Psychiatry and Psychology Commons^™

Horror Vacui: Emptiness Might Distinguish Between Major Suicide Repeaters And Nonmajor Suicide Repeaters: A Pilot Study, Hilario Blasco-Fontecilla, Enrique Baca-Garcia, Philippe Courtet, Rebeca Garcia Nieto, Jose De Leon

Psychiatry Faculty Publications

No abstract provided.

Somatic Experiencing: Using Interoception And Proprioception As Core Elements Of Trauma Therapy, Peter Payne, Peter A. A. Levine, Mardi A. Crane-Godreau

Dartmouth Scholarship

Here we present a theory of human trauma and chronic stress, based on the practice of Somatic Experiencing(®) (SE), a form of trauma therapy that emphasizes guiding the client's attention to interoceptive, kinesthetic, and proprioceptive experience. SE™ claims that this style of inner attention, in addition to the use of kinesthetic and interoceptive imagery, can lead to the resolution of symptoms resulting from chronic and traumatic stress. This is accomplished through the completion of thwarted, biologically based, self-protective and defensive responses, and the discharge and regulation of excess autonomic arousal. We present this theory through a composite case study of …

The Role Of Parental Cognitive, Behavioral, And Motor Profiles In Clinical Variability In Individuals With Chromosome 16p11.2 Deletions, Andres Moreno-De-Luca, David W. Evans, K B. Boomer, Ellen Hanson, R Bernier, R. P. Goin-Kochel, S. M. Myers, Thomas D. Challman, Daniel Moreno-De-Luca, Mylissa M. Slane, Abby E. Hare, W K. Chung, J. Spiro, W. A. Faucett, C. L. Martin, David H. Ledbetter

Faculty Journal Articles

Importance Most disorders caused by copy number variants (CNVs) display significant clinical variability, often referred to as incomplete penetrance and variable expressivity. Genetic and environmental sources of this variability are not well understood.

Objectives To investigate the contributors to phenotypic variability in probands with CNVs involving the same genomic region; to measure the effect size for de novo mutation events; and to explore the contribution of familial background to resulting cognitive, behavioral, and motor performance outcomes in probands with de novo CNVs.

Design, Setting, and Participants Family-based study design with a volunteer sample of 56 individuals with de novo 16p11.2 …

The Neurophysiology Of Intersensory Selective Attention And Task Switching, Jeremy W. Murphy

Dissertations, Theses, and Capstone Projects

Our ability to selectively attend to certain aspects of the world and ignore others is fundamental to our day-to-day lives. The need for selective attention stems from capacity limitations inherent in our perceptual and cognitive processing architecture. Because not every elemental piece of our environment can be fully processed in parallel, the nervous system must prioritize processing. This prioritization is generally referred to as selective attention. Meanwhile, we are faced with a world that is constantly in flux, such that we have to frequently shift our attention from one piece of the environment to another and from one task to …

Piloting A Psychotherapy Group For Transgender Clients: Description And Clinical Considerations For Practitioners, Nicholas C. Heck, Leslie C. Croot, Jennifer S. Robohm

Psychology Faculty Research and Publications

The likelihood that a psychologist will work with a transgender client is greater today than ever before; however, many psychologists report being unfamiliar with the challenges faced by this population. Training programs provide minimal exposure to transgender issues by way of coursework and practicum experiences, and many barriers prevent transgender persons from accessing quality mental health care. The provision of group psychotherapy services in psychology training clinics may help reduce barriers to treatment, but there is little literature to guide professionals interested in facilitating such a group. In response, this article provides psychologists with a description of an experiential/process psychotherapy …

Jackson, Hope Celeste, B. 1972 (Fa 786), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid and full text paper (click Additional Files below) for Folklife Archives Project 786. This collection features a term paper and DVD relating to the pagan folklife in the United States. The project was completed by Western Kentucky University student Hope Celeste Jackson for credit in an “Introduction to Folk Studies” class.

