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Low-Fat Abiraterone Food Effect Is Of Little Consequence, Jill M. Kolesar, Glenn X. Liu 2018 University of Kentucky

Low-Fat Abiraterone Food Effect Is Of Little Consequence, Jill M. Kolesar, Glenn X. Liu

Pharmacy Practice and Science Faculty Publications

No abstract provided.


Morphoregulatory Functions Of The Rna-Binding Motif Protein 3 In Cell Spreading, Polarity And Migration, J. Pilotte, W. Kiosses, S. W. Chan, H. P. Makarenkova, Esther E. Dupont-Versteegden, P. W. Vanderklish 2018 The Scripps Research Institute

Morphoregulatory Functions Of The Rna-Binding Motif Protein 3 In Cell Spreading, Polarity And Migration, J. Pilotte, W. Kiosses, S. W. Chan, H. P. Makarenkova, Esther E. Dupont-Versteegden, P. W. Vanderklish

Physical Therapy Faculty Publications

RNA-binding proteins are emerging as key regulators of transitions in cell morphology. The RNA-binding motif protein 3 (RBM3) is a cold-inducible RNA-binding protein with broadly relevant roles in cellular protection, and putative functions in cancer and development. Several findings suggest that RBM3 has morphoregulatory functions germane to its roles in these contexts. For example, RBM3 helps maintain the morphological integrity of cell protrusions during cell stress and disease. Moreover, it is highly expressed in migrating neurons of the developing brain and in cancer invadopodia, suggesting roles in migration. We here show that RBM3 regulates cell polarity, spreading and migration. RBM3 …


Implementation Of An Evidence-Based Intervention To Improve The Wellbeing Of People With Dementia And Their Carers: Study Protocol For 'Care Of People With Dementia In Their Environments (Cope)' In The Australian Context., Lindy Clemson, Kate Laver, Yun-Hee Jeon, Tracy A. Comans, Justin Scanlan, Miia Rahja, Jennifer Culph, Lee-Fay Low, Sally Day, Monica Cations, Maria Crotty, Susan Kurrle, Catherine V. Piersol, Laura N Gitlin 2018 University of Sydney

Implementation Of An Evidence-Based Intervention To Improve The Wellbeing Of People With Dementia And Their Carers: Study Protocol For 'Care Of People With Dementia In Their Environments (Cope)' In The Australian Context., Lindy Clemson, Kate Laver, Yun-Hee Jeon, Tracy A. Comans, Justin Scanlan, Miia Rahja, Jennifer Culph, Lee-Fay Low, Sally Day, Monica Cations, Maria Crotty, Susan Kurrle, Catherine V. Piersol, Laura N Gitlin

Department of Occupational Therapy Faculty Papers

BACKGROUND: There are effective non-pharmacological treatment programs that reduce functional disability and changed behaviours in people with dementia. However, these programs (such as the Care of People with dementia in their Environments (COPE) program) are not widely available. The primary aim of this study is to determine the strategies and processes that enable the COPE program to be implemented into existing dementia care services in Australia.

METHODS: This study uses a mixed methods approach to test an implementation strategy. The COPE intervention (up to ten consultations with an occupational therapist and up to two consultations with a nurse) will be …


The Impact Of Physical Therapy On An Athletes Decision To Return To Sport, Juliette Zielinski 2018 Bridgewater State University

The Impact Of Physical Therapy On An Athletes Decision To Return To Sport, Juliette Zielinski

Honors Program Theses and Projects

Injury is a reality that many athletes face when performing sport. Throughout time an athlete can cause significant damage to their body. Injuries can range from torn tendons to spinal cord injuries. Some injuries simply require rest while other injuries require surgery. In either case, the application of physical therapy is often prescribed to assist an athlete to return to sport, and in most cases return stronger than before. Once an athlete receives physical therapy and is cleared to return to sport many choose not to return. This proposed research seeks to identify if physical therapy has an impact on …


A Comical Look At Occupational Therapy, Karen McCarthy, Kira Kuwada 2018 Department of Occupational Therapy, Dominican University of California

A Comical Look At Occupational Therapy, Karen Mccarthy, Kira Kuwada

Collected Faculty Scholarship

n 2015, I attended the Association of Occupational Therapists of Ireland Conference and was inspired by the keynote address given by Sue Baptiste, MHSc, OT(C). Baptiste explored how she viewed the profession of occupational therapy as moving away from its roots in occupation and becoming more reductionistic in its practice. The profession of occupational therapy has seen many paradigm shifts—from a paradigm of occupation, to a mechanistic paradigm, and then toward a contemporary paradigm, which embraces (1) emphasizing the importance of occupation to health and well-being, (2) recognizing occupational problems and/or challenges as the focus of occupational therapy, and (3) …


