Psychiatry and Psychology Commons^™

Affect Variability And Physical Health: The Moderating Role Of Mean Affect, Brooke N. Jenkins, Lydia Q. Ong, Hee Youn (Helen) Lee, Anthony D. Ong, Julia K. Boehm

Psychology Faculty Articles and Research

Research has only begun to explore how affect variability relates to physical health and has typically not assessed long-term associations nor considered the moderating role of mean affect. Therefore, we used data from the Midlife in the United States Study waves 2 (N = 1512) and 3 (N = 1499) to test how affect variability predicted concurrent and long-term physical health while also testing the moderating role of mean affect. Results indicated that greater negative affect variability was associated concurrently with a greater number of chronic conditions (p = .03) and longitudinally with worse self-rated physical health (p …

Effects Of Sex And Estrous Cycle On Intravenous Oxycodone Self-Administration And The Reinstatement Of Oxycodone-Seeking Behavior In Rats, Nicole M. Hinds, Ireneusz D. Wojtas, Corinne A. Gallagher, Claire M. Corbett, Daniel F. Manvich

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The increasing misuse of both prescription and illicit opioids has culminated in a national healthcare crisis in the United States. Oxycodone is among the most widely prescribed and misused opioid pain relievers and has been associated with a high risk for transition to compulsive opioid use. Here, we sought to examine potential sex differences and estrous cycle-dependent effects on the reinforcing efficacy of oxycodone, as well as on stress-induced or cue-induced oxycodone-seeking behavior, using intravenous (IV) oxycodone self-administration and reinstatement procedures. In experiment 1, adult male and female Long-Evans rats were trained to self-administer 0.03 mg/kg/inf oxycodone according to a …

Psychological Perspectives On The Presentation Of Video Evidence: How Perceivers Weight What Is Seen And Unseen, Yael Granot, David Igliozzi

Psychology: Faculty Publications

Video evidence is proliferating in the courtroom, outpacing the incremental advances in policies governing its use. Psychological research on attention and perception indicates that people are vulnerable to numerous biases in how they interpret video. The dynamic format of such evidence directs attention in distinct ways, and the visual system selectively captures some pieces of information at the expense of others. Thus, perceivers who must make decisions about video evidence are vulnerable to overweighting the information they see, underweighting the information they do not see, and being overconfident about their interpretation of what they see. We marshal emerging research on …

Unmet Needs And Coping Strategies Of Older Underserved Veterans During The Covid-19 Pandemic, Trenton M. Haltom, Joyce Tiong, Tracy L. Evans, Nipa Kamdar, Gala True, Mark E. Kunik

School of Medicine Faculty Publications

Introduction: The COVID-19 pandemic has had profound impacts on people with diabetes, a group with high morbidity and mortality. Factors like race, age, income, Veteran-status, and limited or interrupted resources early in the COVID-19 pandemic compounded risks for negative health outcomes. Our objective was to characterize the experiences and needs of under-resourced Veterans with type 2 diabetes during the COVID-19 pandemic. Methods: We conducted semi-structured qualitative interviews (March through September 2021) with U.S. military Veterans with diabetes. Transcripts were analyzed using a team-based, iterative process of summarizing and coding to identify key themes. Participants included Veterans (n = 25) who …

What Is Reciprocity?: A Review And Expert-Based Classification Of Cooperative Transfers, Diego Guevara Beltran, Jessica D. Ayers, Andres Munoz, Lee Cronk, Athena Aktipis

Psychological Sciences Faculty Publications and Presentations

After decades of research on the topic of reciprocity, there is still no consensus about the meaning of the term. Instead, there has been a proliferation of reciprocity terms with varied definitions, some of which overlap in ways that lead to confusion for scholars studying cooperation. In this paper, we provide a summary of 34 reciprocity terms and their definitions from across a variety of disciplines. We then report the results of a survey of cooperation experts spanning biology, anthropology, economics, sociology, and psychology (N = 85) about the extent to which they consider 30 of these definitions of …

