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Articles 631 - 660 of 927
Full-Text Articles in Sociology
Shifting The Ultimatum: Political Alienation And Participation, Grace Cale
Shifting The Ultimatum: Political Alienation And Participation, Grace Cale
Theses and Dissertations--Sociology
Common knowledge dictates that cynicism and mistrust of politics is rampant among US citizens, wreaking havoc on participation in the American political process. Social Capital theories are commonly used to effectively explain US political behavior, but fail to account for alienation from the political process or the influence of peers. I argue that models of political participation would be improved by the inclusion of political alienation variables, which have fallen into disuse in recent decades. Using data from the US Citizenship, Involvement, and Democracy Survey (2006), this paper relies upon negative binomial regression with nested models to compare the explanatory …
Social Networks, Drug Use, And Drug Abuse Help-Seeking: A Test Of The Network Episode Model Among African American Women, Erin L. Pullen
Social Networks, Drug Use, And Drug Abuse Help-Seeking: A Test Of The Network Episode Model Among African American Women, Erin L. Pullen
Theses and Dissertations--Sociology
Untreated substance use disorders are a major public health concern that has costly consequences at both the societal and individual level. Identifying the characteristics and resources of those who seek help for substance abuse problems in order to inform more effective intervention and treatment techniques is therefore an important research objective. Using the Network Episode Model (NEM) as a theoretical framework, this dissertation examines both substance abuse help-seeking (i.e. inpatient/outpatient treatment and 12-Step meeting attendance) and patterns of drug use over time among low-income African American women, with a special focus on the role of the social network system in …
Identity And Social Relations: A Case Of Chinese Graduate Students In The U.S., Baiqing Zhang
Identity And Social Relations: A Case Of Chinese Graduate Students In The U.S., Baiqing Zhang
Theses and Dissertations--Sociology
This dissertation research separates out the social relations implied in identity theory and empirically shows the interaction of identity and social relations. I conducted 60 interviews and one online survey with respondents at two public universities in two cities with distinctive sociocultural characteristics. The respondents were graduate students from mainland China pursuing their master’s or doctoral degrees in the U.S. The students’ lengths of stay in the U.S. varied, but all experienced a major life transition from China to the U.S.
The qualitative interview data show that the adoption of a religious identity in the two places, defined as different …
Science Wars As Culture Wars: Fracking And The Battle For The Hearts And Minds Of Women, Jenrose D. Fitzgerald
Science Wars As Culture Wars: Fracking And The Battle For The Hearts And Minds Of Women, Jenrose D. Fitzgerald
Theses and Dissertations--Sociology
In this thesis, I examine how claims regarding the environmental and health impacts of hydraulic fracturing or “fracking” are constructed by industry advocates who promote the practice and environmental and social justice groups who reject it. More specifically, I examine the cultural underpinnings of the debate over fracking, and the prominence of gender as a central framing device in that debate. While the controversy over fracking is often presented as scientific or technical in nature, I maintain that it is as much a culture war as it is a science war. I demonstrate this by showing how both pro-fracking and …
Explaining Public Opinion Towards A Federal Educational Reform: The Impact Of Accountability, Symbolism, Group Interest, And Authoritarianism On Support For The No Child Left Behind Law, Jonathon Holland
Theses and Dissertations--Sociology
This study focuses on public opinion of the No Child Left Behind Act (NCLB). The act is a federal reform act, therefore politicians will pay attention to voters’ opinions of the law when considering if they should pass future legislation like it. Data were collected from a sample population of United States citizens by the Princeton Survey Research Associates International. People’s educational views, political views, group interests, and authoritarian views were all used to measure which groups have a positive attitude toward NCLB. Logistic regression was used to test several models to predict which groups have the strongest opinion of …
Talking Food: Motivations Of Home Food Preservation Practitioners In Kentucky, Lisa Conley
Talking Food: Motivations Of Home Food Preservation Practitioners In Kentucky, Lisa Conley
Theses and Dissertations--Sociology
Recent reports detail a rise in the practice of home food preservation in the United States due to economic woes, nutritional concerns, and increasing devotion to local food production.Home food preservation is the processing of foods in order to extend its shelf-life. Current common approaches to preserving foods at home include pressure canning, freezing, drying, water bath canning, and cellaring/storing. Local food production in four Kentucky counties were examined through in-depth qualitative interviews with home food preservation practitioners to yield a rural/urban comparison. Forty home food preservation practitioners were interviewed between Fall 2009 and Fall 2013. The primary question driving …
Dating Violence On Small Rural College Campuses: Are Administrator And Student Perceptions Similar?, Jean Allen Oldham
Dating Violence On Small Rural College Campuses: Are Administrator And Student Perceptions Similar?, Jean Allen Oldham
Theses and Dissertations--Kinesiology and Health Promotion
In recent years dating violence has become more and more prevalent on college campuses. Reports of the range of dating violence vary widely, with studies reporting from 20% to 85% of college women experiencing dating violence. However, almost all research has been conducted among urban and/or large colleges and universities, with virtually no attention to what is happening on small and/or rural college and university campuses.
