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Full-Text Articles in Experimental Analysis of Behavior
Individual Behavioral And Neurobiological Markers Associated With Vulnerable To Ethanol Use Phenotype, Hannah Elizabeth Manning
Individual Behavioral And Neurobiological Markers Associated With Vulnerable To Ethanol Use Phenotype, Hannah Elizabeth Manning
Honors Theses and Capstones
Alcohol use disorder is a chronic, relapsing brain condition that affects 29.5 million Americans. The disease is characterized by loss of control over drinking, continued use of alcohol in the face of negative consequences, and the experience of withdrawal symptoms. While there are several forms of treatment available for alcohol use disorder, 95% of patients experience at least one relapse during recovery. Currently, the high tendency to relapse remains the major challenge standing in the way of successful treatment for alcohol use disorder. Research is continuing to be conducted into the behavioral and neural mechanisms underlying relapse into alcohol use, …
Effects Of Intermittent Alcohol And Nicotine Cc-Consumption In C57bl/6j Mice, Presley Elizabeth Fletcher
Effects Of Intermittent Alcohol And Nicotine Cc-Consumption In C57bl/6j Mice, Presley Elizabeth Fletcher
Undergraduate Honors Thesis Collection
Two of the world’s leading causes of preventable deaths include the use of alcohol and tobacco. While independently these substances have negative consequences, they are often used in combination. For instance, those who are dependent on nicotine are more likely to engage in hazardous drinking and/or have a dependence on alcohol and vice versa. As different methods of consuming nicotine become more normalized, there is a concern of associated harmful alcohol consumption being that both substances are widely available and rewarding. The goal of the current study was to understand the relationship between nicotine and alcohol and the behavioral effects …
Cannabinoid-Induced Behavioral Sensitization In Adolescent Sprague-Dawley Rats, Michelle Stone
Cannabinoid-Induced Behavioral Sensitization In Adolescent Sprague-Dawley Rats, Michelle Stone
Electronic Theses, Projects, and Dissertations
Adolescent cannabis use has grown because of increased availability and higher societal acceptance. This increase in cannabis use is problematic as adolescents who experiment with cannabis are more likely to abuse cannabis and experiment with other illicit drugs such as cocaine. The reason for the greater susceptibility to drugs use is unclear and may be the result of altered drug sensitivity after cannabis exposure. Thus, the present investigation used the behavioral sensitization paradigm to examine the behavioral response of early adolescent rats to the cannabinoid agonist CP 55,940 (CP) or cocaine after repeated cannabinoid administration. It was hypothesized that: (1) …
Examining The Roles Of Sex, Methamphetamine, And Degree Of Training In Habit Formation In Rats, Hannah Schoenberg
Examining The Roles Of Sex, Methamphetamine, And Degree Of Training In Habit Formation In Rats, Hannah Schoenberg
Graduate College Dissertations and Theses
Addiction is characterized by a progressive loss of executive control over drug-seeking and consumption, and may be associated with a behavioral shift from instrumental goal-directed actions to stimulus-response habits. Sex differences in drug addiction have been linked to changing hormone levels across the estrous cycle, and females exhibit a particular vulnerability to psychostimulants such as cocaine and amphetamines. Psychostimulants and estrogen both influence dopaminergic activity in the dorsal striatum, a region of the brain in which dopamine activity is thought to mediate the shift from action to habit. In the present set of experiments, we examined the roles of sex, …
Evaluating Preference-Seeking And Aversive Qualities Of Salvia Divinorumand Mitragyna Speciosa, Melissa Jane Loria
Evaluating Preference-Seeking And Aversive Qualities Of Salvia Divinorumand Mitragyna Speciosa, Melissa Jane Loria
Electronic Theses and Dissertations
Use of botanicals for self-diagnosed conditions or recreational purposes is increasing. Many readily available botanicals are under-researched and little is known about potential liabilities. This study sought to utilize Conditioned Place Preference (CPP) to quantify rewarding or aversive properties of botanicals and their constituents in rats. This paradigm is based on the notion that animals prefer distinct environments previously paired with rewarding drugs. Our approach to broadly characterize a botanical and its many constituents entails dose response functions of a plant extract, its fractions, and its primary constituent. As a proof of concept, we chose two popular botanicals, one expected …