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Articles 91 - 120 of 415

Full-Text Articles in Biological Psychology

Neural Correlates And Neuroanatomy Of Juvenile And Adult Contextual Fear Memory Retention, Natalie Odynocki Jan 2022

Neural Correlates And Neuroanatomy Of Juvenile And Adult Contextual Fear Memory Retention, Natalie Odynocki

Legacy Theses & Dissertations (2009 - 2024)

AbstractFear is an evolutionarily conserved mechanism that allows an organism to discern potential harm and act accordingly by engaging in defensive behaviors. While fear is an adaptive response, dysregulation of fear by means of a traumatic event can lead to psychiatric conditions such as post-traumatic stress disorder (PTSD). Animal research using rodents in Pavlovian context fear conditioning experiments allows for the ability to study the underlying neural circuitry of threat-appropriate and aberrant fear learning and memory that may contribute to PTSD. However, despite reports that women are more than two times more likely to develop PTSD compared to men, the …


The Ecology And Evolution Of Human Reproductive Behavior, Kaylynne Glover Jan 2022

The Ecology And Evolution Of Human Reproductive Behavior, Kaylynne Glover

Theses and Dissertations--Biology

The complexity of human reproductive behavior has necessitated its examination through a variety of scientific disciplines, each focusing on specific elements of our biology, behavior, and society. However, this complexity also necessitates that we reintegrate the information learned from each discipline into a single framework, one rooted in the evolutionary principles that have shaped the development of all life on earth. In this dissertation, I use this framework to explore human reproductive behavior, with a particular focus on sexual coercion and fertility-mediated sexual behavior.

In Chapter 1, I introduce the approach taken in this document, identify several key limitations, and …


The Evolution Of Quantitative Sensitivity, Margaret A H Bryer, Sarah E. Koopman, Jessica F. Cantlon, Steven T. Piantadosi, Evan L. Maclean, Joseph M. Baker, Michael J. Beran, Sarah M. Jones, Kerry E. Jordan, Salif Mahamane, Andreas Nieder, Bonnie M. Perdue, Friederike Range, Jeffrey R. Stevens, Masaki Tomonaga, Dorottya Ujfalussy, Jennifer Vonk Jan 2022

The Evolution Of Quantitative Sensitivity, Margaret A H Bryer, Sarah E. Koopman, Jessica F. Cantlon, Steven T. Piantadosi, Evan L. Maclean, Joseph M. Baker, Michael J. Beran, Sarah M. Jones, Kerry E. Jordan, Salif Mahamane, Andreas Nieder, Bonnie M. Perdue, Friederike Range, Jeffrey R. Stevens, Masaki Tomonaga, Dorottya Ujfalussy, Jennifer Vonk

Jeffrey Stevens Publications

The ability to represent approximate quantities appears to be phylogenetically widespread, but the selective pressures and proximate mechanisms favouring this ability remain unknown. We analysed quantity discrimination data from 672 subjects across 33 bird and mammal species, using a novel Bayesian model that combined phylogenetic regression with a model of number psychophysics and random effect components. This allowed us to combine data from 49 studies and calculate the Weber fraction (a measure of quantity representation precision) for each species. We then examined which cognitive, socioecological and biological factors were related to variance in Weber fraction. We found contributions of phylogeny …


Integrating Interpersonal Neurobiology In Healthcare Leadership And Organizations, Lynn Redenbach Jan 2022

Integrating Interpersonal Neurobiology In Healthcare Leadership And Organizations, Lynn Redenbach

Antioch University Dissertations & Theses

Interpersonal Neurobiology (IPNB) is an interdisciplinary, science-based field that seeks to understand human reality including the nature of mind, brain, and relationships. IPNB has been used extensively by mental health practitioners as well as child development and parenting experts. While practitioners and scholars have described ways that IPNB can be used in leadership and organizations, there has been no systematic inquiry into the practical and phenomenological experience of this application. IPNB offers an alternative to dominant models of care and leading in healthcare settings and fields, which are characterized by disconnection, objectification, and separation. It offers a relationally centered approach …


Sleep And Cardiovascular Reactivity To An Acute Virtual Stressor, Alaina Grace Tiani Jan 2022

Sleep And Cardiovascular Reactivity To An Acute Virtual Stressor, Alaina Grace Tiani

Graduate Theses, Dissertations, and Problem Reports (ETD)