When a possible 20% of college women have experienced dating violence on college campuses, there becomes a crucial need for administration at a college to have an accurate assessment of the college’s liability, and …
Clinically Relevant Intronic Splicing Enhancer Mutation In Myelin Proteolipid Protein Leads To Progressive Microglia And Astrocyte Activation In White And Gray Matter Regions Of The Brain, Adam D. Bachstetter, Scott J. Webster, Linda J. Van Eldik, Franca Cambi
Clinically Relevant Intronic Splicing Enhancer Mutation In Myelin Proteolipid Protein Leads To Progressive Microglia And Astrocyte Activation In White And Gray Matter Regions Of The Brain, Adam D. Bachstetter, Scott J. Webster, Linda J. Van Eldik, Franca Cambi
Sanders-Brown Center on Aging Faculty Publications
INTRODUCTION: Mutations in proteolipid protein (PLP), the most abundant myelin protein in the CNS, cause the X-linked dysmyelinating leukodystrophies, Pelizaeus-Merzbacher disease (PMD) and spastic paraplegia type 2 (SPG2). Point mutations, deletion, and duplication of the PLP1 gene cause PMD/SPG2 with varying clinical presentation. Deletion of an intronic splicing enhancer (ISEdel) within intron 3 of the PLP1 gene is associated with a mild form of PMD. Clinical and preclinical studies have indicated that mutations in myelin proteins, including PLP, can induce neuroinflammation, but the temporal and spatial onset of the reactive glia response in a clinically relevant mild form of PMD …
The Supplemental Nutrition Assistance Program And Food Insecurity, Christian Gregory, Matthew P. Rabbitt, David C. Ribar
The Supplemental Nutrition Assistance Program And Food Insecurity, Christian Gregory, Matthew P. Rabbitt, David C. Ribar
University of Kentucky Center for Poverty Research Discussion Paper Series
This chapter reviews recent theory and empirical evidence regarding the effect of SNAP on food insecurity and replicates the modelling strategies used in the empirical literature. The authors find that recent evidence suggesting an ameliorative effect of SNAP on food insecurity may not be robust to specification choice or data. Most specifications mirror the existing literature in finding a positive association of food insecurity with SNAP participation. Two-stage least squares and control function methods do show that SNAP reduces food insecurity, but effects are not consistent across sub-populations and are not always statistically significant.
Snap And The School Meal Programs, Judith Bartfeld
Snap And The School Meal Programs, Judith Bartfeld
University of Kentucky Center for Poverty Research Discussion Paper Series
The Great Recession and its immediate aftermath have brought increasing attention both to food insecurity among children and to the associated food safety net. After a decade of largely stable food insecurity rates, the share of children living in food insecure households jumped by one-third between 2007 and 2008, and has remained stubbornly high since then. As of 2012, 21.6% of all children lived in food insecure households (Coleman-Jensen et al. 2013). The scope and reach of the food safety net for children has likewise grown – a response to rising need, efforts to reduce administrative and logistical barriers to …
Diabetes And Prostate Cancer Screening In Black And White Men, Maureen Sanderson, Jay H. Fowke, Loren Lipworth, Xijing Han, Flora Ukoli, Ann L. Coker, William J. Blot, Margaret K. Hargreaves
Diabetes And Prostate Cancer Screening In Black And White Men, Maureen Sanderson, Jay H. Fowke, Loren Lipworth, Xijing Han, Flora Ukoli, Ann L. Coker, William J. Blot, Margaret K. Hargreaves
CRVAW Faculty Journal Articles
PURPOSE: Prior studies conducted primarily among white men find a reduced risk of prostate cancer associated with time since developing diabetes. While biologic explanations are plausible, the association may in part arise from more frequent prostate cancer screening among those with a diabetes diagnosis. The purpose of the present study was to investigate the association between diabetes and prostate cancer screening.