Bridging The Transition To Housing: A Social Justice Framework To Guide The Practice Of Occupational Therapists And Other Professionals Who Support Individuals With Experiences Of Homelessness (2nd Ed), Carrie Marshall, Rebecca Gewurtz, Skye Barbic, Laurence Roy, Abrial Cooke, Rosemary Lysaght

Occupational Therapy Publications

Occupational therapists have been supporting individuals who experience homelessness for several decades in their roles as community mental health therapists, on in-patient units, in traumatic brain injury programs, and in multiple other roles. Only recently, however, has this area of practice been acknowledged as distinct. Homelessness is growing in several high and middle-income countries worldwide. Occupational therapists have increasingly expressed an interest in gaining the knowledge and skills to effectively support individuals who experience homelessness, and in recent years, research in occupational therapy that focuses specifically on persons who experience homelessness has grown. The majority of individuals who have been …

A Public Health Educational Campaign For Sudden Unexpected Infant Death (Suid) Intervention, Elia G. Peralta Landeros

Master's Projects and Capstones

Purpose: The rate of infant mortality serves as a crucial indicator of the overall health of society (CDC, 2022). The five leading causes of infant mortality are birth defects, preterm birth, sudden infant death syndrome, injuries, and maternal pregnancy complications. The prevalence of infant mortality varies across states, with eastern states and minority-ethnicity infants having higher prevalence. This thesis proposes utilizing the Safe to Sleep framework to introduce Giving Breath, a public health education campaign that introduced breastfeeding as an intervention to Sudden Unexpected Infant Death (SUID).

Methods:

1. Analyze current and new policies' impact on women's rights to breastfeed …

Socioeconomic Status And Home Affordances Moderate Effects Of Motor Delay And Intervention, Iryna Babik, Andrea B. Cunha, Dongho Choi, Natalie A. Koziol, Lin-Ya Hsu, Regina T. Harbourne, Stacey C. Dusing, Sarah W. Mccoy, James A. Bovaird, Sandra L. Willett, Michele A. Lobo

Psychological Sciences Faculty Publications and Presentations

This study explored effects of socioeconomic status (SES) and home affordances on motor, language, and cognitive development in children with motor delays; it also tested whether SES and home affordances moderate the effect of the novel START-Play early intervention or motor delay severity on development. Participants were 112 children (64 males, 36.6% low SES) with motor delays tested longitudinally across 12 months (baseline age: Mean = 10.80, SD = 2.59 months). The results showed that more advanced motor, language, and cognitive development of children with motor delays is associated with high SES and enriched home affordances. Importantly, SES and home …

Hippocampal Volume And The Detection Of Mild Cognitive Impairment In An Older Adult Population: Assessing Performance On Cognitive Screeners Administered In-Person And Electronically, Kristen Fabrizi

Dissertations

The present study investigated how performance on in-person and electronic neuropsychological assessment measures predicted subcortical hippocampal volume and cognitive decline consistent with mild cognitive impairment. It was hypothesized that the Montreal Cognitive Assessment would display better predictive strength than the Cogstate Brief Battery when evaluating subcortical hippocampal volume measured via structural magnetic resonance imaging. It was further hypothesized that the Montreal Cognitive Assessment would be more sensitive to predicting group membership to the diagnostic classification of mild cognitive impairment compared to the Cogstate Brief Battery. The sample included 445 older adult participants selected from the Alzheimer’s Disease Neuroimaging Initiative 3. …

The Impact Of Covid-19 On Psychosocial Services And Perceived Supports For Pediatric Patients, Samantha Martinez

Theses and Dissertations

In March 2020, the World Health Organization named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a global pandemic. While the physiological damage of COVID-19 on individuals and communities is itself immeasurable, both because variants continue to spread and because of the unpredictable nature of “long COVID,” we know even less about the long-term psychological impacts on individuals. Lockdown procedures, including school closures, were necessary to prevent transmission of the virus and to protect the most vulnerable bodies (namely, the elderly and immuno-compromised). However, the effect of the closures disproportionately resulted in psychological damage to children and adolescents. Previous studies have …

