Mental Disorders Commons^™

Does Hippotherapy Improve Gross Motor Function In Children With Cerebral Palsy?, Victoria I. Bockius

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Does hippotherapy improve gross motor function in children with cerebral palsy?”.

STUDY DESIGN: A systematic review of three randomized controlled trials (RCTs), with one being a randomized crossover trial. All three were published between 2015 and 2018.

DATA SOURCES: Three RCTs published in peer-reviewed journals were chosen from PubMed. The studies were selected based on their relevance to the clinical question.

OUTCOMES MEASURED: The outcome measured was improvement in gross motor function. Either hip adductor spasticity using Modified Ashworth Scale (MAS) or the Gross Motor Function …

Prenatal Exposure To A Natural Disaster And Early Development Of Psychiatric Disorders During The Preschool Years: Stress In Pregnancy Study, Yoko Nomura, Jeffrey H. Newcorn, Christine Ginalis, Catherine Heitz, Jeenia Zaki, Farzana Khan, Mardia Nasrin, Kathryn Sie, Donato Deingeniis, Yasmin L. Hurd

Publications and Research

Background: Growing evidence shows an association between in utero exposure to natural disasters and child behavioral problems, but we still know little about the development of specific psychopathology in preschool-aged children. Methods: Preschool children (n = 163, mean age = 3.19, 85.5% racial and ethnic minorities) and their parents (n = 151) were evaluated annually at ages 2–5 to assess the emergence of psychopathology using the Preschool Age Psychopathological Assessment (PAPA), a parent-report structured diagnostic interview developed for preschool-age children. Sixty-six (40.5%) children were exposed to Sandy Storm (SS) in utero and 97 (59.5%) were not. Survival analysis evaluated patterns …

Putative Mechanisms Underlying The Antidepressant Actions Of Ketamine: A Review And Study Proposal, Tristan Reece

CMC Senior Theses

Major Depressive Disorder (MDD) is a highly debilitating and common psychiatric disorder that affects over 250 million people globally; it is among the most financially and emotionally burdensome illnesses in the world. Currently approved antidepressants are suboptimal in their efficacy and latency of therapeutic action. In contrast, single administrations of sub-anesthetic ketamine have been shown to rapidly alleviate depressive symptoms within hours, even in treatment-resistant patients. Ketamine is believed to exert these effects by increasing glutamatemediated neurotransmission and promoting rapid neurotrophic factor release, restoring the integrity of neural circuits that are compromised in depression. However, uncertainty surrounding its specific antidepressant …

Family Structure And Maternal Depressive Symptoms: A Cross-National Comparison Of Australia, The United Kingdom, And The United States, Kirsten Rasmussen, Elizabeth K. Sigler, Sadie A. Slighting, Jonathan A. Jarvis, Mikaela J. Dufur, Shana Pribesh

Educational Leadership & Workforce Development Faculty Publications

The purpose of this study is to understand the relationship between family structure and maternal depressive symptoms (MDS) in Australia, the United Kingdom, and the United States. Family structures that involve transitions across life's course, such as divorce, can alter access to resources and introduce new stressors into family systems. Using the stress process model, we examine the links between family structure, stress, resources, and MDS. Using nationally representative data from Australia, the United Kingdom, and the United States and cross-sectional models for each country, we find that family structure may influence MDS differently in the UK than it does …

Effects Of The Selective Gsk3b Inhibitor, Tideglusib, On Ethanol Consumption, Anxiety-Like Behavior, Taste Preference, And Downstream Proteins, Sam Gottlieb, Douglas Bledsoe, Jessica L. Maltman, Alanna Morgan, Jennifer T. Wolstenholme, Michael F. Miles

Graduate Research Posters

Background: We have shown modulations in glycogen synthase kinase 3 beta (GSK3B) abundance or activity regulate ethanol consumption, suggesting potential as a therapeutic target for alcohol use disorder (AUD). Here we report the GSK3B inhibitor tideglusib’s actions on ethanol consumption, basal behaviors, and modulation of GSK3B targets.

Methods: C57BL/6J males and females received i.g. 200mg/kg tideglusib, except drinking-in-the-dark (males;100mg/kg i.p.). Drinking-in-the-dark (DID): Mice given 20% ethanol 4-hours, 4-days/week x 3 weeks and then i.p. tideglusib or vehicle x 4 days in a Latin Square design with ethanol consumption measured daily. Light/Dark Box: Mice gavaged with tideglusib or vehicle …

Transforming Hurt Boys Into Restored Men: The Lack Of Mental Health Treatment For Black Male Trauma Survivors, Shericka Danielle Smith

DSW Capstone Projects

Trauma affects individuals differently, but the prevalence of trauma and its impact on Black males is detrimental. Black males are at higher risk for posttraumatic stress disorder (PTSD), depression, substance abuse, and violent crimes when trauma is left untreated by a mental health professional. As the number of traumatic events experienced by Black males continues to rise, the number of these males who seek mental health treatment remains stagnant and painfully low. Many factors play into these behaviors, yet very little data exists on what is being done to change them.