Inappropriate response and magnitude of cardiovascular reactivity (CVR) to stress is a proposed mechanism through which environmental stressors are linked with poor cardiovascular health outcomes (Chida & Steptoe, 2010; Krantz & Manuck, 1984). Studies of reactivity to various laboratory tasks commonly control for factors known to influence CVR such as smoking, medication use, caffeine intake, and BMI; however, few have considered the influence of sleep on CVR. In order to determine whether sleep characteristics need to be assessed and considered in studies of CVR, this study aimed to examine the association between indices of sleep quality and the magnitude and …


Boosting Brain Waves Improves Memory, Richard J. Addante, Mairy Yousif, Rosemarie Valencia, Constance Greenwood, Raechel Marino Nov 2021

Boosting Brain Waves Improves Memory, Richard J. Addante, Mairy Yousif, Rosemarie Valencia, Constance Greenwood, Raechel Marino

Psychology Student Publications

Have you ever wanted to improve your memory? Or have you struggled to remember what you studied? Memory uses special patterns of activity in the brain. This experiment tested a new way to create brain wave patterns that help with memory. We wanted to see if we could improve memory by using lights and sounds that teach the brain waves to be in sync. People wore special goggles that made flashes of light and headphones that made beeping noises. This trained the brain through a process called entrainment. The entrainment put the brain in sync at a specific brain wave …


Alterations To The Brain Following Traumatic Brain Injury, Jacqueline Mader Oct 2021

Alterations To The Brain Following Traumatic Brain Injury, Jacqueline Mader

Honors Projects

Traumatic brain injuries (TBIs) have been labeled as a modern-day epidemic, increasing exponentially with the advancement of technology and society. Gaining a better understanding of the cognitive paths, including the chemical and electrical signals of the brain, neural correlates, and possible interventions for TBI patients allows for the best possible outcome for every patient, and allows for the further advancement of care. By revising and reassessing the ways in which TBIs are categorized and described the prognosis for recovery paints a more realistic view for each individual patient case. The symptoms and impairments that may occur post-injury can be monitored …


A Randomized Controlled Trial Of Psychological Outcomes Of Mobile Guided Resonant Frequency Breathing In Young Adults With Elevated Stress During The Covid-19 Pandemic, Al Amira Safa Shehab Sep 2021

A Randomized Controlled Trial Of Psychological Outcomes Of Mobile Guided Resonant Frequency Breathing In Young Adults With Elevated Stress During The Covid-19 Pandemic, Al Amira Safa Shehab

Dissertations, Theses, and Capstone Projects

Deep breathing practices have shown promise in reducing stress, anxiety, and depression in different populations, including young adults. Specifically, resonant frequency breathing can exert an impact on stress response systems through the vagus nerve and the hypothalamo-pituitary-adrenal (HPA) axis. This may induce reductions in stress and improvement in emotion regulation. Young adults, including college students, tend to be at a higher risk for psychological distress, as they face several psychosocial challenges. The COVID-19 pandemic has imposed new and unique stressors that resulted in higher levels of stress and emotional symptoms and it has been shown that this may have placed …


Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell Jul 2021

Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell

All NMU Master's Theses

Anxiety and anxiety related disorders are increasing at a drastic rate in the past decade, with the NIMH reporting that 31.1% of U.S. adults will experience an anxiety disorder at some point in their lives. Anxiety is commonly characterized by increased attention bias to threat. Attention Bias Modification (ABM) is a new treatment used to reduce individual’s attention bias towards threat. The extent to which ABM leads to underlying neural changes is still unknown. The cerebellum is a neglected brain structure, with new research provides evidence that cerebellum’s functional connectivity and shared networks with threat processing regions has a direct …


The Effect Of A Mindfulness-Based Intervention On Attention And Cognitive Control As A Function Of Smartphone Notifications., Joshua D. Upshaw Jul 2021

The Effect Of A Mindfulness-Based Intervention On Attention And Cognitive Control As A Function Of Smartphone Notifications., Joshua D. Upshaw

Graduate Theses and Dissertations

Barriers to accessing mobile technology, particularly smartphones, have decreased substantially since the iPhone’s release in 2007, resulting in increased ownership and usage across all ages, genders, and races. Despite their ubiquity in our society, relatively little empirical work has investigated the influence of smartphones on our higher order executive functioning. Prior work has linked smartphone use with impaired cognitive control during cognitively demanding tasks, especially in heavier smartphone users. The goals of the current study were twofold. First, the study aimed to examine the effects of smartphone notifications on cognitive control and attention. And second, to determine the effects of …


