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Articles 1 - 30 of 131
Full-Text Articles in Experimental Analysis of Behavior
Seeing The Unspoken: A Pilot Eye-Tracking Study Of Moral Injury Among Veterans, Eva M. Valdez
Seeing The Unspoken: A Pilot Eye-Tracking Study Of Moral Injury Among Veterans, Eva M. Valdez
Dissertations
This pilot study examined associations between self-reported moral distress, state distress, combat exposure, deployment history, and maximum pupil reactivity among veterans diagnosed with PTSD. Participants viewed neutral and morally relevant images while pupil responses were recorded using eye-tracking technology. Self-report measures included moral distress severity, exposure to potentially morally injurious events, Subjective Units of Distress Scale (SUDS) ratings, total deployments, number of combat deployments, and Combat Exposure Scale scores. Maximum pupil reactivity was calculated by subtracting the mean z-scored maximum pupil response during neutral image presentations from the mean z-scored maximum pupil response during morally relevant image presentations. This variable …
Acute And Chronic Oral Administration Of Cannabidiol-Dominant Cannabis Products: Sex- And Formulation-Dependent Effects On Anxiety-Like Behavioral Patterns In Rats, Carlos R. Maestas-Olguin
Acute And Chronic Oral Administration Of Cannabidiol-Dominant Cannabis Products: Sex- And Formulation-Dependent Effects On Anxiety-Like Behavioral Patterns In Rats, Carlos R. Maestas-Olguin
Psychology ETDs
Interest in the anxiolytic-like effects of cannabidiol (CBD), the non-intoxicating phytocannabinoid found within the genus, Cannabis, has grown significantly in recent years. However, preclinical investigations of CBD’s anxiolytic potential often elect to forgo translationally relevant models that maximize external validity in favor of greater internal and mechanistic validity. As a result, the effects of relatively low dose (< 3mg/kg) oral CBD administration on anxiety-like behaviors are not yet fully characterized. The present studies examined the impact of two orally delivered CBD-dominant cannabis products – a “full-spectrum” formulation derived from the whole plant and a CBD isolate derived from the same chemovar – on innate defensive behaviors exhibited by adult male and female rats in various tests of anxiety. Results indicated that acute and chronic low dose oral CBD administration attenuated anxiety-like behavior in rats, regardless of sex or formulation. These findings extend the growing corpus of literature describing anxiolytic-like effects of CBD.
Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez
Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez
Psychology ETDs
Fetal Alcohol Spectrum Disorders involve morphologic and neurobiological abnormalities in offspring subjected to prenatal alcohol exposure. Although not as well studied as high exposure, moderate prenatal alcohol exposure represents the most common and undetected form in humans. While learning and memory deficits have been well characterized at the behavioral level in humans with Fetal Alcohol Spectrum Disorders and in animal models of moderate prenatal alcohol exposure, few studies have determined the circuit or systems level mechanisms of the behavioral deficits. A complete understanding of the neural bases of memory deficits after moderate prenatal alcohol exposure is needed to ultimately identify …
A Single Administration Of Psilocybin Is Ineffective In Reversing Ptsd-Like Sequelae In A Rat Model Of Stress-Enhanced Fear Learning, Kylie M. King, Marisa J. Savini, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Phillip R. Zoladz
A Single Administration Of Psilocybin Is Ineffective In Reversing Ptsd-Like Sequelae In A Rat Model Of Stress-Enhanced Fear Learning, Kylie M. King, Marisa J. Savini, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Phillip R. Zoladz
ONU Student Research Colloquium
Single treatments with psychedelics produce rapid, long-lasting antidepressant effects. Psychedelics may also exert anxiolytic effects and be useful in treating more complex psychiatric conditions, such as PTSD. However, less is known about the impact of these agents on PTSD-related symptoms. Thus, we aimed to determine whether a single administration of psilocybin could reverse PTSD-like sequelae induced by stress-enhanced fear learning in rats. Sprague-Dawley rats were placed in Context A (circular, white conditioning box) and exposed to several uncontrollable footshocks (Stress) or no footshocks (No Stress). The next day, the rats were placed in Context B (square conditioning box with clear …
