Gestational Age At Birth And Body Size From Infancy Through Adolescence: An Individual Participant Data Meta-Analysis On 253,810 Singletons In 16 Birth Cohort Studies, Johan L. Vinther, Tim Cadman, Demetris Avraam, Claus T. Ekstrøm, Thorkild I. A. Sørensen, Ahmed Elhakeem, Ana C. Santos, Angela Pinot De Moira, Barbara Heude, Carmen Iñiguez, Costanza Pizzi, Elinor Simons, Ellis Voerman, Eva Corpeleijn, Faryal Zariouh, Gilian Santorelli, Hazel M. Inskip, Henrique Barros, Jennie Carson, Jennifer R. Harris, Johanna L. Nader, Justiina Ronkainen, Katrine Strandberg-Larsen, Loreto Santa-Marina, Lucinda Calas, Luise Cederkvist, Maja Popovic, Marie-Aline Charles, Marieke Welten, Martine Vrijheid, Meghan Azad, Padmaja Subbarao, Paul Burton, Puishkumar J. Mandhane, Rae Chi Huang, Rebecca C. Wilson, Sido Haakma, Sílvia Fernández-Barrés, Stuart Turvey, Susana Santos, Suzanne C. Tough, Sylvain Sebert, Theo J. Moraes, Theodosia Salika, Vincent W. V. Jaddoe, Deborah A. Lawlor, Anne-Marie Nybo Andersen

Research outputs 2022 to 2026

Background:

Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as a proxy of prematurity rather than an actual length of gestation. We investigated the association of gestational age (GA) at birth with body size from infancy through adolescence.

Methods and Findings:

We conducted a two-stage individual participant data (IPD) meta-analysis using data from 253,810 mother-child dyads from 16 general population-based cohort …

Fetal Growth Trajectories And Measures Of Insulin Resistance In Young Adults, Ashish Yadav, Lawrence J. Beilin, Rae-Chi Huang, John P. Newnham, Scott W. White, Trevor A. Mori

Research outputs 2022 to 2026

Context: Events during gestation greatly influence the risk of cardiometabolic diseases including diabetes in offspring during later life. Objective: This study aimed to investigate relationships between serial ultrasound-derived fetal growth trajectories and markers of insulin resistance in young adults in the Raine Study, an Australian pregnancy cohort. Methods: Linear mixed modeling examined the relationship between fetal growth trajectory groups, constructed using serial ultrasound-based abdominal circumference (AC), femur length (FL), and head circumference (HC) from 1333 mother-fetal pairs, and offspring Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), as a marker of diabetes risk, at 20 (n = 414), 22 (n = …

Maternal Educational Attainment In Pregnancy And Epigenome-Wide Dna Methylation Changes In The Offspring From Birth Until Adolescence, Priyanka Choudhary, Giulietta S. Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G. Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou, Jason I. Feinberg, Charles Mordaunt, Giancarlo Pesce, Nour Baïz, Rossella Alfano, Dries S. Martens, Congrong Wang, Elena Isaevska, Elina Keikkala, Sanna Mustaniemi, Chris H. L. Thio, Eliza Fraszczyk, Elmar W. Tobi, Anne P. Starling, Marta Cosin-Tomas, Jose Urquiza, Stefan Röder, Thanh T. Hoang, Christian Page, Dereje D. Jima, John S. House, Rachel L. Maguire, Raffael Ott, Xenia Pawlow, Lea Sirignano, Lea Zillich, Anni Malmberg, Sebastian Rauschert, Phillip Melton, Tong Gong, Robert Karlsson, Ruby Fore, Wei Perng, Zachary M. Laubach, Darina Czamara, Gemma Sharp, Carrie V. Breton, Enrique Schisterman, Edwina Yeung, Sunni L. Mumford, M. Daniele Fallin, Janine M. Lasalle, Rebecca J. Schmidt, Kelly M. Bakulski, Isabella Annesi-Maesano, Barbara Heude, Tim S. Nawrot, Michelle Plusquin, Akram Ghantous, Zdenko Herceg, Lorenza Nisticò, Marina Vafeiadi, Manolis Kogevinas, Marja Vääräsmäki, Eero Kajantie, Harold Snieder, Eva Corpeleijn, Regine P. M. Steegers-Theunissen, Ivana V. Yang, Dana Dabelea, Serena Fossati, Ana C. Zenclussen, Gunda Herberth, Maria Magnus, Siri E. Håberg, Stephanie J. London, Monica C. Munthe-Kaas, Susan K. Murphy, Cathrine Hoyo, Anette-G Ziegler, Sandra Hummel, Stephanie H. Witt, Fabian Streit, Josef Frank, Katri Räikkönen, Jari Lahti, Rae-Chi Huang, Catarina Almqvist, Marie-France Hivert, Vincent W. V. Jaddoe, Marjo-Riitta Järvelin, Marko Kantomaa, Janine F. Felix, Sylvain Sebert