Effects Of Two High-Frequency Physical Therapy Programs On Balance, Gait, Fatigue, And Quality Of Life In People With Multiple Sclerosis, Min Liu 2018 University of Nebraska Medical Center

Effects Of Two High-Frequency Physical Therapy Programs On Balance, Gait, Fatigue, And Quality Of Life In People With Multiple Sclerosis, Min Liu

Theses & Dissertations

Multiple sclerosis (MS) is an inflammatory disease involving the inflammation and demyelination in both brain and spinal cord. MS typically affects people in early adulthood in the range of 20-40 years old, and most patients with MS experience symptoms on a daily basis, such as walking difficulties, balance impairment, and fatigue, which can be disabling and impact the Quality of Life (QOL).

The main purpose of this investigation is to determine if our novel, adaptive, high-frequency physical therapy protocol, compared with the conventional therapeutic exercise protocol, has the potential to improve participants’ dynamic balance, gait, fatigue, and overall QOL based …


Selective Generation Of Dopaminergic Precursors From Human Fibroblasts By Direct Lineage Conversion, Miao He 2018 University of Nebraska Medical Center

Selective Generation Of Dopaminergic Precursors From Human Fibroblasts By Direct Lineage Conversion, Miao He

Theses & Dissertations

Transplantation of dopaminergic precursors (DPs) is a promising therapeutic strategy of Parkinson’s disease (PD). However, limited cell source for dopaminergic precursors has become a major obstacle for transplantation therapy. In the first part of the study, we demonstrated that Foxa2 is superior to Lmx1a in inducing dopaminergic neuronal differentiation from induced neural progenitor cells (iNPCs). Based on the results above and some other published results, our group demonstrated that mouse fibroblasts can be reprogrammed into induced dopaminergic precursors (iDPs) through ectopic expression of transcription factors Brn2, Sox2 and Foxa2(1). In the current study, we hypothesized that similar strategy …


An Athletic Training Portfolio: 3 Case Studies, Kristen Dawson 2018 James Madison University

An Athletic Training Portfolio: 3 Case Studies, Kristen Dawson

Senior Honors Projects, 2010-2019

The purpose of this portfolio is to convey the mechanism, evaluation process, and rehabilitation plan for three orthopedic injuries occurring over the course of the past two years. Each case presents patients with whom I played a role in their care, progressively increasing my involvement as I grew and learned professionally. The cases include background information and case descriptions of three individual patients, their evaluation and rehabilitation plans are included. The first case discusses an athlete with a lumbar disc herniation that underwent a microdiscectomy. This case study was revised from it’s original version and submitted to the National Athletic …


Ua61/16 White Coat Ceremony Program, WKU Physical Therapy 2018 Western Kentucky University

Ua61/16 White Coat Ceremony Program, Wku Physical Therapy

WKU Administration Documents

White coat ceremony program for WKU Physical Therapy class of 2018.


Assistive Listening Devices In Primary And Secondary Educational Settings: A Systematic Review, Paige Wagner-Skinner 2018 Minnesota State University Moorhead

Assistive Listening Devices In Primary And Secondary Educational Settings: A Systematic Review, Paige Wagner-Skinner

Dissertations, Theses, and Projects

The purpose of this study was to identify the scientific evidence available to support the use of assistive listening devices in primary and secondary educational settings. The American Speech-Language-Hearing Association (ASHA) makes it clear that it is the role of the speech-language pathologist (SLP) to modify the classroom environment, as needed, to enhance communicative abilities for this population (ASHA, 2016; Carney, 1998). Each journal article included in this study was published in a peer reviewed journal between the years of 2000 and 2018, written in the English language, and comprised of scientific information relevant to the research question proposed. Experimental …


Health And Human Rights Of Syrian Women And Children Refugees: Trafficking, Resettlement, And The United Nations Convention On Refugees Revisited, Lori Maria Walton PhD, DPT, MPH(s), CLT 2018 University of Sharjah

Health And Human Rights Of Syrian Women And Children Refugees: Trafficking, Resettlement, And The United Nations Convention On Refugees Revisited, Lori Maria Walton Phd, Dpt, Mph(S), Clt

Journal of Health Ethics

In 2016, there were approximately 22.5 million refugees displaced outside their home country because of armed conflict, over half of whom are minors. Syria reported the highest number, with over eleven million refugees displaced, both internally and externally, from zones of conflict in 2017. Over five million Syrian refugees, between the years 2011 and 2017, have fled to other countries including: Lebanon (1.1 million), Jordan (660,000), Egypt (122,000), Turkey (2.9 million) and Iraq (241,000). Exposure to war, displacement, and violence deprives women and children of the basic right to health, including the “right to control one’s health and body” and …


