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Full-Text Articles in Sociology

Neural Mechanisms Of The Rejection-Aggression Link, David S. Chester, Donald R. Lynam, Richard Milich, C. Nathan Dewall May 2018

Neural Mechanisms Of The Rejection-Aggression Link, David S. Chester, Donald R. Lynam, Richard Milich, C. Nathan Dewall

Psychology Faculty Publications

Social rejection is a painful event that often increases aggression. However, the neural mechanisms of this rejection–aggression link remain unclear. A potential clue may be that rejected people often recruit the ventrolateral prefrontal cortex’s (VLPFC) self-regulatory processes to manage the pain of rejection. Using functional MRI, we replicated previous links between rejection and activity in the brain’s mentalizing network, social pain network and VLPFC. VLPFC recruitment during rejection was associated with greater activity in the brain’s reward network (i.e. the ventral striatum) when individuals were given an opportunity to retaliate. This retaliation-related striatal response was associated with greater levels of …


On The Development Of Self-Control And Deviance From Preschool To Middle Adolescence, Alexander T. Vazsonyi, Gabriela Ksinan Jiskrova May 2018

On The Development Of Self-Control And Deviance From Preschool To Middle Adolescence, Alexander T. Vazsonyi, Gabriela Ksinan Jiskrova

Family Sciences Faculty Publications

Purpose
The study tested whether developmental changes in self-control stabilize by late childhood (age 10) or continue into early and middle adolescence. Second, it tested the bidirectional, longitudinal relationship between self-control and deviance over an 11-year period.

Methods
Children (N = 1159) from the longitudinal NICHD Study of Early Child Care and Youth Development (SECCYD) were assessed six times, ages 4.5 to 15 years. Latent growth models tested self-control and deviance trajectories, using competing growth functions to capture change over time. The longitudinal, bidirectional self-control-deviance links were examined in a cross-lagged latent model.

Results
Findings showed that children's self-control …


Hiv Clustering In Mississippi: Spatial Epidemiological Study To Inform Implementation Science In The Deep South, Thomas J. Stopka, Lauren Brinkley-Rubinstein, Kendra Johnson, Philip A. Chan, Marga Hutcheson, Richard A. Crosby, Deirdre Burke, Leandro Mena, Amy Nunn Apr 2018

Hiv Clustering In Mississippi: Spatial Epidemiological Study To Inform Implementation Science In The Deep South, Thomas J. Stopka, Lauren Brinkley-Rubinstein, Kendra Johnson, Philip A. Chan, Marga Hutcheson, Richard A. Crosby, Deirdre Burke, Leandro Mena, Amy Nunn

Health, Behavior & Society Faculty Publications

Background: In recent years, more than half of new HIV infections in the United States occur among African Americans in the Southeastern United States. Spatial epidemiological analyses can inform public health responses in the Deep South by identifying HIV hotspots and community-level factors associated with clustering.

Objective: The goal of this study was to identify and characterize HIV clusters in Mississippi through analysis of state-level HIV surveillance data.

Methods: We used a combination of spatial epidemiology and statistical modeling to identify and characterize HIV hotspots in Mississippi census tracts (n=658) from 2008 to 2014. We conducted spatial analyses of all …


Bystander Program Effectiveness To Reduce Violence Acceptance: Rct In High Schools, Ann L. Coker, Heather M. Bush, Candace J. Brancato, Emily R. Clear, Eileen A. Recktenwald Apr 2018

Bystander Program Effectiveness To Reduce Violence Acceptance: Rct In High Schools, Ann L. Coker, Heather M. Bush, Candace J. Brancato, Emily R. Clear, Eileen A. Recktenwald

Obstetrics and Gynecology Faculty Publications

Bystander-based violence prevention interventions have shown efficacy to reduce dating violence and sexual violence acceptance at the individual level yet no large randomized controlled trial (RCT) has evaluated this effect at the high-school level and over time. This rigorous cluster-randomized controlled trial addresses this gap by evaluating intervention effectiveness at both school and individual levels. Kentucky high schools were randomized to intervention or control conditions. In intervention schools educators provided school-wide ‘Green Dot’ presentations and bystander training with student popular opinion leaders. Each spring from 2010 to 2014; 73,044 students completed anonymous surveys with no missing data on relevant outcomes. …


Social Identity Theory And Public Opinion Towards Immigration, Maurice Mangum, Ray Block Jr. Mar 2018

Social Identity Theory And Public Opinion Towards Immigration, Maurice Mangum, Ray Block Jr.

