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Applied Behavior Analysis Commons™

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2024

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Full-Text Articles in Applied Behavior Analysis

Gender, Graduate School Stage, And The Impostor Phenomenon, John-Scott B. Kelley, Angela T. Barlow Feb 2024

Gender, Graduate School Stage, And The Impostor Phenomenon, John-Scott B. Kelley, Angela T. Barlow

Journal of Graduate Education Research

The impostor phenomenon (IP) includes five central factors: (a) a sense of fraudulence or phoniness; (b) a fear of failure and discovery; (c) compensatory perfectionism (i.e., procrastination and/or over-preparation); (d) interpersonal anxiety; and (e) externalized success and/or discounted positive feedback. After the final stage, the process starts over with reinforced vigor, creating a self-reinforcing cycle in which success is associated with psychological suffering. IP was initially used to describe the reports of high-achieving women, but recent studies have shown that IP is experienced across genders. Additionally, while graduate school is an achievement-oriented environment with many characteristics that could promote IP, …


Exploration Of Sustainable Attitudes And Behaviors And The Role Of Planned Behavior Amongst The Auc Community, Natalie Tamer Khairy Feb 2024

Exploration Of Sustainable Attitudes And Behaviors And The Role Of Planned Behavior Amongst The Auc Community, Natalie Tamer Khairy

Theses and Dissertations

This thesis explores the use of a new Framework that was developed by combining both the Theory of Planned Behavior (TPB) and Knowledge, Attitudes, and Practices (KAP) theory to study the sustainability behaviors of students, faculty, and staff at the American University in Cairo (AUC). The research aims to provide insights into the factors influencing sustainable behaviors and how these factors differ across the three groups. The study used a combination of questions from the sustainability awareness questionnaire (SAQ) and Sulitest that was customized to the cultural context of the target group. The survey was administered to a sample of …


High Times, Higher Stakes: Mental Health Impacts In New Recreational Marijuana Legal Landscape, Jason T. Lorenzon J.D., Chris Pezalla, Diana Semilia Feb 2024

High Times, Higher Stakes: Mental Health Impacts In New Recreational Marijuana Legal Landscape, Jason T. Lorenzon J.D., Chris Pezalla, Diana Semilia

National Training Aircraft Symposium (NTAS)

This presentation delves into the societal and mental health consequences arising from the increasing trend of legalizing recreational marijuana. Specifically, we will examine the potential normalization of unconventional behavior among aviation college students, who may grapple with substance use challenges due to stress, sleep difficulties, and the demands of college life. Given the rigorous nature of flight training, prioritizing the mental well-being of pilots becomes imperative.

With the recent legalization of recreational marijuana in Ohio, this presentation integrates insights from Diana Semilia's 2022 study on Kent State Flight Students Ages 19-26. The study's objective was to extract practical recommendations applicable …


The Role Of Glutamate In The Medial Prefrontal Cortex In The Acquistion And Expression Of Conditioned Approach, Rudolf Nisanov Feb 2024

The Role Of Glutamate In The Medial Prefrontal Cortex In The Acquistion And Expression Of Conditioned Approach, Rudolf Nisanov

Dissertations, Theses, and Capstone Projects

A series of experiments were conducted to assess the role of glutamatergic stimulation in the dorsal and ventral regions of the medial prefrontal cortex (mPFC) in both the acquisition and expression of reward-related learning using a Pavlovian conditioning paradigm, the conditioned-approach paradigm. Rats with surgically implanted cannulas were exposed to Pavlovian conditioning sessions that occurred on three alternative days (acquisition) or seven consecutive days (expression). These 60-min conditioning sessions consisted of 30 pairings of light (CS) and food pellets (US) presented under a random time schedule. After a two-day break, rats underwent a session with no CS or US and …


Determining The More Effective Behavior Analytic Intervention For Children With Autism Who Exhibit Pica Behaviors, Jennifer J. Lanham Jan 2024

Determining The More Effective Behavior Analytic Intervention For Children With Autism Who Exhibit Pica Behaviors, Jennifer J. Lanham

Theses and Dissertations

Abstract

Determining the More Effective Behavior Analytic Intervention for Children With Autism Who Exhibit Pica Behaviors. Jennifer J. Lanham, 2024: Applied Dissertation, Nova Southeastern University, Abraham S. Fischler College of Education and School of Criminal Justice. Keywords: autism, pica, eating disorders, intervention, applied behavior analysis