The Emergence And Predictive Utility Of Early Markers Of Social Anxiety In Young Children With Fragile X Syndrome, Conner James Black

Theses and Dissertations

Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder characterized by elevated rates of intellectual disability, autism, and anxiety. Social anxiety affects approximately 60 percent of individuals with FXS and is cited as one of the most impairing comorbid disorders in FXS; however, little is understood about the developmental patterns of social anxiety markers in young children with FXS. The current study investigates cardiac and behavioral markers of social anxiety across the first five years of life and tests the predictive utility of these variables on social anxiety symptomatology. Participants included 80 children with FXS and 50 neurotypical controls. Participants …

Characterization Of Extended-Release Lorazepam: Pharmacokinetic Results Across Phase 1 Clinical Studies, Sanjay J Mathew, Shedly Jean-Lys, Rupinder Phull, Rama Yarasani

Staff and Researcher Publications

Purpose/background: Once-daily extended-release (ER) lorazepam was developed to reduce fluctuations in plasma levels compared with lorazepam immediate-release (IR) for short-term anxiety relief. Here we report a series of phase 1 randomized, open-label, multiperiod crossover studies characterizing ER lorazepam pharmacokinetics and safety in healthy adults.

Methods/procedures: These phase 1 studies assessed the pharmacokinetics of ER lorazepam administered: (study 1) 3 mg once daily versus IR lorazepam 1 mg 3 times a day (TID; every 8 hours), (study 2) with or without food, and (study 3) intact versus sprinkled onto food. Study 3 further evaluated the proportionality of 1 × 4- versus …

A Mendelian Randomization Study Of Genetic Liability To Post-Traumatic Stress Disorder And Risk Of Ischemic Stroke, Skanda Rajasundaram, Jean Mutabaruka, Eugene Rutembesa, Chisom Soremekun, Cisse Cheickna, Mamadou Wele, Joseph Mugisha, Oyekanmi Nash, Eugene Kinyanda, Dorothea Nitsch, Myriam Fornage, Tinashe Chikowore, Dipender Gill, Derek E Wildman, Leon Mutesa, Monica Uddin, Segun Fatumo

Faculty, Staff and Student Publications

Observational studies have shown an association between post-traumatic stress disorder (PTSD) and ischemic stroke (IS) but given the susceptibility to confounding it is unclear if these associations represent causal effects. Mendelian randomization (MR) facilitates causal inference that is robust to the influence of confounding. Using two sample MR, we investigated the causal effect of genetic liability to PTSD on IS risk. Ancestry-specific genetic instruments of PTSD and four quantitative sub-phenotypes of PTSD, including hyperarousal, avoidance, re-experiencing, and total symptom severity score (PCL-Total) were obtained from the Million Veteran Programme (MVP) using a threshold P value (P) of <5 >× 10

Reward Processing In Psychiatric Inpatients With Depression, Hyuntaek Oh, Jaehoon Lee, Michelle A Patriquin, John Oldham, Ramiro Salas

Staff and Researcher Publications

Background: Previous neuroimaging studies have investigated reward-processing dysfunction in major depressive disorder and have led to the common finding that major depressive disorder is associated with reduced reward responses within the reward circuit. Yet it is unclear whether such reward-processing dysfunction is specifically associated with the severity of depressive symptoms in major depressive disorder or is associated with common comorbidities.

Methods: We investigated reward-processing differences using a classic juice-delivery functional magnetic resonance imaging experiment to compare psychiatric patients with severe depressive symptoms (DEPs) to both psychiatric control subjects (PCs) and healthy control subjects. In this study, the DEPs (n = …

A Longitudinal Investigation Of Blood Neurofilament Light Chain Levels In Chronic Cocaine Users, Markus R Baumgartner

