Experimental Analysis of Behavior Commons^™

Acute And Chronic Oral Administration Of Cannabidiol-Dominant Cannabis Products: Sex- And Formulation-Dependent Effects On Anxiety-Like Behavioral Patterns In Rats, Carlos R. Maestas-Olguin

Psychology ETDs

Interest in the anxiolytic-like effects of cannabidiol (CBD), the non-intoxicating phytocannabinoid found within the genus, Cannabis, has grown significantly in recent years. However, preclinical investigations of CBD’s anxiolytic potential often elect to forgo translationally relevant models that maximize external validity in favor of greater internal and mechanistic validity. As a result, the effects of relatively low dose (< 3mg/kg) oral CBD administration on anxiety-like behaviors are not yet fully characterized. The present studies examined the impact of two orally delivered CBD-dominant cannabis products – a “full-spectrum” formulation derived from the whole plant and a CBD isolate derived from the same chemovar – on innate defensive behaviors exhibited by adult male and female rats in various tests of anxiety. Results indicated that acute and chronic low dose oral CBD administration attenuated anxiety-like behavior in rats, regardless of sex or formulation. These findings extend the growing corpus of literature describing anxiolytic-like effects of CBD.

Birth Control Use Alters Memory For A Stressful Experience, Julia N. Gross, Kristie Payment, Boyd R. Rorabaugh, Phillip R. Zoladz

Aurora

Hormonal birth control methods are widely used; however, some users suffer considerable side effects. Previous research suggests oral contraceptive users exhibit a blunted cortisol response to psychosocial stressors and alterations in emotional memory, including differential recall of emotional images and details of emotional stories. However, no studies have examined how birth control influences memory for a stressful experience.

The present study analyzes data previously collected from female undergraduate students. In this study, participants reported contraceptive use, then underwent a modified version of the Trier Social Stress Test (TSST) or the friendly-TSST (f-TSST). The TSST required participants to deliver a ten-minute, …

Investigating The Effects Of Sod1 Knockout On Oxidative Stress And Stress Coping Styles In Zebrafish Using Crispr Technology, Tai Prauner, Ryan Wong

Theses/Capstones/Creative Projects

Reactive oxygen species are byproducts of cellular metabolism that, when not efficiently neutralized, can damage DNA, proteins, and lipids. Superoxide dismutase 1 (SOD1) is an antioxidant enzyme that converts superoxide radicals into less harmful molecules. While its molecular function is well documented, the role of SOD1 in shaping stress-related behavior remains underexplored. This project aimed to establish foundational tools for studying the behavioral impact of SOD1 knockout across proactive and reactive stress-coping styles in zebrafish.

To support future gene-editing experiments, microinjection and breeding protocols were refined across wildtype AB, proactive, and reactive zebrafish lines. No embryos were injected with CRISPR-Cas9 …

Impact Of Acute Stress On Circadian Rhythm Regulation Of Locomotor Activity In Syrian Hamsters, Raquel A. Villarreal, Laura E. Garcia, Mario Gil

Research Symposium

Background: Disruptions of circadian rhythms, caused by factors such as environmental changes or stress, are linked to health conditions, including metabolic disorders, cardiovascular diseases, and mood disorders. Circadian rhythm disturbances are particularly relevant for understanding the etiology of conditions like insomnia, depression, and anxiety. The circadian rhythm, primarily regulated by the suprachiasmatic nuclei (SCN) in the hypothalamus, coordinates biological processes to align with daily environmental cycles. Acute stress, especially when experienced immediately upon waking, has been shown to disrupt these rhythms, impair sleep regulation, and exacerbate mood dysregulation. Given the significant clinical implications, understanding how stress impacts circadian rhythms is …

High Times, Higher Stakes: Mental Health Impacts In New Recreational Marijuana Legal Landscape, Jason T. Lorenzon J.D., Chris Pezalla, Diana Semilia

National Training Aircraft Symposium (NTAS)

This presentation delves into the societal and mental health consequences arising from the increasing trend of legalizing recreational marijuana. Specifically, we will examine the potential normalization of unconventional behavior among aviation college students, who may grapple with substance use challenges due to stress, sleep difficulties, and the demands of college life. Given the rigorous nature of flight training, prioritizing the mental well-being of pilots becomes imperative.