Ethical Dilemmas Experienced By Australian Rehabilitation Counsellors, Vanette McLennan, Kerry Ryan, Christine Randall 2018 Griffith University

Ethical Dilemmas Experienced By Australian Rehabilitation Counsellors, Vanette Mclennan, Kerry Ryan, Christine Randall

Journal of Health Ethics

Private sector rehabilitation counsellors operate in a dynamic and complex environment in which their decisions are influenced by several stakeholder interests including workers’ compensation authority regulators, scheme appointed agents, employers, and injured workers. The potentially competing interests of all parties often challenge the values and professional responsibilities of rehabilitation counsellors. The current study aimed to address the gap identified in the literature concerning ethical dilemmas unique to private sector rehabilitation counselling in Australia. A qualitative methodology was adopted to examine: a) the types of ethical dilemmas most encountered by rehabilitation counsellors working in the context of private sector settings; and …


Type-2 Diabetes Mellitus Reduces Cortical Thickness And Decreases Oxidative Metabolism In Sensorimotor Regions After Stroke., Jennifer K Ferris, Sue Peters, Katlyn E Brown, Katherine Tourigny, Lara A Boyd 2018 Western University

Type-2 Diabetes Mellitus Reduces Cortical Thickness And Decreases Oxidative Metabolism In Sensorimotor Regions After Stroke., Jennifer K Ferris, Sue Peters, Katlyn E Brown, Katherine Tourigny, Lara A Boyd

Physical Therapy Publications

Individuals with type-2 diabetes mellitus experience poor motor outcomes after ischemic stroke. Recent research suggests that type-2 diabetes adversely impacts neuronal integrity and function, yet little work has considered how these neuronal changes affect sensorimotor outcomes after stroke. Here, we considered how type-2 diabetes impacted the structural and metabolic function of the sensorimotor cortex after stroke using volumetric magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). We hypothesized that the combination of chronic stroke and type-2 diabetes would negatively impact the integrity of sensorimotor cortex as compared to individuals with chronic stroke alone. Compared to stroke alone, individuals with …


Trunk Motion Visual Feedback During Walking Improves Dynamic Balance In Older Adults: Assessor Blinded Randomized Controlled Trial., Eric Anson, Lei Ma, Tippawan Meetam, Elizabeth Thompson, Roshita Rathore, Victoria Dean, John Jeka 2018 Johns Hopkins School of Medicine

Trunk Motion Visual Feedback During Walking Improves Dynamic Balance In Older Adults: Assessor Blinded Randomized Controlled Trial., Eric Anson, Lei Ma, Tippawan Meetam, Elizabeth Thompson, Roshita Rathore, Victoria Dean, John Jeka

Department of Physical Therapy Faculty Papers

BACKGROUND: Virtual reality and augmented feedback have become more prevalent as training methods to improve balance. Few reports exist on the benefits of providing trunk motion visual feedback (VFB) during treadmill walking, and most of those reports only describe within session changes.

RESEARCH QUESTION: To determine whether trunk motion VFB treadmill walking would improve over-ground balance for older adults with self-reported balance problems.

METHODS: 40 adults (75.8 years (SD 6.5)) with self-reported balance difficulties or a history of falling were randomized to a control or experimental group. Everyone walked on a treadmill at a comfortable speed 3×/week for 4 weeks …


Performance Of The Promis In Patients After Anterior Cruciate Ligament Reconstruction, Elizabeth J. Scott, Robert Westermann, Nathalie A. Glass, Carolyn Hettrich, Brian R. Wolf, Matthew J. Bollier 2018 University of Iowa

Performance Of The Promis In Patients After Anterior Cruciate Ligament Reconstruction, Elizabeth J. Scott, Robert Westermann, Nathalie A. Glass, Carolyn Hettrich, Brian R. Wolf, Matthew J. Bollier

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) is designed to advance patient-reported outcome (PRO) instruments by utilizing question banks for major health domains.

Purpose: To compare the responsiveness and construct validity of the PROMIS physical function computer adaptive test (PF CAT) with current PRO instruments for patients before and up to 2 years after anterior cruciate ligament (ACL) reconstruction.

Study Design: Cohort study (diagnosis); Level of evidence, 2.