Influence Of Drd4 Receptor Gene Polymorphism On Aspirational Quality And Approach Motivation, Harry Henry-Ojo Jun 2021

Influence Of Drd4 Receptor Gene Polymorphism On Aspirational Quality And Approach Motivation, Harry Henry-Ojo

ATU Theses and Dissertations 2021 - Present

The present study investigates the presence of a molecular genetic basis of the quality of aspiration and motivation for behavior described by Ryan and Deci’s self-determination theory and Gray’s biopsychological theory of personality respectively. In this study, investigation was carried out to determine the impact of DRD4 receptor gene polymorphism on intrinsic and extrinsic aspiration as well as approach motivation using the Aspiration Index scales and Behavioral Inhibition and Activation (BIS/BAS) scales as our psychometric instrument of evaluation. In a pilot study consisting of 9 healthy subjects, the 7R allele of DRD4 receptor gene was associated with higher mean score …


Learning To Feel Safe: A Translational Study Of The Influence Of Safety Learning On Anxiety-Related Overgeneralized Fear, Hyein Cho Jun 2021

Learning To Feel Safe: A Translational Study Of The Influence Of Safety Learning On Anxiety-Related Overgeneralized Fear, Hyein Cho

Dissertations, Theses, and Capstone Projects

Anxiety disorders are among the most common mental health diagnoses, affecting about a third of the population in their lifetime. However, approximately a third of individuals with anxiety do not respond to current treatment approaches, highlighting the need to identify additional potential therapeutic mechanisms. Safety learning is one such mechanism, but methodological challenges and a dearth of research have prevented the field from advancing the understanding of the role of safety learning in the etiology and remediation of anxiety disorders. Animal research, using single-cued safety learning paradigms, has yielded promising early findings, demonstrating that safety learning directly reduces anxiety-related behaviors …


Circuits Underlying Serotonin Mediated Sex Differences In Fear Learning, Rebecca Ravenelle Jun 2021

Circuits Underlying Serotonin Mediated Sex Differences In Fear Learning, Rebecca Ravenelle

Dissertations, Theses, and Capstone Projects

Post-traumatic stress disorder (PTSD) is a trauma-related disorder characterized by intense fearful memory formation. Women are twice as likely as men to develop PTSD, indicating there may be sex differences in the underlying neural circuits. Given that serotonin (5-HT) dysfunction is implicated in PTSD, and 5-HT modulates fear learning, we investigated whether there are sex differences in the modulation of fear learning by 5-HT. We administered the selective serotonin reuptake inhibitor (SSRI) citalopram (20mg/kg or 10m/kg, i.p.) once to male and female mice prior to auditory fear conditioning and tested the effects on fear memory the next day. We found …


Empathy And Fairness In Nonhuman Primates: Evolutionary Bases Of Human Morality, Colt Halter May 2021

Empathy And Fairness In Nonhuman Primates: Evolutionary Bases Of Human Morality, Colt Halter

Intuition: The BYU Undergraduate Journal of Psychology

Darwin offered an evolutionary perspective on the origins of human morality, suggesting that humans share a biological foundation with nonhuman primates. This paper reviews the current literature on moral and prosocial behaviors of nonhuman primates, specifically examining whether nonhuman primates exhibit behaviors that are typical of empathy and fairness. The literature documents that nonhuman primates exhibit empathetic behaviors regarding emotional contagion and sympathetic concern. There is also evidence that nonhuman primates have a sense of fairness, seen in their reciprocal behaviors and aversion to inequity. Taken together, this suggests that there are evolutionary roots of morality, lending empirical support to …


Exploring Tactile Art-Making With Deafblind Students And Their Families: An Opportunity For Creative Play, Alice Rodgers May 2021

Exploring Tactile Art-Making With Deafblind Students And Their Families: An Opportunity For Creative Play, Alice Rodgers

Expressive Therapies Capstone Theses

The impact of a deafblind diagnosis on an individual’s mental health and the well-being of the family involved can be profound. However, current research and available literature for the mental health treatment and therapy practices of deafblind persons and their families is limited (Kyzar et al., 2016; “WFDB Global Report 2018,” n.d.). This thesis used the Leeds Family Psychology and Therapy Service principles (Leeds FPTS) and the Expressive Therapies Continuum with established deafblind teaching strategies to facilitate an original arts-based community project entitled: “Things We Like.” This project provided an opportunity for deafblind students (ages three to 22) and their …