With the recent legalization of recreational marijuana in Ohio, this presentation integrates insights from Diana Semilia's 2022 study on Kent State Flight Students Ages 19-26. The study's objective was to extract practical recommendations applicable …

Assessing The Effects Of Experimentally Contrived Negative Emotional Contexts On Affect, Willingness, And Impulsivity, Amanda Nicole Middleton

Graduate Theses/Dissertations

Emotions are a naturally occurring and unavoidable part of life. To investigate the role that negative emotional experiencing plays in transfer of stimulus function, relational behavior, and intervention effectiveness, this thesis combines and explores the implications of two manuscripts that examine the effects of negative emotional contexts. Specifically, the first chapter presents research demonstrating the ability of operant schedules of reinforcement and respondent relational training to result in acquired affective and willingness stimulus functions. A between groups design demonstrated that when paired with a frustration-inducing task, negatively valenced functions can be established for arbitrary stimuli, and when observational pairing was …

Sex Differences In Stress Reactivity, Brain Morphology, And Oxytocin In The Hypothalamus Of The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Zacarias, Daniela Rodriguez, Alexandra Chalons, Sasawan Heingraj, Nicole Altamirano, Joseph Rafac, John L. Vandeberg, Mario Gil

Research Colloquium

Understanding the effects of stress on behavior and cognition is important due to its impact on mental health and wellbeing (Schneiderman et al. 2005). Translational animal research can contribute to the development of new treatments that can improve therapeutic outcomes and our understanding of the neurobiology of stress. In the present study, we complement behavioral stress reactivity with immunohistochemical localization of oxytocin in the hypothalamus, a neuropeptide that regulates stress (Neumann & Slattery, 2016). Oxytocin has potential therapeutic use for mental health disorders (Neumann & Slattery, 2016), and the effects of oxytocin seem to be sexually dimorphic (Love, 2018). Using …

The Impact Of Biological Sex On Motor Function And Responses To Novel Environments In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Ismael Perez, Sasawan Heingraj, Katelynn Renteria, Cristian M. Botello, Joseph C. Cantu, John L. Vandeberg, Mario Gil

Research Symposium

Background: Understanding the different stress reactions in different environments can help us understand stress factors. Studying animal behavior is important for translational research for mental health improvement.

Previous literature has shown that stress is a risk factor for higher cancer incidence and poorer cancer survival. (Klejbor & Turlejski., 2012), as well as mental health outcomes. Understanding of how stress is related to cancer can help improve therapeutic outcomes as preventive measures (Glaser et al., 1987).

Methods: Using the Rota Rod apparatus, 12 animals (3 males, 9 females) were tested at 36 rpm for a maximum of 400 seconds (Madroñal et …

Comparison Between The Effects Of Acute Physical And Psychosocial Stress On Feedback-Based Learning, Xiao Yang, Brittany Nackley, Bruce H. Friedman

Psychology Faculty Publications

Stress modulates feedback-based learning, a process that has been implicated in declining mental function in aging and mental disorders. While acute physical and psychosocial stressors have been used interchangeably in studies on feedback-based learning, the two types of stressors involve distinct physiological and psychological processes. Whether the two types of stressors differentially influence feedback processing remains unclear. The present study compared the effects of physical and psychosocial stressors on feedback-based learning. Ninety-six subjects (Mage = 19.11 years; 50 female) completed either a cold pressor task (CPT) or mental arithmetic task (MAT), as the physical or psychosocial stressor, while electrocardiography and …

The Benefits Of Art Therapy On Stress And Anxiety Of Oncology Patients During Treatment, Helen Shiepe

Expressive Therapies Capstone Theses

Within the last ten years research on art therapy and its positive impact on oncology patients’ stress and anxiety during treatment has been minimal. Oncology patients whether they are children or adults when diagnosed experience similar reactions due to their diagnosis, treatment, and in some cases end of life care. The current question is whether or not art therapy does have a positive impact on decreasing the stress and anxiety with oncology patients while undergoing treatment. Deane, Fitch & Carmen (2000), discussed art therapy as a healing art that is “intended to integrate physical, emotional, and spiritual care by facilitating …

Success Over Stress Support Group, Sophia Pescador-Torrance

Capstone Projects and Master's Theses

The Harden Wellness Center is located in Salinas, California on the campus of Harden Middle School. After surveying and interviewing eighth-grade students at Harden Middle School, it was determined that there was a need to provide healthy coping skills for stress and anxiety. The project provided students a place to learn healthy coping skills along with normalizing mental health services among adolescents. In order to engage students and keep them interested each week, focus on a new skill with an activity attached to reinforce the coping skill. By the end of the six weeks, the group started to talk about …

