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Full-Text Articles in Science and Technology Policy

U.S. Government Agency Podcasts, Bert Chapman Apr 2024

U.S. Government Agency Podcasts, Bert Chapman

Libraries Faculty and Staff Presentations

Presents podcasts from U.S. Government agencies which can be discovered through the U.S. Government Publishing Office's Catalog of Government Publications. Agencies whose podcasts are presented include the National Institutes of Health, U.S. Peace Corps, U.S. Department of Agriculture, Government Accountability Office (GAO), National Park Service, Department of Justice, Federal Reserve System, and U.S. Naval War College.


Challenges On Public Security System In Ai Era—Preface For Special Column “Artificial Intelligence And Public Security”, Juan Cao, Qiang Sheng, Guojie Li Mar 2024

Challenges On Public Security System In Ai Era—Preface For Special Column “Artificial Intelligence And Public Security”, Juan Cao, Qiang Sheng, Guojie Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The rapid development of artificial intelligence generated content (AIGC) technology has triggered new public security risks, posing a serious threat to national security and social stability. This study exhibits the recent advances of artificial intelligence (AI) content generation and detection techniques, points out the challenges of detection techniques in real-world scenarios, and advocates that it is necessary to develop AIGC detection technology for public security needs and build a whole-process detection technology system from generative models to online platforms, which supports AIGC to be labeled at the generation phase, identifiable during dissemination and source-traceable after the incident occurs.


Research On Artificial Intelligence Crime And China’S Countermeasures, Jianxin Gao, Jinping Sun, Yukun Cai, Chongpeng Wang, Yanyan Yang, Kaiyue Wang Mar 2024

Research On Artificial Intelligence Crime And China’S Countermeasures, Jianxin Gao, Jinping Sun, Yukun Cai, Chongpeng Wang, Yanyan Yang, Kaiyue Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The rapid development of artificial intelligence technology has constantly given rise to new scenarios, models, and markets, changing the way information and knowledge are generated. Nevertheless, the security risks exposed by technology, such as algorithm bias, data leakage, false content generation, and improper use, are also prone to trigger various new types of crimes. There are still loopholes in legal regulation and technological prevention under the current situation, which poses severe challenges to crime crackdown. In order to effectively meet the new challenges of China’s artificial intelligence (AI) crime, we should supplement and improve the existing legal norms, improve the …


Intelligent Algorithm Safety: Concepts, Scientific Problems And Prospects, Xueqi Cheng, Wei Chen, Huawei Shen, Shiguang Shan, Xilin Chen, Guojie Li Mar 2024

Intelligent Algorithm Safety: Concepts, Scientific Problems And Prospects, Xueqi Cheng, Wei Chen, Huawei Shen, Shiguang Shan, Xilin Chen, Guojie Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Intelligent algorithms refer to the methods embodied in the computational processes that realize intelligence. These methods are often characterized by being data-driven, involving uncertain computations, and with unexplainable model inferences. These characteristics simultaneously introduce potential safety risks to the application of intelligent algorithms and AI. This study firstly explores the concepts of intelligent algorithm safety. Specifically, intelligent algorithm safety, based on the degree of human-machine integration, extends from the univariate safety of the algorithm itself to the bivariate applicational safety when the algorithm serves humans, and finally evolves into the multivariate systemic safety arises within complex socio-technical systems of human-machine …


Embodied Artificial Intelligence Security And Governance, Wenyuan Xu, Xiaoyu Ji, Chen Yan, Yushi Cheng Mar 2024

Embodied Artificial Intelligence Security And Governance, Wenyuan Xu, Xiaoyu Ji, Chen Yan, Yushi Cheng

Bulletin of Chinese Academy of Sciences (Chinese Version)

