Experimental Analysis of Behavior Commons^™

Evaluating Preference-Seeking And Aversive Qualities Of Salvia Divinorumand Mitragyna Speciosa, Melissa Jane Loria

Electronic Theses and Dissertations

Use of botanicals for self-diagnosed conditions or recreational purposes is increasing. Many readily available botanicals are under-researched and little is known about potential liabilities. This study sought to utilize Conditioned Place Preference (CPP) to quantify rewarding or aversive properties of botanicals and their constituents in rats. This paradigm is based on the notion that animals prefer distinct environments previously paired with rewarding drugs. Our approach to broadly characterize a botanical and its many constituents entails dose response functions of a plant extract, its fractions, and its primary constituent. As a proof of concept, we chose two popular botanicals, one expected …