Big Five Personality Traits And Political Orientation: An Inquiry Into Political Beliefs, Ian E. Phillips May 2021

Big Five Personality Traits And Political Orientation: An Inquiry Into Political Beliefs, Ian E. Phillips

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Personality research centered on the Big Five personality traits has heavily impacted our understanding in regards to what forces orient a person on a political spectrum. Examining how personality differences interact with political orientation, this research seeks to provide information on what makes someone either more or less likely to be liberal or conservative based on their temperament. In this paper, previous personality research is synthesized into one discussion, centered on what the effects of each trait are and how they impact political orientation, the heritability of personality, and what implications there are for such research in the realm of …


The Neurobiological Relationship Between Childhood Maltreatment And Major Depressive Disorder (Mdd), Morgan Clinton Apr 2021

The Neurobiological Relationship Between Childhood Maltreatment And Major Depressive Disorder (Mdd), Morgan Clinton

Global Tides

Childhood maltreatment compromises healthy development, impacts neurobiology, and is associated with lasting alterations to emotional perception, processing, and regulation. Most significantly, childhood maltreatment increases the risk for later development of emotional disorders such as major depressive disorder (MDD). The stress associated with both childhood maltreatment and MDD can lead to lasting alterations to the fronto-limbic circuitry. Using functional and structural magnetic resonance imaging, researchers have observed hippocampal atrophy and amygdala hyperresponsiveness in participants who’ve experienced both childhood maltreatment and MDD. Furthermore, researchers have also observed increased connectivity between the hippocampus and amygdala in victims of childhood maltreatment. Because childhood maltreatment …


Effects Of Human-Animal Interactions On Affect And Cognition, Elise L. Thayer, Jeffrey R. Stevens Jan 2021

Effects Of Human-Animal Interactions On Affect And Cognition, Elise L. Thayer, Jeffrey R. Stevens

Jeffrey Stevens Publications

Human-animal interaction has clear positive effects on people’s affect and stress. But less is known about how animal interactions influence cognition. We draw parallels between animal interactions and exposure to natural environments, a research area that shows clear improvements in cognitive performance. The aim of this study is to investigate whether interacting with animals similarly enhances cognitive performance, specifically executive functioning. To test this, we conducted two experiments in which we had participants self-report their affect and complete a series of cognitive tasks (long-term memory, attentional control, and working memory) before and after either a brief interaction with a dog …


Dog And Owner Characteristics Predict Training Success, Jeffrey R. Stevens, London M. Wolff, Megan Bosworth, Jill Morstad Jan 2021

Dog And Owner Characteristics Predict Training Success, Jeffrey R. Stevens, London M. Wolff, Megan Bosworth, Jill Morstad

Jeffrey Stevens Publications

Teaching owners how to train their dogs is an important part of maintaining the health and safety of dogs and people. Yet we do not know what behavioral characteristics of dogs and their owners are relevant to dog training or if owner cognitive abilities play a role in training success. The aim of this study is to determine which characteristics of both dogs and owners predict success in completing the American Kennel Club Canine Good Citizen training program. Before the first session of a dog training course, owners completed surveys evaluating the behavior and cognition of their dog and themselves. …


Are Capuchin Monkeys (Sapajus Spp.) Sensitive To Lost Opportunities? The Role Of Opportunity Costs In Intertemporal Choice, Elsa Addessi, Valeria Tierno, Valentina Focaroli, Federica Rossi, Serena Gastaldi, Francesca De Petrillo, Fabio Paglieri, Jeffrey R. Stevens Jan 2021

Are Capuchin Monkeys (Sapajus Spp.) Sensitive To Lost Opportunities? The Role Of Opportunity Costs In Intertemporal Choice, Elsa Addessi, Valeria Tierno, Valentina Focaroli, Federica Rossi, Serena Gastaldi, Francesca De Petrillo, Fabio Paglieri, Jeffrey R. Stevens

Jeffrey Stevens Publications

Principles of economics predict that the costs associated with obtaining rewards can influence choice. When individuals face choices between a smaller, immediate option and a larger, later option, they often experience opportunity costs associated with waiting for delayed rewards because they must forego the opportunity to make other choices. We evaluated how reducing opportunity costs affects delay tolerance in capuchin monkeys. After choosing the larger option, in the High cost condition, subjects had to wait for the delay to expire, whereas in the Low cost different and Low cost same conditions, they could perform a new choice during the delay. …


Social Comparison Tendencies And The Reward Value Of Same-Sex Beauty Among Heterosexual Women, Melissa M. Martin Ms. Jan 2021

Social Comparison Tendencies And The Reward Value Of Same-Sex Beauty Among Heterosexual Women, Melissa M. Martin Ms.

