Mental Disorders Commons^™

Persistent Stress-Induced Neuroplastic Changes In The Locus Coeruleus/Norepinephrine System, Olga Borodovitsyna, Neal Joshi, Daniel Chandler

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Neural plasticity plays a critical role in mediating short- and long-term brain responses to environmental stimuli. A major effector of plasticity throughout many regions of the brain is stress. Activation of the locus coeruleus (LC) is a critical step in mediating the neuroendocrine and behavioral limbs of the stress response. During stressor exposure, activation of the hypothalamic-pituitary-adrenal axis promotes release of corticotropin-releasing factor in LC, where its signaling promotes a number of physiological and cellular changes. While the acute effects of stress on LC physiology have been described, its long-term effects are less clear. This review will describe how stress …

The Moderating Relationship Of Comorbid Psychopathology And Treatment Outcome For Young Adult Offenders In Drug Court, Patrick Mcgonigal, Kathleen A. Moore, Matthew Scott Young

Mental Health Law & Policy Faculty Publications

Title: The moderating relationship of comorbid psychopathology and treatment outcome for young adult offenders in drug court.

Background: The drug court system is an alternative to incarceration that provides offenders with non-violent, substance motivated crimes with an opportunity to dismiss their charges and undergo a rigorous substance abuse treatment program. It is unknown whether drug court is effective for young adult clients and the role of co-occurring psychopathology within this context.

Methods: This study evaluated the overall effectiveness of a drug court system applied to young adult offenders ages 18-26, and additionally explored the moderating relationship of psychiatric symptoms on …

Wecan! A 12-Month Evaluation Of A Drug Court Treatment Program Serving Females Addicted To Prescription Drugs, Kathleen A. Moore, M. Scott Young

Mental Health Law & Policy Faculty Publications

Prescription drug abuse represents a national public health concern. This study reports on 12-month outcomes of a drug court treatment program for 102 female offenders addicted to prescription drugs. The program utilized two evidence-based treatment models (i.e., Motivational Enhancement Therapy/Cognitive Behavioral Therapy-12 and Seeking Safety). In addition, participants were required to attend monthly judicial reviews, weekly AA/NA groups, and two random drug screens per week. Participants were interviewed at baseline and 12-month follow-up. Analyses examined self-reported substance use, traumatic experiences, criminal justice involvement, readiness to change, and therapeutic alliance. Participants reported significant decreases in substance use, increased readiness to change, …

The Duration Of Untreated Psychosis: A Phenomenological Study, Sarah R. Kamens, Larry Davidson, Emily Hyun, Nev Jones, Jill G. Morawski, Matthew M. Kurtz, Jessica Pollard, Gerrit Ian Van Schalkwyk, Vinrod Srihari

Mental Health Law & Policy Faculty Publications

Mounting evidence has indicated that early intervention leads to improved clinical and functional outcomes for young persons experiencing recent onset psychosis. As part of a large early detection campaign, the present study aimed to investigate subjective experiences during the duration of untreated psychosis (DUP), or time between psychosis onset and treatment contact. Participants were 10 young adults participating in early intervention services for psychosis. After DUP was estimated during standardized baseline assessment, participants engaged in qualitative interviews focused on their life experiences prior to treatment and leading up to the present. Mixed methods data analyses compared standardized DUP estimates with …

The Relationship Between Resilience, Coping, And Social Media, Lillian N. Hurley

Masters Theses

This study was designed to explore relationships between measures of resilience, coping strategies, social media usage, and depression. Resilience refers to one's ability to endure and recover from adversity. Many theories about what contributes to the development resilience have been explored without a clear consensus. Taormina (2015) argued that adult personal resilience is comprised of four dimensions - determination, endurance, adapatability, and recuperability. Coping, a construct related to resilience, is the process of regulating emotions, cognition, behavior, physiological responses, and the environment in response to stressful events. Past research indicated those with poorer mental health have the tendency to use …

Resilience Concepts In Psychiatry Demonstrated With Bipolar Disorder, David G. Angeler, Craig R. Allen, Maj-Liz Persson

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Background: The term resilience describes stress–response patterns of subjects across scientific disciplines. In ecology, advances have been made to clearly distinguish resilience definitions based on underlying mechanistic assumptions. Engineering resilience (rebound) is used for describing the ability of subjects to recover from adverse conditions (disturbances), and is the rate of recovery. In contrast, the ecological resilience definition considers a systemic change: when complex systems (including humans) respond to disturbances by reorganizing into a new regime (stable state) where structural and functional aspects have fundamentally changed relative to the prior regime. In this context, resilience is an emergent property of complex …

The Anorexic's Anorexia: Depictions Of Anorexia In Popular Culture, Samantha L. Tomson

Undergraduate Honors Theses

No abstract provided.

