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Experimental Analysis of Behavior Commons™
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- Drug discrimination (2)
- Amphetamine (1)
- Antipsychotic (1)
- Chlorpromazine (1)
- Clozapine (1)
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- Conditioned place preference (1)
- Discriminative stimulus (1)
- Estradiol (1)
- Gabapentin (1)
- Locomotion (1)
- MAOI (1)
- Methylene blue (1)
- Mice (1)
- Monoamine oxidase inhibitor (1)
- Nicotine (1)
- Norharmane (1)
- Quinacrine (1)
- Rats (1)
- Schedule-induced polydipsia (1)
- Sex differences (1)
- Stereotypy (1)
- Stimulus generalization (1)
- The estrous cycle (1)
Articles 1 - 4 of 4
Full-Text Articles in Experimental Analysis of Behavior
Assessment Of Sex Differences And Amphetamine On Schedule-Induced Polydipsia, Min Park
Assessment Of Sex Differences And Amphetamine On Schedule-Induced Polydipsia, Min Park
All NMU Master's Theses
Amphetamine (AMPH) is one of the most common psychotropic drugs abused in the United States. Its major pharmacological effect is to increase synaptic dopamine levels in the mesolimbic reward pathway, which in turn causes behavioral effects in animals, and subjective effects in humans. These reinforcing properties of AMPH trigger very strong levels of craving the drug, and eventually result in patterns of compulsive use of AMPH. Regarding psychostimulant action, female rats have been reported to be more vulnerable to the reinforcing effects of psychostimulants. In the current study, schedule-induced polydipsia (SIP), an animal model of compulsive behavior, was applied for …
Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander
Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander
All NMU Master's Theses
This study attempted to further explore the discriminative stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do so reliably, however nine of ten rats trained to discriminate 1.25 mg/kg clozapine from vehicle were able to acquire the discrimination in 19.1 sessions. The clozapine cue partially generalized (63.13% drug lever responding [SEM = ± 18.91]) to the antimalarial drug methylene blue at the 7.5 mg/kg dose, but not to the antimalarial quinacrine. …
Effects Of Norharmane And Nicotine On The Conditioned Place Preference Of Mice, Lindsey Galbo
Effects Of Norharmane And Nicotine On The Conditioned Place Preference Of Mice, Lindsey Galbo
All NMU Master's Theses
Tobacco smoking in the United States is used by approximately 25% of adults. Many studies using animal models have suggested that nicotine has rewarding properties. Contrastingly, several studies have also found it to be a weakly reinforcing substance at low and high dose levels. Due to this, other tobacco constituents, such as the monoamine oxidase inhibitor norharmane which is found in tobacco leaf and smoke, may be responsible for tobacco addiction by potentiating the rewarding properties of nicotine. Several studies have attempted to observe this phenomenon, however, monoamine oxidase inhibitors that are not found in tobacco leaf or smoke have …
Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
All NMU Master's Theses
The present study sought to evaluate the discriminative stimulus effects of the anticonvulsant gabapentin in rats trained to discriminate 30.0 mg/kg gabapentin from vehicle in a two-lever drug discrimination task. All of the ten rats tested were able to establish gabapentin as an interoceptive cue. Gabapentin produced full generalization (≥ 80% gabapentin-lever responding) for itself at 30.0, 60.0, and 120.0 mg/kg doses. Pentobarbital produced full substitution, while pregabalin, carbamazepine, fentanyl, and buspirone produced partial substitution (≥ 60% gabapentin-lever responding) for gabapentin. Ethanol and raclopride did not substitute for gabapentin. The psychostimulant amphetamine did not produce substitution; however, the 0.25 mg/kg …