Embodied artificial intelligence (EAI) is progressively integrated into the fabric of our daily lives, enhancing various sectors such as industrial production, healthcare, and national defense. Nevertheless, the diverse range of hardware devices, software algorithms, and data communications that constitute these complex systems may contain vulnerabilities that could be exploited by attackers, posing a serious threat to personal, social, and national security. Thus, this study examines the security implications and proposes a security framework of EAI, from the perspectives of the information domain, physical domain, and social domain, focusing on its ontological security, interaction security, and application security. To mitigate these …


On Global Security Governance’S New Trends And China’S Responses From Perspective Of Scientific And Technological Revolution, Haoguang Liang, Linman Wu, Zhujun Liu, Yaojun Zhang Mar 2024

On Global Security Governance’S New Trends And China’S Responses From Perspective Of Scientific And Technological Revolution, Haoguang Liang, Linman Wu, Zhujun Liu, Yaojun Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Due to the new round of sci-tech revolution and industrial transformation, the relation between scientific progress and national security has been upgraded to an unprecedented strategic height. Therefore, it is vitally important to explore the current situation and future trajectory of the relation between the two. This study discusses the new trends between global scientific progress and the security of sovereign countries. It believes that scientific progress has catalyzed the new geopolitical contests, development contradiction and hegemonic tools in global security governance, thereby enlightening China’s approach to national security. To maintain holistic national security, China should formulate an overall strategic …


Computing Power Security Governance From Perspective Of Overall National Security Concept, Hui Li, Na Wang, Long Wang Mar 2024

Computing Power Security Governance From Perspective Of Overall National Security Concept, Hui Li, Na Wang, Long Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Currently, with the rapid development of computing technology and the continuous expansion of computing applications, various types of computing security incidents occur frequently. As an emerging security issue, computing security has become a key fact affecting national security. Strengthening the governance of computing power security has become an important part of the modernization of the national security governance system and governance capacity in China. To clarify the theoretical connotation, risk manifestations, and governance strategies of computing power security governance, this study takes the overall national security concept as guidance and the logical guidance of “issue identification-risk deconstruction-governance response” to analyze …


Breaking Through “Data Bottleneck” Of Ai Large Models—Reflections On Building A National Corpus Operation Platform, Xingteng Li, Feng Feng, Liqiang Huang Mar 2024

Breaking Through “Data Bottleneck” Of Ai Large Models—Reflections On Building A National Corpus Operation Platform, Xingteng Li, Feng Feng, Liqiang Huang

Bulletin of Chinese Academy of Sciences (Chinese Version)

At present, the competition within the global artificial intelligence (AI) large model industry is intensifying, and corpus resources emerging as a critical determinant for enhancing the technical performance and practical efficacy of AI systems. Nevertheless, China’s corpus development faces dual challenges in both quantity and quality, struggling to meet the escalating training demands of the rapidly evolving AI large model sector. Internationally, nations are ramping up efforts to develop their corpus infrastructures, particularly prioritizing the creation and deployment of high-quality linguistic datasets. In this context, through comparative analysis of international benchmarks and domestic conditions, this study proposes a strategic framework …


Views Of Chinese And American Think Tanks From Perspective Of Sino-Us Geo-Technological Competition And Its Implications For China, Xi Chen, Guangyan Shao, Jiayu Hu, Xufeng Zhu, Dong Wang Mar 2024

Views Of Chinese And American Think Tanks From Perspective Of Sino-Us Geo-Technological Competition And Its Implications For China, Xi Chen, Guangyan Shao, Jiayu Hu, Xufeng Zhu, Dong Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The geo-political and technological competition (geo-technological competition) between China and the United States is the main arena of great power competition in the 21st century, which has impacted the global technology, supply chain, and economic development landscape in unexpected ways. Although this issue has been widely discussed in the academic community, there is a lack of a systematic study of the actions of first-class think tanks in China and the United States. Therefore, this study selects the Information Technology and Innovation Foundation (ITIF), the Brookings Institution, and the Chinese Academy of Social Sciences (CASS) as the research objects, collects, sorts …