Development And Preclinical Evaluation Of Long-Lasting Cocaine Hydrolases For Cocaine Overdose And Cocaine Use Disorder Treatment, Ting Zhang

Theses and Dissertations--Pharmacy

Cocaine is a plant-based illicit drug commonly involved in substance use disorder. Although cocaine overdose and cocaine use disorders cause adverse health consequences to individuals and the economic burden on their family and society, there are no FDA (Food and Drug Administration) approved medications for treatment. Recently, it has been recognized that delivery of cocaine hydrolase (CocH) is a promising therapeutic strategy. Human butyrylcholinesterase (hBChE), the primary enzyme involved in cocaine metabolism in human, have advantages over other candidates for the development of CocH. Previous studies in our laboratory have designed and characterized hBChE mutants that have ~4,000-fold improved catalytic …

Into The Wild: Factors Mediating The Positive Outcomes Of Wilderness Based Therapy, Layla Moehring

Scripps Senior Theses

Wildnerness therapy is becoming increasingly popular as a treatment for adolescents. It has been established as an efficacious treatment in previous literature, but the mechanisms as to why have thus far remained a mystery. This research is looking at the connection between wilderness therapy and DBT, another evidence-based treatment. This study will examine 156 adolescents, comparing the efficacy of wilderness therapy to traditional inpatient and intensive outpatient. Pre-treatment assessments of suicidal ideation, emotional regulation, and distress tolerance will be taken. It is expected that there will be main effects for each of the treatments, but that wilderness therapy will be …

Mental Health In Commercial Aviation - Depression & Anxiety Of Pilots, Maurice C. Dehoff, Stephen K. Cusick

International Journal of Aviation, Aeronautics, and Aerospace

Two landmark accidents invigorated the discussion regarding pilot mental health. Other incidents may also have a mental health component that is related to, but not the direct cause of, the event. It is suspected that these “other incidents” are much more commonplace and while not catastrophic, erode safety. Depression and anxiety are two commonly occurring mental health concerns. Research indicates that a considerable portion of the U. S. population suffers from some form of mental health issue. Most go undiagnosed and untreated. A similar rate of occurrence appears to be found within the airline pilot population. The stigma of mental …

Development Of The Clark And Becker Scale Of Symptomatology (Cbs): Symptom-Level Item Performance, Michael Clark

All Master's Theses

Depression and anxiety are common, often comorbid, mental disorders. Many researchers have developed efficient self- and clinician-report measures of depression and anxiety. Most of these existing measures of depression and anxiety measures yield overall or specific subscale scores. The Clark and Becker Scale of Symptomatology (CBS) was designed to measure individual symptoms of depression and anxiety. It utilizes a different type of bipolar scaling to aid in accurate symptom endorsement. Unlike other pre-existing measures, the CBS is designed to be interpreted at the symptom level. The CBS was administered to a nationally representative sample (n = 530). Concurrent validity …

New Ways Of Predicting Efficacy Of Antidepressants, Kayla Ternes

Physician Assistant Scholarly Project Papers

Major depressive disorder (MDD) is a neuropsychiatric condition that is becoming increasingly prevalent in our country. According to Cai, Huang, and Hao (2015), MDD is “common and devastating” (p. 61) and has a very complex pathophysiology. Until recently, a definitive etiology had not been found, however, new evidence has suggested that Brain-derived neurotrophic factor (BDNF) and cognitive-emotional biomarkers may be a key into the mechanism of this disorder.

My literature review of articles found in PubMed, CINAHL, Cochrane Library, and PsychINFO within the last ten years focused on the hypotheses of the pathophysiology of MDD, cognitive-emotional biomarkers, and BDNF. The …

New Ways Of Predicting Efficacy Of Antidepressants, Kayla Ternes

Physician Assistant Scholarly Project Posters

Major depressive disorder (MDD) is a neuropsychiatric condition that is becoming increasingly prevalent in our country. According to Cai, Huang, and Hao (2015), MDD is “common and devastating” (p. 61) and has a very complex pathophysiology. Until recently, a definitive etiology had not been found, however, new evidence has suggested that Brain-derived neurotrophic factor (BDNF) and cognitive-emotional biomarkers may be a key into the mechanism of this disorder.

