervical spine contribution may have important implications for rehabilitation and coaching of overhead throwers.

Purpose

The purpose of this study was to investigate the effect of performing active cervical retraction and retraction with extension exercises between innings of pitching a simulated game on shoulder IR ROM and ER strength following completion of the game.

Study Design

Randomized controlled study …

Planning A Clinical Practice Guideline Revision For A Core Set Of Outcome Measures In Adults Undergoing Neurologic Physical Therapy, Part 1: Assessing Dissemination And Scholarly Uptake, Jennifer Moore, Jane E. Sullivan, Marghuretta D. Bland, Wendy Romney, Elizabeth Anderl, Zeynep Gulen Erkoc, Kristen Potter

Physical Therapy Faculty Publications

Introduction

Clinical Practice Guidelines (CPGs) facilitate evidence-based decision-making and standardising care, yet their dissemination and scholarly uptake vary widely. The Core Set of Outcome Measures for Adults With Neurologic Conditions Undergoing Rehabilitation CPG (Core Set) has been broadly referenced within neurologic physical therapy. As the next revision approaches, understanding its scholarly influence, citation patterns, and published feedback is essential. This study evaluated the dissemination and use of the Core Set across the peer-reviewed literature and identified areas for refinement.

Methods

A medical librarian conducted comprehensive searches of Web of Science, CINAHL, and Scopus to identify peer-reviewed English-language articles citing the …

Bridging The Gap: A Resource Toolkit To Support Clients Beyond Discharge, Kaleigh G. Williams

Occupational Therapy Doctorate Capstone Posters

This Occupational Therapy Doctoral Capstone was completed at The Medical Center–Franklin, a rural critical access hospital offering outpatient, acute, and post-acute rehabilitation services. The project aligned with the Accreditation Council for Occupational Therapy Education (ACOTE) focus areas of Leadership, Education, and Advocacy through the development of a Resource Toolkit to support caregivers, clients, and rehabilitation specialists during hospitalization and discharge planning.Through discussions with stakeholders regarding social determinants of health and occupational justice, a need for improved access to community resources was identified. In response, a comprehensive toolkit was developed containing more than 60 resources focused on client education, caregiver support, …

Simulated Traffic Stops For Neurodiverse Drivers, Addie Wilson

Occupational Therapy Doctorate Capstone Posters

The goal of this capstone project was to create a simulated traffic stop event for neurodiverse drivers to decrease anxieties and promote positive interactions with local law enforcement. This project was completed under the ACOTE standards of project development and clinical skills, and in collaboration with the University of Kentucky Driving Rehabilitation Program and a Certified Driving Rehabilitation Specialist. Previous simulated traffic stops have been completed specifically for the ASD population and showed improvements in anxiety and understanding of traffic stops. Additionally, resources like the Blue Envelope Program have been implemented across the country to allow for interactions between autistic …

Occupational Therapy’S Role In Health, Wellness, And Community Engagement In Rural Texas, Maggie Hall

Occupational Therapy Doctorate Capstone Posters

This Applied Leadership Experience (ALE) and Doctoral Capstone was completed at Colston Physical Rehabilitation & Wellness Center in Kingsville, Texas. The primary ACOTE focus areas addressed were advocacy and education. This capstone aimed to explore community perspectives on health and wellness while identifying gaps in health knowledge and access to community resources and streamline acute care evaluations to minimize readmission rates.

A needs assessment was conducted through community health and wellness questionnaires, stakeholder collaboration, and review of local demographic and health data.  Kingsville, TX is a rural community with higher-than-average rates of poverty and obesity. Findings revealed a need for …

I Am God's Masterpiece- Inclusive Vacation Bible School For Adults With Disabilities, Chelsea Lee M. Beverly

Occupational Therapy Doctorate Capstone Posters

A SWOT analysis revealed a substantial need of local events for adults with IDD, therefore, the goal of this capstone project was to host an event promoting inclusivity in rural communities and offering opportunities for meaningful engagement in social participation and leisure activities in diverse populations. I specifically focused on the community impacts of this project, what the needs were for this area, and how this could benefit the community now and in the future. This event was held on June 6, 2026 from 10am-3pm. Participants were offered engagement opportunities through completing crafts, participating in worship, interactive Bible lessons, outdoor …

Improving Fall Prevention In Assisted Living Through Resident Engagement, Staff Education And Environmental Safety Initiatives, Sarah Emmons

