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Articles 1 - 30 of 2644
Full-Text Articles in Emergency and Disaster Management
Cyberspace Collaborative Awareness: A Model For Unity Of Effort In Homeland Defense, Mike Knapp, Sean Atkins, Matthew Mclaughlin
Cyberspace Collaborative Awareness: A Model For Unity Of Effort In Homeland Defense, Mike Knapp, Sean Atkins, Matthew Mclaughlin
Joint Force Quarterly
The increasing frequency and severity of cyberattacks against U.S. critical infrastructure continue to confound homeland defense efforts. Defending against state cyber campaigns that threaten the nation’s most critical systems requires a new awareness model that can enable unity of effort across public and private actors. Examining homeland defense awareness in other domains reveals principles and approaches that can inform the development of a collaborative awareness model in cyberspace. This new framework acknowledges the interconnectedness of government and commercial networks and the independent goals of each player in the domain. Doing so provides a viable path to achieving shared domain awareness …
From Himalayan Catastrophe To National Resilience: Lessons From The 2026 Bhote Koshi And Trishuli River Floods In Nepal, Keshav Bhattarai, Ambika P. Adhikari
From Himalayan Catastrophe To National Resilience: Lessons From The 2026 Bhote Koshi And Trishuli River Floods In Nepal, Keshav Bhattarai, Ambika P. Adhikari
Himalayan Research Papers Archive
On the morning of 26 August 2026, the mountains above Nepal’s northern frontier delivered a disaster of almost unimaginable speed and scale. A massive mass of ice, rock, and sediment detached in the high Himalayan terrain near the Nepal–Tibet border, descended roughly 1,200 metres, interacted with the Lhende Khola system, and generated a debris-rich flood that surged through the Bhote Koshi and Trishuli river corridors, destroying settlements, markets, roads, bridges, hydropower facilities, and an international border crossing and transforming them into fields of mud, boulders, and wreckage within minutes (ICIMOD, 2026b; Reuters, 2026a). Satellite analysis indicates that a substantial section …
Dynamic Flood Risk Assessment For Transportation Infrastructure In Fresno, Ca, Yushin Ahn, Fayzul Pasha
Dynamic Flood Risk Assessment For Transportation Infrastructure In Fresno, Ca, Yushin Ahn, Fayzul Pasha
Mineta Transportation Institute
Urban roadway flooding in flat metropolitan environments often shows up as small areas of standing water rather than large, flowing floods. In low-gradient urban environments, subtle micro-topographic features—such as pavement crowns, curbs, and localized depressions—often control where surface water accumulates following rainfall. Accurately identifying these localized ponding areas is important for roadway flood screening and infrastructure management. This study develops a LiDAR-based depression mapping framework to identify roadway segments susceptible to surface ponding in flat urban environments. High-resolution airborne LiDAR datasets were used to generate detailed elevation maps (down to less than a foot in resolution) from ground-classified point clouds …
Business Educational Skills For Successful Aviation Fire Officers, Leo Sedlmeyer
Business Educational Skills For Successful Aviation Fire Officers, Leo Sedlmeyer
All Faculty and Staff Scholarship
Purpose: This paper explored the business educational skills aviation fire officers use to manage airport fire departments.
Design/Methodology/Approach: The methodology was a qualitative phenomenological study design. The participants began with 10 aviation fire officers from airports throughout the USA who were at least 28 years old, in a leadership role, and had at least 10 years of experience as aviation fire officers (Buttenschon, 2016). Saturation was reached at seven during the interview phase. The limitations of this study were gaining participants' trust and obtaining comprehensive information from them.
Findings: Six themes emerged from this study, with the top three identified: …
Protecting America’S Critical Infrastructure: A Shared Responsibility In An Era Of Escalating Cyber Threats, Alan Saquella
Protecting America’S Critical Infrastructure: A Shared Responsibility In An Era Of Escalating Cyber Threats, Alan Saquella
Publications
The recent cyberattacks targeting municipal water facilities across multiple U.S. states serve as another reminder that America’s critical infrastructure remains under constant attack. According to the FBI, Environmental Protection Agency (EPA), and the Cybersecurity and Infrastructure Security Agency (CISA), attackers successfully compromised operational technology (OT) devices, including programmable logic controllers (PLCs), by exploiting Internet-connected systems, changing administrator credentials, and disrupting normal operations. Fortunately, local operators responded quickly by isolating affected systems, restoring backups, and preventing what could have become a significant public health crisis.