Psilocybin And The Related Tryptamine, Norbaeocystin, Exert Acute Anxiogenic Effects That Depend On Sex, Marisa J. Savini, Kylie M. King, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Andrew Jones, Phillip R. Zoladz
Psilocybin And The Related Tryptamine, Norbaeocystin, Exert Acute Anxiogenic Effects That Depend On Sex, Marisa J. Savini, Kylie M. King, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Andrew Jones, Phillip R. Zoladz
ONU Student Research Colloquium
Single treatments with psychedelics have demonstrated rapid, long-lasting antidepressant effects. However, psychedelics often produce unfavorable psychoactive effects that could worsen existing psychological distress. Thus, we compared the effects of psilocybin and the related tryptamine, norbaeocystin, on anxiety-like behavior in male and female rats. In Experiment 1, rats were treated with 1 mg/kg psilocybin (PSIL), 1 mg/kg norbaeocystin (NOR), or vehicle 30 min before a 5-min trial on an elevated plus maze (EPM) or in an open field test (OFT). On the EPM, PSIL led to decreased open arm time and fewer arm entries in males and females. NOR led to …
Emotional And Social Perception In Hearing And Deaf Individuals, Julie Klenotic
Emotional And Social Perception In Hearing And Deaf Individuals, Julie Klenotic
Williams Honors College, Honors Research Projects
This study will compare the differences in emotional recognition and social dynamic understanding between hearing and Deaf people. I will investigate the differences in these areas between hearing and Deaf individuals, as well as the role American Sign Language use has in performance. It will utilize point light walkers which will display the emotions happy, angry, sad, and neutral. Participants will be asked which emotion is being displayed based on the presented gait of the point light walker. Second, they will view 15 videos from the Interpersonal Perception Task without audio. The questions from the IPT 15 will then be …
Physiological Response To Concealed Information In A Mock-Crime Paradigm, Ezra Koenigsberg, Tamya Mchenry, Jasmine Manzana, Taylor Powell, Samantha Jackson
Physiological Response To Concealed Information In A Mock-Crime Paradigm, Ezra Koenigsberg, Tamya Mchenry, Jasmine Manzana, Taylor Powell, Samantha Jackson
Science University Research Symposium (SURS)
The Concealed Information Test (CIT), based on Lykken’s guilty knowledge framework, measures physiological responses when individuals recognize crime-related details compared to neutral alternatives. Previous studies show that variations in stimulus presentation enhance the CIT’s accuracy, especially through changes in electrodermal activity and heart rate. However, few studies have tested whether a Qualtrics-based mock-crime version of the CIT can replicate these physiological patterns. This study addresses that gap by adapting the CIT for a digital research environment. The goal is to determine whether participants show greater physiological arousal—measured through skin conductance, heart rate, and respiration—when exposed to crime-related “critical” stimuli compared …
Investigating The Relationship Between Noun Classes And Plant Folk Taxonomy In Chasu Language Of Kilimanjaro Region In Tanzania, Peter Rabson Mziray
Investigating The Relationship Between Noun Classes And Plant Folk Taxonomy In Chasu Language Of Kilimanjaro Region In Tanzania, Peter Rabson Mziray
Journal of Humanities and Social Sciences
The current study investigates the relationship between noun classes and plant folk taxonomy in Chasu (G 22). The study focuses on two objectives: the first objective is to describe the plant folk taxonomy in Chasu and the second objective is to determine the relationship between noun classes and plant folk taxonomy in Chasu. Data were collected from rural villages in Same and Mwanga districts by using free listing, field interviews (jungle-walk-and-identify), and written texts containing Chasu plant names. The findings reveal that Chasu folk taxonomy reflects different ethnobotanical categories; including a unique beginner which is mmea/mimea ‘plant(s)’, and three life …
Claiming More To Cope: Does Ostracism Increase Overclaiming?, Katy Q. Chen
Claiming More To Cope: Does Ostracism Increase Overclaiming?, Katy Q. Chen
Honors Theses
In a pre-registered online study, we investigated the relationship between ostracism and overclaiming. Ostracism is the act of deliberately or unintentionally excluding and ignoring others. Overclaiming refers to the behavior of exaggerating one’s knowledge or familiarity with specific topics, often as a way of attempting to present oneself as more knowledgeable or competent than one actually is. Drawing from the temporal need-threat model, we hypothesized that ostracized individuals, as a compensatory response, would likely overclaim more compared to included individuals. This online study simulated a work experience where participants were asked to answer questions about their work-related experiences and opinions. …