This dissertation was designed to determine which behavior analytic intervention was more effective in the treatment and reduction of mouthing non-nutritive substances in children diagnosed with autism. This study included four participants in an A-B-A reversal design with a component analysis across four intervention phases. The study participants were enrolled in a center-based treatment environment …


The Essential Roles Of Forensic Linguists And Expert Interrogators In National Security, Alan Saquella Jan 2024

The Essential Roles Of Forensic Linguists And Expert Interrogators In National Security, Alan Saquella

Publications

Language is a multifaceted element intricately woven into the tapestry of human behavior, serving as a pivotal medium for comprehending and deterring crime. Within this realm, forensic linguists and expert interrogators emerge as distinct yet interconnected professions, playing vital roles in unraveling the complexities of language to ensure public safety and national security. This article sheds light on the shared responsibilities and significance of these professionals in crime prevention and explores why their expertise is crucial for Executive Protection and Security Professionals.


Identifying Youth Appeals In Alcohol Alternative Social Media Content Through Framing, Melina Oneal Jan 2024

Identifying Youth Appeals In Alcohol Alternative Social Media Content Through Framing, Melina Oneal

West Chester University Master’s Theses

Proposed regulations for alcohol advertising prevent beverage companies from targeting people under the legal drinking age. However, similar regulations for alcohol alternative beverages are less explored, which could allow alcohol alternative products to create awareness for alcoholic beverages among youth. Alcohol alternatives beverages, including no-alcohol and low-alcohol products, are increasing in popularity and can function as compliments to alcoholic products to decrease the total alcohol volume consumed or as substitutes for alcoholic products. Framing theory can be operationalized through the Content Appealing to Youth Index, an index of content elements found in research literature to be appealing to youth, to …


Exploring Social Inclusion And Community Participation Opportunities For Adults With Developmental Disabilities, Arilyn Jewel Baldowski Jan 2024

Exploring Social Inclusion And Community Participation Opportunities For Adults With Developmental Disabilities, Arilyn Jewel Baldowski

Honors College Theses

Social Inclusion and community participation among adults with developmental disabilities (DD) have remained critically underexplored, despite their essential role in promoting equal opportunities and access to fulfilling lives. This study addressed a significant gap in the literature by investigating the experiences of individuals within the population. The research aimed to explore social inclusion and community participation opportunities on adults with DD. Participants were recruited through an organization that offers residential camp programs to adults with developmental disabilities, and an online survey was used to collect data on the availability of opportunities, the extent of involvement, and the perceived impacts on …


Examining The Intersection Of Policing And Mental Health: Analyzing Baker Act Admissions In Davie, Florida, Matthew Goodnow Jan 2024

Examining The Intersection Of Policing And Mental Health: Analyzing Baker Act Admissions In Davie, Florida, Matthew Goodnow

Theses and Dissertations

This study focused on the Police Department of the City of Davie, Florida. It analyzed the rate of involuntary admissions under the Florida Mental Health Act, commonly known as the Baker Act, focusing on factors such as officer experience, training, demographics, and other variables. Using descriptive and inferential statistics, the research provides insights into Baker Act admissions to inform policies and interventions to improve mental health services and relieve strain on law enforcement resources.

Key findings indicate that Crisis Intervention Team training significantly increases the likelihood of officers performing Baker Acts. In contrast, more experienced officers tend to perform fewer …


Character Strengths In Applied Behavior Analysis And The Treatment Of Autism Spectrum Disorder: A Pilot Study, Michael G. Johansen Jan 2024

Character Strengths In Applied Behavior Analysis And The Treatment Of Autism Spectrum Disorder: A Pilot Study, Michael G. Johansen

Dissertations and Theses

Diagnoses of Autism Spectrum Disorder (ASD) have continued to rise. Individuals diagnosed with ASD may display a range of deficits in social communication, behaviors, and symptoms that limit everyday functioning. Among the treatments for ASD, Applied Behavior Analysis (ABA) is typically the earliest and longest intervention individuals with ASD are exposed to. Concerns have been raised over ABA being a compliance-based therapy which potentially produces prompt reliance, reinforcement dependency, and a lack of intrinsic motivation. In an attempt to address these concerns, this study aimed to assess the potential benefits of including the concept of character strengths from the field …