Police Flight Oversight: Lapd Drone As First Responder Implementation, Nathaniel Worley Jan 2024

Police Flight Oversight: Lapd Drone As First Responder Implementation, Nathaniel Worley

CMC Senior Theses

This thesis explores the feasibility of implementing a Drone as First Responder (DFR) program within the Los Angeles Police Department (LAPD), analyzing the operational, social, and financial implications compared to traditional police helicopter usage. The thesis investigates helicopter flight patterns, demographic correlations, and the potential for drones to provide a less invasive and more cost-effective aerial support system. Key findings include the use of incorrect identifying hex codes by LAPD helicopters, suggesting potential transparency issues in aerial operations. The thesis recommends DFR due to substantial cost savings and enhanced surveillance transparency and asserts that a DFR program can mitigate negative …


Space And Defense Journal Spring 2023 Vol. 14 Issue 1 May 2023

Space And Defense Journal Spring 2023 Vol. 14 Issue 1

Space and Defense

Table of Contents

Letter from the Editor...................................................................................................................... 5

by Dr. Michelle Black

Articles

A Great Nuclear Rejuvenation: What China can do with an Expanded Nuclear Arsenal................................................................................................. 7

by Grant Van Robays, SrA Chloe Reynolds, Lieutenant Will Jackson, and Major Tom Hammerle

Technology: The Air and Space Force's Barrier to

Innovation................................................................................................................... 22

by William F. Cosgrove

Addressing the American Approach to Emerging Technologies: Utilizing the AI Arms Race to Highlight the Need to Develop Public-Private Partnerships in C4ISR and 5G............................................................................................... 44

by Hugh Harsono and Nick Ondovcisk

Special Correspondence

Dr. Kori Schake Keynote Address................................................................................................................... 54

2022 U.S Strategic Deterrence and Assurance …


What Senior U.S. Leaders Say We Should Know About Cyber, Dr. Joseph H. Schafer May 2023

What Senior U.S. Leaders Say We Should Know About Cyber, Dr. Joseph H. Schafer

Military Cyber Affairs

On April 6, 2023, the Atlantic Council’s Cyber Statecraft Initiative hosted a panel discussion on the new National Cybersecurity Strategy. The panel featured four senior officials from the Office of the National Cyber Director (ONCD), the Department of State (DoS), the Department of Justice (DoJ), and the Department of Homeland Security (DHS). The author attended and asked each official to identify the most important elements that policymakers and strategists must understand about cyber. This article highlights historical and recent struggles to express cyber policy, the responses from these officials, and the author’s ongoing research to improve national security cyber policy.


U.S. And China: Microchip Policy Implications, Gro Kelrick Apr 2023

U.S. And China: Microchip Policy Implications, Gro Kelrick

Undergraduate Research Symposium

Microchips have become a crucial influence on a country’s military and commercial sectors; a nation’s capacity to produce large volumes of quality microchips indicates its importance on the world stage. Recently, both the United States and China have promoted many domestic and foreign industrial policies that address each country’s interests in the production and sophistication of its microchips, establishing for themselves a dominant position in the global microchip market. Both countries’ policies aim to simultaneously control/influence microchip production abroad and also stimulate development and production domestically. I have collected commercial, economic, and government budget data provided by various United States …


Accelerating Biosafety Capacity Building To Ensure National Biosecurity, Peipei Liu, Jiafu Jiang, Hao Lu, Peilei Cong, Lilin Zhao, Gexia Qiao, Dongsheng Zhou, Guizhen Wu Mar 2023