Investigating Prefrontal Cortex Neuronal Signatures Of Opioid-Induced Risk-Taking Behavior, Cana Quave
Investigating Prefrontal Cortex Neuronal Signatures Of Opioid-Induced Risk-Taking Behavior, Cana Quave
Dissertations and Theses (Open Access)
Opioid use disorder occurs alongside impaired risk-related decision-making, but the underlying neural correlates are unclear. We developed an approach-avoidance conflict task using a modified conditioned place preference procedure to study neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. While the saline-exposed control group avoided cat odor, the morphine group included two subsets of rats that either maintained a preference for the paired side despite the presence of …
Terpenes Mitigate Thc-Induced Working Memory Deficits: Behavioural Evidence Of The Entourage Effect Using A 2-Component Operant Memory Task, Lara Mitchell
Theses and Dissertations (Comprehensive)
Most research on cannabis and cognitive function has focused on delta-9-tetrahydrocannabinol (THC). However, this approach overlooks the complex chemical composition of cannabis products consumed by the public, which often includes cannabidiol (CBD) and various terpenes. These additional constituents may interact with THC to modulate its effects, a phenomenon known as the entourage effect. While this theory has gained traction, experimental evidence for the cognitive impact of terpenes in combination with THC remains limited. This study aimed to assess whether terpenes can mitigate THC-induced cognitive deficits using a 2-Component Operant Memory task. Male Sprague-Dawley rats received intraperitoneal injections of either …
The Role Of 5-Ht6 Receptor Activation In Learning Consolidation, Jasmine Alyssa Robinson
The Role Of 5-Ht6 Receptor Activation In Learning Consolidation, Jasmine Alyssa Robinson
Electronic Theses, Projects, and Dissertations
The focus on serotonergic dysfunction as a contributor to cognitive deficits in disorders such as autism spectrum disorder, Alzheimer's disease, and schizophrenia drives researchers to investigate the functional impact of specific serotonin receptor types on executive functioning. By discerning the potential enhancement or impairment effects, this endeavor seeks to unravel the complex interplay between serotonin receptors and cognitive abilities. Specifically, within the three domains of learning, acquisition, consolidation, and retrieval, we find serotonergic modulation to be pivotal. Recent studies have highlighted the 5-HT6 receptor as a novel target for cognitive enhancement. However, the majority of the research investigates the effects …
Serotonin 1a Receptor Modulation On Behavioral Flexibility In Btbr And C57bl/6j Mice, Cassandra Cavazos
Serotonin 1a Receptor Modulation On Behavioral Flexibility In Btbr And C57bl/6j Mice, Cassandra Cavazos
Electronic Theses, Projects, and Dissertations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by a subset of symptoms known as restricted repetitive behaviors (RRBs). RRBs are categorized into both lower order and higher order RRBs, where the latter can be described as behavioral inflexibility. The BTBR T+ tf/J (BTBR) mouse strain has been an extensively used animal model that demonstrate the behavioral symptoms of these individuals, including inflexible behavior. Currently, there are few effective treatments for individuals with ASD that express RRBs. Past research has investigated treatments that target serotonin due its historic involvement in ASD. 8-OH-DPAT (8-hydroxy-2-(di-n-propylamine) tetralin) is a research …
Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep, Charles Ethan Coombs
Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep, Charles Ethan Coombs
Psychological Science Undergraduate Honors Theses
Women overrepresent men for sub-optimal sleep, a consequence of hormone fluctuation in the menstrual cycle affecting sleep regulatory pathways. While research has examined the prevalence of sub-optimal sleep through cycle phases, little research has examined how hormonal contraceptives (HC’s) could similarly affect women’s sleep, while also neglecting to utilize subjective sleep measures. In this study, we examine subjective sleep quality among naturally cycling (NC) women, women using different HC types, and between active and inactive phase pill users by subjecting 463 women to a subjective sleep battery. We hypothesized that HC users would report more sub-optimal sleep than NC women. …
Mate Guarding Against Strong Men Displaying Affiliative And Aggressive Humor, Jacob Pauley
