Experimental Analysis of Behavior Commons^™

Exercise As A Therapeutic For Hiv-1-Associated Neurocognitive Deficits, Michael N. Cranston

Theses and Dissertations

Human Immunodeficiency Virus (HIV-1) afflicts nearly 38 million individuals worldwide (Joseph et al., 2013; “WHO | HIV/AIDS,” 2016). Despite the reduction in disease mortality due to increased use of antiretroviral medication, HIV-1 associated neurocognitive disorder (HAND) affects approximately 50% of HIV infected individuals (Antinori et al., 2007; Castellon, Hinkin, Wood, & Yarema, 1998; Castelo, Sherman, Courtney, Melrose, & Stern, 2006; Cysique & Brew, 2009; Heaton et al., 2011, 2015). The brain itself is particularly sensitive to HIV-1 related viral proteins and viral infection (Masliah, DeTeresa, Mallory, & Hansen, 2000), thus, it is vital to empirically examine potentially effective therapeutics which …

Advancing Understanding Of Dynamic Mechanisms In Onset To Event Models: Discrete Time Survival Mediation With A Time Variant Mediator, Heather Lasky Mcdaniel

Theses and Dissertations

Integrating discrete time survival and mediation analytic approaches, discretetime survival mediation models (DTSM) help researchers elucidate the impact of predictors on the timing of event occurrence. Though application of this model has been gainful in various applied developmental and intervention research contexts, empirical work has yet to consider how DTSM models operate with a mediator that has a varying effect over time. The importance of examining this situation has important impacts for application of the model, given more complex statistical models are required, and subsequent interpretation of model parameters differ from the basic DTSM model. The overarching purpose of this …

Questioning The Modality Of The Occipital Lobe, William J. Brixius

Theses and Dissertations

This dissertation explores the occipital lobe’s response to non-visual inputs, and whether this responsivity partitions into separate localization and identification pathways as seen with visual inputs. We hypothesized that occipital areas may merely prefer visual inputs, while maintaining similar task-based sensory recruitment in response to other senses. Our secondary hypothesis was that the robust occipital activation seen in late-blind participants stems at least initially from standard connections present even in the typically sighted, and that these standard connections are functionally utilized by the typically sighted in spatially relevant non-visual analyses. Our initial literature review supported our hypotheses that the occipital …

Evaluative Conditioning Of Product Preferences: An Eye-Tracking Perspective, Christine E. Weber

Theses and Dissertations

In evaluative conditioning, the affective response toward a neutral stimulus is altered by pairing it with a positive or negative stimulus. One behavioral and two eye tracking studies were conducted to investigate how evaluative conditioning operates on consumer preferences by pairing neutral products with valenced music and using multiple product exemplars and test trials in order to test evaluative effects at the individual level. Study 1 showed an overall positive effect of evaluative conditioning on choice and liking ratings, although there were individual differences in the magnitude and direction of the effect. Study 2 found significant results at the individual …

Neurochemistry, Physiology, And Behavior In A Model Of Gulf War Illness, Victoria A. Macht

Theses and Dissertations

Upon returning from the first Gulf War, soldiers cited a plethora of unexplained physical and cognitive deficits which have since been termed Gulf War Illness (GWI). Presentation of GWI is positively correlated with pyridostigmine bromide (PB) use, which was prophylactically administered to soldiers in response to threats of chemical warfare. To test the overarching hypothesis that PB interacted with stress of deployment to alter neural, endocrine, and immune systems, the following studies used a 2×2 rodent model with 14 days of drug treatment (vehicle; PB) and 10 days of repeated restraint stress (stressed) or non-stressed-control conditions. Results indicate that PB …

Development Of Brain Functional Connectivity And Its Relation To Infant Sustained Attention In The First Year Of Life, Wanze Xie

Theses and Dissertations

This dissertation project studies the development of infant sustained attention and its relation to brain functional connectivity from 6 to 12 months of age. Chapter 1 is a general introduction of the dissertation project. Chapter 2 is a review of the existing literature on the development of infant sustained attention. This chapter includes theories on infant sustained attention and findings from studies using behavioral and psychophysiological measurements. Chapter 3 is a review of the recent advances made in the study of the development of functional connectivity in brain networks. This chapter covers some empirical evidence for the development of functional …

Dimensionality And Instrument Validation In Factor Analysis: Effect Of The Number Of Response Alternatives, Alexander G. Hall