METHODS: We examined differences in prostate cancer screening (prostate-specific antigen and/or digital rectal examination) testing practices after a diabetes diagnosis among lower-income persons living in the southeastern United States and enrolled in the Southern Community Cohort Study between 2002 …
Sexual Coercion And Sexual Violence At First Intercourse Associated With Sexually Transmitted Infections, Corrine M. Williams, Emily R. Clear, Ann L. Coker
Sexual Coercion And Sexual Violence At First Intercourse Associated With Sexually Transmitted Infections, Corrine M. Williams, Emily R. Clear, Ann L. Coker
CRVAW Faculty Journal Articles
BACKGROUND: Violence against women has been associated with subsequent risky sexual behaviors and sexually transmitted infections (STIs). We explored whether sexual coercion or violence at first intercourse was associated with self-reported STIs.
METHODS: Using nationally representative data from the 2006 to 2010 National Survey of Family Growth, we analyzed female respondents aged 18 to 44 (n = 9466) who answered questions on coercion at first intercourse (wantedness, voluntariness, and types of force used) and STIs using logistic regression analyses. We explored degrees of coercion, which we label as neither, sexual coercion (unwanted or nonphysical force), or sexual violence (involuntary or …
The Effect Of Snap On Poverty, Laura Tiehen, Dean Jolliffe, Timothy Smeeding
The Effect Of Snap On Poverty, Laura Tiehen, Dean Jolliffe, Timothy Smeeding
University of Kentucky Center for Poverty Research Discussion Paper Series
On signing the Food Stamp Act of 1964, President Johnson noted that “as a permanent program, the food stamp plan will be one of our most valuable weapons for the war on poverty” (Johnson, 1964). From a humble beginning of 2.9 million recipients per month and $228 million in benefits in 1969 (earliest national figures), the program has grown to serve 47 million persons with benefits of over $74.6 Billion in 2012 (USDA, 2013a). In the late 60’s and early 70’s, when the average monthly benefit was under $20 per month per month, we did not record the effects of …
Why Are So Many Americans On Food Stamps? The Role Of The Economy, Policy, And Demographics, James P. Ziliak
Why Are So Many Americans On Food Stamps? The Role Of The Economy, Policy, And Demographics, James P. Ziliak
University of Kentucky Center for Poverty Research Discussion Paper Series
1 in 7 Americans received assistance from SNAP in FY2012, which is a rate 141 percent higher than in FY2000, but only 59 percent higher than in FY1980. In this chapter I describe the socioeconomic and policy climate in recent decades that had bearing on SNAP participation, along with a formal empirical analysis of those determinants and detailed simulations of the relative contributions of the economy, policy, and demographics to changes in SNAP participation over time. The results suggest that SNAP is operating effectively as an automatic fiscal stabilizer—nearly 50 percent of the increase in participation from 2007-2011 is due …
The Influence Of Parental Aspirations, Attitudes, And Engagement On Children's Very Low Food Security, Elizabeth T. Powers
The Influence Of Parental Aspirations, Attitudes, And Engagement On Children's Very Low Food Security, Elizabeth T. Powers
University of Kentucky Center for Poverty Research Discussion Paper Series
Survey of Income and Program Participation data are used to investigate the relationship between parenting and children’s very low food security. Parenting is characterized along five domains (emotional outlook, support, education desires, activities with the child excluding meals, and television viewing rules). Food security definitions are obtained from questions in a special SIPP module that are based on the USDA’s core food security module. Graphical evidence indicates that parenting patterns differ distinctly for households experiencing various levels of food insecurity. Descriptive regression evidence suggests that some of the parenting attributes are significantly associated with children’s food insecurity, even controlling for …
Risk And Protective Factors Associated With Prevalence Of Vlfs In Children Among Children Of Foreign-Born Mothers, John Cook
University of Kentucky Center for Poverty Research Discussion Paper Series