What Cognitive Processes Drive Attentional Bias, And How Does Stress Affect Them?, Colton L. Hunter

Graduate Theses and Dissertations

Attentional biases toward or away from emotionally evocative stimuli have been well documented and related to clinical outcomes such as social anxiety. Some work has suggested that stress modulates attentional biases, but there are a number of inconsistencies in this literature regarding the direction of that modulation, highlighting a need to examine moderators of that effect. Sex differences in stress effects could potentially explain this inconsistency, as acute stress can affect males and females differently. It is also possible that stress differentially influences multiple component processes underpinning attentional bias, but these processes have not been well character, and to date …

Effects Of A Psychological Stressor On Methamphetamine Seeking In Rats., Kayla B. Cox

Psychology ETDs

Although methamphetamine abuse and fatality rates are on the rise in the United States, there are currently no FDA approved drugs to treat methamphetamine use disorder (MUD). To better understand factors contributing to addiction, researchers have designed various rodent models of stress including the use of footshock, social defeat and maternal separation, however, these models involve physical or early life stress exposure and thus are less translatable to human psychological stress. The present study implemented predatory odors as a model of psychological stress and examined whether chronic exposure to these stressors enhanced subsequent vulnerability to a subthreshold dose of methamphetamine. …

Effects Of Social Context On Salivary Cortisol And Attention In Tufted Capuchins (Cebus [Sapajus] Apella), Andrew Desana

Master’s Theses

Social context alters cognitive performance, but the mechanisms for this remain unclear. One possibility is that stressors associated with social contexts mediate changes in cognitive performance by influencing attention. We conducted two experiments to investigate how social context affects performance on an attention task in capuchin monkeys (Cebus [Sapajus] apella). We additionally validated and measured physiological stress through salivary cortisol. In experiment one, capuchins were exposed to three conditions where they were either isolated or paired with an affiliative or agonistic social partner separated by a barrier. In experiment two, subjects received affiliative and agonistic conditions without barriers to allow …

The Impact Of Mindfulness Practices In Teachers, Shawn M. Martin Hettinga

ATU Theses and Dissertations 2021 - Present

Mindfulness training has been identified as a promising means for cultivating social and emotional competencies and reducing stress. The purpose of the quantitative pre-post study using convenience sampling of educators in a rural K-12 in the Arkansas River Valley was to examine whether teachers’ participation in mindfulness activities were associated with changes in levels of stress, anxiety, depression, and job satisfaction. The study used the Depression, Anxiety, and Stress Scale (DASS-21) and the Job Satisfaction Survey (JSS) and measured the responses from novice (0-3 years) and experienced (4+ years) teachers. The findings revealed that there was no difference between the …

Evaluation Of Hippocampal Allostatic Load-Associated Factors In Animal Models Of Post-Traumatic Stress Disorder: Relevance To Human Ptsd, Dennis Parker Kelley

LSU Doctoral Dissertations

Post-traumatic stress disorder (PTSD) is associated with elevated allostatic load, nearly double the risk for metabolic syndrome, reduced hippocampal volume, and contextual memory processing deficits. Emerging evidence suggests that these stress effects may predispose individuals to the development of PTSD, and there is a known relationship between chronic stress and metabolic dysfunction. In this work, we utilized two rat models of PTSD to explore these connections. We used an acute predator odor stressor to investigate the relationship between PTSD-like behaviors and mitochondrial dysfunction in the hippocampus of rats, and we observed that conditioned place avoidance was associated with reduced mitochondrial …

Differences In Compulsive-Like Ethanol Consumption In Adolescent-Trained And Adult-Trained Rats Exposed To Acute Isolation Stressors, Maria J. Lopez

Seton Hall University Dissertations and Theses (ETDs)

The Pavlovian Conditioned Approach (PCA) procedure is an experimental procedure used with animals to induce compulsive-like behaviors directed towards an object conditioned stimulus (CS) paired with a sucrose pellet unconditioned stimulus (US) presented in a nearby food tray (sign tracking). When the object CS is an alcohol-containing bottle, the rats demonstrate compulsive-like interactions with the bottle object (e.g., approach, contact, and licking) that also results in alcohol consumption (drinking) in most rats. Compulsive alcohol drinking in a sign-tracking procedure is a result of the combined effects of schedule-induced compulsive-like behavior and the intake of alcohol (Tomie & Sharma, 2013).