Accelerating Biosafety Capacity Building To Ensure National Biosecurity, Peipei Liu, Jiafu Jiang, Hao Lu, Peilei Cong, Lilin Zhao, Gexia Qiao, Dongsheng Zhou, Guizhen Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Biosafety is an essential part of the national security system, which is related to people's lives and health, the country's longterm stability, and sustainable development, which is the bottom line that must be guaranteed. The international biosafety situation is grim and complex, while domestic biosafety faces challenges. Therefore, biosafety capacity building has become an international hot spot, among which scientific and technological innovation, talent training, and infrastructure platform construction are the top priorities. Although China has achieved strategic results in the rapid identification of pathogens, research, and development of specific vaccines and medicine in fighting against COVID-19 by relying on …


Implications For Defense Strategy Stemming From Geopolitical Transformation Fueled By Climate Change, Steven R. Burrows Jan 2023

Implications For Defense Strategy Stemming From Geopolitical Transformation Fueled By Climate Change, Steven R. Burrows

Graduate Theses/Dissertations

Climate change has quickly become one of the most globally significant geopolitical issues facing all of humanity. Left unfettered, climate change is poised to impact nearly every facet of our environment ranging from increasingly dangerous and damaging storms, rising sea levels, increasingly extensive droughts to glacial melting, loss of arctic sea ice and a myriad of other catastrophic events. While still evolving, the current identified environmental threats will initiate long standing impacts not only to the environment, but to the global geopolitical and security climate of nearly every nation on the Earth. This project will not provide a synthesis of …


Enter The Age Of Csywar: Some Reflections On An Emergent Trend, Kumar Ramakrishna Oct 2022

Enter The Age Of Csywar: Some Reflections On An Emergent Trend, Kumar Ramakrishna

New England Journal of Public Policy

This article uses the current Russian-Ukrainian conflict as a jumping-off point for a broader, preliminary reflection on the continuing evolution of war in the digital age. It is the contention here that we are witnessing an emergent phenomenon of what we might call csywar. Intervening states engaged in csywar—best understood as an indirect, hybrid strategy—seek to attain data, infrastructural, and epistemic dominance over the target state. This article discusses various defensive counter-csywar strategies that target states could pursue, such as fostering data, infrastructural, and epistemic resilience internally, and makes the case for developing deterrent counter-csywar capabilities against hostile intervening states.


The Role Of Public And Private Sectors: How To Promote National Cybersecurity Strategies And Critical Infrastructure Protection In Southeastern Europe, Larry Cruz Oct 2021

The Role Of Public And Private Sectors: How To Promote National Cybersecurity Strategies And Critical Infrastructure Protection In Southeastern Europe, Larry Cruz

Independent Study Project (ISP) Collection

This paper seeks to address the important role of public and private interests in protecting critical infrastructure in Southeastern Europe, providing examples from Serbia. While the public sector does have a role in protecting critical infrastructure needs, it is the private sector which holds major oversight of the critical infrastructures of the region, therefore having an important role in maintaining their functionality and protection. The literature in this field argues for more collaboration and information sharing between the public and private sectors of the region, though the task is not as simple as it appears given the varying aspirations of …


Biden Administration U.S. Space Force Policy Literature, Bert Chapman Sep 2021

Biden Administration U.S. Space Force Policy Literature, Bert Chapman

Libraries Faculty and Staff Presentations

Provides details on U.S. Space Force policy literature produced by the Biden Administration during its first eight months. Includes announcements that the Biden Administration will continue this new armed services branch begun during the Trump Administration. Features congressional testimony of Biden Administration officials such as Secretary of Defense Lloyd Wilson and Air Force Space Command leader General James Dickinson, the text of Space Force's 2021 Digital Force Vision document, congressionally approved FY 2022 space force budget figures, congressional committee comments and report requirements contained in emerging defense spending legislation, the emergence of collaboration between Space Force and universities such as …


Shedding Of Marburg Virus In Naturally Infected Egyptian Rousette Bats, South Africa, 2017, Janusz T. Pawęska, Nadia Storm, Wanda Markotter, Nicholas Di Paola, Michael R. Wiley, Gustavo Palacios, Petrus Jansen Van Vuren Dec 2020