This research examined VLFS in children among households with foreign-born (FB) mothers compared to US-born mothers through three research questions: Is mother’s foreign-born status (FBS) associated with VLFS in children, and can association be explained by mothers’ socio-demographic characteristics? Are FB mothers more or less likely to receive nutrition or non-nutrition assistance benefits, or work for pay than US-born mothers? Do mothers’ FBS, or protective/risk factors associated with FBS, modify associations of negative economic shocks and hardships with VLFS in children? Data are on approximately 44,000 mother-child (ages<48 Mos.) dyads collected from household surveys administered under a "sentinel surveillance" system over 1998-2012 at teaching hospitals and clinics in seven US cities. Bivariate and multivariate logistic regression models tested study hypotheses. Mothers' FBS is strongly positively associated with VLFS in children after controlling for available risk and protective factors. FB mothers are less likely to receive SNAP and non-nutrition assistance (TANF, LIHEAP or housing subsidies), but more likely to receive WIC and to be employed than US-born mothers. FB mothers are no more likely to report negative reasons for not receiving SNAP or TANF, or losing jobs or decreasing work hours than US-born, and reported "immigration concerns" rarely. No need/chose not to participate are most frequently reported reasons for not receiving SNAP and TANF; pregnancy/maternity leave and "market conditions" for lost jobs and decreased work hours. Economic shocks and hardships are positively associated with VLFS in children, but Mothers' FBS does not interact with shocks and hardships to modify those associations.
Food Insecurity During Childhood: Understanding Persistence And Change Using Linked Current Population Survey Data, Sheela Kennedy, Catherine A. Fitch, John Robert Warren, Julia A. Rivera Drew
Food Insecurity During Childhood: Understanding Persistence And Change Using Linked Current Population Survey Data, Sheela Kennedy, Catherine A. Fitch, John Robert Warren, Julia A. Rivera Drew
University of Kentucky Center for Poverty Research Discussion Paper Series
Our paper examines the prevalence and determinants of children’s transitions into and out of food insecurity since 2001. We use longitudinally linked data from the Food Security Supplements to the Current Population Surveys to estimate one-year transition probabilities of entry and exit from food insecurity. Our results indicate that child hunger is typically short-lived, but children experiencing very low food security frequently experience multiple consecutive years of food insecurity. We demonstrate large demographic and socioeconomic differences in rates of entry into very low food security and persistence in children's food insecurity. Income and employment shocks are important predictors of child …
Use Of Alternative Financial Services And Childhood Food Insecurity, Katie Fitzpatrick
Use Of Alternative Financial Services And Childhood Food Insecurity, Katie Fitzpatrick
University of Kentucky Center for Poverty Research Discussion Paper Series
Low- and moderate-income (LMI) households with children often face considerable difficulties in ensuring enough financial resources for an adequate diet. This project investigates the use of financial services and other financial decisions parents make that may affect the risk of very low food security and food insecurity of children. With households in both the December 2008 Current Population Survey (CPS) Food Security Supplement and the January 2009 CPS Unbanked and Underbanked Supplement, the project studies the relationship between bank account ownership, use of alternative financial service (AFS) providers, the organization of household finances, and the food security of children. Both …
Circulating Micrornas In Alzheimer's Disease: The Search For Novel Biomarkers, Véronique Dorval, Peter T. Nelson, Sébastien S. Hébert
Circulating Micrornas In Alzheimer's Disease: The Search For Novel Biomarkers, Véronique Dorval, Peter T. Nelson, Sébastien S. Hébert
Sanders-Brown Center on Aging Faculty Publications
Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. While advancements have been made in understanding the genetic and molecular basis of AD, the clinical diagnosis of AD remains difficult, and post-mortem confirmation is often required. Furthermore, the onset of neurodegeneration precedes clinical symptoms by approximately a decade. Consequently, there is a crucial need for an early and accurate diagnosis of AD, which can potentially lead to strategies that can slow down or stop the progression of neurodegeneration and dementia. Recent advances in the non-coding RNA field have shown that microRNAs (miRNAs) can function as powerful biomarkers …
Dose- And Time-Dependent Neuroprotective Effects Of Pycnogenol® Following Traumatic Brain Injury, Mubeen A. Ansari, Kelly N. Roberts, Stephen W. Scheff
Dose- And Time-Dependent Neuroprotective Effects Of Pycnogenol® Following Traumatic Brain Injury, Mubeen A. Ansari, Kelly N. Roberts, Stephen W. Scheff
Sanders-Brown Center on Aging Faculty Publications
After traumatic brain injury (TBI), both primary and secondary injury cascades are initiated, leading to neuronal death and cognitive dysfunction. We have previously shown that the combinational bioflavonoid, Pycnogenol® (PYC), alters some secondary injury cascades and protects synaptic proteins when administered immediately following trauma. The purpose of the present study was to explore further the beneficial effects of PYC and to test whether it can be used in a more clinically relevant fashion. Young adult male Sprague-Dawley rats were subjected to a unilateral moderate/severe cortical contusion. Subjects received a single intravenous (i.v.) injection of PYC (1, 5, or 10 mg/kg) …
The Effect Of Household Financial, Time And Environmental Constraints On Very Low Food Security Among Children, Helen H. Jensen, Oleksandr Zhylyevskyy
The Effect Of Household Financial, Time And Environmental Constraints On Very Low Food Security Among Children, Helen H. Jensen, Oleksandr Zhylyevskyy
University of Kentucky Center for Poverty Research Discussion Paper Series
Food insecurity is detrimental to children’s well-being. A better understanding of factors contributing to low and very low food security among children in the United States can guide the design of food assistance programs. We analyze the effects of household characteristics and local food environment attributes, including food prices and availability of food stores and eating places, on children’s food insecurity. We also investigate the effects of these characteristics and attributes on food preparation time. Using Becker’s household production approach, we propose an economic model that formalizes the use of constrained financial and time resources in the household. The model …
Development Of Novel In Vivo Chemical Probes To Address Cns Protein Kinase Involvement In Synaptic Dysfunction, D Martin Watterson, Valerie L. Grum-Tokars, Saktimayee M. Roy, James P. Schavocky, Brinda Desai Bradaric, Adam D. Bachstetter, Bin Xing, Edgardo Dimayuga, Faisal Saeed, Hong Zhang, Agnieszka Staniszewski, Jeffrey C. Pelletier, George Minasov, Wayne F. Anderson, Ottavio Arancio, Linda J. Van Eldik
Development Of Novel In Vivo Chemical Probes To Address Cns Protein Kinase Involvement In Synaptic Dysfunction, D Martin Watterson, Valerie L. Grum-Tokars, Saktimayee M. Roy, James P. Schavocky, Brinda Desai Bradaric, Adam D. Bachstetter, Bin Xing, Edgardo Dimayuga, Faisal Saeed, Hong Zhang, Agnieszka Staniszewski, Jeffrey C. Pelletier, George Minasov, Wayne F. Anderson, Ottavio Arancio, Linda J. Van Eldik
Sanders-Brown Center on Aging Faculty Publications
Serine-threonine protein kinases are critical to CNS function, yet there is a dearth of highly selective, CNS-active kinase inhibitors for in vivo investigations. Further, prevailing assumptions raise concerns about whether single kinase inhibitors can show in vivo efficacy for CNS pathologies, and debates over viable approaches to the development of safe and efficacious kinase inhibitors are unsettled. It is critical, therefore, that these scientific challenges be addressed in order to test hypotheses about protein kinases in neuropathology progression and the potential for in vivo modulation of their catalytic activity. Identification of molecular targets whose in vivo modulation can attenuate synaptic …
Intracranial Injection Of Gammagard, A Human Ivig, Modulates The Inflammatory Response Of The Brain And Lowers AΒ In App/Ps1 Mice Along A Different Time Course Than Anti-AΒ Antibodies, Tiffany L. Sudduth, Abigail Greenstein, Donna M. Wilcock