While these incidents focused on water treatment facilities, they represent a much larger national security issue. …
Wildfire Risk & Preparedness For Urban Rail Operators Supporting Large Stadium Events, Karl Kim, Eric Yamashita, Daniele Spirandeli, David Rother
Wildfire Risk & Preparedness For Urban Rail Operators Supporting Large Stadium Events, Karl Kim, Eric Yamashita, Daniele Spirandeli, David Rother
Mineta Transportation Institute
The project team, in collaboration with partners and stakeholders, developed a four-hour training course designed to build a foundational understanding of how wildfire hazards affect rail systems infrastructure operations and how this knowledge can help equip urban rail operators with tools and best practices for proactive risk management. Led by the University of Hawaiʻi and the National Disaster Preparedness Training Center, in partnership with Haley & Aldrich, Inc., this technical report presents an overview of the four modules and scenario planning exercise that together make up the four-hour Wildfire Risk & Preparedness for Urban Rail Operators Supporting Large Stadium Events …
Enhancing Wildfire Resilience In The Rail Industry: Developing A Community Resilience Extreme Events Portal (Creep), Karl Kim, Eric Yamashita, Daniele Spirandeli, David Rother, Chris Chiesa, Greg Hampe, Michele Toner
Enhancing Wildfire Resilience In The Rail Industry: Developing A Community Resilience Extreme Events Portal (Creep), Karl Kim, Eric Yamashita, Daniele Spirandeli, David Rother, Chris Chiesa, Greg Hampe, Michele Toner
Mineta Transportation Institute
The Community Resilience Extreme Events Portal (CREEP) provides a centralized platform for accessing wildfire danger indices, critical asset locations, and vulnerability scores for rail segments. The project team developed a data-driven, indicator-based vulnerability assessment framework that defines vulnerability as a function of exposure, sensitivity, and adaptive capacity. To build this framework, the team selected publicly available datasets, prioritizing national datasets whenever possible to ensure transparency, reproducibility, and scalability. The portal allows users to analyze and visualize vulnerability across 1-kilometer segments of Class I freight and passenger rail lines in California, supporting planning and mitigation prioritization to help reduce rail-related fatalities, …
Mind The Gap: Freight And Rail System Resilience Between Planning And Practice A Synthesis Of Freight Plan Best Practices And Survey Results From U.S. Transportation Professionals, Serena Alexander, Carmella Uwineza
Mind The Gap: Freight And Rail System Resilience Between Planning And Practice A Synthesis Of Freight Plan Best Practices And Survey Results From U.S. Transportation Professionals, Serena Alexander, Carmella Uwineza
Mineta Transportation Institute
Freight and rail networks across the United States face mounting risks from weather-related hazards and other systemic disruptions that threaten operational continuity, economic stability, and community well-being. While state freight plans are federally mandated, local and metropolitan freight planning varies widely, leaving gaps in how resilience is addressed across scales. This study examines how resilience is being integrated into freight and rail planning through a two-part approach: (1) a content analysis of 43 recent state and metropolitan freight plans, and (2) a nationwide survey of 56 transportation professionals engaged in freight and rail planning. Findings show broad consensus on the …
The Impact Of The Interaction Between Negotiation Strategies And Tactics On Enhancing Security Crisis Management At The General Headquarters Of Ras Al Khaimah Police, Abdulrahman Obeid Al Khatri
The Impact Of The Interaction Between Negotiation Strategies And Tactics On Enhancing Security Crisis Management At The General Headquarters Of Ras Al Khaimah Police, Abdulrahman Obeid Al Khatri
Journal of Police and Legal Sciences
The study falls within the context of emphasis on negotiation as a strategic tool in the management of security crises owing to challenges that have become so complicated and dynamic against security institutions. According to reports by the UAE Ministry of Interior, more than 1,200 different types of security crises have been recorded within the last five years. This can range from field to organizational and emergency crises. Therefore, there is an immediate requirement for developing new negotiation methodologies through which response capacities can be boosted to make swift and precise decisions during critical moments.