The …

Understanding Racial Experiences And The Influence Of Family On Stress And Familism Attitudes, Jaqueline Miranda

College of Graduate Studies: Theses & Dissertations

Sixty-five percent of undergraduates reported family as their most important in-group and 79% reported family as being in their top three in-groups (McConnell, 2019). Familial bonds are vital for racial ethnic minorities because of their unique experiences as minorities such as experienced racism, acculturative stress, and other forms of adversity. The current study examined the effects of a racially-based stress induction and imaginal exercise on state stress levels and familial attitudes, and the relationship between racial-ethnic socialization and racial battle fatigue including kinship social support as a moderator. The study used an experimental design, manipulating stress induction through a script …

Frontal Alpha Wave Asymmetry In Regard To Affect, Monica Leigh Sewell

All Master's Theses

This study examines frontal alpha brain wave asymmetry (FAA) in relation to emotion processing. Previous research has shown that differences between left versus right FAA could exhibit a neurological marker for emotional intelligence (EI), mental health, and stress. Behavioral data were collected using Profile of Emotional Competence Questionnaire, Perceived Stress Questionnaire, Patient Health Questionnaire-9, and the Generalized Anxiety Disorder-7. This was followed by a series of resting EEG recordings. This study hypothesizes that participants who are mentally healthy, have higher EI scores and lower stress will display greater left FAA. The hypothesis is partially supported; participants with depression had greater …

The Influence Of Wearing A Fitbit On Eating Behaviors While Stressed, Maria C.M. Sparacino

Honors Theses

Research has demonstrated stress leads to consuming foods of lower nutritional quality as well as a greater quantity of foods. Visual primes have been shown to reduce these detrimental eating behaviors. The present study sought to determine if a fitbit would prime healthy eating behaviors in stressful situations. Participants (N = 41) were randomly assigned to a high or low stress condition, manipulated through the Stroop Test, and were either given a fitbit prime or not. Participant’s food preferences were assessed with the Macronutrient Preference Checklist- Modified for use in North America following the stress manipulation. The results generally …

Finding Meaning At Work: The Role Of Inspiring And Funny Youtube Videos On Work-Related Well-Being, Sophie Janicke-Bowles, Diana Rieger, Winston Connor Iii

Communication Faculty Articles and Research

Watching online videos on social media is a common activity in today’s digital age, but its’ impact on employee well-being at work has not been investigated yet. The current study tried to fill this gap by investigating the role hedonic and eudaimonic online videos play on employee’s stress levels and well-being at work. An online experiment with 200 full time employees in the US was conducted exploring the role of inspiring affect and positive affect on three distinct well-being outcomes: subjective well-being, psychological well-being and social well-being at the workplace. A path model suggests unique effects for inspiring videos on …

Reward Preferences In Domestic Horses (Equus Caballus), Elizabeth E. Jaeger

Theses and Dissertations

The present study examined stress response in domestic horses (Equus caballus) to determine if horses show preference for either traditional or natural horsemanship training methods to test the hypothesis that natural horsemanship would induce less stress. Our results show that natural horsemanship rewards elicited lower stress response in horses.

The Psychophysiological Correlates Of Personality, Trauma, Posttraumatic Stress Disorder And Social Support, Meghan E. Pierce

UNLV Theses, Dissertations, Professional Papers, and Capstones

Theories considering the etiology of psychopathy suggest that trauma exposure, specifically childhood maltreatment and sexual abuse, is related to the development of callous-unemotional traits in children and adolescents, which are precursors to psychopathic traits in adulthood. Furthermore, posttraumatic stress disorder has an opposite relationship with many of the emotional and behavioral components of the two-factor model of psychopathy. Specifically, PTSD is positively associated to IA and traits associated with it and negatively associated with FD. Thus, this study sought to expand upon the current theories of a trauma-based etiology of psychopathy by investigating the relationship between trauma, PTSD, and psychopathic …

One-Session Mindfulness Meditation: The Effects Of Stress Anticipation, Christina Dorothy Colgary

Seton Hall University Dissertations and Theses (ETDs)