Spatial And Temporal Characteristics Of Error-Related Activity In The Human Brain, Maital Neta, Francis M. Miezin, Steven M. Nelson, Joseph W. Dubis, Nico U.F. Dosenbach, Bradley L. Schlaggar, Steven E. Petersen

Center for Brain, Biology, and Behavior: Faculty Publications

A number of studies have focused on the role of specific brain regions, such as the dorsal anterior cingulate cortex during trials on which participants make errors, whereas others have implicated a host of more widely distributed regions in the human brain. Previous work has proposed that there are multiple cognitive control networks, raising the question of whether error-related activity can be found in each of these networks. Thus, to examine error-related activity broadly, we conducted a meta-analysis consisting of 12 tasks that included both error and correct trials. These tasks varied by stimulus input (visual, auditory), response output (button …

Exposure To Kynurenic Acid During Adolescence Increases Sign-Tracking And Impairs Long-Term Potentiation In Adulthood, Nicole E. Deangeli, Travis P. Todd, Stephen E. Chang, Hermes H. Yeh, Pamela W. Yeh, David J. Bucci

Dartmouth Scholarship

Changes in brain reward systems are thought to contribute significantly to the cognitive and behavioral impairments of schizophrenia, as well as the propensity to develop co-occurring substance abuse disorders. Presently, there are few treatments for persons with a dual diagnosis and little is known about the neural substrates that underlie co-occurring schizophrenia and substance abuse. One goal of the present study was to determine if a change in the concentration of kynurenic acid (KYNA), a tryptophan metabolite that is increased in the brains of people with schizophrenia, affects reward-related behavior. KYNA is an endogenous antagonist of NMDA glutamate receptors and …

Integrating Basic Research With Prevention/Intervention To Reduce Risky Substance Use Among College Students, Danielle M. Dick, Linda C. Hancock

Psychiatry Publications

Too often basic research on etiological processes that contribute to substance use outcomes is disconnected from efforts to develop prevention and intervention programming. Substance use on college campuses is an area of concern where translational efforts that bring together basic scientists and prevention/intervention practitioners have potential for high impact. We describe an effort at a large, public, urban university in the United States to bring together researchers across the campus with expertise in college behavioral health with university administration and health/wellness practitioners to address college student substance use and mental health. The project “Spit for Science” examines how genetic and …

Stress Reactivity To An Electronic Version Of The Trier Social Stress Test: A Pilot Study, Sage E. Hawn, Lisa Paul, Suzanne Thomas, Stephanie Miller, Ananda B. Amstadter

Psychiatry Publications

Social stressors that rely on the inclusion of confederates (i.e., Trier Social Stress Test, TSST) are often used in clinical laboratory research paradigms to elicit a measurable stress response in participants. Although effective, the TSST is labor intensive and may introduce error variance as a function of confederate race, gender, and/or response characteristics. The present study aimed to develop and validate an electronic version of the TSST (e-TSST). The primary aim was to compare the e-TSST to an e-neutral control condition; the exploratory aim was to compare the magnitude of stress response elicited by the e-TSST to that elicited by …

Distmix: Direct Imputation Of Summary Statistics For Unmeasured Snps From Mixed Ethnicity Cohorts, Donghyun Lee, T. Bernard Bigdeli, Vernell S. Williamson, Vladimir I. Vladimirov, Brien P. Riley, Ayman H. Fanous, Silviu-Alin Bacanu

Psychiatry Publications

Motivation: To increase the signal resolution for large-scale meta-analyses of genome-wide association studies, genotypes at unmeasured single nucleotide polymorphisms (SNPs) are commonly imputed using large multi-ethnic reference panels. However, the ever increasing size and ethnic diversity of both reference panels and cohorts makes genotype imputation computationally challenging for moderately sized computer clusters. Moreover, genotype imputation requires subject-level genetic data, which unlike summary statistics provided by virtually all studies, is not publicly available. While there are much less demanding methods which avoid the genotype imputation step by directly imputing SNP statistics, e.g. Directly Imputing summary STatistics (DIST) proposed …

Stress Reactivity To An Electronic Version Of The Trier Social Stress Test: A Pilot Study, Sage E. Hawn, Lisa Paul, Suzanne Thomas, Stephanie Miller, Ananda B. Amstadler

