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Ten Measures To Jointly Explore Shenzhen Model Of Synthetic Biology Development, Xian-En Zhang
Ten Measures To Jointly Explore Shenzhen Model Of Synthetic Biology Development, Xian-En Zhang
Bulletin of Chinese Academy of Sciences (Chinese Version)
The iteration of biotechnology and the transformative development of biomanufacturing driven by synthetic biology are drawing the blueprint for the future bioeconomy. Around this strategic goal, in the past 10 years, Shenzhen has collaborated with relevant national departments and has taken a series of measures to initially create a sound ecological and innovative chain for synthetic biology and bioindustry. This study summarizes these 10 measures into three major categories: the construction of new R&D institutions and innovation bases, the implementation of technology transformation carriers and synthetic biology industry park, and the measures to encourage students’ innovative spirit. The successful implementation …
Current Status And Applications Of Microbial Chassis Strains For Chinese Biomanufacturing Industry, Guoqiang Chen, Fuqing Wu, Shuang Zheng, Jun Ding, Junting Sheng
Current Status And Applications Of Microbial Chassis Strains For Chinese Biomanufacturing Industry, Guoqiang Chen, Fuqing Wu, Shuang Zheng, Jun Ding, Junting Sheng
Bulletin of Chinese Academy of Sciences (Chinese Version)
Biomanufacturing is an important component of new quality productive forces, representing the commanding height of the new round of technological revolution and serving as a new engine for industrial transformation following information technology. It demonstrates vast application prospects in fields such as renewable energy, advanced materials, biomedicine, green food, and environmental protection. Biomanufacturing utilizes chassis microorganisms similar as “microchip” to produce various bioproducts via processes including chassis design and construction, large-scale cell cultivation, and product purifications. Most chassis microorganisms in biomanufacturing were not domestically identified. This study summarizes the types of common chassis microorganisms both domestically and internationally, as well …
Microbial Production Of Feed Amino Acids Promotes Reduction And Replacement Of Soybean Meal, Jia Liu, Qi Sheng, Kaifang Liu, Liming Liu
Microbial Production Of Feed Amino Acids Promotes Reduction And Replacement Of Soybean Meal, Jia Liu, Qi Sheng, Kaifang Liu, Liming Liu
Bulletin of Chinese Academy of Sciences (Chinese Version)
With the promotion of soybean meal reduction and substitution as well as lower-protein diet technologies, China has become a leading global producer of feed amino acids. However, the amino acid industry faces significant challenges due to its relatively late start in independently developing industrial strains, resulting in relatively lagging key economic and technical parameters and a less robust intellectual property framework. The rapid progress of synthetic biology has provided promising avenues for the design and optimization of industrial amino acid-producing strains, offering new opportunities for the amino acid fermentation industry to enhance the global competitiveness. This study offers an in-depth …
Current Status And Prospect Of Industrial Filamentous Fungi In Biomanufacturing, Zhiqiang Du, Ping Men, Yu Zhou, Xuan Zhang, Xuenian Huang, Xuefeng Lyu
Current Status And Prospect Of Industrial Filamentous Fungi In Biomanufacturing, Zhiqiang Du, Ping Men, Yu Zhou, Xuan Zhang, Xuenian Huang, Xuefeng Lyu
Bulletin of Chinese Academy of Sciences (Chinese Version)
Filamentous fungi, a critical class of industrial microorganisms pivotal to the biomanufacturing industry, has extensive applications in various fields such as pharmaceuticals, food, agriculture, and chemical materials, which are playing a vital role in human life. Recently, innovations in synthetic biology have further driven the application of industrial filamentous fungi in biomanufacturing, highlighting their critical role in this field. This article presents a comprehensive review of the recent progress in the field, covering the latest developments in genetic modification techniques for industrial filamentous fungi, successful cases of rational strain improvement strategies aimed to enhance the quality and efficiency of current …