Political Science Faculty Publications

Several scholars have called upon social identity theory to investigate the relationship between an American national identity and American public opinion on immigration. Lacking a uniform measure of American identity, by and large, scholars find that a two-dimensional conception of American identity influences these opinions. Our review suggests that the extant measures of American identity do not fully account for the various aspects of social identity theory. We capture more fully the different components of social identity theory. By doing so, we find that American identity has five dimensions. Therefore, in this analysis, we advance a more comprehensive measure of …


A Longitudinal Analysis Of The Impact Of Child Custody Loss On Drug Use And Crime Among A Sample Of African American Mothers, Kathi L. H. Harp, Carrie B. Oser Mar 2018

A Longitudinal Analysis Of The Impact Of Child Custody Loss On Drug Use And Crime Among A Sample Of African American Mothers, Kathi L. H. Harp, Carrie B. Oser

Health Management and Policy Faculty Publications

This study examines the influence of child custody loss on drug use and crime among a sample of African American mothers. Two types of custody loss are examined: informal custody loss (child living apart from mother but courts not involved), and official loss (child removed from mother’s care by authorities).

Methods—Using data from 339 African American women, longitudinal random coefficient models analyzed the effects of each type of custody loss on subsequent drug use and crime.

Results—Results indicated that both informal and official custody loss predicted increased drug use, and informal loss predicted increased criminal involvement. Findings demonstrate …


Factors Impacting Parental Acceptance Of An Lgbt Child, Dani E. Rosenkrantz Jan 2018

Factors Impacting Parental Acceptance Of An Lgbt Child, Dani E. Rosenkrantz

Theses and Dissertations--Educational, School, and Counseling Psychology

Chrisler’s (2017) Theoretical Framework of Parental Reactions When a Child Comes Out as Lesbian, Gay, or Bisexual suggests that parental reactions to having a non-heteronormative child are impacted by a process of cognitively appraising information about their child’s identity and experiencing and coping with emotional responses, both of which are influenced by contextual factors such as a parent’s value system. However, some religious values can challenge parents in the process of accepting a lesbian, gay, bisexual, or transgender (LGBT) child. The purpose of this study was to test a model that examines the influence of cognitive-affective factors (cognitive flexibility, emotional …


“The Best Thing That’S Happened In My Life”: The Journey Toward Acceptance Of One’S Lgbtq Child In A Sample Of Cuban-Americans And Puerto Ricans, Roberto Luis Abreu Jan 2018

“The Best Thing That’S Happened In My Life”: The Journey Toward Acceptance Of One’S Lgbtq Child In A Sample Of Cuban-Americans And Puerto Ricans, Roberto Luis Abreu

Theses and Dissertations--Educational, School, and Counseling Psychology

Acceptance by a parental figure is one of the most important protective factors for LGBTQ (Lesbian, Gay, Bisexual, Transgender, and Queer) youth and young adults (e.g., Ryan, 2009, 2010). Lack of parental acceptance may lead to a disruption in parent-child relationships and may increase risk for maladaptive behaviors and poorer psychosocial outcomes in LGBTQ youth (e.g., Bouris et al., 2010). Researchers have called for more inclusive samples and methods to better understand the experiences of families from diverse ethnic and racial backgrounds (e.g., Heatherington & Lavner 2008). Specific to Latinas/os, cultural factors and theoretically informed interventions that facilitate parental acceptance …


Mom To Mom: Online Breastfeeding Advice, Jennifer D. Furkin Jan 2018

Mom To Mom: Online Breastfeeding Advice, Jennifer D. Furkin

Theses and Dissertations--Communication

Exploring online support groups has gained more and more popularity in the last decade. Investigating the type of support messages users send each other has broadened the already extensive social support framework built in the last forty years. Mothers utilize online support for various topics, and a very common topic is breastfeeding. The perception of breastfeeding has changed throughout history with shifting beliefs and societal norms coupled with solid facts about its importance in the sustaining of infants. Online breastfeeding support has been previously explored through the categorization of types of support and themes within the interactions. This study extended …


Desistance From Crime Of Serious Juvenile Offenders: Examining The Social And Individual Differences, Lisa Dunkley Jan 2018

Desistance From Crime Of Serious Juvenile Offenders: Examining The Social And Individual Differences, Lisa Dunkley