This study has tried to …
Synoptic Conditions Favoring Tropical Cyclone-Enhanced Southwest Monsoon High Precipitation Events In The Philippines, Alwin Andriel L. Bathan, Lyndon Mark P. Olaguera, Faye Abigail T. Cruz, Jose Ramon T. Villarin, John A. Manalo, Jun Matsumoto
Synoptic Conditions Favoring Tropical Cyclone-Enhanced Southwest Monsoon High Precipitation Events In The Philippines, Alwin Andriel L. Bathan, Lyndon Mark P. Olaguera, Faye Abigail T. Cruz, Jose Ramon T. Villarin, John A. Manalo, Jun Matsumoto
SOSE Affiliate: Manila Observatory
The interaction of tropical cyclones (TCs) with the southwest monsoon frequently causes heavy precipitation events (HPEs) and widespread flooding across the Philippines. Despite their substantial socio-economic impacts, the synoptic conditions that favor these events remain insufficiently understood, underscoring the need for systematic investigation to help improve forecasting and risk assessment. Lag composite analysis of daily rainfall records and reanalysis data from July to September for the period 1981–2023 shows that HPEs are more likely to occur when: (1) enhanced monsoon westerlies are present over the tropical Indian Ocean for at least nine days before the HPE, (2) a TC passes …
Influence Of Stormwater Flooding Events On The Mobile County School District Student Population, Kadence Kali Johnston
Influence Of Stormwater Flooding Events On The Mobile County School District Student Population, Kadence Kali Johnston
Honors Theses
Mobile County, Alabama, receives among the highest annual rainfall totals in the United States resulting in frequent stormwater flooding that intersects with existing socioeconomic vulnerabilities. Within the Mobile County Public School System (MCPSS), 77% of students are economically disadvantaged and over 10% experience homelessness, creating heightened risk for educational disruption during flood events. This study investigates how stormwater flooding influences school attendance, closures, and academic performance across MCPSS, providing insight into how climate-driven hazards exacerbate educational inequities. The research integrates flood frequency, school performance metrics, and GIS flood-zone mapping and teacher perceptions to understand how flooding affects student learning opportunities. …
From Risk Perception To Readiness: Understanding Us Wildfire Preparedness Drivers, Dominic Kyei, William Donner, Arlett Sophia Lomeli, Dean Kyne
From Risk Perception To Readiness: Understanding Us Wildfire Preparedness Drivers, Dominic Kyei, William Donner, Arlett Sophia Lomeli, Dean Kyne
Sociology Faculty Publications
Background: Wildfires in the USA are becoming more frequent and severe as climate change and population growth expand exposure in fire-prone regions. Understanding the human dimensions of wildfire preparedness—particularly how individuals perceive risk, build awareness, and develop evacuation readiness—is critical for effective fire management.
Methods: This study examines cognitive, experiential, behavioral, and sociodemographic predictors of wildfire preparedness using the wildfire-specific subsample (n = 509) from the 2023 FEMA National Household Survey. Generalized structural equation modeling (GSEM) was used to analyze three key outcomes: readiness awareness, evacuation readiness, and perceived wildfire risk.
Results: Results show that readiness awareness and preparedness self-efficacy …
The Role Of Urban Forests In Mitigating Flooding Effects: A Case Study In Savannah, Georgia, Gillian Bush
The Role Of Urban Forests In Mitigating Flooding Effects: A Case Study In Savannah, Georgia, Gillian Bush
Undergraduate Theses, Capstones, and Recitals
Flooding in coastal communities is shaped by the interaction between natural systems and urban development. Chatham County, a low-elevation region in the Savannah, Georgia metropolitan area along the eastern coast of the United States, is prone to coastal storms and frequently affected by flooding. It serves as a useful case study to better understand the factors behind flooding and the areas that are most at risk. This study uses GIS-based analysis to examine the overlap between flood risk, urban forest cover, and impervious surfaces. The results indicate elevated vulnerability along major transportation corridors and barrier islands, where high-risk flood zones …
Does The Availability Of An Additional Set Of Bunker Gear Impact Firefighter Health, Safety, And Operational Readiness?, Ryan Riley
Certified Public Manager® Applied Research
Firefighting is a complex and inherently dangerous profession. Firefighters today face a growing array of occupational hazards, not just from the effects of being exposed to fire and smoke, but also from the personal protective gear they wear, commonly referred to as “bunker” or “turnout” gear. While this gear is designed to protect firefighters in dangerous environments, prolonged use and repeated exposure to smoke, chemicals, and products of combustion can compromise the gear. Research has shown that bunker gear contains and can also retain cancer-causing chemicals. To this end, this paper examines whether the availability of an additional set of …
Breaking Barriers: Harnessing Collaboration Between Individuals With Disabilities And Emergency Management In New Jersey, Daniel Wrinn
Breaking Barriers: Harnessing Collaboration Between Individuals With Disabilities And Emergency Management In New Jersey, Daniel Wrinn
Master of Science in Emergency & Disaster Management Capstones
No abstract provided.