Research outputs 2022 to 2026

Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was …

Altered Dietary Behaviour During Pregnancy Impacts Systemic Metabolic Phenotypes, Charlotte E. Rowley, Samantha Lodge, Siobhon Egan, Catherine Itsiopoulos, Claus T. Christophersen, Desiree Silva, Elizabeth Kicic-Starcevich, Therese A. O’Sullivan, Julien Wist, Jeremy Nicholson, Gary Frost, Elaine Holmes, Nina D’Vaz

Research outputs 2022 to 2026

Rationale: Evidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and urine samples to assess differences between women who were stratified into high and low alignment to a MD throughout pregnancy and investigate the relationship of the diet to inflammatory markers. Methods: From the ORIGINS cohort, 51 pregnant women were stratified for persistent high and low alignment to a MD, based on validated MD questionnaires. 1H Nuclear Magnetic Resonance (NMR) spectroscopy was used to investigate the …

Racial Discrimination, Social Support And Psychological Distress Among Black Pregnant Women, Camilla Carey

Electronic Theses and Dissertations, 2020-2023

The purpose of this dissertation research was to examine the associations among racial discrimination, social support, and psychological distress among Black pregnant women. The dissertation was guided by the Ecological Systems theory which has three domains that pertain to this research: individual, interpersonal, and community. A literature review was conducted to investigate what is known about the association between racial discrimination and psychological distress among Black pregnant women. This review found that seventeen of the nineteen studies included reported a positive association between racial discrimination and psychological distress among Black pregnant or postpartum women. Limited research focused on the potential …

Virtual Home Visits During Covid-19 Pandemic: Mothers' And Home Visitors' Perspectives, Abdullah Al-Taiar, Michele A. Kekeh, Stephanie Ewers, Amy L. Prusinski, Kimberly J. Alombro, Nancy Welch

Community & Environmental Health Faculty Publications

Background

The experiences of mothers enrolled in Maternal, Infant and Early Childhood Home Visiting (MIECHV) program with virtual home visiting (VHV) during the pandemic remain mostly unknown. This study aimed to describe in detail the experience of home visitors and mothers with VHV during COVID-19 pandemic. This is a prerequisite for guiding future efforts to optimize MIECHV services that are provided through virtual operation.

Methods

Focus groups discussion were conducted with home visitors (n = 13) and mothers (n = 30) who were enrolled in BabyCare program in Virginia from January 2019 to June 2022. This included mothers who received …

Medically Accurate Evidence-Based Sex Education And Abstinence-Only Sex Education: Impact On Teen Pregnancies In The United States, Nicole Chiu

Nursing | Senior Theses

The U.S. has funded abstinence-only programs to combat pregnancy rates for a long time. With numerous factors contributing to teen pregnancies, there have been a lot of ways that people have decided to try to decrease the number of teen pregnancies. For example, schools have either decided that they intend to fully educate their teenage students using medically accurate evidence-based sex education or come from a more conservative approach and give abstinence-only education. The objective of this investigation is to identify whether evidence-based sex education or abstinence-only sex education is more effective at combating teen pregnancy and abortion rates. This …

Maternal Postnatal Depressive Symptoms And Its Effects On Infant Bonding, Tammy Nguyen