Cal Poly Humboldt theses and projects

Previous studies have suggested that heterosexual women, but not heterosexual men, find same sex beauty rewarding. This finding has been attributed to a “greater bisexual interest among heterosexual women”, but no other explanations have been offered or tested. The current study aimed to explore social comparison tendencies as a potential alternate explanation to this previously observed finding. Twenty-three heterosexual women completed a series of questionnaires designed to assess their social comparison tendencies (the social comparison orientation scale, the physical appearance comparison scale, and the intrasexual competition scale). They also completed a “pay-per-view” keypress task to measure the reward value of …


Behavioral, Endocrine, And Neural Responses To Stress In Postpartum And Nulliparous Rats : Potential Mechanisms Of Postpartum Stress Resilience, Joanna Medina Jan 2021

Behavioral, Endocrine, And Neural Responses To Stress In Postpartum And Nulliparous Rats : Potential Mechanisms Of Postpartum Stress Resilience, Joanna Medina

Legacy Theses & Dissertations (2009 - 2024)

Major depressive disorder is one of the most pervasive psychiatric illnesses in the United States. Women are at greater risk for developing depression, particularly during their childbearing years. Approximately 17% of new mothers develop postpartum depression within 4 weeks after parturition. The risk for postpartum depression is even greater in women who do not breastfeed or stop breastfeeding early. Major depressive disorder and postpartum depression share the same symptomology and common etiological bases. Dysregulated stress responses, dopamine activity, and neuroinflammation are recognized mechanisms for depression. The transition to motherhood encompasses physiological and behavioral adaptations in the brain essential for ensuring …


Developmental Influences On The Initial Subjective Rewarding Effects Of Etoh, Madison Waldron Jan 2021

Developmental Influences On The Initial Subjective Rewarding Effects Of Etoh, Madison Waldron

Master’s Theses

The present studies were aimed to better understand developmental contributions to the risk for disordered drinking, and facilitate the long-term goal of developing effective interventions for individuals at high risk for alcohol use disorders. Experiment 1 assessed the effect of adolescent pre-exposure to ethanol on adult place preference, as well as, sex- and beta-endorphin(bE)-related contributions. Adolescent C57BL/6J and bE deficient mice were injected with 1.5g/kg of ethanol or saline and put back into their home cages. At the time of adulthood, we employed a single-exposure conditioned place preference paradigm (SE-CPP) to investigate the impact of preexposure on the initial subjective …


Analysis Of Circadian Rhythm Irregularities On The Health Of Shift Workers, Sahil Rajan Jan 2021

Analysis Of Circadian Rhythm Irregularities On The Health Of Shift Workers, Sahil Rajan

Williams Honors College, Honors Research Projects

Circadian rhythms involve the natural 24 wake-sleep cycle that governs proper maintenance of biological sleep schedules. Circadian rhythm disruption has been associated with health issues such as diabetes, obesity, and mental health disorders such as bipolar and sleep disorders. In this study, a survey method was utilized in order to analyze specific population demographics to determine whether working day or night shifts predisposed individuals to health issues due to disruptions in their circadian rhythms. This study was also carried out to observe popular coping strategies among night shift workers. Of all the variables tested comparing the difference between day and …


Pharmacokinetics And Reward-Related Behaviors Of Ethanol In Male And Female Japanese Quail (Coturnix Japonica), Shannon Eaton Jan 2021

Pharmacokinetics And Reward-Related Behaviors Of Ethanol In Male And Female Japanese Quail (Coturnix Japonica), Shannon Eaton

Theses and Dissertations--Psychology

Ethanol is one of the most widely used and abused drugs. Problem use is associated with many different health problems and the economic burden is in the billions of dollars. Additionally, many people have difficulty controlling their ethanol consumption and about 5% of adults end up with an alcohol use disorder (AUD). Many people with an AUD often find themselves in a cycle of binge, remission, and relapse.