The current study concerns three main questions that are related to mindfulness meditation: the benefits of a brief preventative one-session mindfulness meditation, the effects of mindfulness meditation compared to a concentrative meditation, and correlations between rumination and stress when facing anticipated and unanticipated stressors. Type of meditation and whether or not participants could anticipate an upcoming stressor were varied in four conditions. Participants completed one 20-minute session of either mindfulness meditation or guided imagery meditation and were informed of a speech preparation task either before or after completing the meditation. Both one-session of mindfulness meditation and guided imagery meditation were …

Locus Of Control, Self-Efficacy, And The Mediating Effect Of Outcome Control: Predicting Course-Level And Global Outcomes In An Academic Context, Evelyn W. M. Au

Research Collection School of Social Sciences

Background and Objectives. The current study utilizes Skinner's framework to examine the unique contributions of internal locus of control, self-efficacy, and perceived outcome control over course performance on students' academic experiences. Method. Undergraduate students (N = 225) took part in a longitudinal study and completed two surveys (Time 1: just before their mid-term exams; Time 2: just before their final exam in the same semester). Results. Both locus of control and self-efficacy at Time 1 predicted course-level perceived control over course performance at Time 2. Student-level perceived control over course performance at Time 2 mediated the relationship between self-efficacy at …

Effects Of Early-Adolescent, Mid-Adolescent, Or Adult Stress On Morphine Conditioned Place Preference, Chloe Shields

Senior Theses

In light of previous work demonstrating that stress can increase subjective drug reward in adult rats, the present study investigated the influence of stress on morphine conditioned place preference (CPP) in early-adolescent, mid-adolescent, and adult male Sprague-Dawley rats. Subjects in each age group were assigned to either a no stress condition or a stress condition in which they were exposed to an unpredictable eight-day schedule of elevated platform and synthetic fox odor stressors. Place conditioning then evaluated subjective morphine reward in all animals. Using a biased procedure, subjects were assigned to receive morphine on the initially non-preferred side of the …

The Interaction Between The Physical Environment And Metaphysical States: The Role Of Social Anxiety And Stress In Informing Spatial Perception, Emily Koelmel

Senior Independent Study Theses

No abstract provided.

The Effect Of Improvisations And Observations On Standardized Patient Encounters, Subjective Workload And Stress, Elizabeth T. Newlin-Canzone

Psychology Theses & Dissertations

Standardized patients (SPs) are people trained to present a medical case for teaching and assessing medical students and they simultaneously perform several demanding tasks including portraying the patient, assessing the learner, and providing feedback. This study investigated the effect of improvisations and multiple task performance on the ability to observe another's nonverbal (NV) behaviors and rate their communication skills. Subjective reports of mental workload and stress were also obtained. The first study involved undergraduates interviewing for a job. Type of interview (rote and improvisational) and type of observation (passive and active) were manipulated within groups. Based on theories of attention …

Aged Rats: Sex Differences And Responses To Chronic Stress, Rachel E. Bowman, Neil J. Maclusky, Samantha Diaz-Weinstein, Mark C. Zrull, Victoria N. Luine

Psychology Faculty Publications

Cognitive, as well as physiological, sex differences exist in young adult rats under both basal conditions and following chronic stress; however, few studies have examined whether sex differences remain in aged subjects and whether responses to stress are altered. We compared aged male and female Fischer 344 rats (21.5 months at testing) without stress and when given 21 days of restraint for 6 h/day on locomotion, anxiety-related behaviors, object recognition (non-spatial memory), object placement (spatial memory), body weight and serum steroid hormone levels. Control (unstressed) females had lower levels of estradiol and testosterone and higher corticosterone than males, and stress …

Chronic Restraint Stress Enhances Radial Arm Maze Performance In Female Rats, Rachel E. Bowman, Mark C. Zrull, Victoria N. Luine

Psychology Faculty Publications

Effects of chronic restraint stress (21 and 28 days) on physiological and behavioral parameters in female rats were examined. Total (bound and free) and free corticosterone (CORT) levels were measured at different time points during the stress period. Higher total CORT levels were observed in stressed rats during the stress period but returned to baseline at 15 days poststress. Additionally, free CORT levels decreased across the stress period. Estrous cyclicity was monitored daily in all animals. Stress had no apparent effects on estrous cyclicity, in rats with either normal length or elongated estrous cycles, but stressed females gained less weight …