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Pavlovian Conditioning: History And Application Of The Revaluation Procedure, Bana Odeh May 2018

Pavlovian Conditioning: History And Application Of The Revaluation Procedure, Bana Odeh

Honors College Theses

While Pavlovian conditioning is a widely recognized form of learning, the nature of this learned association continues to be debated and has significant implications for human and animal behavior. This paper will first address the basic structure of Pavlovian conditioning as well as the two major historical hypotheses—Stimulus-Stimulus (S-S) learning and Stimulus-Response (SR) learning—regarding the underlying neural representation of first-order conditioning. Next, the revaluation procedure, an experimental method used to distinguish between these two hypotheses, will be discussed. Furthermore, the history of revaluation studies on rats will be analyzed, with an emphasis on the specificity of the learned association formed, …


The Contribution Of Nmda Receptors Within The Central Nucleus Of The Amygdala To The Suppression Of Pain Affect, Catherine Ann Spuz Jan 2010

The Contribution Of Nmda Receptors Within The Central Nucleus Of The Amygdala To The Suppression Of Pain Affect, Catherine Ann Spuz

Wayne State University Dissertations

The amygdala processes stimuli that threaten an individual and organizes the execution of affective behaviors designed to cope with the threat. The prototypical threat to an individual is exposure to a noxious stimulus. The central nucleus of the amygdala (CeA) receives nociceptive afferents and exhibits neuronal activation in response to noxious peripheral stimulation. NMDA receptors within CeA mediate this noxious-evoked neural excitation, and previous studies in the laboratory have shown that blockade of CeA NMDA receptors via the antagonist APV elevates the threshold for noxious tail-shock-induced vocalization afterdischarges (VADs), a validated measure of pain affect in the rat. The present …