Shedding Of Marburg Virus In Naturally Infected Egyptian Rousette Bats, South Africa, 2017, Janusz T. Pawęska, Nadia Storm, Wanda Markotter, Nicholas Di Paola, Michael R. Wiley, Gustavo Palacios, Petrus Jansen Van Vuren

University of Nebraska's National Strategic Research Institute: Publications

We detected Marburg virus RNA in rectal swab samples from Egyptian rousette bats in South Africa in 2017. This finding signifies that fecal contamination of natural bat habitats is a potential source of infection for humans. Identified genetic sequences are closely related to Ravn virus, implying wider distribution of Marburg virus in Africa.

The genus Marburgvirus, family Filoviridae, comprises 1 species, Marburg marburgvirus, which comprises 2 marburgviruses, Marburg virus (MARV) and Ravn virus (RAVV) (1). Marburgviruses cause sporadic but often fatal MARV disease in humans and nonhuman primates (2). The Egyptian rousette bat (Rousettus aegyptiacus) …


Alternate Warfare: The Unseen Weapons Of Mass Destruction, Elyse Keener Jul 2020

Alternate Warfare: The Unseen Weapons Of Mass Destruction, Elyse Keener

Liberty University Journal of Statesmanship & Public Policy

Biological warfare is a national security concern that transcends centuries. In the current international climate, biowarfare is of particular interest due to the COVID-19 pandemic. This article seeks to follow historical cases of biological warfare and international response to these cases in order to understand the implications of COVID-19, if it were to be weaponized. Also covered is the current capabilities that Russia, China, and Iran are assessed to possess.


Literature Review: How U.S. Government Documents Are Addressing The Increasing National Security Implications Of Artificial Intelligence, Bert Chapman Jun 2020

Literature Review: How U.S. Government Documents Are Addressing The Increasing National Security Implications Of Artificial Intelligence, Bert Chapman

Libraries Faculty and Staff Scholarship and Research

This article emphasizes the increasing importance of artificial intelligence (AI) in military and national security policy making. It seeks to inform interested individuals about the proliferation of publicly accessible U.S. government and military literature on this multifaceted topic. An additional objective of this endeavor is encouraging greater public awareness of and participation in emerging public policy debate on AI's moral and national security implications..


Congressional Committee Resources On Space Policy During The 115th Congress (2017-2018): Providing Context And Insight Into Us Government Space Policy, Bert Chapman May 2020

Congressional Committee Resources On Space Policy During The 115th Congress (2017-2018): Providing Context And Insight Into Us Government Space Policy, Bert Chapman

Libraries Faculty and Staff Presentations

Article 1 of the US Constitution assigns the US Congress numerous responsibilities. These include creating new laws, revising existing laws, funding government programs, and conducting oversight of these programs' performance. Oversight of US Government agency space policy programs is executed by various congressional space policy committees including the House and Senate Science Committees, Armed Services, and Appropriations Committees. These committees conduct many public hearings on space policy, which invite expert witnesses to testify on US space policy programs and feature debate on the strengths and weaknesses of these programs. Documentation produced by these committees is widely available to the public, …


Congressional Committee Resources On Space Policy During The 115th Congress (2017-2018): Providing Context And Insight Into U.S. Government Space Policy, Bert Chapman Jan 2020

Congressional Committee Resources On Space Policy During The 115th Congress (2017-2018): Providing Context And Insight Into U.S. Government Space Policy, Bert Chapman

Libraries Faculty and Staff Scholarship and Research

Article 1 of the US Constitution assigns the US Congress numerous responsibilities. These include creating new laws, revising existing laws, funding government programs, and conducting oversight of these programs' performance. Oversight of US Government agency space policy programs is executed by various congressional space policy committees, including the House and Senate Science Committees, Armed Services, and Appropriations Committees. These committees conduct many public hearings on space policy which invite witnesses to testify on US space policy programs and feature debate on the strengths and weaknesses of these programs. Documentation produced by these committees is widely available to the public, except …