Product one is a systematic literature review in which …

Building Tools For Improved Modulation Of The Human Gabaa Receptor, A Central Nervous System Target For The Treatment Of Anxiety, Garrett Edward Zinck

Theses and Dissertations--Pharmacy

In the U.S., anxiety is recognized as an increasing range of mentally and physically debilitating psychiatric health disorders with significant economic repercussions. Over the last 20 years, several novel anti-anxiety therapies have entered the drug development pipeline, but none have made it to market.

The work in this dissertation focused on structurally modifying valerenic acid (VA), a structurally unique carboxylated sesquiterpene acid found in Valeriana officinalis. VA is putatively reported to have allosteric modulatory activity of the human GABA_A receptor, a ligand-gated ion channel responsible for attenuating neurotransmissions. Structural modeling of VA’s GABA_A receptor interaction suggests that …

Equine Assisted Psychotherapy: Implications For Treating Trauma, Kara L. Harrison Psy.D.

Psychology Doctoral Specialization Projects

Trauma related symptoms and Posttraumatic Stress Disorder (PTSD) have been increasingly recognized for the key roles they occupy in mental health and overall individual well-being within both adult and childhood populations. They often represent significant barriers to the provision of mental healthcare within military populations and individuals diagnosed with serious mental illness (SMI). This original contribution to practice explores the significance of Equine Assisted Psychotherapy as a novel adjunctive approach to treating trauma. symptoms in adults and children. An extensive literature review examines current research and discussion on common definitions and nomenclature. It begins with discussion on the broader areas …

Quality Of Life Before And After Cosmetic Surgery: Should Body Dysmorphic Disorder Be Considered An Absolute Or Relative Contraindication For Cosmetic Surgery?, Lindsay Conlisk

Capstone Showcase

Body Dysmorphic Disorder (BDD) has historically been regarded as a strong contraindication for cosmetic plastic surgery. New research now suggests that the contraindications to cosmetic surgery in patients with BDD may not be so absolute. This paper reviews diagnostic criteria, diagnostic challenges, and current standard of treatment of BDD. It then presents the idea of insight analysis in the BDD patient as a significant factor in determining if patients with BDD may or may not benefit from cosmetic surgery or procedures.

Quality Of Life Before And After Cosmetic Surgery: Should Body Dysmorphic Disorder Be Considered An Absolute Or Relative Contraindication For Cosmetic Surgery?, Lindsay Conlisk

Capstone Showcase

Body Dysmorphic Disorder (BDD) has historically been regarded as a strong contraindication for cosmetic plastic surgery. New research now suggests that the contraindications to cosmetic surgery in patients with BDD may not be so absolute. This paper reviews diagnostic criteria, diagnostic challenges, and current standard of treatment of BDD. It then presents the idea of insight analysis in the BDD patient as a significant factor in determining if patients with BDD may or may not benefit from cosmetic surgery or procedures.

Does Gua Sha Therapy Reduce Pain Intensity In Patients With Chronic Back Pain?, Anh Y. Cao

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine “Does Gua shatherapy reduce pain intensity in patients with chronic back pain?”

STUDY DESIGN: A systematic review of three randomized controlled trials/studies published in English between 2013-2019.

DATA SOURCES: All articles were published in peer-reviewed journals and obtained from PubMed. The studies were selected based on their applicability to the topic listed above.

OUTCOMES MEASURED: A common outcome measured across all three articles included pain intensity. Each study used the 100 mm Visual Analog Scale (VAS). Participants were asked to rate their pain before and after therapeutic interventions. A …

Is Acupuncture Effective In Improving Pain In Patients With Knee Osteoarthritis?, Despina Lianidis

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Is acupuncture effective in improving pain in patients with knee osteoarthritis?”

Study design: A systematic review of three randomized controlled trials (RCTs) published in between 2015-2018.

Data sources: All three RCTs were discovered using PubMed. The articles were published in English in peer-reviewed journals and selected based on applicability to the clinical question.

Outcome measured: Based on the studies done by Lin et al. and Chen et al., using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), a self-reported measure of lower extremity pain, stiffness, …

Does Exercise Decrease The Level Of Anxiety In Adults?, Alexa N. Wister

PCOM Physician Assistant Studies Student Scholarship

 Objective: The objective of this selective EBM review is to determine whether or not “Does exercise decrease the level of anxiety in adults?”

Study Design: A systematic review of three randomized controlled trials (RCTs) that were peer reviewed and published between 2016 and 2020.

Data Sources: All articles were published in peer-reviewed journals. Two of the RCTs were researched using Pubmed and one RCT was found using Academic Search Premier, AMED. All studies were selected based on applicability to the clinical question presented in the objective, and if the researched outcomes were patient oriented.

