Sociology Commons^™

Time-Dependent Effects Of Cx3cr1 In A Mouse Model Of Mild Traumatic Brain Injury, Heidi Y. Febinger, Hannah E. Thomasy, Maria N. Pavlova, Kristyn M. Ringgold, Paulien R. Barf, Amrita M. George, Jenna N. Grillo, Adam D. Bachstetter, Jenny A. Garcia, Astrid E. Cardona, Mark R. Opp, Carmelina Gemma

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Neuroinflammation is an important secondary mechanism that is a key mediator of the long-term consequences of neuronal injury that occur in traumatic brain injury (TBI). Microglia are highly plastic cells with dual roles in neuronal injury and recovery. Recent studies suggest that the chemokine fractalkine (CX3CL1, FKN) mediates neural/microglial interactions via its sole receptor CX3CR1. CX3CL1/CX3CR1 signaling modulates microglia activation, and depending upon the type and time of injury, either protects or exacerbates neurological diseases.

METHODS: In this study, mice deficient in CX3CR1 were subjected to mild controlled cortical impact injury (CCI), a model of TBI. We evaluated …

Temporary Assistance For Needy Families, James P. Ziliak

University of Kentucky Center for Poverty Research Discussion Paper Series

The provision of public assistance to families with children in America faced a watershed moment with the passage of the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA). PRWORA replaced the Aid to Families with Dependent Children (AFDC) program, which was an entitlement funded via a federal-state matching grant, with Temporary Assistance for Needy Families (TANF), which is no longer an entitlement and is financed with a fixed federal block-grant to the states. The impetus for reform had been building for at least the two decades prior to passage, but took on greater currency with the dramatic growth …

Trouble In The Tails? What We Know About Earnings Nonresponse Thirty Years After Lillard, Smith, And Welch, Christopher R. Bollinger, Barry T. Hirsch, Charles M. Hokayem, James P. Ziliak

University of Kentucky Center for Poverty Research Discussion Paper Series

Earnings nonresponse in household surveys is widespread, yet there is limited evidence on whether and how nonresponse bias affects measured earnings. This paper examines the patterns and consequences of nonresponse using internal Current Population Survey individual records linked to administrative Social Security Administrative data on earnings for calendar years 2005-2010. Our findings confirm the conjecture by Lillard, Smith, and Welch (1986) that nonresponse across the earnings distribution is U-shaped. Left-tail “strugglers” and right-tail “stars” are least likely to report earnings. Household surveys understate earnings dispersion, reporting too few low and too few extremely high earners. Throughout much of the earnings …

Ebony And Ivory? Interracial Dating Intentions And Behaviors Of Disadvantaged African American Women In Kentucky, David J. Luke, Carrie B. Oser

Sociology Faculty Publications

Using data from 595 predominantly disadvantaged African American women in Kentucky, this study examines perceptions about racial/ethnic partner availability, cultural mistrust, and racism as correlates of interracial dating intentions and behaviors with both white and Hispanic men. Participants reported levels of dating intentions and behaviors were significantly higher with whites than Hispanics. The multivariate models indicate less cultural mistrust and believing it is easier to find a man of that racial/ethnic category were associated with higher interracial dating intentions. Women were more likely to have dated a white man if they believed it was easier to find a white man …

Albumin Administration In Acute Ischemic Stroke: Safety Analysis Of The Alias Part 2 Multicenter Trial, Michael D. Hill, Renee H. Martin, Yuko Y. Palesch, Claudias S. Moy, Diego Tamariz, Karla J. Ryckborst, Elizabeth B. Jones, David Weisman, L. Creed Pettigrew, Myron D. Ginsberg

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Albumin treatment of ischemic stroke was associated with cardiopulmonary adverse events in previous studies and a low incidence of intracranial hemorrhage. We sought to describe the neurological and cardiopulmonary adverse events in the ALIAS Part 2 Multicenter Trial.

METHODS: Ischemic stroke patients, aged 18-83 and a baseline NIHSS ≥ 6, were randomized to treatment with ALB or saline control within 5 hours of stroke onset. Neurological adverse events included symptomatic intracranial hemorrhage, hemicraniectomy, neurological deterioration and neurological death. Cardiopulmonary adverse events included pulmonary edema/congestive heart failure, acute coronary syndromes, atrial fibrillation, pneumonia and pulmonary thromboembolism.