Following ethanol consumption ethanol enters the bloodstream from the small intestine where it gets distributed to peripheral tissues. Ethanol in the bloodstream is cleared from the system by the liver. The primary …


Neurodevelopmental Mechanisms Of Adverse Trauma Outcomes In Emerging Adulthood, Olena Kleshchova Sep 2020

Neurodevelopmental Mechanisms Of Adverse Trauma Outcomes In Emerging Adulthood, Olena Kleshchova

Dissertations, Theses, and Capstone Projects

Background: Exposure to traumatic stress and adversity during the formative years of development can have adverse effects on mental health, neuroendocrine stress system function, and the brain, that persist into adulthood. One candidate mechanism that might confer vulnerability to enduring adverse outcomes of early life trauma is disruption of normal brain maturation. As the brain matures, functional interactions among brain regions change until the functional brain architecture (i.e., the functional connectome) reaches a mature state in adulthood. Given that different neural circuits have distinct developmental trajectories and sensitive periods, traumatic stress at a given point in development might have …


The Role Of Dopamine In Decision Making Processes In Drosophila Melanogaster, Michelle C. Bowers May 2020

The Role Of Dopamine In Decision Making Processes In Drosophila Melanogaster, Michelle C. Bowers

Undergraduate Honors Theses

Understanding the neural processes that mediate decision making is a relatively new field of investigation in the scientific community. With the ultimate goal of understanding how humans decide between one path and another, simpler models such as Drosophila Melanogaster, the common fruit fly, are often utilized as a way of determining the neural circuits involved in these decision-making processes. One of the most important decisions flies make is the decision of where to lay their eggs (oviposit). Choosing the proper substrate upon which to lay eggs is a crucial decision that can ultimately impact their fecundity. This paper investigates the …


Regional Differences In Wild North American River Otter (Lontra Canadensis) Behavior And Communication, Sarah Walkley May 2020

Regional Differences In Wild North American River Otter (Lontra Canadensis) Behavior And Communication, Sarah Walkley

Dissertations

This study focuses on the vocalization repertoires of wild North American river otters (Lontra canadensis) in New York and California. Although they are the same species, these two established populations of river otters are separated by a significant distance and are distinct from one another. River otters are semi-aquatic social predators that can be found throughout North America. This is the first study to examine the vocalizations of wild river otters, and results are compared across field sites in the different regions. River otter vocalizations and behaviors in New York were recorded using Bushnell Aggressor trail cameras that …


Sedative And Neurotoxic Properties Of Brexanolone Compared To Midazolam In The Developing Rodent Brain, Jacob Huffman Apr 2020

Sedative And Neurotoxic Properties Of Brexanolone Compared To Midazolam In The Developing Rodent Brain, Jacob Huffman

Dissertations

The developing brain is susceptible to extensive neurotoxicity following exposure to sedative/anesthetic drugs (SADs). Every year hundreds of thousands of children around the world are exposed to SADs with no viable non-neurotoxic agents approved for clinical use. Allopregnanolone (AlloP) has well-established sedative effects in adults and neonates. AlloP and many SADs produce sedation/anesthesia through allosteric modulation of GABAA receptors, which is one of two principal mechanisms behind SAD-induced neurotoxicity. Evidence suggests AlloP has the unique capacity to regulate key apoptotic factors in adults and is widely involved with critical stages of neurodevelopment, indicating this neurosteroid might serve as a …


Influences Of Salvinorin A And Sex Differences On Depressive- And Anxiety-Like Behaviors In A Chronic Mild Stress Paradigm, Sarah Mitchell Apr 2020

Influences Of Salvinorin A And Sex Differences On Depressive- And Anxiety-Like Behaviors In A Chronic Mild Stress Paradigm, Sarah Mitchell

Theses

Kappa opioid receptors are colocalized with dopamine receptors and are frequently associated with depression, anxiety, stress, and drug use and abuse. KOR antagonism has widely been considered anti-depressive and anxiolytic in animal models while agonism is pro-depressive and anxiogenic. However, recent findings suggest that SalvA, a natural kappa agonist derived from a plant in the mint family, can reduce depressive- and anxiety-like behavior in rats. The current study investigated the effects of chronic mild stress on behavior, attenuation by SalvA, and sex differences. 52 Long-Evans rats, 26 males and 26 females, were exposed to six weeks of CMS. Animals received …