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

There is an overrepresentation of youths with disabilities in the juvenile justice system. As a result, each year thousands of juvenile offenders despite of the seriousness of the crimes committed, are released from incarceration with the hopes of living a successful life in society. Despite progressive research on identifying factors associated with desistance, it is still unclear what factors contribute to desistance for serious juvenile offenders and especially those with disabilities. The current study investigated the individual differences (e.g., moral disengagement, motivation to succeed and impulse control) and social factors (e.g., employment, education and maternal warmth) that are important in …


Determining Millennial Food Buying Preferences: Based On Product Marketing With “Buzzwords”, Victoria N. Hamilton Jan 2018

Determining Millennial Food Buying Preferences: Based On Product Marketing With “Buzzwords”, Victoria N. Hamilton

Theses and Dissertations--Community & Leadership Development

This research focuses on the importance on the Millennial Generation and their perceptions of food buzzwords. Since the Millennial Generation is the largest group purchasing and preparing their own foods, the food industry is becoming dependent on their buying preferences. A survey reflected the participants’ demographics and their buying preferences based on a series of food buzzwords when they are purchasing foods. Results show the Millennial Generation prefers “local” buzzwords. As the Millennial Generation continues to purchase foods for themselves and their families, it can be expected their choices will encourage others to do the same based on their family …


Medium To Long Term Impacts On Former Participants Of The Shoulder To Shoulder Global Brigades To Ecuador, Craig Borie Jan 2018

Medium To Long Term Impacts On Former Participants Of The Shoulder To Shoulder Global Brigades To Ecuador, Craig Borie

Theses and Dissertations--Community & Leadership Development

Medium to Long Term Impacts on Former Participants of the Shoulder to Shoulder Global Brigades to Ecuador. International service learning and voluntourism programs in global health evoke benefits for both community and the intervener. While it is clear that the Shoulder to Shoulder Global program at the University of Kentucky provides a service to an economically resource poor community in Santo Domingo, Ecuador, what is unclear is the impact these interprofessional experiences have on the participants that travel with the four times a year health brigades. This study proposes to answer the question of what are the educational, personal and …


Increasing Inclusion: The Pursuit Of Racial Diversity In Three Historically White Universities In Kentucky, Michigan, And Ontario From 2000 To 2012, David J. Luke Jan 2018

Increasing Inclusion: The Pursuit Of Racial Diversity In Three Historically White Universities In Kentucky, Michigan, And Ontario From 2000 To 2012, David J. Luke

Theses and Dissertations--Sociology

The University of Kentucky (UK) and University of Michigan (UM) present very different patterns in terms of black student enrollments and completions from 2000 to 2012 because of a structural explanation, a qualitative explanation, and a statistical explanation. Unfortunately, the patterns at the University of Western Ontario (UWO) are partial due to a lack of data.

First, the structural explanation is that UK, as a university in the state of Kentucky, was under a mandate from the U.S. Department of Education to desegregate because they were in violation of Title VI of the Civil Rights Act. The Kentucky Council on …


The Influence Of Life Domains On Adolescent And Adult Offending: Testing An Extension Of Agnew’S General Theory, Joseph Mark Calvert Jan 2018

The Influence Of Life Domains On Adolescent And Adult Offending: Testing An Extension Of Agnew’S General Theory, Joseph Mark Calvert

Theses and Dissertations--Sociology

More than a decade has passed since Agnew (2005) introduced his General Theory of Crime and Delinquency (GTCD). Despite this interval, GTCD remains a relatively untested theory. Drawing on previous testing efforts, the current research provides a systematic assessment of Agnew's theoretical propositions. It also provides only the second empirical examination of Cochran's (2015) extension of GTCD, which incorporates religion as a sixth distinct life domain. Nested negative binomial regression modeling and Poisson regression modeling are used to assess the effects of life domains on several diverse forms of self-reported criminal behavior at two distinct stages of development: adolescence and …


Social Support, Relationship Quality, And Self-Care Behaviors In Patients With Heart Failure, Majdi Mohammad Rababa Jan 2018

Social Support, Relationship Quality, And Self-Care Behaviors In Patients With Heart Failure, Majdi Mohammad Rababa