Nursing | Senior Theses

The objective of this thesis is to gain insight on precipitating factors that increase postpartum mother’s depressive symptoms, including stress and anxiety, and how attachment is influenced. Maternal-infant bonding is defined as the emotional relationship and interaction between mother and infant. Postnatal depressive symptoms typically are under-diagnosed due to a lack of education and the stigma of believing that the effects are “normal” consequences of motherhood. Those affected may not seek professional help. Unrealistic expectations about bonding with their infants can have a negative mental health impact on mothers and influence infants’ behaviors. High expectations of needing to be a …

Kangaroo Care Education For Low Socioeconomic Status Families In The Neonatal Intensive Care Unit., Joara Peterson

Nursing | Senior Theses

The early contact between mother and baby is known as skin-to-skin, also referred to as “kangaroo care” (KC). It involves placing the baby on the mother’s chest as soon as it is appropriate (Thompson et al., 1979). This interaction was primarily for bonding but many researchers have discovered additional benefits. There is significant correlation between kangaroo care and weight gain (especially for low birth weight infants), as well as body temperature and heart rate regulation, which reduces the risk of medical complications. It also decreases levels of stress in mothers and babies by lowering the release of cortisol hormone (Mohammadi …

Dnp Final Report: Implementation Of A Prenatal Electronic Education Program To Improve Exclusive Breastfeeding Initiation Rates In New Mothers, Karen Bledsoe

DNP Final Reports

Breastfeeding is accepted as the best source of infant nutrition exclusively for the first six months of life. Because it is important to both mother and infant for long-term health benefits, exclusive breastfeeding at discharge has been a CMS Perinatal Core Measure since 2015. It is essential that hospitals have personnel and programs in place to support breastfeeding mothers to support the Healthy People 2030 goal of exclusive breastfeeding for the first six months of life. COVID-19 changed how the world interacted and medical staff had to use innovative techniques to engage and educate patients virtually since social distancing prohibited …

Empowering Maternal Resilience: A Prenatal Education Program For Mothers And Their Chosen Support Persons For Postpartum Depression, Jennifer Medina

Nursing | Student Research Posters

No abstract provided.

The Effects Of Kangaroo Care On The Stress Levels Of Parents In The Nicu, Niyati Sishodia

Honors Undergraduate Theses

Background: Parents of NICU patients have high stress levels compared to other populations, which negatively impact their mental health. The kangaroo care (KC) method has been used for its numerous benefits for infants, but not as widely studied for its impacts on parental stress. The purpose of this integrative literature review is to examine and synthesize the existing evidence regarding kangaroo care and its impact on the stress levels of NICU parents.

Methods: A literature search was conducted utilizing CINAHL Plus with Full Text, MEDLINE, and APA PsychInfo databases to identify relevant articles. Articles were included if they were published …

Education Interventions And Preeclampsia Knowledge Among Pregnant Women, Shantel Mir

Honors Undergraduate Theses

Aim: The aim of this literature review was to explore the impacts of educational interventions integrated into antenatal care on knowledge of preeclampsia among pregnant women. Background: Preeclampsia has remained one of the leading causes of preventable maternal and infant mortality and morbidity. A lack of patient education and awareness of preeclampsia may lead to missed opportunities for diagnosis and preeclampsia complications. Methods: CINAHL Plus with Full Text, MEDLINE, and Education Full Text (H.W. Wilson) databases were utilized. Literature specifically focusing on preeclampsia educational interventions among pregnant women were considered. Results: There were eleven articles that fit the criteria …

Implementation Of Virtual Reality For The Laboring Patient: A Quality Improvement Project, Chantal Cole

DNP Scholarly Projects

BACKGROUND: Having a baby can be one of the most challenging and painful experiences a woman has in their lifetime. Being able to choose between a variety of pharmacological and non-pharmacological pain-control methods is important to improve the patient experience and outcomes. This quality improvement project aimed to introduce a virtual reality device into the labor and delivery setting as a non-pharmacological pain control method. The goal was to decrease pain and anxiety levels, decrease the rate of epidural anesthesia use, and decrease the length of time epidural anesthesia medication was running before delivery.

