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Full-Text Articles in Biological Psychology
Relationships Between Adverse Childhood Experiences, Inflammation And Pain In Youth And Emerging Adults With Sickle Cell Disease, Angela Pascale
Relationships Between Adverse Childhood Experiences, Inflammation And Pain In Youth And Emerging Adults With Sickle Cell Disease, Angela Pascale
Theses and Dissertations
Sickle cell disease (SCD) is a prevalent genetic disorder involving red blood cells. SCD is a multisystem disease and is connected to various severe medical complications, including debilitating pain. Though pain and inflammation have been connected to adverse childhood experiences (ACEs) in other populations, no prior work has investigated ACEs within a SCD population. The current study examined the prevalence of ACEs as well as the association of ACEs, inflammation, and pain in a sample of youth and young adults with SCD. Utilizing the biopsychosocial model of pain, I examined individual and cumulative ACEs as possible factors relating to inflammation, …
Neuropsychological Implications Of Nocturnal Hypoxemia In Sickle Cell Disease, Sheena Ram
Neuropsychological Implications Of Nocturnal Hypoxemia In Sickle Cell Disease, Sheena Ram
Theses and Dissertations
Neuropsychological impairments have been observed in both individuals with sleep-disordered breathing and in individuals with sickle cell disease (SCD), but there has been little research on the potential effect of sleep-disordered breathing on neuropsychological function in individuals with SCD. This study aims to examine the effect nocturnal oxygen desaturations have on neuropsychological functioning in individuals with sickle cell disease when compared to those with non-sickle anemia and healthy controls. Thirty-four participants with SCD, 18 non-sickle anemia controls (ACTL), and 29 healthy controls (CTL), ages 9 to 63 years, participating in an IRB-approved Children’s Hospital Los Angeles study of cerebral blood …