Theses and Dissertations--Nursing

The purpose of this dissertation was to examine the associations among social support, gender, relationship quality, and self-care behaviors in patients with heart failure (HF). Specific aims were to: 1) compare the psychometric properties of the 12-item and the 9-item European Heart Failure Self-Care Behavior Scale (EHFScBS) when used to measure self-care behaviors in patients with HF in the United States; 2) determine whether gender moderated the association between perceived social support and daily sodium intake in patients with HF; and 3) determine whether a patient’s gender and relationship with the primary family caregiver (spousal or non-spousal) moderated the association …


The Application Of Spectral And Cross-Spectral Analysis To Social Sciences Data, Matthew James Vowels Jan 2018

The Application Of Spectral And Cross-Spectral Analysis To Social Sciences Data, Matthew James Vowels

Theses and Dissertations--Family Sciences

The primary goal of this paper is to demonstrate the application of a relatively esoteric and interdisciplinary technique, called spectral analysis, to dyadic social sciences data. Spectral analysis is an analytical and statistical technique, commonly used in engineering, that allows times series data to be analyzed for the presence of significant regular/periodic fluctuations/oscillations. These periodic fluctuations are reflected in the frequency domain as amplitude or energy peaks at certain frequencies. Furthermore, a Magnitude Squared Coherence analysis may be used to interrogate more than one time series concurrently in order to establish the degree of frequency domain correlation between the two …


“Dad, Do You Want To Play With Me?” The Impact Of Fathers Who Make Time For Play, Michael S. Sitton Jan 2018

“Dad, Do You Want To Play With Me?” The Impact Of Fathers Who Make Time For Play, Michael S. Sitton

Theses and Dissertations--Family Sciences

With an increase in the pace of life in the United States, there comes a recognition of the importance of prioritizing time, especially for fathers. Of the two-thirds of children who live with their father, only a percentage of them have fathers who report regular play time with their children. However, literature in the field does not explain specifically whether or not this play between father and child influences the child’s later risk taking behaviors in high school. Using data from the 2003 Fragile Families and Child Wellbeing Study (FFCWS), waves 3, 4, and 6, this quantitative study sought to …


The Association Between Smartphone Use And Emotional Intelligence On Romantic Relationship Satisfaction Among Young Adults, Ellen Kaiser Jan 2018

The Association Between Smartphone Use And Emotional Intelligence On Romantic Relationship Satisfaction Among Young Adults, Ellen Kaiser

Theses and Dissertations--Family Sciences

This study bridges the gap in the literature about the association between smartphone use and emotional intelligence on romantic relationship satisfaction. A sample of 161 undergraduate students between the ages of 18 and 26 at the University of Kentucky were recruited to complete an online survey about their smartphone usage, emotional intelligence, and romantic relationship satisfaction. Associations between smartphone usage and emotional intelligence, smartphone usage and romantic relationship satisfaction, and emotional intelligence and romantic relationship satisfaction were found. Specifically, productive smartphone usage was found to be positively associated with romantic relationship satisfaction, while problem smartphone usage was found to be …


Identifying Perceived Risks To Environmental Pollutants And Needs For Risk Communication In A Rural Appalachian Community, Elizabeth H. Travis Jan 2018

Identifying Perceived Risks To Environmental Pollutants And Needs For Risk Communication In A Rural Appalachian Community, Elizabeth H. Travis

Theses and Dissertations--Nutrition and Food Systems

The goal of this study is to determine issues rural Appalachian residents consider most important, their perceived environmental health risk, and how community engagement can potentially improve those issues. The University of Kentucky Superfund Research Center held the Appalachian Community Health and Well-being Forum at the Letcher County Cooperative Extension Office in Eastern Kentucky. A four-member panel consisted of two local health officials, a nutrition expert, and a federal scientist; answered questions from community members. The expert panel and audience members shared concerns, success stories, and highlighted efforts to promote health in the region. Community members completed a questionnaire collecting …


Exploring Factors Facilitating Sexual Self-Disclosure For Women, Caitlin Marie Grasson Jan 2018

Exploring Factors Facilitating Sexual Self-Disclosure For Women, Caitlin Marie Grasson

Theses and Dissertations--Family Sciences

Sexual Self-Disclosure is an important part of a relationship, however, often times, women do not feel it is appropriate to engage in. Specifically, many women do not disclose their sexual preferences, or what acts they do or do not find satisfying, with their partner. This lack of sexual self-disclosure keeps women from being able to have their own sexual needs met. This phenomenological study aimed to understand the factors that facilitate sexual self-disclosure for women in relationships. The participants (n=8) were women between the age of 24-30 who were in a committed sexual relationship for more than three months, but …


