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Articles 391 - 420 of 445
Full-Text Articles in Science and Technology Policy
Containerization Of Seafarers In The International Shipping Industry: Contemporary Seamanship, Maritime Social Infrastructures, And Mobility Politics Of Global Logistics, Liang Wu
Dissertations, Theses, and Capstone Projects
This dissertation discusses the mobility politics of container shipping and argues that technological development, political-economic order, and social infrastructure co-produce one another. Containerization, the use of standardized containers to carry cargo across modes of transportation that is said to have revolutionized and globalized international trade since the late 1950s, has served to expand and extend the power of international coalitions of states and corporations to control the movements of commodities (shipments) and labor (seafarers). The advent and development of containerization was driven by a sociotechnical imaginary and international social contract of seamless shipping and cargo flows. In practice, this liberal, …
Regulating Online Hate Speech: The Singapore Experiment, Siyuan Chen
Regulating Online Hate Speech: The Singapore Experiment, Siyuan Chen
Research Collection Yong Pung How School Of Law
In Singapore, the introduction of the Protection from Online Falsehoods and Manipulation Act 2019 (POFMA) generated considerable debate and feedback. One of the main concerns was whether the law would unduly restrict the freedom of expression. In focusing on the provisions of POFMA that could possibly apply to hate speech, this paper situates the criticisms within the larger framework of international human rights law and international practices and proposes some ways forward to improve the regulatory framework for online hate speech.
The Impact Of Accessible Data On Cyberstalking, Elise Kwan
The Impact Of Accessible Data On Cyberstalking, Elise Kwan
The Journal of Purdue Undergraduate Research
No abstract provided.
Editorial For Special Column “Biomanufacturing: Retrospect And Prospects”
Editorial For Special Column “Biomanufacturing: Retrospect And Prospects”
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
Current Status And Applications Of Microbial Chassis Strains For Chinese Biomanufacturing Industry, Guoqiang Chen, Fuqing Wu, Shuang Zheng, Jun Ding, Junting Sheng
Current Status And Applications Of Microbial Chassis Strains For Chinese Biomanufacturing Industry, Guoqiang Chen, Fuqing Wu, Shuang Zheng, Jun Ding, Junting Sheng
Bulletin of Chinese Academy of Sciences (Chinese Version)
Biomanufacturing is an important component of new quality productive forces, representing the commanding height of the new round of technological revolution and serving as a new engine for industrial transformation following information technology. It demonstrates vast application prospects in fields such as renewable energy, advanced materials, biomedicine, green food, and environmental protection. Biomanufacturing utilizes chassis microorganisms similar as “microchip” to produce various bioproducts via processes including chassis design and construction, large-scale cell cultivation, and product purifications. Most chassis microorganisms in biomanufacturing were not domestically identified. This study summarizes the types of common chassis microorganisms both domestically and internationally, as well …
Recent Progress And Perspectives On Development Of Gene Editing Tools, Zixian Liu, Chengping Li, Gogo Jun-Jie Liu
Recent Progress And Perspectives On Development Of Gene Editing Tools, Zixian Liu, Chengping Li, Gogo Jun-Jie Liu
Bulletin of Chinese Academy of Sciences (Chinese Version)
The gene editing field has witnessed remarkable advancements in recent years, leading to the establishment and refinement of multidimensional gene editing platforms. These innovations have enabled precise targeted gene knockout, repair, and insertion. These tools have stimulated significant progress in fundamental research, therapeutics, agriculture, environment protection, and industrial applications. In this review, we provide a comprehensive overview of the milestones in gene editing tool development and offer perspectives on potential future directions for this rapidly evolving field.