Psychiatry Publications

Social stressors that rely on the inclusion of confederates (i.e., Trier Social Stress Test, TSST) are often used in clinical laboratory research paradigms to elicit a measurable stress response in participants. Although effective, the TSST is labor intensive and may introduce error variance as a function of confederate race, gender, and/or response characteristics. The present study aimed to develop and validate an electronic version of the TSST (e-TSST). The primary aim was to compare the e-TSST to an e-neutral control condition; the exploratory aim was to compare the magnitude of stress response elicited by the e-TSST to that elicited by …

Genetic Network Properties Of The Human Cortex Based On Regional Thickness And Surface Area Measures, Anna R. Docherty, Chelsea K. Sawyers, Matthew S. Panizzon, Michael C. Neale, Lisa T. Eyler, Christine Fennema-Notestine, Carol E. Franz, Chi-Hua Chen, Linda K. Mcevoy, Brad Verhulst, Ming T. Tsuang, William S. Kremen

Psychiatry Publications

We examined network properties of genetic covariance between average cortical thickness (CT) and surface area (SA) within genetically-identified cortical parcellations that we previously derived from human cortical genetic maps using vertex-wise fuzzy clustering analysis with high spatial resolution. There were 24 hierarchical parcellations based on vertex-wise CT and 24 based on vertex-wise SA expansion/contraction; in both cases the 12 parcellations per hemisphere were largely symmetrical. We utilized three techniques—biometrical genetic modeling, cluster analysis, and graph theory—to examine genetic relationships and network properties within and between the 48 parcellation measures. Biometrical modeling indicated significant shared genetic covariance between size of several …

Behind The Scenes Of The Nas: Human Factors Taxonomy For Investigating Service Integrity Events, Katherine A. Berry, Michael W. Sawyer, Jordan Hinson

International Symposium on Aviation Psychology - 2015

The Federal Aviation Administration (FAA) deployed the Service Integrity Risk Analysis Process (SI-RAP) with the goal of assessing the risk of technical occurrence events where the ability to provide safe air traffic management technical services is compromised. As a post-event tool, SI-RAP assesses the risk associated with an occurrence based on severity and repeatability. The SI-RAP taxonomy was developed to provide a consistent framework for supporting the assessment of event repeatability. The SI-RAP taxonomy synthesizes existing human factors taxonomies with customized factors representing the technical operations domain. The SI-RAP taxonomy is comprised of four tiers: Personnel Factors, Contextual Factors, Equipment …

Techniques For The Human Centered Evaluation Of Designs For The Future Aviation System, Philip J. Smith, Kathy Abbott, Lawrence J. Prinzel, Amy Pritchett, Tanya Yuditsky

International Symposium on Aviation Psychology - 2015

In order to evaluate new operational concepts, system designs, procedures and technologies for the future aviation system, we need to develop and validate a range of techniques to ensure the safe and effective performance of human-machine systems. This becomes increasingly important as such systems incorporate increasing levels of automation and autonomy for technologies, and as they attempt to integrate increasingly complex subsystems. It is challenging to evaluate the individual components of such systems relative to meeting their design requirements. It is orders of magnitude more challenging to evaluate performance when they are embedded in the larger system context. While there …

Pupillary Response As An Indicator Of Processing Demands Within A Supervisory Control Simulation Environment, Ciara Sibley, Joseph Coyne, Akshith Doddi, Phillip Jasper

International Symposium on Aviation Psychology - 2015

Current Unmanned Aerial Vehicle (UAV) operator task demands are highly variable and unbalanced across team members, resulting in sub-optimal operator utilization which leads to mishaps. This has driven the Department of Defense’s desire for more flexible team structures and task allocation tools. Unobtrusive and continuous measures of operator state are needed to effectively allocate tasking to operators and prevent errors. Twenty participants completed two twenty minute supervisory control sessions where task load was manipulated by varying event frequency (e.g., information requests) and eye tracking data was collected. Pupillometry data revealed increased mean and maximum pupil sizes with increased task load …

The Effects Of Bright Light Intervention On Flight Crew Behavioral Alertness And Cognitive Fatigue, Lori Brown, Geoffrey Whitehurst