Mate Guarding Against Strong Men Displaying Affiliative And Aggressive Humor, Jacob Pauley
Biological Sciences Undergraduate Honors Theses
Mate retention behaviors serve to discourage partner defection from a current pairbond. Such behaviors are oftentimes more prevalent toward intrasexual rivals exhibiting physical and behavioral cues implicating that rival as an optimal mate. Among these features in men are their upper body strength, a feature diagnostic of heritable fitness, and men's ability to produce humor, a cue to their social competence. This study considered the intersection of these desirable features in shaping men's mate retention behavior toward an intrasexual rival. After learning of a hypothetical interloper exhibiting high or low upper body strength while similarly using humor in an affiliative …
Proteomic Profiles Of Cytokines And Chemokines In Moderate To Severe Depression: Implications For Comorbidities And Biomarker Discovery, Kathleen T. Watson, Jennifer Keller, Caleb M. Spiro, Isaac B. Satz, Samantha V. Goncalves, Heather Pankow, Idit Kosti, Benoit Lehallier, Adolfo Sequeira, William E. Bunney, Natalie L. Rasgon, Alan F. Schatzberg
Proteomic Profiles Of Cytokines And Chemokines In Moderate To Severe Depression: Implications For Comorbidities And Biomarker Discovery, Kathleen T. Watson, Jennifer Keller, Caleb M. Spiro, Isaac B. Satz, Samantha V. Goncalves, Heather Pankow, Idit Kosti, Benoit Lehallier, Adolfo Sequeira, William E. Bunney, Natalie L. Rasgon, Alan F. Schatzberg
Psychology Division Scholarship
Objective: This study assessed the proteomic profiles of cytokines and chemokines in individuals with moderate to severe depression, with or without comorbid medical disorders, compared to healthy controls. Two proteomic multiplex platforms were employed for this purpose. Metods: An immunofluorescent multiplex platform and an aptamer-based method were used to evaluate 32 protein analytes from 153 individuals with moderate to severe major depressive disorder (MDD) and healthy controls (HCs). The study focused on determining the level of agreement between the two platforms and evaluating the ability of individual analytes and principal components (PCs) to differentiate between the MDD and HC groups. …
Opioid System's Potential Involvement In Ketamine's Cognitive And Antidepressant-Like Effects In Rats, Fan Zhang
Theses and Dissertations
Depression stands as one of the most pervasive mental health challenges worldwide, including the United States. Conventional antidepressants typically display a delayed onset of therapeutic action (4-8 weeks) and lack efficacy in a substantial portion of patients (over 40% of depressed patients are treatment-resistant). The dissociative anesthetic ketamine, which is a glutamatergic N-methyl-D-aspartate (NMDA) antagonist, has emerged as a promising novel treatment due to its rapid and prolonged antidepressant effects, and it is especially beneficial for treatment-resistant depression. Nevertheless, the precise neurochemical mechanisms underlying ketamine’s antidepressant properties remain elusive, hampering the development of safer and more efficacious treatments. The present …
Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor
Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor
Electronic Theses, Projects, and Dissertations
Serotonin has been found to regulate several cognitive and physiological functions, and its role in depression and other neuropsychiatric disorders has been a focus of research. More specifically, a wealth of research regarding serotonin focuses on serotonergic medications in the treatment of neuropsychiatric disorders, such as depression and anxiety, and stimulates the 5-HT1A and 5-HT1B receptors. Within the last decade, there has been an increase in prescriptions of psychotropic medication for children, however, the efficacy and adverse effects of these drugs have not been evaluated in younger populations. While antidepressants reduce symptoms of depression in adults, they are …
Sex Differences In Stress Reactivity And Responses To Novelty In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Nicole Altamirano, Joseph Rafac, Katelynn Renteria, John L. Vandeberg, Mario Gil
Sex Differences In Stress Reactivity And Responses To Novelty In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Nicole Altamirano, Joseph Rafac, Katelynn Renteria, John L. Vandeberg, Mario Gil
Research Colloquium
Introduction: Investigating how exposures to stress and novel environments influence behavior is important for translational research that aims to improve mental health. Previous studies have focused on reactions to novelty and revealed changes in defense reactions and exploratory behavior. (Pisula et al., 2012).