Microbial Production Of Feed Amino Acids Promotes Reduction And Replacement Of Soybean Meal, Jia Liu, Qi Sheng, Kaifang Liu, Liming Liu
Microbial Production Of Feed Amino Acids Promotes Reduction And Replacement Of Soybean Meal, Jia Liu, Qi Sheng, Kaifang Liu, Liming Liu
Bulletin of Chinese Academy of Sciences (Chinese Version)
With the promotion of soybean meal reduction and substitution as well as lower-protein diet technologies, China has become a leading global producer of feed amino acids. However, the amino acid industry faces significant challenges due to its relatively late start in independently developing industrial strains, resulting in relatively lagging key economic and technical parameters and a less robust intellectual property framework. The rapid progress of synthetic biology has provided promising avenues for the design and optimization of industrial amino acid-producing strains, offering new opportunities for the amino acid fermentation industry to enhance the global competitiveness. This study offers an in-depth …
Current Status And Prospect Of Industrial Filamentous Fungi In Biomanufacturing, Zhiqiang Du, Ping Men, Yu Zhou, Xuan Zhang, Xuenian Huang, Xuefeng Lyu
Current Status And Prospect Of Industrial Filamentous Fungi In Biomanufacturing, Zhiqiang Du, Ping Men, Yu Zhou, Xuan Zhang, Xuenian Huang, Xuefeng Lyu
Bulletin of Chinese Academy of Sciences (Chinese Version)
Filamentous fungi, a critical class of industrial microorganisms pivotal to the biomanufacturing industry, has extensive applications in various fields such as pharmaceuticals, food, agriculture, and chemical materials, which are playing a vital role in human life. Recently, innovations in synthetic biology have further driven the application of industrial filamentous fungi in biomanufacturing, highlighting their critical role in this field. This article presents a comprehensive review of the recent progress in the field, covering the latest developments in genetic modification techniques for industrial filamentous fungi, successful cases of rational strain improvement strategies aimed to enhance the quality and efficiency of current …
Efficient Discovery And Industrialized Manufacture Of Terpenoids, Haoming Chi, Liying Er, Tiangang Liu
Efficient Discovery And Industrialized Manufacture Of Terpenoids, Haoming Chi, Liying Er, Tiangang Liu
Bulletin of Chinese Academy of Sciences (Chinese Version)
Terpenoids, a class of chemical entities with diverse biological activities in nature, demonstrate significant potential for applications in fields such as drug discovery, flavor industry, and agriculture. However, traditional methods face challenges, including inefficiency and high costs, in the discovery and industrialization of terpenoids. The rapid development of synthetic biology, genomics, artificial intelligence, and automation provides new opportunities for efficient terpenoid discovery and industrialization. This study comprehensively analyzes how these technologies synergistically contribute to the discovery, optimization, and large-scale production of terpenoids, and summarizes the current high-yield situations of terpenoids. The aim is to propose innovative strategies to accelerate technological …
Digitalized Design Of Cell Factory Enables Green Biomanufacturing, Fanze Meng, Rui Cao, Bing Hu, Lei Qin, Chun Li
Digitalized Design Of Cell Factory Enables Green Biomanufacturing, Fanze Meng, Rui Cao, Bing Hu, Lei Qin, Chun Li
Bulletin of Chinese Academy of Sciences (Chinese Version)
Green manufacturing is a modern manufacturing mode in the consideration of both environmental impact and efficiency of resource utilization, it represents a significant component of the “new productive force”. Centered on cell factories, green biomanufacturing leverages renewable resources to efficiently produce products that conform to the concepts of low-carbon, green, and sustainable development. The design of high-performance cell factories is pivotal for achieving efficient green biomanufacturing. Nevertheless, traditional cell factory design processes are complex, time-consuming, and labor-intensive. With advancements in artificial intelligence, digital-assisted cell factory design has emerged as a solution to save time and reduce costs. By integrating technologies …
Microsphere Core Technology Boosts Innovation Of Biopharmaceutical Industry Chain, Jie Wu, Weiqing Zhou, Lan Zhao, Guanghui Ma
Microsphere Core Technology Boosts Innovation Of Biopharmaceutical Industry Chain, Jie Wu, Weiqing Zhou, Lan Zhao, Guanghui Ma
Bulletin of Chinese Academy of Sciences (Chinese Version)
Advancements in life science and biotechnology have boosted the evolution of the biopharmaceutical industry with the continual emergence of biomedical products for disease prevention, diagnosis, and treatment. Microspheres, as crucial functional materials, play a significant role in the discovery, preparation, separation, and delivery of biological drugs due to their flexible size, morphology, structure, and function. This study reviews recent significant advancements in microspheres and their applications in cell culture, chromatographic separation, drug delivery, and as vaccine adjuvants. Additionally, it proposes future trends for the development of microspheres.