RESULTS: …

The Crisis Of Identity In Post-Revolutionary Cuban Film: A Sociological Analysis Of Strawberry And Chocolate, Andrew Zachary Shultz

Kaleidoscope

This paper analyzes Tomás Gutiérrez Alea and Juan Carlos Tabío´s Strawberry and Chocolate (1993) from the sociological perspective of film as a cultural text informed by the political, historical, and social world in which it is produced. A symbolic interactionist/cultural studies model is used as a guide for the interpretive and qualitative methods utilized in approaching the film. Of particular interest to the sociological analysis of the film is the changing political context of the Cuban Revolution during the “special period” of the early 1990s, the use of stereotypes in the characterization of the actors, and finally its representation of …

Altered Lysosomal Proteins In Neural-Derived Plasma Exosomes In Preclinical Alzheimer Disease, Edward J. Goetzl, Adam Boxer, Janice B. Schwartz, Erin L. Abner, Ronald C. Petersen, Bruce L. Miller, Dimitrios Kapogiannis

Sanders-Brown Center on Aging Faculty Publications

OBJECTIVE: Diverse autolysosomal proteins were quantified in neurally derived blood exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered neuronal autophagy.

METHODS: Blood exosomes obtained once from patients with AD (n = 26) or frontotemporal dementia (n = 16), other patients with AD (n = 20) both when cognitively normal and 1 to 10 years later when diagnosed, and case controls were enriched for neural sources by anti-human L1CAM antibody immunoabsorption. Extracted exosomal proteins were quantified by ELISAs and normalized with the CD81 exosomal marker.

RESULTS: Mean exosomal levels of cathepsin D, lysosome-associated membrane …

Low Neural Exosomal Levels Of Cellular Survival Factors In Alzheimer's Disease, Edward J. Goetzl, Adam Boxer, Janice B. Schwartz, Erin Abner, Ronald C. Petersen, Bruce L. Miller, Olga D. Carlson, Maja Mustapic, Dimitrios Kapogiannis

Sanders-Brown Center on Aging Faculty Publications

Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2-10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

The Streets As Examples Of “True” Democracy? The South-American Experience, Carlos De La Torre

Sociology Faculty Publications

Building on the existing literature this paper analyzes how – at the turn of the century and into the 21st century – activists in Ecuador, Venezuela and Bolivia constructed narratives that focused on “the people in action”. Advocates of the insurrections framed myths of the pure and oppressed people revolting against the tyranny of economic and political elites. Elites responded by differentiating the authentic people from the mob. Indigenous and other poor and non-white protestors were portrayed by elites as the rabble, as uncivilized, and in general, as a danger to democracy.

Apoε2 And Education In Cognitively Normal Older Subjects With High Levels Of Ad Pathology At Autopsy: Findings From The Nun Study, Diego Iacono, Peter Zandi, Myron Gross, William R. Markesbery, Olga Pletnikova, Gay Rudow, Juan C. Troncoso

Sanders-Brown Center on Aging Faculty Publications

Asymptomatic Alzheimer's disease (ASYMAD) subjects are individuals characterized by preserved cognition before death despite substantial AD pathology at autopsy. ASYMAD subjects show comparable levels of AD pathology, i.e. β-amyloid neuritic plaques (Aβ-NP) and tau-neurofibrillary tangles (NFT), to those observed in mild cognitive impairment (MCI) and some definite AD cases. Previous clinicopathologic studies on ASYMAD subjects have shown specific phenomena of hypertrophy in the cell bodies, nuclei, and nucleoli of hippocampal pyramidal neurons and other cerebral areas. Since it is well established that the allele APOε4 is a major genetic risk factor for AD, we examined whether specific alleles of APOE …

Calcium Channel Blockers, Progression To Dementia, And Effects On Amyloid Beta Peptide Production, Mark A. Lovell, Erin Abner, Richard Kryscio, Liou Xu, Shuling X. Fister, Bert C. Lynn