Occupational Therapy Doctorate Capstone Posters

My doctoral capstone project and Applied Leadership Experience (ALE) were completed at Parkview Assisted Living in Danville, Kentucky. The project focused on the ACOTE areas of education, program development, clinical practice, and leadership, with the goal of improving resident safety and independence through evidence-based fall prevention initiatives. A needs assessment was completed through staff interviews, resident observations, collaboration with facility leadership, and a review of current literature. Findings identified opportunities to enhance staff education related to fall prevention, dementia-informed communication, purposeful rounding, and environmental safety. To address these needs, I developed and implemented Steady Steps, a weekly occupation-based balance group …

Expanding Access To Age-Typical Social Experiences For Children With Disabilities: Camp Quest, Megan Duffy

Occupational Therapy Doctorate Capstone Posters

The purpose of this capstone project was to expand access to social participation and community integration experiences for children with disabilities in order to address the gap in access when compared with age-level peers. In order to accomplish this, I developed and administered summer camp programming in partnership with Easterseals Crossroads (ESC), a nonprofit organization that serves individuals with disabilities across the lifespan. In collaboration with a multitude of clinicians, students, topic experts, and organizational members of ESC, I developed camp programming and staff training for Camp QUEST. Following program development, I coordinated and guided the counselors, clinicians, volunteers, students, …

Pre-Writing/Writing Program Development For Elementary School Children With An Emphasis On Sensory Integration, Kayla A. Bingham

Occupational Therapy Doctorate Capstone Posters

For my Capstone project and Applied Leadership Experience I focused on the importance of handwriting in elementary school children. So, the practice setting I chose to complete my project at was three elementary schools in Petoskey, Michigan. Also, my primary ACOTE focus area for this specific project was program development.

The goals of my capstone includes: Gathering present information (research, work samples, and classroom observation) of pre-writing skills, hand writing skills, and sensory implications of handwriting for students with ASD/SPD, analyze observation notes to target identified factors that are contributing to difficulties in handwriting in students, develop pre-writing skills interventions …

Understanding The Role Of Occupational Therapy In Hospice Care: A Needs Assessment And Advocacy Project, Keeton Thornsberry

Occupational Therapy Doctorate Capstone Posters

This advocacy and education capstone project used a needs assessment questionnaire and literature review to evaluate perceptions of occupational therapy in hospice care. Findings guided the development of educational resources aimed at increasing awareness, supporting appropriate referrals, and promoting occupational therapy as an integral member of the hospice interdisciplinary team.

The Development And Implementation Of A Music-Based Engagement Toolkit To Support Occupations In Long-Term Care Settings, Clay Rains

Occupational Therapy Doctorate Capstone Posters

This doctoral capstone project, completed as part of the Occupational Therapy Doctorate program, focused on developing, implementing, and evaluating an evidence-based Music-Based Engagement Toolkit to support occupational therapy practitioners working with older adults in long-term care. The Applied Leadership Experience (ALE) was completed at Morning Pointe Senior Living, serving residents with dementia, Parkinson's disease, mild cognitive impairment, and age-related functional decline. The project emphasized the ACOTE focus areas of clinical practice, program development, leadership, and evidence-based practice.

The primary objectives were to create an evidence-based toolkit, implement individualized music interventions during occupational therapy sessions, and evaluate their impact on occupational …

Accessibility And Inclusion Within Girl Scouts, Morgan N. Minter

Occupational Therapy Doctorate Capstone Posters

My 14-week doctoral capstone and Applied Leadership Experience (ALE) was completed with the Girl Scouts of Kentucky’s Wilderness Road Council. Focusing on Program Development and Advocacy, the project aimed to increase accessibility and inclusion through occupational therapy-informed resources and leader education. A literature review and needs assessment identified a need for practical accessibility resources within Girl Scout programming. Drawing on my experience as both a former Girl Scout and occupational therapy student, I recognized opportunities to better support neurodivergent youth and youth with disabilities through evidence-based, inclusive practices. Using evidence review, program observation, and collaboration, I completed an accessibility assessment …

First Responders' Best Friends: A Mental Health And Trauma-Informed Care Program For First Responders, Jordan Postiglione

Entry Level Occupational Therapy Doctoral Capstone Projects Class of 2026

First responders experience consistent exposure to traumatic events in their day-to-day profession, placing them at increased risk for mental health challenges, including stress, burnout, anxiety, depression, and post-traumatic stress disorder.  The First Responder’s Best Friends doctoral capstone quality improvement project aimed to increase mental health and well-being in first responders as well as to bring awareness to the importance of mental health and the impact of trauma.  The capstone project consisted of three different areas of focus: program development and implementation, advocacy, and clinical practice skills.  Program development and implementation was a 12-week mental health program at the Kingston Fire …