Intracranial Injection Of Gammagard, A Human Ivig, Modulates The Inflammatory Response Of The Brain And Lowers AΒ In App/Ps1 Mice Along A Different Time Course Than Anti-AΒ Antibodies, Tiffany L. Sudduth, Abigail Greenstein, Donna M. Wilcock
Sanders-Brown Center on Aging Faculty Publications
Gammagard IVIg is a therapeutic approach to treat Alzheimer's disease currently in phase 3 clinical trials. Despite the reported efficacy of the approach the mechanism of action is poorly understood. We have previously shown that intracranial injection of anti-Aβ antibodies into the frontal cortex and hippocampus reveals important information regarding the time course of events once the agent is in the brain. In the current study we compared IVIg, mouse-pooled IgG, and the anti-Aβ antibody 6E10 injected intracranially into the frontal cortex and hippocampus of 7-month-old APP/PS1 mice. We established a time course of events ranging from 1 …
Comprehensive Behavioral Characterization Of An App/Ps-1 Double Knock-In Mouse Model Of Alzheimer's Disease, Scott J. Webster, Adam D. Bachstetter, Linda J. Van Eldik
Comprehensive Behavioral Characterization Of An App/Ps-1 Double Knock-In Mouse Model Of Alzheimer's Disease, Scott J. Webster, Adam D. Bachstetter, Linda J. Van Eldik
Sanders-Brown Center on Aging Faculty Publications
INTRODUCTION: Despite the extensive mechanistic and pathological characterization of the amyloid precursor protein (APP)/presenilin-1 (PS-1) knock-in mouse model of Alzheimer's disease (AD), very little is known about the AD-relevant behavioral deficits in this model. Characterization of the baseline behavioral performance in a variety of functional tasks and identification of the temporal onset of behavioral impairments are important to provide a foundation for future preclinical testing of AD therapeutics. Here we perform a comprehensive behavioral characterization of this model, discuss how the observed behavior correlates with the mechanistic and pathological observations of others, and compare this model with other commonly used …
An Ehealth System Supporting Palliative Care For Patients With Non-Small Cell Lung Cancer: A Randomized Trial, David H. Gustafson, Lori L. Dubenske, Kang Namkoong, Robert Hawkins, Ming-Yuan Chih, Amy K. Atwood, Roberta Johnson, Abhik Bhattacharya, Cindy L. Carmack, Anne M. Traynor, Toby C. Campbell, Mary K. Buss, Ramaswamy Govindan, Joan H. Schiller, James F. Cleary
An Ehealth System Supporting Palliative Care For Patients With Non-Small Cell Lung Cancer: A Randomized Trial, David H. Gustafson, Lori L. Dubenske, Kang Namkoong, Robert Hawkins, Ming-Yuan Chih, Amy K. Atwood, Roberta Johnson, Abhik Bhattacharya, Cindy L. Carmack, Anne M. Traynor, Toby C. Campbell, Mary K. Buss, Ramaswamy Govindan, Joan H. Schiller, James F. Cleary
Community & Leadership Development Faculty Publications
BACKGROUND: In this study, the authors examined the effectiveness of an online support system (Comprehensive Health Enhancement Support System [CHESS]) versus the Internet in relieving physical symptom distress in patients with non-small cell lung cancer (NSCLC).
METHODS: In total, 285 informal caregiver-patient dyads were assigned randomly to receive, for up to 25 months, standard care plus training on and access to either use of the Internet and a list of Internet sites about lung cancer (the Internet arm) or CHESS (the CHESS arm). Caregivers agreed to use CHESS or the Internet and to complete bimonthly surveys; for patients, these tasks …
21st Century Crofting: Strengths And Opportunities For Community Development, Bryan J. Hains, Ronald Hustedde, Kristina G. Ricketts
21st Century Crofting: Strengths And Opportunities For Community Development, Bryan J. Hains, Ronald Hustedde, Kristina G. Ricketts
Community & Leadership Development Faculty Publications
Scotland has one of the most uneven land ownership patterns in the world. In a country of 5.2 million people, about 969 people control 60% of the land. Over 20% of privately owned land in Scotland is held in some form of offshore or beneficial ownership (Committee on the Inquiry of Crofting, 2008). This land ownership pattern has a unique expression in the northern and western parts of the Scottish Highlands and Islands with a 300-year-old system of tenant farmers known as crofters. Unlike other tenant farmers across the world, crofters have gained legal rights to stay on the land …