Objective: The focus of the present study is to investigate sex differences in behavioral responses to novel environments and restraint stress in the gray short-tailed opossums (Monodelphis domestica). Using the Monodelphis is innovative because it is a non-traditional animal model that is ideal for developmental research.
Methods: Using AnyMaze video tracking software, animals’ behaviors (6 males, 6 …
The Impact Of Biological Sex On Motor Function And Responses To Novel Environments In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Ismael Perez, Sasawan Heingraj, Katelynn Renteria, Cristian M. Botello, Joseph C. Cantu, John L. Vandeberg, Mario Gil
The Impact Of Biological Sex On Motor Function And Responses To Novel Environments In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Ismael Perez, Sasawan Heingraj, Katelynn Renteria, Cristian M. Botello, Joseph C. Cantu, John L. Vandeberg, Mario Gil
Research Symposium
Background: Understanding the different stress reactions in different environments can help us understand stress factors. Studying animal behavior is important for translational research for mental health improvement.
Previous literature has shown that stress is a risk factor for higher cancer incidence and poorer cancer survival. (Klejbor & Turlejski., 2012), as well as mental health outcomes. Understanding of how stress is related to cancer can help improve therapeutic outcomes as preventive measures (Glaser et al., 1987).
Methods: Using the Rota Rod apparatus, 12 animals (3 males, 9 females) were tested at 36 rpm for a maximum of 400 seconds (Madroñal et …
You Hurt My Feelings: Autonomic And Behavioral Responses To Social Exclusion And The Moderating Effect Of Psychopathic Traits, Liat Kofler
Dissertations, Theses, and Capstone Projects
Humans have a fundamental need to form and maintain social connections, and thus experiencing social exclusion is extremely distressing as it threatens this basic human need. Individuals who are socially excluded often respond aggressively, not only towards their ostracizers but also towards innocent bystanders, with ostracism being implicated in extreme acts of violence such as school shootings. However, individual differences in behavior exist within the context of social exclusion as not everyone responds aggressively after being ostracized. Identifying risk factors for retaliatory aggressive behavior following experiences of social exclusion may facilitate the development of targeted interventions aimed at mitigating such …
Comparison Between The Effects Of Acute Physical And Psychosocial Stress On Feedback-Based Learning, Xiao Yang, Brittany Nackley, Bruce H. Friedman
Comparison Between The Effects Of Acute Physical And Psychosocial Stress On Feedback-Based Learning, Xiao Yang, Brittany Nackley, Bruce H. Friedman
Psychology Faculty Publications
Stress modulates feedback-based learning, a process that has been implicated in declining mental function in aging and mental disorders. While acute physical and psychosocial stressors have been used interchangeably in studies on feedback-based learning, the two types of stressors involve distinct physiological and psychological processes. Whether the two types of stressors differentially influence feedback processing remains unclear. The present study compared the effects of physical and psychosocial stressors on feedback-based learning. Ninety-six subjects (Mage = 19.11 years; 50 female) completed either a cold pressor task (CPT) or mental arithmetic task (MAT), as the physical or psychosocial stressor, while electrocardiography and …
Local Field Potentials In The Male Rat Nucleus Accumbens During Effort-Based Behavior, Celine Aliko, John Salamone, Alev Ecevitoglu
Local Field Potentials In The Male Rat Nucleus Accumbens During Effort-Based Behavior, Celine Aliko, John Salamone, Alev Ecevitoglu
Honors Scholar Theses
Major depression is a devastating disorder that consists of multiple symptoms such as low mood and motivational dysfunction. It has been shown that motivational dysfunction can be studied in animal models by using effort-based choice paradigms, which vary in their response requirements. It has been reported that dopamine depletion in the nucleus accumbens decreases ratio-scheduled lever-pressing in a manner related to the size of the ratio requirement. One dopamine depleting agent is tetrabenazine (TBZ), which has been shown to decrease lever-pressing and induce low-effort bias. The current study aims to investigate behavioral and electrophysiological changes that occur with animals performing …