Research Progress In High-Throughput Phenotype Testing Technology And Equipment For Engineering Cells Based On Microfluidics, Shuang Li, Xiaojie Guo, Haibo Chen, Sisi Chen, Xin Da, Zhenghui Li, Qinxiu Liu, Yi Wang, Xinhui Xing, Chong Zhang
Research Progress In High-Throughput Phenotype Testing Technology And Equipment For Engineering Cells Based On Microfluidics, Shuang Li, Xiaojie Guo, Haibo Chen, Sisi Chen, Xin Da, Zhenghui Li, Qinxiu Liu, Yi Wang, Xinhui Xing, Chong Zhang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Engineering cells are a core component of green bio-manufacturing. The efficient testing and acquisition of engineering cells with the desired phenotype is a critical factor in the successful implementation of bio-manufacturing. In recent years, based on microfluidics technologies, non-culture type single-cell phenotype high-throughput test equipment and culture type phenotype high-throughput test equipment for the growth and metabolism of single cell in a bioreactor have been developed such as microdroplet and microchamber, realizing high-throughput, automated, miniaturized, and integrated testing of the phenotypes of engineering cells and providing a powerful tool for the breeding of engineering cells. This review systematically compiles the …
Bioprocess Engineering And Intelligent Biomanufacturing, Guan Wang, Yingping Zhuang
Bioprocess Engineering And Intelligent Biomanufacturing, Guan Wang, Yingping Zhuang
Bulletin of Chinese Academy of Sciences (Chinese Version)
In the era of rapid development of synthetic biology, biomanufacturing, as a bridge between life sciences and engineering technologies, is gradually demonstrating its extraordinary potential to reshape industrial landscapes. However, challenges such as production efficiency, cost control, and process monitoring still hinder the smooth transition from laboratory innovations to industrial-scale implementation. Intelligent biomanufacturing has emerged as a new form of productive force, offering innovative solutions to these problems. This study reviews the latest advances in bioprocess engineering and intelligent biomanufacturing, focusing on three key technological systems: intelligent sensing, intelligent analysis, and intelligent control. Intelligent sensing technology acts as the “eyes” …
Analysis And Reflections On Key Platform Facilities Construction Of Global Biomanufacturing Industry, Xiaoyan Wu, Fang Chen, Yaoying Shan, Anjing Lu
Analysis And Reflections On Key Platform Facilities Construction Of Global Biomanufacturing Industry, Xiaoyan Wu, Fang Chen, Yaoying Shan, Anjing Lu
Bulletin of Chinese Academy of Sciences (Chinese Version)
Biomanufacturing, an emerging production method, is becoming a significant trend in global economic development and has garnered widespread international attention. Platform facilities are vital to the biomanufacturing industry’s development, serving as both the foundation for technological innovation and the bridge between research outcomes and practical applications. This study analyzes three key types of platform facilities and their operational mechanisms: technology innovation platforms (exemplified by the U.S. Agile BioFoundry), pilot-scale platforms (represented by European Bio Base Europe Pilot Plant), and industry incubation platforms (illustrated by the UK SynbiCITE). Drawing from these successful examples and examining China’s current platform infrastructure, this paper …
Research On Innovative Development Path And Policy Guarantee Of China’S Synthetic Biology Industry, Hongjun Geng, Chang Wang
Research On Innovative Development Path And Policy Guarantee Of China’S Synthetic Biology Industry, Hongjun Geng, Chang Wang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Synthetic biology is hailed as the third revolution in life sciences after the discovery of the DNA double helix structure and genomic technology, and is the core driving force for the leapfrog development of next-generation biomanufacturing and the future bioeconomy, opening up an opportunity window for the reshaping of the global manufacturing map. How to strategically position the synthesis biology industry and seize the strategic high ground in the industry is a core topic of interest for global science and technology powers and manufacturing powers. Based on the identification of problems in the development of China’s synthesis biology industry, this …
Artificial Intelligence Driven Information Technology System Restructuring And Reconstruction—Review Of Information Science & Technology In China: A Roadmap To 2050, Xuehai Hong
Bulletin of Chinese Academy of Sciences (Chinese Version)
The Information Science & Technology in China: A Roadmap to 2050 and Information Technology: Accelerating the Integration of Human Machine Things have predicted the long-term development of China’s information technology field. This study reviews the development and changes in the field of information technology in the past 15 years, and compares them with the initial predictions, pointing out that some important judgments made at the beginning were in line with expectations. In recent years, the global development of information technology has entered a slow period, while the rapid evolution of the new generation of artificial intelligence will bring new opportunities …