Outcome Measured: A reduction in anxiety …

Are Quarterly Fremanezumab Injections As Effective As Monthly Fremanezumab Injections At Reducing The Number Of Migraine Days Per Month In Adults With Chronic Migraines?, Elaine Mellinger

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic EBM review is to determine “Are quarterly fremanezumabinjections as effective as monthly fremanezumab injections at reducing the number of migraine days per month in adults with chronic migraines?”

STUDY DESIGN: A systematic review of three randomized controlled trials (RCTs) that were peer reviewed and published in English after 2015 comparing quarterly versus monthly fremanezumab injections in adults 18-70 with chronic migraines.

DATA SOURCE: Three RCTs were obtained from PubMed and selected based on their relevance to the clinical question and if the RCTs addressed patient oriented outcomes.

OUTCOMES: The three selected RCTs for review, …

Does Endometrial Scratching Increase Live Birth Rates For Women Undergoing Ivf?, Caitlyn Kratzer

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Endometrial Scratching Increases Live Birth Rates for Women Undergoing IVF?”

STUDY DESIGN: A systematic review of three randomized control trials (RCTs) published between 2010 and 2017.

DATA SOURCES: All three RCTs were discovered using PubMed. Studies were published in English in peer-reviewed journals and selected based on applicability to the clinical question.

OUTCOMES MEASURED: In all three articles, the main outcome that will be reviewed is live birth rate. This was measured by the number of live births per embryos transferred divided by the total number …

Is Exercise Effective In Improving The Cognitive And Behavioral Executive Functions In Children Diagnosed With Adhd?, Cara Scatena

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine “Is exercise effective in improving the cognitive and behavioral functions in children diagnosed with ADHD?”

Study Design: A systematic review of three randomized control trials (RCTs). All three of these studies were published between 2011 and 2016.

Data Sources: All three of the RCTs were found using PubMed. All of the studies were published in English in peer-reviewed journals and selected based on their relevance to the clinical question.

Outcome Measured: The outcome measured in these studies is the measurable improvement in executive functions related to the effects of …

Is Aquatic Therapy An Effective Treatment For Reducing Fatigue In Adult Females Living With Ms?, Hanna L. Ozarski

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine, “Is aquatic therapy an effective treatment for reducing fatigue in adult females living with MS?”

Study Design: A systematic review of three randomized controlled trials (RCTs) published between 2015 and 2018.

Data Sources: All three RCTs were published in English peer reviewed journals and were discovered on PubMed using selective search criteria. Studies were chosen based on their relevance and competency to answer the clinical question proposed.

Outcome Measured: The main outcome of focus in each of the articles selected for this review was fatigue reduction. Outcomes were measured …

Is Perioperative Intravenous Lidocaine A Sufficient Adjunct To Traditional Opioid Therapy At Decreasing Post-Operative Pain In Male And Female Patients Ages 18-75 Following A Laparoscopic Cholecystectomy?, Desiree Malacusky

PCOM Physician Assistant Studies Student Scholarship

 OBJECTIVE: The objective of this systematic review is to determine “Is perioperative intravenous lidocaine a sufficient adjunct to traditional opioid therapy at decreasing post operative pain in male and female patients ages 18-75 following a laparoscopic cholecystectomy?”

STUDY DESIGN: A review of three randomized control trials (RCTs) that were peer reviewed and published in English after 2015.

DATA SOURCE: All articles were published in peer reviewed journals and were researched using PubMed and EBSCO databases. Studies were selected based on their ability to answer the question posed in the objective, and if the researched outcomes were patient oriented.

OUTCOMES: The …

Does The Application Of Kt Tape Decrease Pain In Chronic Low Back Pain?, Jordan Vitelli

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine “Does the application of KT tape decrease pain in chronic low back pain?”

Study Design: A systematic review of three randomized controlled trials (RCTs) published between 2018 and 2019.

Data Sources: The three RCTs were published in English in peer reviewed journals and obtained from PubMed. The studies were selected based on their relevance to the clinical question.

Outcome Measured: The outcome measured within all three RCTs was pain intensity using the Visual Analog Scale (VAS). The VAS scoring ranges from 0 to 10, defining 0 as no pain …

Does The Use Of Docosahexaenoic Acid (Dha) Supplementation Decrease The Rate Of Cognitive Decline, As Measured By The Adas-Cog Scale, For Patients With Alzheimer’S Disease?, Erin C. Nakamura

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Does the use of docosahexaenoic acid (DHA) supplementation decrease the rate of cognitive decline, as measured by the ADAS-Cog scale, for patients with Alzheimer’s Disease?”

Study Design: A systematic review of three randomized controlled trials (RCTs) published between 2010 and 2018.

Data Sources: All three RCTs were published in English into peer reviewed journals and discovered via PubMed. The studies were selected based on relevance and ability to answer the clinical question.

Outcome Measured: Cognitive function is the outcome measured using the Alzheimer Disease Assessment Scale- …