Sucrose Demand And Essential Value In Mice With Early-Life Exposure To Risperidone, Megan Federoff
Sucrose Demand And Essential Value In Mice With Early-Life Exposure To Risperidone, Megan Federoff
LSU Master's Theses
Second-generation antipsychotics (SGAs), such as risperidone, are widely prescribed to children, but the long-term effects of SGA treatment are not well understood. This study investigated the impact of early-life risperidone treatment on sucrose demand in mice in adulthood. Mice were administered risperidone or vehicle from postnatal day (PND) 33 to 60 and trained in adulthood (>PND 120) to nose poke for a sucrose solution reinforcer. The fixed ratio (FR) value (the number of responses required to produce sucrose delivery; the “price” of sucrose) was varied from 1 to 45, and the resulting consumption versus FR value data were analyzed …
Trait Sadism In Bdsm Practitioners And Non-Practitioners, Marley Russell
Trait Sadism In Bdsm Practitioners And Non-Practitioners, Marley Russell
Psychology ETDs
Sadism is an elusive construct within psychology. Multiple types are studied without clear psychometric or theoretical distinctions, and operationalizations of these respective sub-constructs lack validity. This study explores the empirical distinction between two sadism types: consensual sexual sadism (i.e. in the context of BDSM) and trait sadism. Trait sadism is widely synonymized with “everyday sadism”, but here conceptualized as a higher-order construct encompassing both everyday and a novel “prosocial sadism”. I develop and pilot the BDSM Identities and Behaviors (BIB) checklist in a sample of BDSM practitioners. I then compare those practitioners to non-practitioners on trait sadism and dark triad …
No Fixed Limit For Storing Simple Visual Features: Realistic Objects Provide An Efficient Scaffold For Holding Features In Mind, Yong Hoon Chung
No Fixed Limit For Storing Simple Visual Features: Realistic Objects Provide An Efficient Scaffold For Holding Features In Mind, Yong Hoon Chung
Dartmouth College Master’s Theses
Prominent theories of visual working memory postulate that the capacity to maintain a particular visual feature is fixed. In contrast to these theories, recent studies have demonstrated that meaningful objects are better remembered than simple, non-meaningful stimuli. Here, we test whether this is solely because meaningful stimuli can recruit additional features — and thus more storage capacity — or whether simple visual features that are not themselves meaningful can also benefit from being part of a meaningful object. Across five experiments (each N=30) we demonstrate that visual working memory capacity for color is increased when colors are part of recognizable …
Hiv And Early Life Stress On Neuroimaging And Risky Behavior, Paola Garcia Egan
Hiv And Early Life Stress On Neuroimaging And Risky Behavior, Paola Garcia Egan
Dissertations
This study examined the interactive effects of early life stress (ELS) and HIV on brain morphometry, diffusion-basis-spectrum-imaging (DBSI), risky decision-making, and sex-risk behavior. 122 people with HIV (PWH) and 113 people without HIV (PWoH), free of major psychiatric illness and neurological confounds, were stratified into high (≥ 3 events) vs. low (< 3 events) ELS [PWoH/low ELS (n = 57), PWoH/high ELS (n =56), PWH/low ELS (n = 43), PWH/high ELS (n = 79)] and underwent structural magnetic resonance imaging, DBSI, neuropsychological, and risky-behavior assessment; all PWH were virologically controlled. Compared to PWoH, PWH had smaller orbitofrontal cortex (OFC), parietal lobes, insula, caudate and anterior cingulate. No ELS effects were detected in volumetric measures. Significant interactions were found between HIV serostatus and ELS on the OFC and on cellularity of the inferior fronto-occipital fasciculus after multiple comparisons adjustment. Specifically, PWH/high ELS exhibited significantly smaller OFC and PWoH/high ELS show significantly larger OFC than the other groups. PWoH/high ELS exhibited higher DBSI cellularity (neuroinflammation proxy) of the