Theses and Dissertations

Despite the great prevalence in both research and application of Factor Analysis (FA), widespread misinterpretation continues to pervade the psychological community in its application for the development and evaluation of psychometric tools. Fundamental measurement questions such as the number of response alternatives needed, and the power to detect poor model fit in non-normal or misspecified data, still remain in need of further investigation. For example, the power of the chi-square statistic used in structural equation modeling decreases as the absolute value of excess kurtosis of the observed data increases. This issue is further compounded with discrete variables, where increasing kurtosis …

Scene Search Guidance Under Salience-Driven And Memory-Driven Demands, Jenn Ha’Aheo Olejarczyk

Theses and Dissertations

Visual search involves selecting relevant information while ignoring irrelevant information. Most search models predict what relevant features attract gaze; yet few consider search guidance from previous knowledge of scenes. This dissertation used eye movements to examine the guidance of attention when an immediate or delayed distractor appeared during novel and repeated searches.

The experiments showed efficient search for repeated scenes, a classic result of contextual cueing. During repeated searches, an immediate attentional bias was found for distractors close to the target location. Automatic and controlled selective attention processes, measured using the antisaccade, were found within search behavior. The final experiment …

Perceived Emotional Invalidation In A Developmental Context: Does Gender Matter?, Brian B. Johnson

USC Aiken Psychology Theses

Emotional invalidation is the dismissal, minimization, or punishment of an individual’s emotional experience (Linehan, 1993). Although it has been sparsely studied, the research that has been conducted indicates that it is likely implicated in a multitude of psychopathology and adjustment issues. The current study had three main objectives. The first of these was to investigate the current perceptions of emotional invalidation in a peer interaction for emerging adults and how that is predicted by gender, perceptions of childhood emotional invalidation via caregivers, and gender of the caregivers. The second objective of this study was to investigate the propagation of emotionally …

Reinstatement Of Second-Order Fear, Matthew Nelson

USC Aiken Psychology Theses

The purpose of this study was to determine if, after conditioning and extinction of a second-order stimulus, reinstatement of extinguished fear could be produced. The findings of Holmes et al. (2014) do not support reinstatement of second-order fear following post-extinction presentation of the unconditioned stimulus (US). The present study provides a second attempt at uncovering reinstatement following extinction of second-order conditioning. Rat subjects were randomly assigned to 5 groups (n=12), which received first- and second-order conditioning with Light and Tone counterbalanced. Responding to the second-order stimulus (S2) was extinguished through S2-alone presentations for all but the control subjects (Group NE-NR). …

The Neural Representation Of Duration In Event Concepts, Christopher Todd Hackett

Theses and Dissertations

Little is known about the neural basis of temporal concepts. Some have suggested that temporal concepts are grounded in spatial or temporal processes. Here we aimed to examine the representation of duration of event concepts, and compare them with judgments of object size, which may entail spatial processing. A 2x2 block design used event and object nouns as stimuli that were presented during functional imaging. Participants made judgments about event duration, object size, and event and object valence. In addition to whole-brain analyses, we examined activations in areas known to be involved in temporal processing and spatial processing. Knowledge of …

Iv Prenatal Nicotine Exposure Modulates Α6, Α7, And Α4Β2 Nicotinic Acetylcholinergic Receptor Subunit Expression In Male And Female Neonatal And Adolescent Rat Offspring: An Autoradiographical Analysis, Amanda Morgan

Theses and Dissertations

Maternal smoke exposure produces long-term adverse cognitive and behavioral outcomes in offspring, including an increased likelihood of attention problems (e.g., attention deficit hyperactivity disorder; ADHD) and drug abuse. Preclinical research shows that gestational exposure to nicotine, the primary psychoactive compound in tobacco smoke, influences the neurodevelopment of attention and reward neuronal circuits. This study investigated hypotheses about five brain regions, to determine if prenatal nicotine (PN) exposure altered expression of nicotinic acetylcholine receptors (nAChRs). A low dose, intravenous nicotine (IV) exposure method was used to administer nicotine (0.05 mg/kg/injection) or saline, 3x/day on gestational days 8–21 (Treatment). Brain tissue was …

Structural, Functional, And Behavioral Alterations To The Dopamine System In The Female Hiv-1 Transgenic Rat, Robert Francis Roscoe Jr.