Methods: Initially, 157 patients completed the PROMIS PF CAT, Short Form-36 Health Survey (SF-36 physical function [PF] and general health [GH]), Marx Activity Rating Scale (MARS), Knee injury and Osteoarthritis Outcome …


Age-Related Changes In Visual Processing Speed: A Pilot Study Using The Motor Free Visual Perception Test- 4, Amber Zadravecz, Kassidy Ha, Lauren Gollnick, Stephanie Pawek, Zoe Studer 2018 Dominican University of California

Age-Related Changes In Visual Processing Speed: A Pilot Study Using The Motor Free Visual Perception Test- 4, Amber Zadravecz, Kassidy Ha, Lauren Gollnick, Stephanie Pawek, Zoe Studer

Dissertations, Masters Theses, Capstones, and Culminating Projects

Older adults are at a significantly increased risk of being involved in motor vehicle accidents. Evidence reveals that visual processing speed decreases with age, which may impact driving. The Motor-Free Visual Perception Test- Third Edition (MVPT-3) is used as a pre-driving assessment and has an age-normed Response Time Index that measures visual processing speed. In 2015, a new version, the new Motor-Free Visual Perception Test- Fourth Edition (MVPT-4), was published. The new MVPT-4 does not yet demonstrate its utility in measuring visual processing speed. The purpose of this study was to explore if differences in visual processing speed between younger …


Normative Percent Differences Between Inter-Day And Inter-Limb Upper Extremity Volume In Healthy Adult Females, Lauren Canady, Emily Henry, Mollie McCormick, Gabrielle Whisler 2018 University of Dayton

Normative Percent Differences Between Inter-Day And Inter-Limb Upper Extremity Volume In Healthy Adult Females, Lauren Canady, Emily Henry, Mollie Mccormick, Gabrielle Whisler

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Current diagnostic thresholds vary, but a 5% volume difference between limbs is generally accepted to diagnose lymphedema. Newer research among women with breast cancer-related lymphedema established a 3% threshold for diagnosis of preclinical lymphedema. Understanding normal limb volume fluctuations and side to side differences is important to determine whether this 3% cut point for diagnosis of subclinical lymphedema should be made compared to same or contralateral limbs.


The Effects Of An 8 Vs. 16 Week Yoga Practice On Balance, Strength, Flexibility, And Mindfulness In Children Ages 4-10 Years: A Pilot Study, Betsy Donahoe-Fillmore, Samantha Brown, Katherine Chu, Kelly Clancy, Jordan McMillan, Lesley Park, Kari Shank, Safiyeh Shalash 2018 University of Dayton

The Effects Of An 8 Vs. 16 Week Yoga Practice On Balance, Strength, Flexibility, And Mindfulness In Children Ages 4-10 Years: A Pilot Study, Betsy Donahoe-Fillmore, Samantha Brown, Katherine Chu, Kelly Clancy, Jordan Mcmillan, Lesley Park, Kari Shank, Safiyeh Shalash

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Yoga has been shown to have positive benefits in: Improving cardiovascular, neuromuscular, musculoskeletal, and pulmonary function in ages 0-21 years and improving mindfulness to manage pain and anxiety in adults. There is limited evidence regarding the use of yoga to improve balance, strength, flexibility, and mindfulness in children ages 4-10 years.


Using The Classification And Regression Tree Analysis In Determining The Relationship Between Functional Movement Assessment, Clinical Measures, And Injury In Nba Players, Philip A. Anloague, Matt Gundlach, Andrew Hackney, Jacob Hoying, Meg Saunders 2018 University of Dayton

Using The Classification And Regression Tree Analysis In Determining The Relationship Between Functional Movement Assessment, Clinical Measures, And Injury In Nba Players, Philip A. Anloague, Matt Gundlach, Andrew Hackney, Jacob Hoying, Meg Saunders

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Musculoskeletal pathology has been linked to games missed in the NBA due to player injury. Sports medicine professionals utilize functional assessments and clinical measures in order to minimize injury risk and maximize performance. The investigation of interactions among non-linear factors may help further the understanding of the interdependence of various measures and missed games due to injury.


The Influence Of Carbon Composite And Plastic Ankle Foot Orthoses On Balance And Gait In Individuals With Multiple Sclerosis: A Pilot Study, Hana Goubeaux, Carmen Macy, Tabatha Trauner, Kurt Jackson 2018 University of Dayton

The Influence Of Carbon Composite And Plastic Ankle Foot Orthoses On Balance And Gait In Individuals With Multiple Sclerosis: A Pilot Study, Hana Goubeaux, Carmen Macy, Tabatha Trauner, Kurt Jackson

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Multiple sclerosis (MS) can cause lower extremity weakness which may impair balance and gait. Ankle-foot orthoses (AFOs) are frequently prescribed to reduce the effects of these impairments. Despite numerous recent advances in the design and materials used for AFOs, there is a lack of evidence to guide clinicians in effective AFO prescription. The purpose of this research was to compare the effects of an anterior shell carbon AFO with a traditional plastic AFO on measures of balance and gait performance.


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