Sanders-Brown Center on Aging Faculty Publications

Previous epidemiologic studies suggest that antihypertensive drugs may be protective against cognitive decline. To determine if subjects enrolled in the University of Kentucky longitudinal aging study who used antihypertensive drugs showed diminished progression to dementia, we used a 3-parameter logistic regression model to compare the rate of progression to dementia for subjects who used any of the five common categories of antihypertensive drugs to those with similar demographic characteristics but who did not use antihypertensives. Regression modeling showed that subjects who used calcium channel blockers (CCBs) but not the other classes of antihypertensives showed a significant decrease in the rate …

Encouraging Victims: Responding To A Recent Study Of Battered Women Who Commit Crimes, Andrea L. Dennis, Carol E. Jordan

Office for Policy Studies on Violence Against Women Publications

No abstract provided.

Building The Capacity For Community Food Work: The Geographic Distribution Of Usda Community Food Projects Competitive Grant Program Grantees, Keiko Tanaka, Erica Indiano, Graham T. Soley, Patrick H. Mooney

Community & Leadership Development Faculty Publications

Projects Competitive Grants Program, or USDA CFPCGP, supports community efforts to address food system issues. Over the last 15 years the program has funded diverse community-based projects across the nation, including youth education programs on healthy eating, farm-to-table initiatives, and community food assessments. In this initial study, we endeavor to understand the contribution of the CFPCGP in building a community's capacity to address its own challenges for food security. To analyze funding patterns of the CFPCGP program between 1996 and 2012, we used the websites of the CFPCGP and the WhyHunger Network to identify 420 competitive grant applications successfully funded …

Gold Mining And Unequal Exchange In Western Amazonia: A Theoretical Photo Essay, Gordon L. Ulmer

disClosure: A Journal of Social Theory

I combine fieldwork photography and ethnographic documentation of gold mining in Madre de Dios, Peru, to examine the localized material, social, environmental, and health outcomes of the global gold boom. This 'theoretical photo essay’ examines how local and global forces coalesce around gold mining and influence peoples and environments in Western Amazonia. I use embodiment theory in anthropology, ecological economics, and theories of underdevelopment to understand local consequences of the global gold trade and to elucidate how opulence and the machinations of capital accumulation in economic centers of the world occur at the expense of human lives and environments in …

Race Vs. Class: Is The Market Colorblind?, David Luke

disClosure: A Journal of Social Theory

For decades, social scientists have debated the nature of inequality in the United States. A false dichotomy of race versus class is a common way of interpreting this. This brief article provides a detailed review of some of the important literature on racial and social class equality, as well as a view of current levels of inequality and the trends exacerbated in the market failure and Great Recession of 2008. Ultimately, this review results in policy recommendations to address the gap, and challenges the claims that the various "markets" in the United States are colorblind.

Closed Head Injury In An Age-Related Alzheimer Mouse Model Leads To An Altered Neuroinflammatory Response And Persistent Cognitive Impairment, Scott J. Webster, Linda J. Van Eldik, D. Martin Watterson, Adam D. Bachstetter

Sanders-Brown Center on Aging Faculty Publications

Epidemiological studies have associated increased risk of Alzheimer's disease (AD)-related clinical symptoms with a medical history of head injury. Currently, little is known about pathophysiology mechanisms linked to this association. Persistent neuroinflammation is one outcome observed in patients after a single head injury. Neuroinflammation is also present early in relevant brain regions during AD pathology progression. In addition, previous mechanistic studies in animal models link neuroinflammation as a contributor to neuropathology and cognitive impairment in traumatic brain injury (TBI) or AD-related models. Therefore, we explored the potential interplay of neuroinflammatory responses in TBI and AD by analysis of the temporal …

Attenuation Of Traumatic Brain Injury-Induced Cognitive Impairment In Mice By Targeting Increased Cytokine Levels With A Small Molecule Experimental Therapeutic, Adam D. Bachstetter, Scott J. Webster, Danielle S. Goulding, Jonathan E. Morton, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Evidence from clinical studies and preclinical animal models suggests that proinflammatory cytokine overproduction is a potential driving force for pathology progression in traumatic brain injury (TBI). This raises the possibility that selective targeting of the overactive cytokine response, a component of the neuroinflammation that contributes to neuronal dysfunction, may be a useful therapeutic approach. MW151 is a CNS-penetrant, small molecule experimental therapeutic that selectively restores injury- or disease-induced overproduction of proinflammatory cytokines towards homeostasis. We previously reported that MW151 administered post-injury (p.i.) is efficacious in a closed head injury (CHI) model of diffuse TBI in mice. Here we test …

Unlocking The Mysteries Of Tdp-43, Keith A. Josephs, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

No abstract provided.