Theses and Dissertations

HIV-associated cognitive disorders continue to affect approximately 25 million individuals worldwide, and its prevalence is expected to increase as the lifespan of HIV-1 infected individuals continues to improve. The HIV-1 transgenic rat expresses 7 of the 9 genes that encompass the virus, and is an appropriate model for studying chronic HIV-1 infection at a level that is controlled through combined antiretroviral therapy. Psychostimulant abuse is known to exacerbate HAND symptomology, but the psychostimulant methylphenidate is a first line of treatment for HIV associated cognitive inhibition. Dopamine transport abnormalities in the HIV-1 Tg rat have been well characterized through behavioral testing; …

Adult Attachment Styles And Psychopathic Traits: A Relationship Mediated By Empathy And Emotional Regulation?, Chelsea Heim

USC Aiken Psychology Theses

Psychopathic personality traits encompass an array of characteristics that emerge early in life and are influenced by insecure attachments between children and their parents. Disruptions in parent-child interactions also affect the development of empathy (Panfile & Laible, 2010) and emotion regulation (Waters, S. F., Virmani, E. A., Thompson, R. A., Meyer, S., Raikes, H. A. & Jochem, R., 2010), which contributes to lasting impairments in interpersonal working models about the self and others (Mack, Hackney & Pile, 2010). The interactions between psychopathy and insecure attachment, low levels of empathy, and the ability to regulate one’s emotions have been separately investigated …

Representation Of Affect From Fmri Data As A Function Of Stimulus Modality And Judgment Task, Jongwan Kim

Theses and Dissertations

The theory of core affect posits that the neural system processes affective aspects of stimuli encountered by the organism quickly and automatically, resulting in a unified affective state described along the dimensions of valence and arousal. Core affect theory posits two functional subsystems that guide affective processing: a sensory integration and a visceramotor network. The proposed study investigates how the representation of affective dimensions depends on sensory modality, features of the task, and brain regions. A series of behavioral studies was run to develop an experimental stimulus set of silent videos and musical clips that met requirements of equating valence …

The Syntax-Space Effect, Timothy W. Boiteau

Theses and Dissertations

Previous research has linked the concept of number and other ordinal series to space via a spatially-oriented number line. Other researchers have shown that language as well may have an underlying spatial representation, though this seems to be tied to visual scene recognition and production and is potentially an idiosyncratic effect of a limited set of concrete verbs. In this dissertation, employing a novel method that measures the underlying spatial biases of actors in transitive sentences, I show that findings from previous studies showing a relationship between transitivity and space reflect an interaction between word order in the sentence, order …

Sleep Extension And Stable Sleep Schedules In Older Adults, Alexandria M. Reynolds

Theses and Dissertations

There is consistent evidence demonstrating a “U-shaped” association between sleep duration and mortality, as well as several morbidities, such as increased systemic inflammation, decreased cognitive performance, and mood disturbances. Much of the information on long sleep is epidemiological in nature. The present study examined the associations between sleep duration and extension on mood, inflammation, and cognition. Ten (50-79 y) healthy adults who report sleeping 6-8 h were assessed on cognitive, emotional, and inflammatory measures in a cross-over design. Following a baseline week, participants were randomized to one of two three-week treatments: (1) a control treatment of habitual time in bed; …

Alterations To Taste Preference In Mc4r Haploinsufficiency Manifest Prior To Dietary Induced Obesity And Are Accompanied By Dendritic Spine Alterations To Medium Spiny Neurons Of The Nucleus Accumbens In Adulthood, Robert Francis Roscoe Jr.

Theses and Dissertations

Obesity has reached epidemic proportions in the United States and has become an increasing public health concern for developed nations. Haploinsufficiency of melanocortin receptor 4 has been identified as the single most common monogenetic cause of obesity in humans. Using the MC4R +/- haploinsufficient rat, we sought to determine potential alterations in body weight and morphology, locomotor activity, sucrose concentration preference, and progressive-ratio operant testing in a dietary-induced obesity environment. Rats were placed on four separate diets corresponding to 1.7% saturated fat with 12.2% total kcal/fat, 6% saturated fat with a 40% total kcal/fat, 12% saturated fat with a 40% …

Generalization Of Fear Effects In Reinstatement To A Discrete Stimulus, Lauren Best

USC Aiken Psychology Theses

The purpose of this study was to investigate generalization of reinstated fear effects to a discrete stimulus. McAllister and McAllister (2006) reported that reinstated fear could generalize over time to similar contexts. The present study aimed to determine if reinstated fear could generalize to similar or different stimuli than conditioning after a long delay between reinstatement and testing. Rat subjects were randomly assigned to six groups (n = 10) which received conditioning and extinction to a 3000 Hz tone. Reinstatement conditioning was then conducted with either the same, similar, or different CS as used in conditioning. Testing for reinstated fear …

Language Characteristics Of Individuals With Down Syndrome, Gary E. Martin, Jessica Klusek, Bruno Estigarribia, Joanne E. Roberts

Faculty Publications

No abstract provided.