Scientific Approach To Building A Highland Of Ecological Civilization In Xizang Of China, Xiaodan Wang, Jianxin Zhang, Da Wei, Hui Zhao, Jiangtao Hong, Yuling Liang, Yahui Qi, Zhengrong Yuan
Scientific Approach To Building A Highland Of Ecological Civilization In Xizang Of China, Xiaodan Wang, Jianxin Zhang, Da Wei, Hui Zhao, Jiangtao Hong, Yuling Liang, Yahui Qi, Zhengrong Yuan
Bulletin of Chinese Academy of Sciences (Chinese Version)
Xizang, which plays an important barrier role in maintaining national ecological security, is a unique region that ensures China’s sustainable development and leads the construction of national ecological civilization. The Seventh Central Conference on the Work of Xizang has set clear goals and specific requirements for building an ecological civilization highland on the Qinghai-Xizang Plateau, which were identified as a new mission and task of Xizang government for environmental protection and sustainable development in the new era. Based on the previous research achievements about national ecological security barrier, this work further carried out the systematic study of ecological civilization highland …
Internal Logic And Policy Recommendations Of Big Data To Support High-Quality Development Of Modern Agricultural Industry, Yingming Li, Zitong Wang, Mingyue Wang, Shiyi Liu
Internal Logic And Policy Recommendations Of Big Data To Support High-Quality Development Of Modern Agricultural Industry, Yingming Li, Zitong Wang, Mingyue Wang, Shiyi Liu
Bulletin of Chinese Academy of Sciences (Chinese Version)
Clarifying the internal logic of big data to support modern agricultural production is helpful to cultivate and develop new quality productive forces in agriculture. From the perspective of economics, this study proposes that the role of big data in modern agricultural production is mainly reflected in two levels. Firstly, it improves the total factor productivity of the traditional agricultural production function. Secondly, it changes the factor endowment structure of agricultural production and forms a new agricultural production function. Based on these, the realization form of big data to support modern agricultural production can be summarized as improving the efficiency of …
Strengthen Research On Environmental Control Technologies And Management Policies For Emerging Contaminants In China, Ying Ma, Xiang Li, Yongming Luo
Strengthen Research On Environmental Control Technologies And Management Policies For Emerging Contaminants In China, Ying Ma, Xiang Li, Yongming Luo
Bulletin of Chinese Academy of Sciences (Chinese Version)
The prevention and management of emerging contaminants (ECs) have become critical measures in China’s battle against environmental pollution. This study focuses on the environmental control technologies and policy governance related to emerging contaminants (ECs), analyzing their environmental pathways and challenges to public health, and highlighting advancements and limitations in current physical, chemical, and biological control technologies. Based on a comprehensive analysis of international policies and regulations on ECs control, the study identifies existing challenges and shortcomings in domestic management. Recommendations are proposed to enhance research on environmental control technologies and policies for ECs in China, aiming to provide insights for …
Development And Utilization Of Mineral Resources In The Arctic And China’S Strategic Countermeasures, Yina Su
Development And Utilization Of Mineral Resources In The Arctic And China’S Strategic Countermeasures, Yina Su
Bulletin of Chinese Academy of Sciences (Chinese Version)
There are abundant strategic mineral resources as oil, gas, iron ore, copper, and nickel in the Arctic region. If the Arctic routes can be opened in the future, they will become another important transportation channels connecting the Pacific and Atlantic Oceans, following the Panama Canal and the Suez Canal, which may reshape the world’s maritime trade and transportation pattern. With the development of science and technology, increase in mineral resources consumption and changes in the international environment, the strategic position of the Arctic region is increasingly elevated, and the United States, Russia and some other countries of the European Union …
Redesign And De Novo Design Of Circular Blue Bioindustry, Wei Zhang, Shufeng Zhang, Hantao Zhou, Minhan Dai
Redesign And De Novo Design Of Circular Blue Bioindustry, Wei Zhang, Shufeng Zhang, Hantao Zhou, Minhan Dai
Bulletin of Chinese Academy of Sciences (Chinese Version)
The future marine bioindustry, which features advanced green intelligent biomanufacturing and high-value marine bioproducts, is a strategically emerging marine industry. This study proposes a new industrial development model for the circular blue bioindustry, founded on simultaneously optimizing the sustainable utilization of marine bioresources and protecting the ecological environment. Through in-depth analysis of the current situation, challenges, and potential development opportunities of the global and Chinese marine bioindustries underpinning sustainable development, theoretical framework, approaches and implementation pathways have been established to redesign the existing marine bioindustry and de novo design of the emerging marine bioindustry. Future key development priorities are suggested …