Urban Conflagrations: Structural Ash And Soil Metal(Loid) Contamination After California’S Eaton And Palisades Fires, S. Anselme Dossou, Leon Kelly, P. Louis Lu, Robin Jones, Oliver O'Donnell, Justin St. P. Walsh, Daniel D. Richter
Urban Conflagrations: Structural Ash And Soil Metal(Loid) Contamination After California’S Eaton And Palisades Fires, S. Anselme Dossou, Leon Kelly, P. Louis Lu, Robin Jones, Oliver O'Donnell, Justin St. P. Walsh, Daniel D. Richter
Art Faculty Articles and Research
In the weeks after California’s Eaton-Palisades wildfires, structural ash of burned homes and soils from yards and curbsides were sampled for analysis of Pb, As, and eight metals from 32 burned residences. About six months after fires and after US Army Corps of Engineers’ Phase 2 cleanups removed 15 cm from structural ash footprints, 17 properties were resampled within about a meter of original sampling sites. Concentrations of metal(oid)s in structural ash and residential soils varied between and within properties with significant spatial and temporal patterns. Lead concentrations were highest in structural ash and soil of yards of select pre-1970s …
Research On Knowledge Service For Emergency Supplies Supply Under The Framework Of Cognition, Architecture And Operation, Xun Jiang, Mingwei Tang
Research On Knowledge Service For Emergency Supplies Supply Under The Framework Of Cognition, Architecture And Operation, Xun Jiang, Mingwei Tang
Journal of Scientific Information Research
[Purpose/significance] To address the challenges in matching supply-demand information within the emergency material supply domain, this study constructs a knowledge service framework from three dimensions cognition, architecture, and operation to enhance the agility of emergency response and the resilience of supply chains. [Method/process] A cognition-centered knowledge service framework is proposed for the emergency material supply field, encompassing five dimensions: scenario, approach, structure, perspective, and model. Subsequently, a system architecture is developed focusing on three aspects: emergency data integration, knowledge-driven supply, and emergency scenario perception. The operationalization of the proposed knowledge service is explored in terms of its logic, mechanisms, and …
Community Resilience In The Absence Of Aid: Recovery After The 2018 Father’S Day Flood In Houghton County, Michigan, Abby Heggem
Community Resilience In The Absence Of Aid: Recovery After The 2018 Father’S Day Flood In Houghton County, Michigan, Abby Heggem
University Honors Program Senior Projects
Community networks influenced resilience and recovery after the 2018 Father’s Day Flood in Houghton County Michigan, particularly in the absence of strong institutional support. The flood caused widespread damage to homes, roads, and infrastructure, forcing residents to rely on immediate local action before state or federal aid arrived. Rural locations like Houghton County are often neglected by government funding and support during disasters and are forced to rely on themselves. Community networks matter in disasters because neighbors, volunteer groups, and local leaders respond faster than formal institutions. This project uses a qualitative case study approach that includes content analysis of …
Taylor Swift And The Social Construction Of Risk: Harms Realized And Avoided, Jack L. Rozdilsky, Talia Shortt
Taylor Swift And The Social Construction Of Risk: Harms Realized And Avoided, Jack L. Rozdilsky, Talia Shortt
The Manuscript: Journal of Taylor Swift Studies
An especially difficult ten-day period for Taylor Swift and her fans occurred in late July to early August 2024 as the Eras Tour was wrapping up its European leg. On July 29, 2024, a Taylor Swift themed yoga and dance workshop taking place in Southport, United Kingdom, was attacked. A disaster was realized as three children were killed during a criminal mass stabbing attack. On August 7, 2024, a sequence of three Eras Tour concerts intended to be held in Vienna, Austria, was suddenly cancelled due to the discovery of an anticipated terrorist attack that was in the advanced stages …
Coexistence Of“Emotion”And“Rationality”:Analysis Of The Impact Mechanism Of Frequent Reversal Events On The Evolution Of Online Public Opinion, Liqiang Wang, Xueqi Li, Yixian Wang
Coexistence Of“Emotion”And“Rationality”:Analysis Of The Impact Mechanism Of Frequent Reversal Events On The Evolution Of Online Public Opinion, Liqiang Wang, Xueqi Li, Yixian Wang
Journal of Scientific Information Research
[Purpose/significance] In recent years, frequent reversal events have negatively impacted the online media environment, leading to an increasing number of skeptical voices during the evolution of public opinion.These doubts are no longer merely emotional outbursts but also involve rational understanding of the event's authenticity. This study aims to gain a deeper understanding of this phenomenon and attempts to reveal the impact mechanism of frequent reversal events on the evolution of online public opinion. [Method/process] Through surveys and computer simulation experiments, the study analyzes various elements such as individuals, media environment, and evolution patterns in online public opinion,then according to the …
Applications Of Suas Thermal Imaging And Lidar At Letort Spring Garden Preserve: An Independent Study, Kelsey Wardell
Applications Of Suas Thermal Imaging And Lidar At Letort Spring Garden Preserve: An Independent Study, Kelsey Wardell
Harrisburg University Other Works
No abstract provided.