Lassa Virus Circulating In Liberia: A Retrospective Genomic Characterisation, Michael R. Wiley, Lawrence S. Fakoli, Andrew G. Letizia, Stephen R. Welch, Jason T. Ladner, Karla Prieto, Daniel Reyes, Nicole Espy, Joseph A. Chitty, Catherine B. Pratt, Nicholas Di Paola, Fahn Taweh, Desmond Williams, Jon Saindon, William G. Davis, Ketan Patel, Mitchell Holland, Daniel Negrón, Ute Ströher, Stuart T. Nichol, Shanmuga Sozhamannan, Pierre E. Rollin, John Dogba, Tolbert Nyenswah, Fatorma Bolay, César G. Albariño, Mosoka Fallah, Gustavo Palacios Dec 2019

Lassa Virus Circulating In Liberia: A Retrospective Genomic Characterisation, Michael R. Wiley, Lawrence S. Fakoli, Andrew G. Letizia, Stephen R. Welch, Jason T. Ladner, Karla Prieto, Daniel Reyes, Nicole Espy, Joseph A. Chitty, Catherine B. Pratt, Nicholas Di Paola, Fahn Taweh, Desmond Williams, Jon Saindon, William G. Davis, Ketan Patel, Mitchell Holland, Daniel Negrón, Ute Ströher, Stuart T. Nichol, Shanmuga Sozhamannan, Pierre E. Rollin, John Dogba, Tolbert Nyenswah, Fatorma Bolay, César G. Albariño, Mosoka Fallah, Gustavo Palacios

University of Nebraska's National Strategic Research Institute: Publications

Background An alarming rise in reported Lassa fever cases continues in west Africa. Liberia has the largest reported per capita incidence of Lassa fever cases in the region, but genomic information on the circulating strains is scarce. The aim of this study was to substantially increase the available pool of data to help foster the generation of targeted diagnostics and therapeutics.

Methods Clinical serum samples collected from 17 positive Lassa fever cases originating from Liberia (16 cases) and Guinea (one case) within the past decade were processed at the Liberian Institute for Biomedical Research using a targeted-enrichment sequencing approach, producing …


How U.S. Government Policy Documents Are Addressing The Increasing National Security Implications Of Artificial Intelligence, Bert Chapman Oct 2019

How U.S. Government Policy Documents Are Addressing The Increasing National Security Implications Of Artificial Intelligence, Bert Chapman

Libraries Faculty and Staff Presentations

Artificial intelligence is affecting many areas of our lives and governmental policy. National security is one arena in which artificial intelligence is playing an increasingly important and controversial role. U.S. Government and military agencies are producing a steadily expanding corpus of publicly available literature on this topic. This literature documents how these agencies have this topic's national security implications historically and currently while also addressing potentially emerging national security issues where artificial intelligence will intersect with national security. This presentation demonstrates examples of the growing variety of publicly available national security artificial intelligence literature while also addressing the implications of …


Transhumanism (Dot) Mil: A Bibliometric Analysis Of Technoprogressive Terms In Military Publications, K. Durwood Evans Sep 2019

Transhumanism (Dot) Mil: A Bibliometric Analysis Of Technoprogressive Terms In Military Publications, K. Durwood Evans

Library Philosophy and Practice (e-journal)

Has transhumanism influenced military thinking? Previous work found that transhumanist terms did not appear widely in military publications. The present work analyzes and improves on previous content analysis of transhumanist terms in military literature using the tools of library and information studies.