inferior-occipital-fasciculus compared to PWoH/high ELS. Regardless of HIV status, executive function moderated the relationship between the OFC and sex-risk behavior such that individuals within the sample who performed above average on a measure of executive function and had a larger OFC reported fewer sex partners in past six months than individuals with smaller volumes. No interaction was found between HIV serostatus and ELS on risky behavior measures. Clustering analyses defined ELS subgroups in PWH that were determined by demographic characteristics, duration of infection, recent CD4+ T-cell count, nadir CD4+ T-cell count and high/low ELS.Even in PWH that are virologically controlled, without major current psychiatric comorbidities, there is evidence of a synergistic impact of ELS and HIV on OFC volumes. Higher volumes in the OFC were detrimental when associated with lower executive function scores or advantageous when associated with higher executive function. Findings suggest that ELS is associated with different brain signatures among PWoH and virally suppressed PWH. However, ELS was not directly associated with risky behaviors, and subgroups in PWH were characterized by demographic variables, past substance use and HIV clinical variables.
Impact Of Adolescent Social Isolation On Adult, Binge-Like Ethanol Consumption And Plasma Corticosterone In High-Alcohol-Preferring Mice, Eva Cullins
The Journal of Purdue Undergraduate Research
Adolescent stress exposure increases the likelihood of alcohol misuse and alcohol use disorder (AUD) in adulthood; however, it is not clear how genetic and environmental factors interact to increase risk. This study examined how adolescent social isolation affects adult binge-like ethanol drinking and levels of the stress hormone corticosterone in male and female mice with a genetic predisposition toward high alcohol preference (HAP). Twenty-eight HAP mice were separated into group-housed (GH) and socially isolated (SI) conditions (n = 13, 13). Binge drinking was assessed using a drinking in the dark (DID) procedure. Blood samples were taken before DID and after …
Event-Related Potentials Of Individuals With Attention-Deficit/Hyperactivity Disorder Performing The Attention Network Task, P. Dennis Rodriguez, Justin E. Stauffacher
Event-Related Potentials Of Individuals With Attention-Deficit/Hyperactivity Disorder Performing The Attention Network Task, P. Dennis Rodriguez, Justin E. Stauffacher
Midwest Social Sciences Journal
The current study sought to investigate the neural basis of attention-deficit/hyperactivity disorder (ADHD) by examining the performance of individuals with ADHD on the Attentional Networks Test (ANT) by Fan, McCandliss, Sommer, Raz, and Posner (2002), while recording electroencephalography (EEG) utilizing event-related potentials (ERP) methodology. Fifty-seven university students were divided into three groups: control, ADHD-inattentive subtype (ADHD-IA), and ADHD-combined/hyperactive impulsive subtype (ADHD-C/HI). The average peak amplitudes of the P300 waveform for each group were compared and analyzed for performance on each attention network measured by the ANT: the alerting network, the orienting network, and the executive control network. The average P3 …
Differential Neural Correlates Underlying Different Cognitive Control Strategies And Their Relationship With The Barratt Impulsiveness Scale, Carroll Bentley
Differential Neural Correlates Underlying Different Cognitive Control Strategies And Their Relationship With The Barratt Impulsiveness Scale, Carroll Bentley
Psychological Science Undergraduate Honors Theses
Impulsivity is defined as a rapid unplanned action to a stimulus, where the person does not consider the consequences of their actions (Moeller et al., 2001). Various measurement techniques exist in the study of impulsivity and include self-report, behavioral and physiological measures. This breadth of measurement techniques affords researchers the opportunity to understand what is likely a multifaceted nature of this construct. Previous literature shows mixed results between the relationship of the three measures. The present study seeks to add clarity between the three different modalities of measuring impulsivity. To address this relationship, an undergraduate sample (n = 171) completed …