Faculty, Staff and Student Publications

The identification of a blood marker of brain pathology that is sensitive to substance-induced neurotoxicity and dynamically responds to longitudinal changes in substance intake would substantially improve clinical monitoring in the field of substance use and addiction. Here, we explored the hypothesis that plasma levels of neurofilament light chain (NfL), a promising marker of neuroaxonal pathology, are elevated in chronic cocaine users and longitudinally associated with changes in cocaine use. Plasma NfL levels were determined using single molecule array (SIMOA) technology at baseline and at a 4-month follow-up. Substance use was subjectively assessed with an extensive interview and objectively measured …

Predictors Of Self-Reported General Health Status In People Experiencing Homelessness With Serious Mental Illness

Faculty, Staff and Student Publications

PURPOSE: The growing homeless population in the U.S.A. is disproportionately impacted by poor mental and physical health status, including a higher incidence of acute and chronic health problems, increased hospitalizations, and premature mortality compared to the general population. This study examined the association between demographic, social, and clinical factors and perceptions of general health status among the homeless population during admission to an integrated behavioral health treatment program.

METHODS: The study sample included 331 adults experiencing homelessness with a serious mental illness or co-occurring disorder. Participants were enrolled in services at a day program for unsheltered homeless adults, a residential …

On-Campus Mental Health Service Use Among College Students With Autism: A Case Study Applying The Andersen Behavioral Model Of Health Services Use, Estella C. Lilyquist

Electronic Theses and Dissertations

The unique set of impairments and limitations presented by students with autism spectrum disorder (ASD) make the accessing of campus-based nonacademic resources more difficult and complicated than their typically developed peers. Each year, the rate of students entering college with disabilities continues to grow, but their mental well-being is relatively poor. The purpose of this qualitative case study was to apply the conceptual framework of the Andersen behavioral model of health services use (ABMHSU) to the experiences of college students with ASD to understand and predict their utilization of campus-provided mental health resources. The participants were seven college students with …

The Role Of Expressed Emotion On Post-Traumatic Stress Disorder, Steven Drosky, Natasha Reddy, Eduardo Espiridion

Transformative Medicine

Introduction: This case report explores the impact of expressed emotion (EE) on the management of a patient with post-traumatic stress disorder. EE is a term used to denote the attitude of familial caregivers toward a person with a mental disorder.

Clinical Findings: We describe the case of a paraplegic patient living in an environment of high expressed emotion. The patient had no history of psychiatric illness prior to suffering a spinal cord injury. Since the injury the patient reports recurring symptoms consistent with post-traumatic stress disorder and worsening of symptoms due to family members expressing negative attitudes.

Conclusion: The construct …

Arnold-Chiari Malformation-I Borderline Personality Disorder, Aric Huber, Matthew Driben, Eduardo Espiridion

Transformative Medicine

Introduction:
Arnold-Chiari Malformation I (AM-I) is a congenital anomaly that manifests with cerebellar dysfunction. There is a displacement of cerebellar tonsils into the foramen magnum. Several mood disorders, personality disorders, and intellectual disabilities are associated with AM-I. Borderline personality disorder (BPD) is characterized by symptoms of mood lability, impulsivity, extreme efforts of abandonment, splitting and dysfunctional relationships.

Case Description:
The patient is an early aged adult with a past medical history of AM-I, hypothyroidism, Wolff-Parkinson-White syndrome, and diabetes mellitus type II. The patient was admitted to the hospital after ingesting foreign bodies. He/she presented with mood lability, sad mood, anhedonia, …

Understanding The Effects Of Empathy And Masculine Gender Role Stress On The Relationship Between Gender And The Understanding Of Consent In Adolescents: A Moderated Mediation Framework, Kate Degenhardt

Clinical Psychology Dissertations

This research examined the relationship between masculine gender role stress and empathy in youths ages 11-19 and their ability to understand the concept of consent. I examined a moderated mediation model where the effect of gender on the understanding of consent via masculine gender role stress was permitted to differ as a function of levels of empathy. The moderated mediation was evaluated in a stepwise fashion. A simple mediation examining the degree to which MGRS mediated the relation of gender on consent revealed all effects were significant, including the indirect effect (B = 0.561, SE = .292 95, CI 0.100, …