A Practical Algorithm For Managing Alzheimer's Disease: What, When, And Why?, Jeffrey L. Cummings, Richard S. Isaacson, Frederick A. Schmitt, Drew M. Velting

Sanders-Brown Center on Aging Faculty Publications

Alzheimer's disease (AD) is the most common form of dementia and its prevalence is increasing. Recent developments in AD management provide improved ways of supporting patients and their caregivers throughout the disease continuum. Managing cardiovascular risk factors, maintaining an active lifestyle (with regular physical, mental and social activity) and following a Mediterranean diet appear to reduce AD risk and may slow cognitive decline. Pharmacologic therapy for AD should be initiated upon diagnosis. All of the currently available cholinesterase inhibitors (ChEIs; donepezil, galantamine, and rivastigmine) are indicated for mild-to-moderate AD. Donepezil (10 and 23 mg/day) and rivastigmine transdermal patch (13.3 mg/24 …

Husband's Response To Infidelity, Toby Q. Jenkins

Theses and Dissertations--Family Sciences

Infidelity is the most often cited reason for divorce in the United States and much of the world. Providing therapy for a couple trying to recover from infidelity is one of the most difficult and complex presenting problems for therapists. Much of the existing research that predicts responses to infidelity subscribes to an evolutionary psychology perspective, predicting response by gender differently based on motives concerning procreation. Males would find sexual infidelity more threatening because paternity would be uncertain, females would find emotional infidelity more threatening because of the risk of resources and protection being diverted to another female’s offspring. Much …

Impact Of Welfare Participation During Childhood On Adult Income, Curran A. Prettyman

Lewis Honors College Capstone Collection

This paper analyzes the impact of welfare participation during childhood on adult income. In the United States, welfare programs have a long history originating from the 1800s, and over $20 billion are currently allocated to various anti-poverty programs, such as Aid to Families with Dependent Children and Supplemental Security Income. Many people believe that these programs effectively eradicate childhood poverty. However, ordinary least squares and instrumental variables regression models suggest welfare programs are counterproductive. On average, holding all else constant, with 95% confidence, the total dollar amount of funding received from welfare programs during childhood is statistically significant to a …

Discrimination Of Mild Cognitive Impairment And Alzheimer's Disease Using Transfer Entropy Measures Of Scalp Eeg, Joseph Mcbride, Xiaopeng Zhao, Nancy Munro, Gregory Jicha, Charles Smith, Yang Jiang

Sanders-Brown Center on Aging Faculty Publications

Mild cognitive impairment (MCI) is a neurological condition related to early stages of dementia including Alzheimer's disease (AD). This study investigates the potential of measures of transfer entropy in scalp EEG for effectively discriminating between normal aging, MCI, and AD participants. Resting EEG records from 48 age-matched participants (mean age 75.7 years)-15 normal controls, 16 MCI, and 17 early AD-are examined. The mean temporal delays corresponding to peaks in inter-regional transfer entropy are computed and used as features to discriminate between the three groups of participants. Three-way classification schemes based on binary support vector machine models demonstrate overall discrimination accuracies …

Safety Concerns, Fear And Precautionary Behavior Among College Women: An Exploratory Examination Of Two Measures Of Residency, Adam J. Pritchard, Carol E. Jordan, Pamela Wilcox

Office for Policy Studies on Violence Against Women Publications

This study examines the impact of two distinct measures of residency on college women's perceptions of safety, fear of crime and precautionary behaviors within both on-campus and off-campus areas. A student's current residency either on- or off-campus and a student's prior residency in a metropolitan, micropolitan or rural county prior to college are compared across these three aspects of campus safety. Current residency is found to be significantly related to a student's perceptions of safety in off-campus areas around campus, as well as the likelihood of engaging in precautionary behaviors such as avoiding specific locations on campus or carrying or …

Syphilis: The Forgotten Sexually Transmitted Disease. A Brief Case Report, Amy Burnett, Hatim A. Omar

Pediatrics Faculty Publications

Syphilis has declined significantly over the last 30 years. Due to that success, many physicians no longer have the skills to recognize its symptoms. We present a case of syphilis as a demonstration of this fact.