When Flood Warnings Fail: Psychological Predictors Of Information Clarity And Evacuation Intention, Katsuya Tanaka, Tadashi Kito, Kohji Tanaka
When Flood Warnings Fail: Psychological Predictors Of Information Clarity And Evacuation Intention, Katsuya Tanaka, Tadashi Kito, Kohji Tanaka
Center for Public Service Publications and Reports
Flood warnings are often assumed—particularly within traditional average-effect models—to prompt uniform behavioral responses, yet real-world evidence suggests that message effectiveness varies widely across the population. This study empirically identifies and explains such heterogeneity using a factorial survey experiment (n = 1671) conducted among residents in flood-prone regions of Japan. We estimate finite mixture beta regression models to disentangle the distinct behavioral patterns underlying information clarity and evacuation intention. Results reveal two psychological segments: a Responsive majority, whose decisions are shaped by concrete and credible warning attributes (e.g., specific breach point, forecast basis, large-font display), and a Non-Responsive minority, who remain …
Gamification And Serious Games In Undergraduate Nursing Education For Disaster Preparedness In The United States, Jacob Fast
Dissertations
Disaster preparedness is a critical component of undergraduate nursing education, yet traditional instructional approaches often inadequately prepare students for the complexity and uncertainty of real-world emergencies. Emerging literature suggests that gamification and serious games may enhance engagement and applied learning; however, limited research has examined their integration within nursing curricula from the perspective of faculty responsible for instructional design. This convergent mixed-methods study investigated the extent of integration, perceived effectiveness, and practical utility of gamification and serious games in undergraduate nursing education for disaster preparedness. Quantitative data were collected through a national survey of faculty teaching in CCNE- and ACEN-accredited …
Foxbuddy, Luis Eduardo Garza Jr.
Foxbuddy, Luis Eduardo Garza Jr.
Posters - 2026
Emergency preparedness remains a significant challenge for individuals due to disorganized resource management and lack of accessible guidance. Additionally, cybersecurity risks during emergencies are often overlooked, leaving individuals vulnerable to digital threats such as phishing, scams, and data exposure. FoxBuddy provides a centralized, user-friendly platform that enhances both physical preparedness and cybersecurity awareness.
Quantifying Global Internal Displacement Risk At The Hazard-Vulnerability-Conflict Nexus, Wenzhao Li, Surendra Maharjan, Rejoice Thomas, Hesham Morgan, Ali Elgendy, Susan Mikhail, Hesham El-Askary
Quantifying Global Internal Displacement Risk At The Hazard-Vulnerability-Conflict Nexus, Wenzhao Li, Surendra Maharjan, Rejoice Thomas, Hesham Morgan, Ali Elgendy, Susan Mikhail, Hesham El-Askary
Mathematics, Physics, and Computer Science Faculty Articles and Research
This study introduces a novel, diagnostic hazard-specific displacement risk index that integrates high-resolution hazard data with social vulnerability metrics and historical displacement records, uncovering overlooked compound risks in conflict areas and links between environmental stress and instability. Our methodology combines historical displacement records with environmental, demographic, and socioeconomic indicators to identify high-risk regions and quantify interactions between hazards and conflict across six major hazard types. Results reveal floods as the primary displacement driver, particularly in South Asia (Bangladesh, India, Pakistan) and Sub-Saharan Africa (Nigeria, Ethiopia), where dense populations in flood-prone areas intersect with low socioeconomic resilience. Droughts disproportionately impact arid …
Simulating Cyber-Resilience: The Strategic Role Of The Locked Shields Exercise In Enhancing International Cyber Preparedness, Christopher A. Ramezan, Ludwig Christian Schaupp, Elizabeth A. Vitullo, William J. Walker
Simulating Cyber-Resilience: The Strategic Role Of The Locked Shields Exercise In Enhancing International Cyber Preparedness, Christopher A. Ramezan, Ludwig Christian Schaupp, Elizabeth A. Vitullo, William J. Walker
Journal of Cybersecurity Education, Research and Practice