Analysis On Development Status And Characteristics Of Non-Governmental Bio-Safety And Bio-Security Think Tanks In The United States, Wenbing Ma, Qiang Song, Lei Wang
Analysis On Development Status And Characteristics Of Non-Governmental Bio-Safety And Bio-Security Think Tanks In The United States, Wenbing Ma, Qiang Song, Lei Wang
Bulletin of Chinese Academy of Sciences (Chinese Version)
At present, the complexity of bio-safety governance is becoming increasingly prominent, and complex issues such as security and development in the bio-economy, preparedness and response to infectious disease pandemics, the interweaving and integration of bio-security and other security factors, and the integration of scientific and technological factors and security factors urgently require think tanks to conduct systematic, comprehensive and forward-looking assessments and provide professional solutions. Rooted in the relatively mature experience in the construction of think tanks in the United States, a number of bio-safety and bio-security think tanks with greater influence have been developed, which have acted as an …
Policy Overview (December, 2024)
Policy Overview (December, 2024)
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
Outstanding Articles In 2023 Of Journal Of Chinese Academy Of Sciences
Outstanding Articles In 2023 Of Journal Of Chinese Academy Of Sciences
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
Striving For Progress, Steadily Going Forward——The Imprint Of Journal Of Chinese Academy Of Sciences In 2024
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
Journal Of Chinese Academy Of Sciences Was Selected Into The List Of F5000 Articles In 2023 And 2024
Journal Of Chinese Academy Of Sciences Was Selected Into The List Of F5000 Articles In 2023 And 2024
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
Ai Helps To Establish A New Paradigm For Scientific Research, Weinan E
Ai Helps To Establish A New Paradigm For Scientific Research, Weinan E
Bulletin of Chinese Academy of Sciences (Chinese Version)
The main purpose of scientific research is to discover fundamental principles and solve practical problems. Although tremendous progress has been made on both fronts, the lack of effective tools and efficient organizational structure still stands as the main bottleneck for scientific progress. The rapid development of artificial intelligence (AI) offers a new possibility. In recent years, deep learning has had an impressive performance, both in helping to solve fundamental scientific problems and in improving the effectiveness of scientific research tools. A new set of infrastructure is emerging, leading us to a new paradigm, the“Android paradigm”, for doing scientific research.
Ai4r: The Fifth Scientific Research Paradigm, Guojie Li
Ai4r: The Fifth Scientific Research Paradigm, Guojie Li
Bulletin of Chinese Academy of Sciences (Chinese Version)
This article refers to “AI for Research（AI4R）” as the fifth research paradigm and summarizes its characteristics, including: (1) the fully integration of artificial intelligence into various scientific and technology researches; (2) machine intelligence has become an integral part of scientific research; (3) effectively handles the combinatorial explosion problem with high computational complexity; (4) probability and statistical models play a greater role in scientific research; (5) realize the integration of four existing research paradigms, cross disciplinary cooperation has become the mainstream research method; (6) scientific research relies more on large research platforms characterized by large models. This article points out that …
Digital Scientists And Parallel Sciences: The Origin And Goal Of Ai For Science And Science For Ai, Feiyue Wang, Yutong Wang
Digital Scientists And Parallel Sciences: The Origin And Goal Of Ai For Science And Science For Ai, Feiyue Wang, Yutong Wang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Based on recent development in foundation model, parallel intelligence, decentralized science (DeSci), and other artificial intelligence (AI) technologies, from AI for Science (AI4S) to Science for AI (S4AI), this study discusses parallel sciences and digital scientists, and their impact and significance in paradigm shift for research and development as well as Industry 5.0 and intelligent industry, which demonstrate that paradigm shift is emerging and accelerating, and we must be prepared.
Computing System For Simulation Intelligence, Guangming Tan, Weile Jia, Zhan Wang, Guojun Yuan, En Shao, Ninghui Sun
Computing System For Simulation Intelligence, Guangming Tan, Weile Jia, Zhan Wang, Guojun Yuan, En Shao, Ninghui Sun
Bulletin of Chinese Academy of Sciences (Chinese Version)
This study refers computer simulation in scientific research to as scientific simulation. Based on its narrow and broad definitions, this study divides scientific simulation into three stages: numerical computation, simulation intelligence, and science brain. Now, scientific simulation is entering the era of simulation intelligence, i. e., driven by scientific big data and artificial intelligence technology, scientific simulation is shifting from traditional numerical simulation to simulation integrated with artificial intelligence. In order to understand what the right computing system for simulation intelligence is, the design guidelines, basic methods, and key technical problems are discussed.