International Symposium on Aviation Psychology - 2015

The study aimed to investigate the efficacy of bright light intervention to improve behavioral alertness and reduce cognitive fatigue in flight crew-members. During the four week study, crewmembers wore actigraph bands to monitor sleep behaviors. Self-assessed levels of sleepiness were recorded using the Karlosinska Sleepinees Scale (KSS), and self-assessed fatigue was measured using the Samn-Perelli (SP) fatigue scale. Participants completed psychomotor vigilance tests (PVT) to measure behavioral alertness. On the third and fourth weeks of the study, participants were exposed to short wavelength bright light (465nm blue) light intervention. The results show that there was a significant difference in alertness …

Integrating Mrna And Mirna Weighted Gene Co-Expression Networks With Eqtls In The Nucleus Accumbens Of Subjects With Alcohol Dependence, Mohammed Mamdani, Vernell Williamson, Gowon O. Mcmichael, Tana Blevins, Fazil Aliev, Amy Adkins, Laura Hack, Tim Bigdeli, Andrew D. Van Der Vaart, Bradley Todd Webb, Silviu-Alin Bacanu, Gursharan Kalsi, Coga Consortium, Kenneth S. Kendler, Michael F. Miles, Danielle Dick, Brien P. Riley, Catherine Dumur, Vladimir I. Vladimirov

Psychiatry Publications

Alcohol consumption is known to lead to gene expression changes in the brain. After performing weighted gene co-expression network analyses (WGCNA) on genome-wide mRNA and microRNA (miRNA) expression in Nucleus Accumbens (NAc) of subjects with alcohol dependence (AD; N = 18) and of matched controls (N = 18), six mRNA and three miRNA modules significantly correlated with AD were identified (Bonferoni-adj. p≤ 0.05). Cell-type-specific transcriptome analyses revealed two of the mRNA modules to be enriched for neuronal specific marker genes and downregulated in AD, whereas the remaining four mRNA modules were enriched for astrocyte and microglial specific marker genes and …

Integrating Mrna And Mirna Weighted Gene Co-Expression Networks With Eqtls In The Nucleus Accumbens Of Subjects With Alcohol Dependence, Mohammed Mamdani, Vernell Williamson, Gowon O. Mcmichael, Tana Blevins, Fazil Aliev, Amy Adkins, Laura Hack, Tim Bigdeli, Andrew D. Van Der Vaart, Bradley Todd Web, Silviu-Alin Bacanu, Gursharan Kalsi, Coga Consortium, Kenneth S. Kendler, Michael F. Miles, Danielle Dick, Brien P. Riley, Catherine Dumur, Vladimir I. Vladimirov

Psychiatry Publications

Alcohol consumption is known to lead to gene expression changes in the brain. After performing weighted gene co-expression network analyses (WGCNA) on genome-wide mRNA and microRNA (miRNA) expression in Nucleus Accumbens (NAc) of subjects with alcohol dependence (AD; N = 18) and of matched controls (N = 18), six mRNA and three miRNA modules significantly correlated with AD were identified (Bonferoni-adj. p≤ 0.05). Cell-type-specific transcriptome analyses revealed two of the mRNA modules to be enriched for neuronal specific marker genes and downregulated in AD, whereas the remaining four mRNA modules were enriched for astrocyte and microglial specific marker genes and …

Brief Consultation To Families Of Treatment Refusers With Symptoms Of Obsessive Compulsive Disorder: Does It Impact Family Accommodation And Quality Of Life?, Melanie M. Vandyke, C. Alec Pollard, Jacob Harper, Kyle E. Conlon

Faculty Publications

Family members are often directly and significantly impacted by the restrictive demands of OCD, a frequently disabling disorder. Family accommodation behaviors (i.e., doing things for or because of the OCD sufferer that a person would not normally do) are associated with dysfunction, including poorer treatment responses in OCD sufferers and greater distress in family members. Although evidence suggests family-based intervention can reduce symptoms in OCD sufferers who participate in treatment, there is a lack of research documenting the impact of interventions designed for the families of OCD treatment refusers (TR). Brief Family Consultation (BFC) was developed by our clinical team …