Pathways From Religiosity To Couple’S Satisfaction Through Relational Virtues And Equality In Two Cultures, Ilya A. Okhotnikov Jan 2018

Pathways From Religiosity To Couple’S Satisfaction Through Relational Virtues And Equality In Two Cultures, Ilya A. Okhotnikov

Theses and Dissertations--Family Sciences

To explore relational processes of couple’s satisfaction this study drew on the relational spirituality framework (Mahoney, 2010) in order to test a relational religiosity model to evaluate the effects of public, private, ideological, intellectual, and experiential religiosity that were mediated by relational virtues of commitment, sacrifice, forgiveness, and sanctification and relational equality on couple’s satisfaction in two cultures. Data for this component used convenience samples of English-speaking respondents (hereafter American sample; n = 1,529) and Russian-speaking respondents (hereafter Russian sample; n = 529). Results provided evidence to partially support relational religiosity model; specifically commitment, while a statistically significant intervening element, …


An Examination Of Relations Among Fear, Guilt, Self-Compassion, And Multicultural Attitudes In White Adults, Whitney W. Black Jan 2018

An Examination Of Relations Among Fear, Guilt, Self-Compassion, And Multicultural Attitudes In White Adults, Whitney W. Black

Theses and Dissertations--Educational, School, and Counseling Psychology

Structural racism is often perpetuated by well-intentioned White individuals who passively accept or are unaware of its existence. However, when their perceptions and understanding of the world are challenged through learning about structural racism, White people may experience emotions such as fear, and guilt, which seem to serve either a debilitating or a motivating role in multicultural attitude development. Self-compassion, which is the ability to process distressing emotions without resorting to avoidance of the emotional experience, may help White individuals work through strong negative affect that accompanies an awareness of structural racism and ultimately aid in the development of multicultural …


The Allocation Of State Appropriations And Students Across Different Types Of Public Institutions Of Higher Education, Joshua L. Bush Jan 2018

The Allocation Of State Appropriations And Students Across Different Types Of Public Institutions Of Higher Education, Joshua L. Bush

Theses and Dissertations--Public Policy and Administration

Public higher education has evolved over time under the control of each individual state. The public system in each state is made up of distinctive types of institutions that together provide higher education in different formats. Public institutions may largely be classified into three groups based on the level of education provided including community colleges, regional institutions, and research universities. While the institutions employed are largely the same in each state, the extent to which each is utilized and the support given reflect the individual characteristics of the state.

This dissertation examines appropriations and enrollments by state and year in …


Changing Minds Or Transforming Social Worlds? Re-Envisioning Media Literacy Education As Feminist Arts-Activism, Margaret Louise Mcgladrey Jan 2018

Changing Minds Or Transforming Social Worlds? Re-Envisioning Media Literacy Education As Feminist Arts-Activism, Margaret Louise Mcgladrey

Theses and Dissertations--Sociology

This dissertation project seeks to address the sociological processes, dynamics, and mechanisms inflecting how and why U.S. society reproduces a sexually dimorphic, binary gender structure. The project builds upon the work of sociologists of gender on the doing gender framework, intersectional feminist approaches to identity formation, and hegemonic masculinity and relational theories of gender. In a 2012 article in Social Science and Medicine presenting contemporary concepts in gender theory to the health-oriented readers of the journal, R. W. Connell argues that much public policy on gender and health relies on categorical understandings of gender that are now inadequate. Connell contends …


“Well, Don’T Walk Around Naked... Unless You’Re A Girl”: Gender, Sexuality, And Risk In Jamtronica Festival Subcultural Scenes, Kaitlyne A. Motl Jan 2018

“Well, Don’T Walk Around Naked... Unless You’Re A Girl”: Gender, Sexuality, And Risk In Jamtronica Festival Subcultural Scenes, Kaitlyne A. Motl

Theses and Dissertations--Sociology

The purpose of this study was to explore emerging issues surrounding gendered fear, threat, and violence perpetration at music festivals – particularly events that feature a synthesis of jam band and electronic dance music acts – a genre termed jamtronica by its fans. Though gendered violence perpetration and prevention have been widely studied within other party-oriented settings (i.e., sexual violence perpetration on college campuses), very little research exists to address how wider disparities of gender and sexuality permeate a community whose members frequently claim the scene’s immunity from external inequalities.