Efficient Discovery And Industrialized Manufacture Of Terpenoids, Haoming Chi, Liying Er, Tiangang Liu
Efficient Discovery And Industrialized Manufacture Of Terpenoids, Haoming Chi, Liying Er, Tiangang Liu
Bulletin of Chinese Academy of Sciences (Chinese Version)
Terpenoids, a class of chemical entities with diverse biological activities in nature, demonstrate significant potential for applications in fields such as drug discovery, flavor industry, and agriculture. However, traditional methods face challenges, including inefficiency and high costs, in the discovery and industrialization of terpenoids. The rapid development of synthetic biology, genomics, artificial intelligence, and automation provides new opportunities for efficient terpenoid discovery and industrialization. This study comprehensively analyzes how these technologies synergistically contribute to the discovery, optimization, and large-scale production of terpenoids, and summarizes the current high-yield situations of terpenoids. The aim is to propose innovative strategies to accelerate technological …
Digitalized Design Of Cell Factory Enables Green Biomanufacturing, Fanze Meng, Rui Cao, Bing Hu, Lei Qin, Chun Li
Digitalized Design Of Cell Factory Enables Green Biomanufacturing, Fanze Meng, Rui Cao, Bing Hu, Lei Qin, Chun Li
Bulletin of Chinese Academy of Sciences (Chinese Version)
Green manufacturing is a modern manufacturing mode in the consideration of both environmental impact and efficiency of resource utilization, it represents a significant component of the “new productive force”. Centered on cell factories, green biomanufacturing leverages renewable resources to efficiently produce products that conform to the concepts of low-carbon, green, and sustainable development. The design of high-performance cell factories is pivotal for achieving efficient green biomanufacturing. Nevertheless, traditional cell factory design processes are complex, time-consuming, and labor-intensive. With advancements in artificial intelligence, digital-assisted cell factory design has emerged as a solution to save time and reduce costs. By integrating technologies …
Research Progress In High-Throughput Phenotype Testing Technology And Equipment For Engineering Cells Based On Microfluidics, Shuang Li, Xiaojie Guo, Haibo Chen, Sisi Chen, Xin Da, Zhenghui Li, Qinxiu Liu, Yi Wang, Xinhui Xing, Chong Zhang
Research Progress In High-Throughput Phenotype Testing Technology And Equipment For Engineering Cells Based On Microfluidics, Shuang Li, Xiaojie Guo, Haibo Chen, Sisi Chen, Xin Da, Zhenghui Li, Qinxiu Liu, Yi Wang, Xinhui Xing, Chong Zhang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Engineering cells are a core component of green bio-manufacturing. The efficient testing and acquisition of engineering cells with the desired phenotype is a critical factor in the successful implementation of bio-manufacturing. In recent years, based on microfluidics technologies, non-culture type single-cell phenotype high-throughput test equipment and culture type phenotype high-throughput test equipment for the growth and metabolism of single cell in a bioreactor have been developed such as microdroplet and microchamber, realizing high-throughput, automated, miniaturized, and integrated testing of the phenotypes of engineering cells and providing a powerful tool for the breeding of engineering cells. This review systematically compiles the …
Research On Innovative Development Path And Policy Guarantee Of China’S Synthetic Biology Industry, Hongjun Geng, Chang Wang
Research On Innovative Development Path And Policy Guarantee Of China’S Synthetic Biology Industry, Hongjun Geng, Chang Wang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Synthetic biology is hailed as the third revolution in life sciences after the discovery of the DNA double helix structure and genomic technology, and is the core driving force for the leapfrog development of next-generation biomanufacturing and the future bioeconomy, opening up an opportunity window for the reshaping of the global manufacturing map. How to strategically position the synthesis biology industry and seize the strategic high ground in the industry is a core topic of interest for global science and technology powers and manufacturing powers. Based on the identification of problems in the development of China’s synthesis biology industry, this …