As cyberthreats to critical infrastructure remain prevalent, national response mechanisms must evolve beyond the technical domain to incorporate legal, communicative, strategic, and cross-sector coordination. This work explores Locked Shields, an annual exercise conducted by NATO's Cooperative Cyber Defence Centre of Excellence, as a pedagogical and conceptual framework for simulating whole-of-government responses to cyber incidents. Unlike traditional cyber exercises, Locked Shields engages legal advisors, media strategists, and civil-military roles in realistic, scenario-driven simulations that portray the political and operational conditions of a real international-scale cyber crisis. We detail the exercise architecture, contrast with other cyber exercises, and assess its pedagogical and …
When Disaster Strikes Y’All Street: A Study On Cross-Sector Collaboration In Protecting U.S. Financial Critical Infrastructure, Rachael A. Zerr, John Friedlander
When Disaster Strikes Y’All Street: A Study On Cross-Sector Collaboration In Protecting U.S. Financial Critical Infrastructure, Rachael A. Zerr, John Friedlander
Publications and Research
This exploratory research examines public-private collaboration between corporate security leaders and local emergency responders in the North Texas financial corridor known as “Y’all Street.” Using perception-based survey data from senior representatives in the private and public sectors, the paper evaluates partnership strength, preparedness activities, information sharing, and operational coordination. Findings indicate that collaborative practices such as facility tours, joint exercises, and emergency planning are present, but that partnership maturity remains uneven and is not yet fully standardized across the corridor. The research concludes that more formalized and institutionalized coordination will be necessary to strengthen resilience as the region’s financial significance …
After A Wildfire: Considerations For Building Environmental Testing, Andrew J. Whelton, E. Bollens, C. Ferrarezzi
After A Wildfire: Considerations For Building Environmental Testing, Andrew J. Whelton, E. Bollens, C. Ferrarezzi
Resilience to Emergencies and Disasters
No abstract provided.
From Sparks To Insights: An Aggregate Analysis On Arson And Explosive Data Reporting Published By The Atf (2014-2024), Zahra A. Khan
From Sparks To Insights: An Aggregate Analysis On Arson And Explosive Data Reporting Published By The Atf (2014-2024), Zahra A. Khan
Electronic Theses & Dissertations (2024 - present)
This thesis provides an aggregate assessment of arson and explosives incidents reported by the Bureau of Alcohol, Firearms, and Tobacco, from 2014 to 2024. This thesis is written to highlight trends, investigative outcomes, and evolving patterns of criminal activity. Analysis of the data reveals notable shifts in incident frequencies, data distributions, and case resolution rates. This suggests both emerging technologies and changing operational dynamics that have affected long-term trends in arson and explosive incidents. Variations in incident types and investigative outcomes underscore the interplay between law enforcement priorities, resource allocation, and reporting practices over the ten-year period. The study also …
Yk-4-250, A Synthetic Telmisartan-Tempol Conjugate: Crystal Structure Of A Stabilized Free Radical Containing An Angiotensin At₁ Receptor Inhibitor, Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton
Yk-4-250, A Synthetic Telmisartan-Tempol Conjugate: Crystal Structure Of A Stabilized Free Radical Containing An Angiotensin At₁ Receptor Inhibitor, Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton
Department of Biomedical and Translational Sciences Faculty Publications
We report the first crystal structure of the telmisartan-tempol conjugate 2,2,6,6-tetramethyl-1-(λ'-oxidaneyl)piperidin-4-yl 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl]-[1,1'-biphenyl]-2-carboxylate free radical (YK-4-250, C₄₂H₄₆N₅O₃), a dual-function inhibitor designed to target both the angiotensin II type 1 receptor (AT₁R) and reactive oxygen species (ROS). Structural analysis reveals a unique crystal architecture in which the nitroxide radical is stabilized within a sterically protected environment while preserving the telmisartan pharmacophore essential for high-affinity receptor antagonism. YK-4-250 is a novel small-molecule conjugate of telmisartan and tempol that incorporates a catalytic stabilized nitroxide radical and was rationally designed to mitigate gastrointestinal acute radiation syndrome (GI-ARS).