Intracranial Injection Of Aav Expressing Nep But Not Ide Reduces Amyloid Pathology In App+Ps1 Transgenic Mice, Nikisha Carty, Kevin R. Nash, Milene Brownlow, Dana Cruite, Donna M. Wilcock, Maj-Linda B. Selenica, Daniel C. Lee, Marcia N. Gordon, Dave Morgan
Intracranial Injection Of Aav Expressing Nep But Not Ide Reduces Amyloid Pathology In App+Ps1 Transgenic Mice, Nikisha Carty, Kevin R. Nash, Milene Brownlow, Dana Cruite, Donna M. Wilcock, Maj-Linda B. Selenica, Daniel C. Lee, Marcia N. Gordon, Dave Morgan
Sanders-Brown Center on Aging Faculty Publications
The accumulation of β-amyloid peptides in the brain has been recognized as an essential factor in Alzheimer's disease pathology. Several proteases, including Neprilysin (NEP), endothelin converting enzyme (ECE), and insulin degrading enzyme (IDE), have been shown to cleave β-amyloid peptides (Aβ). We have previously reported reductions in amyloid in APP+PS1 mice with increased expression of ECE. In this study we compared the vector-induced increased expression of NEP and IDE. We used recombinant adeno-associated viral vectors expressing either native forms of NEP (NEP-n) or IDE (IDE-n), or engineered secreted forms of NEP (NEP-s) or IDE (IDE-s). In a six-week study, immunohistochemistry …
Bapineuzumab Alters Aβ Composition: Implications For The Amyloid Cascade Hypothesis And Anti-Amyloid Immunotherapy, Alex E. Roher, David H. Cribbs, Ronald C. Kim, Chera L. Maarouf, Charisse M. Whiteside, Tyler A. Kokjohn, Ian D. Daugs, Elizabeth Head, Carolyn Liebsack, Geidy Serrano, Christine Belden, Marwan N. Sabbagh, Thomas G. Beach
Bapineuzumab Alters Aβ Composition: Implications For The Amyloid Cascade Hypothesis And Anti-Amyloid Immunotherapy, Alex E. Roher, David H. Cribbs, Ronald C. Kim, Chera L. Maarouf, Charisse M. Whiteside, Tyler A. Kokjohn, Ian D. Daugs, Elizabeth Head, Carolyn Liebsack, Geidy Serrano, Christine Belden, Marwan N. Sabbagh, Thomas G. Beach
Sanders-Brown Center on Aging Faculty Publications
The characteristic neuropathological changes associated with Alzheimer's disease (AD) and other lines of evidence support the amyloid cascade hypothesis. Viewing amyloid deposits as the prime instigator of dementia has now led to clinical trials of multiple strategies to remove or prevent their formation. We performed neuropathological and biochemical assessments of 3 subjects treated with bapineuzumab infusions. Histological analyses were conducted to quantify amyloid plaque densities, Braak stages and the extent of cerebral amyloid angiopathy (CAA). Amyloid-β (Aβ) species in frontal and temporal lobe samples were quantified by ELISA. Western blots of amyloid-β precursor protein (AβPP) and its C-terminal (CT) fragments …
Snap And Obesity, Craig Gundersen
Snap And Obesity, Craig Gundersen
University of Kentucky Center for Poverty Research Discussion Paper Series
No abstract.
Predictors Of The Change In The Expression Of Emotional Support Within An Online Breast Cancer Support Group: A Longitudinal Study, Woohyun Yoo, Ming-Yuan Chih, Min-Woo Kwon, Junghwan Yang, Eunji Cho, Bryan Mclaughlin, Kang Namkoong, Dhavan V. Shah, David H. Gustafson
Predictors Of The Change In The Expression Of Emotional Support Within An Online Breast Cancer Support Group: A Longitudinal Study, Woohyun Yoo, Ming-Yuan Chih, Min-Woo Kwon, Junghwan Yang, Eunji Cho, Bryan Mclaughlin, Kang Namkoong, Dhavan V. Shah, David H. Gustafson
Community & Leadership Development Faculty Publications
OBJECTIVES: To explore how the expression of emotional support in an online breast cancer support group changes over time, and what factors predict this pattern of change.
METHODS: We conducted growth curve modeling with data collected from 192 participants in an online breast cancer support group within the Comprehensive Health Enhancement Support System (CHESS) during a 24-week intervention period.
RESULTS: Individual expression of emotional support tends to increase over time for the first 12 weeks of the intervention, but then decrease slightly with time after that. In addition, we found that age, living situation, comfort level with computer and the …