When Security Dominates The Agenda: The Influence Of Interstate Rivalry On Women's Status, Theresa Schroeder

Theses and Dissertations--Political Science

The overarching theme of my dissertation is the effect of interstate rivalries on women’s status. Specifically, I investigate the influence of rivalries on the election of women, the adoption of a gender quota, and the overall level of gender equality. National security is a prime concern in states involved in an interstate rivalry, which can influence women’s lives in a number of key ways. Through the actions of individual voters and rational parties, I find that being in an interstate rivalry leads to lower levels of female representation. In addition, I theorize that rivalries lessen societal pressure to increase female …

Social Capital At The Capitol: A Social Network Analysis Of Interest Group Influence In The 111th Congress, Steven A. Martin

Theses and Dissertations--Political Science

This dissertation builds on existing scholarship in political science and political sociology to explore the influence of interest groups in legislative action networks. The primary theoretical insight is that as the number of interest group affiliations between two members of Congress increases, so does the frequency with which they forge other sorts of social ties necessary to advance the interests of their interest group constituencies. In particular, the analysis looks at interest group donation strategies, legislative co-sponsorships, and roll-call votes during the 111^th Congress (2009-2010). The analysis uses social network analysis methods to create network models of 19 different …

Living Without God: Female Atheists And Stigma Management In The South Of The United States, Jamie L. Pond

Theses and Dissertations--Sociology

This study focuses upon the experiences and perceptions of women Atheists in the Southern U.S., a region which is highly religious and, therefore, has comparatively low numbers of Atheists. Taking a Symbolic Interactionist approach, I examine how these Southern Atheists understood what it means to be an “Atheist,” how they became Atheist, their strategies to manage their stigmatized identity as Atheists, and finally the role gender has in managing this stigma. I utilize a Feminist methodology to investigate and foreground women’s experiences. I conducted participant observation at 23 Atheist and Humanist meetings in two southern cities in two different states; …

Sex, Dementia, And Long-Term Care: Public Perspectives, Erin L. Yelland

Theses and Dissertations--Family Sciences

The current mixed methods study utilized an ecological framework to examine public perspectives toward sexual behaviors among long-term care residents with dementia. Analyzing attitudes of the public is an integral component of understanding the entire ecological system that affects the development and overall well-being of a long-term care resident. Attitudes were examined using a multiple segment factorial vignette with a probability sample of 329 respondents from a southern state. Results indicate that attitudes were not statistically affected by sex or the elapsed time since diagnosis, and age, spousal disposition, and degree of intimacy predicted attitudes. A respondent’s education level also …

Understanding The Pathways To Youth Involvement In The Juvenile Justice System: A Longitudinal Investigation Of Poor, Inner-City African American Adolescents, Charlene Harris

Theses and Dissertations--Family Sciences

It is widely recognized that African American youth are disproportionately represented in the juvenile justice system in comparison to other ethnic/racial groups, and this has generated a large body of research into the etiology and prevention of crime in this population. Although there has been considerable research attention to identifying and reducing the disproportionate contact among African American youth within the juvenile justice system, it is still unclear what factors contribute to their involvement in the criminal justice system. Accordingly, the dissertation tests whether self-reports of behaviors in early adolescence are predictive official offending behaviors in late adolescence, as measured …

Divorces Of Marriage Immigrants In South Korea: An Examination Of Factors Affecting Divorce, Sanghee Kim

MPA/MPP/MPFM Capstone Projects

In South Korea, as of 2013, ten out of a hundred newlywed couples included a marriage immigrant, i.e. someone who came to the country for the purpose of getting married to a native (Statistics Korea). South Korea, a traditionally homogeneous society, has seen an increase in marriage immigrants, primarily women, in recent years. Multicultural families face a variety of challenges. Marriage immigrants experience cultural and lifestyle differences, language problems, poverty, and domestic violence. In 2011, the divorce rate in multicultural families reached 10 percent and the average length of a marriage that ended in divorce was 4.9 years (Statistics Korea). …