In this three-year multi-sited ethnography, I incorporate participant observations, group …


Growing Economic Possibility In Appalachia: Stories Of Relocalization And Representation On Stinking Creek, Kathryn Engle Jan 2018

Growing Economic Possibility In Appalachia: Stories Of Relocalization And Representation On Stinking Creek, Kathryn Engle

Theses and Dissertations--Sociology

This project explores the agricultural heritage and current social landscape of the Stinking Creek community of Knox County, Kentucky, and the legacy of the local nonprofit organization the Lend-A-Hand Center. Through participatory research, this project presents a reflexive account of the Lend-A-Hand Center Grow Appalachia Gardening Program examining the diverse economy of the Stinking Creek watershed and possibilities for new economic imaginings and post-coal futures for central Appalachia. This dissertation includes an oral history project, a theoretical examination, and an ethnographic reflection, bridging several literatures in the fields of agricultural history, Appalachian Studies, Participatory Action Research, research within the diverse …


Sex Composition And Female Offending: Under The Impact Of The One-Child Policy, Ting Wang Jan 2018

Sex Composition And Female Offending: Under The Impact Of The One-Child Policy, Ting Wang

Theses and Dissertations--Sociology

This dissertation explores the mechanisms of the increasing female crime in China from the effect of the one-child policy, which is treated herein as a natural experiment. Data reveal that the women’s share of documented crime dramatically increased after the mid-1990s when the first one-child generation reached the age of legal responsibility. This change reflects the interplay of the behavioral change and the net-widening effect.

The increasing criminality of the one-child generation is attributable to the gap between the equal gender expectations of the individual, which has been reshaped by the unique socialization practices under the influence of the policy, …


Between A Rock And A Hard Place: Urbanormativity And Rural Located Private Higher Education, Jonathan Jared Friesen Jan 2018

Between A Rock And A Hard Place: Urbanormativity And Rural Located Private Higher Education, Jonathan Jared Friesen

Theses and Dissertations--Sociology

As urban areas have come to increasing dominate the social landscape, rurality is often defined in negative ways such as being backwards, simple, or even deviant. Urbanormativity is a theoretical approach developed to capture the normative and structural impacts and implications of privileging the urban. The result is not only the construction of urban as correct and positive and rurality as abnormal and backwards, the cultural ideology impacts the structural flow of resources which negatively impacts and results in a marginalization of rural areas.

The primary question motivating this research is how does urbanormativity shape the interactions between rural towns …


“We’Re Being Left To Blight”: Green Urban Development And Racialized Space In Kansas City, Chhaya Kolavalli Jan 2018

“We’Re Being Left To Blight”: Green Urban Development And Racialized Space In Kansas City, Chhaya Kolavalli

Theses and Dissertations--Anthropology

In this dissertation, I explore ‘green’ urban development and urban agriculture projects from the perspective of residents of an African American majority neighborhood in Kansas City—who reside in an area referred to as a ‘blighted food desert’ by local policy makers. In Kansas City, extensive city government support exists for urban agricultural projects, which are touted not just as a solution to poverty associated issues such food insecurity and obesity, but also as a remedy for ‘blight,’ violence and crime, and vacant urban land. Specific narratives of Kansas City’s past are used to prop up and legitimate these future visions …


Hyperhomocysteinemia-Induced Gene Expression Changes In The Cell Types Of The Brain, Erica M. Weekman, Abigail E. Woolums, Tiffany L. Sudduth, Donna M. Wilcock Dec 2017

Hyperhomocysteinemia-Induced Gene Expression Changes In The Cell Types Of The Brain, Erica M. Weekman, Abigail E. Woolums, Tiffany L. Sudduth, Donna M. Wilcock

Sanders-Brown Center on Aging Faculty Publications

High plasma levels of homocysteine, termed hyperhomocysteinemia, are a risk factor for vascular cognitive impairment and dementia, which is the second leading cause of dementia. While hyperhomocysteinemia induces microhemorrhages and cognitive decline in mice, the specific effect of hyperhomocysteinemia on each cell type remains unknown. We took separate cultures of astrocytes, microglia, endothelial cells, and neuronal cells and treated each with moderate levels of homocysteine for 24, 48, 72, and 96 hr. We then determined the gene expression changes for cell-specific markers and neuroinflammatory markers including the matrix metalloproteinase 9 system. Astrocytes had decreased levels of several astrocytic end feet …