A literature review of articles found in PubMed, CINAHL, Cochrane Library, and PsychINFO within the last ten years focused on the hypotheses of the pathophysiology of MDD, cognitive-emotional biomarkers, and BDNF. The …

Investigating The Relationship Between Sulcogyral Patterns And Structural And Functional Connectivity Metrics In The Orbitofrontal Cortex, Bethany M. Blass

Honors Theses

Located within the frontal lobe, the human orbitofrontal cortex (OFC) is widely known for its roles in sensory integration, emotion processing, decision-making, and goal-directed behaviors. Atypical structural organization of the OFC may explain atypical social or motivational behaviors displayed by individuals with brain disorders, such as bipolar disorder patients (BP).

The human brain can be imaged using magnetic resonance imaging (MRI) to reveal interesting aspects of the underlying brain architecture. This brain is composed of different tissue types, including gray and white matter, as well as various morphological features, including sulci & gyri. Within the OFC, the sulci can be …

Shared Genetic And Environmental Influences On Fear, Anxiety, Posttraumatic Stress, And Brain Morphometry, Chelsea Sawyers

Theses and Dissertations

Anxiety disorders (ADs) and stress-related disorders are some of the most common psychiatric disorders in the United States. Like other c0mplex psychiatric illness, genetics and neuroimaging research has focused on understanding their underlying neurobiology. Areas within the fear-network play important roles in threat perception, fear conditioning/learning, cognitive processing, and modulation of fear responses including contextual modulation and extinction and have been implicated in ADs as well as stress disorders such as posttraumatic stress disorder (PTSD). The primary gap in the current search for underlying biological mechanisms is in whether biomarkers associated with disorders share genetic influences with the disorders they …

Suicidal Ideation In The Perinatal Period: A Systematic Review, Avril O'Connor, Sadie Geraghty, Gemma Doleman, Annemarie De Leo

Research outputs 2014 to 2021

Objective: To examine literature surrounding suicidal ideation and suicidality in the perinatal period. Design: Systematic Literature Review of published 15 research studies. Findings: There is a scarcity of prospective studies conducted in suicidal ideation during the perinatal period. More research is needed to ensure childbearing women at risk of suicidal ideation during pregnancy receive the appropriate care and maternity services required to support them throughout this period. Key conclusions: Midwives play an important role in screening women for possible emotional distress and mood disorders during pregnancy. Therefore, midwives need to have knowledge of risk factors so vulnerable women are monitored …

Building Competencies And Skills Among Service Providers Working With Young People Who Experience Serious Mental Health Conditions: State Of The Science, Janet S. Walker, Pauline Jivanjee, Eileen M. Brennan, Leigh Grover

School of Social Work Faculty Publications and Presentations

This paper explores what is currently known about the most promising strategies for increasing providers’ capacity to deliver effective behavioral health services and supports. The paper also describes how this information has been—or could be—applied to the design of cutting-edge approaches for building skills and competencies among providers that work with young people who experience serious mental health conditions.

Black Males, Trauma, And Mental Health Service Use: A Systematic Review., Robert Motley, Andrae Banks

Brown School Faculty Publications

Objective: To systematically review the evidence of and synthesize results from relevant studies that have examined barriers and facilitators to professional mental health service use for Black male trauma survivors ages 18 and older.

Methods: A thorough search of selected databases that included EBSCO, ProQuest, and Web of Science Core Collection and careful consideration of inclusion and exclusion criteria yielded a final six studies for detailed review.

Results: Black male trauma survivors were significantly less likely to be utilizing mental health services than other sex-ethnic groups. High levels of daily crises, a lack of knowledge of steps to …

Beyond The End Line - Putting The Mental Health Of Female Athletes First, Katherine Scholten

Honors Projects

Currently one in five adults are affected by mental illness. Student-athletes are a population that is under diagnosed for mental illness. In the world of college athletics, mental pain is as regular as physical pain. Coaches often push their athletes to suffer in silence for the betterment of the team. The NCAA has recognized the importance of mental health in college athletics, yet there is still much work to be done among universities across the country. This document is to serve as a resource and a guide on the effects of mental health among female student athletes and the best …

Differences In Mental Health Education Across Baby Boomers, Generation X, And Millennials, Ashlyn M. Avera

Honors College Theses

There is no denying that mental illness has gained a strong prevalence in the United States. According to the National Alliance on Mental Illness, approximately one in five adults in the United States experiences a mental illness in any given year. Although mental health stigmas have played a role in the past, it does not mean they must continue to play the same role in the future. Research is now looking toward ways to decrease mental health stigma through increasing mental health knowledge. This study examines the starting point for which a society becomes literate in mental health. Using a …