METHODS: The four key components of …

Gender Differences In Administration Of Tpa In Treatment Of Ischemic Stroke, Christina Annerino

CURE Proceedings

As medicine and pharmacology advance through the years, new life-saving treatments are studied or discovered every day, and a medical emergency is no longer a death sentence. Even with conditions as serious as ischemic stroke, there is hope for survival and rehabilitation with the ‘clot-busting’ drug, tissue plasminogen activator, colloquially known as ‘tPA’. tPA is a thrombolytic agent, a substance that acts on fibrin in clots to dissolve them so they can no longer cause ischemia in blood vessels that results in a stroke. (Vega, 2022). tPA is an extremely effective treatment for ischemic stroke, demonstrated in 2013 by a …

Incorporating Non-Pharmacological Labor Coping Methods To Improve Nursing Care And Reduce Primary Cesarean Section Rates: A Quality Improvement Project, Cait Maccabe

Honors Theses and Capstones

Abstract

BACKGROUND: Cesarean sections (c-sections), while life-saving in some circumstances, carry a significantly higher risk of morbidity and mortality than vaginal birth for birthing patients and neonates alike. Despite this, rates of c-section have continued to rise in the US and around the world. As primary cesarean births are highly likely to lead to repeat cesarean births, concerted efforts are being made to reduce them both broadly and within the setting of this quality improvement (QI) project: a labor and delivery unit located within a Level II trauma center in New Hampshire. A literature review provided evidence supporting the use …

Disrespect And Abuse In Maternity Care In A Low-Resource Setting In Tanzania: Provider’S Perspectives Of Practice, Loveluck Mwasha, Lucy Kisaka, Eunice Pallangyo

School of Nursing & Midwifery, East Africa

Background

Globally, women experience disrespectful and abusive care from maternity healthcare providers at health facilities, committed intentionally or unintentionally, particularly during labor and delivery. Disrespectful care affects women’s childbirth experience and birth outcomes.

Methods

This study used a descriptive qualitative design to obtain thick and rich data on disrespect and abuse in maternity care in a low-resource setting in Tanzania. Three days workshop was conducted at the Aga Khan University comprising maternity healthcare providers from diverse settings. The workshop was designed based on the existing evidence and anecdotal data and inspired by the authors’ experiences of disrespectful and abusive care …

Incorporating Non-Pharmacological Labor Coping Methods To Improve Nursing Care And Reduce Primary Cesarean Section Rates: A Quality Improvement Project, Cait Maccabe

Master's Theses and Capstones

Abstract

BACKGROUND: Cesarean sections (c-sections), while life-saving in some circumstances, carry a significantly higher risk of morbidity and mortality than vaginal birth for birthing patients and neonates alike. Despite this, rates of c-section have continued to rise in the US and around the world. As primary cesarean births are highly likely to lead to repeat cesarean births, concerted efforts are being made to reduce them both broadly and within the setting of this quality improvement (QI) project: a labor and delivery unit located within a Level II trauma center in New Hampshire. A literature review provided evidence supporting the use …

Streamlining The Postpartum Educational Process For Safe And Equitable Patient Care: A Quality Improvement Initiative, Shea N. Cook

Master's Theses and Capstones

Abstract

BACKGROUND:

Postpartum discharge education is essential in the care of mothers, newborns, and their families as they transition from the hospital setting to home. The U.S Department of Health and Human Services has identified postpartum discharge education content as a public health priority to reduce physical and mood-related postpartum complications. Over half of all serious morbidity and mortality complications occur after a postpartum patient leaves the hospital. It is essential that hospitals utilize the best evidence-based practices to maximize the impact of patient education during maternity care in the hospital.

LOCAL PROBLEM:

Within the given microsystem there is a …

Standardizing Patient Transfer Process Among Nurses From Labor & Delivery To Mother-Baby Unit: A Quality Improvement Project, Kiratraj Kaur Grewal

Master's Projects

Purpose: To implement and evaluate the efficacy of a standardized patient transfer process among registered nurses (RN) from Labor & Delivery (L&D) to Mother-Baby Unit (MBU) using PDSA cycle to improve RN satisfaction and reduce patient transfer time
Conceptual Framework: PDSA Cycle
Setting: Labor & Delivery and Mother-Baby Unit of a tertiary care hospital
Methods: The project consisted of collecting both objective (estimated patient transfer time from L&D to MBU) and subjective data (anonymous nursing pre- and post-intervention surveys). Standardization of transfer process included implementing a transfer checklist, patient transfer tool, updating the workflow, and a sample patient transfer video. …