Enhancing Your Intelligence Agency Information Resource Iq: Pt. 4: National Geospatial Intelligence Agency (Ngia), National Intelligence University (Niu), And National Reconnaissance Office (Nro), Bert Chapman Nov 2018

Enhancing Your Intelligence Agency Information Resource Iq: Pt. 4: National Geospatial Intelligence Agency (Ngia), National Intelligence University (Niu), And National Reconnaissance Office (Nro), Bert Chapman

Libraries Faculty and Staff Presentations

Webinar presentation on publicly accessible information resources produced by the U.S. National Geospatial Intelligence Agency (NGIA), National Intelligence University (NIU), and National Reconnaissance Office. Places significant emphasis on missions of these agencies, their historical accomplishments, coverage of their educational activity, and information on the technologies they have used and are currently using to fulfill their institutional objectives.


Underestimated: Our Not So Peaceful Nuclear Future (Second Edition), Henry D. Sokolski Aug 2018

Underestimated: Our Not So Peaceful Nuclear Future (Second Edition), Henry D. Sokolski

Books, Monographs & Collaborative Studies

No abstract provided.


Qualitative Profiling Of The Humoral Immune Response Elicited By Rvsv-Δg-Ebov-Gp Using A Systems Serology Assay, Domain Programmable Arrays, Mariano Sanchez-Lockhart, Daniel S. Reyes, Jeanette C. Gonzalez, Karla Y. Garcia, Erika C. Villa, Bradley P. Pfeffer, John C. Trefry, Jeffrey R. Kugelman, Margaret L. Pitt, Gustavo Palacios Jul 2018

Qualitative Profiling Of The Humoral Immune Response Elicited By Rvsv-Δg-Ebov-Gp Using A Systems Serology Assay, Domain Programmable Arrays, Mariano Sanchez-Lockhart, Daniel S. Reyes, Jeanette C. Gonzalez, Karla Y. Garcia, Erika C. Villa, Bradley P. Pfeffer, John C. Trefry, Jeffrey R. Kugelman, Margaret L. Pitt, Gustavo Palacios

University of Nebraska's National Strategic Research Institute: Publications

Development of an effective vaccine became a worldwide priority after the devastating 2013–2016 Ebola disease outbreak. To qualitatively profile the humoral response against advanced filovirus vaccine candidates, we developed Domain Programmable Arrays (DPA), a systems serology platform to identify epitopes targeted after vaccination or filovirus infection. We optimized the assay using a panel of well-characterized monoclonal antibodies. After optimization, we utilized the system to longitudinally characterize the immunoglobulin (Ig) isotype-specific responses in non-human primates vaccinated with rVSV-ΔG-EBOV-glycoprotein (GP). Strikingly, we observed that, although the IgM response was directed against epitopes over the whole GP, the IgG and IgA responses were …


Genetic Characterization Of Enterovirus A71 Circulating In Africa, Maria Dolores Fernandez-Garcia, Romain Volle, Marie-Line Joffret, Serge Alain Sadeuh-Mba, Ionela Gouandjika-Vasilache, Ousmane Kebe, Michael R. Wiley, Manasi Majumdar, Etienne Simon-Loriere, Anavaj Sakuntabhai, Gustavo Palacios, Javier Martin, Francis Delpeyroux, Kader Ndiaye, Maël Bessaud Apr 2018

Genetic Characterization Of Enterovirus A71 Circulating In Africa, Maria Dolores Fernandez-Garcia, Romain Volle, Marie-Line Joffret, Serge Alain Sadeuh-Mba, Ionela Gouandjika-Vasilache, Ousmane Kebe, Michael R. Wiley, Manasi Majumdar, Etienne Simon-Loriere, Anavaj Sakuntabhai, Gustavo Palacios, Javier Martin, Francis Delpeyroux, Kader Ndiaye, Maël Bessaud

University of Nebraska's National Strategic Research Institute: Publications

We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochthonous EV-A that might contribute to the emergence of pathogenic lineages.

Genogroup E was previously identified and characterized only on the basis of VP1 analysis (3). This study confirms the circulation in West and Central Africa of EV-A71 isolates belonging to the new genogroup E on the basis of the characterization of whole genomes. The divergence among isolates indicates that this genogroup …