Objectification And Meaning Transference: Does Showing More Skin Mean Less Perceived Agency For Brands?, Zachariah Schlichting Jan 2024

Objectification And Meaning Transference: Does Showing More Skin Mean Less Perceived Agency For Brands?, Zachariah Schlichting

CMC Senior Theses

The purpose of this study is to explore the effects of sexual imagery in advertisements on consumers’ perceptions of brand competence and agency. The effect of a brand’s expected agency was also manipulated between two groups, high expected agency (e.g., tech companies) vs low expected agency (e.g., alcohol companies). 167 participants (M=22.48, 54% women) were recruited through Sona Systems and social media to partake in an online survey conducted through Qualtrics. Participants were randomly assigned to one of four experimental groups and shown seven fictional advertisements; four target advertisements and three deception advertisements. They were then asked to rate their …


Pixels Or People: A Comparison Of The Differenital Effects Of Animated And Human Video Models On Exercise Behaviors For Hgh School Students With Intellectual Disability, Jade Alexis Fulkerson Jan 2024

Pixels Or People: A Comparison Of The Differenital Effects Of Animated And Human Video Models On Exercise Behaviors For Hgh School Students With Intellectual Disability, Jade Alexis Fulkerson

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Individuals with intellectual disabilities, with or without autism spectrum disorder, often require structured programming to facilitate acquisition of skills. Video modeling, an evidence-based strategy, offers a promising avenue for skill instruction. While research has demonstrated the effectiveness of human-modeled video interventions, limited research has been conducted into the efficacy of animated models. Addressing this gap, the present study employed an alternating treatments design to compare the effectiveness of human and animated models in teaching exercise behaviors to high school students with intellectual disabilities, with or without autism spectrum disorder. Results revealed variability among participants: one individual exhibited superior performance with …


The Effects Of Hierarchical Training On The Emergence Of Emotion-Related Metaphors In Autistic Children, Katherine Lynch Jan 2024

The Effects Of Hierarchical Training On The Emergence Of Emotion-Related Metaphors In Autistic Children, Katherine Lynch

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Recently, research on derived relational responding has increased in volume, along with the publication of assessments, curricula, and textbooks on this topic. The allure of engineering derived relations due to purported accelerated learning makes this topic interesting to researchers and practitioners. Recent reviews have examined types of verbal operants, and specific relational frames studied in this body of literature, but there is scarcity in terms of the instructional procedures and variations thereof, and there is little available to focus on single case design (SCD) evaluations of these procedures. Hierarchical training (HT) to produce derived relations between arbitrary stimuli has shown …


Influencing Others: How Can We Benefit Society?, Caleb Roten Jan 2024

Influencing Others: How Can We Benefit Society?, Caleb Roten

Undergraduate Honors Theses

Understanding both how we perceive others and how others perceive us through social situations is vital for improving communication and thus improving relational connections. Successful interactions with people are crucial in many circumstances, especially in interview-type situations, due to the creation of cognitive biases upon such interactions. Whether the goal is to impress a hopeful romantic partner, interview for a job, negotiate a raise, interview for a scholarship, or any number of various reasons to strive for a successful social interaction, understanding how information about the people we meet and connect with is extremely important. Many cognitive examinations have been …


Child Language And Happiness Behaviors: Evaluating The Effects Of Caregiver Coaching, Ashlen Grubbs Jan 2024

Child Language And Happiness Behaviors: Evaluating The Effects Of Caregiver Coaching, Ashlen Grubbs

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Caregivers of young children who have or are at risk for disabilities may struggle supporting their child’s language development. This study used a tailored rapid coaching intervention to teach a caregiver different naturalistic language interventions that can be used with their child during play. Evidence-based naturalistic skills for increasing child communication were chosen to teach the caregiver based on baseline levels of skills. The purpose of this study was to evaluate the effectiveness of a tailored RCI (training and coaching) with caregivers of children with developmental disabilities. Like other studies, this study involved evaluating child-level communication but extended child measures …


Guideline For Creating A Support Group For Adults With Down Syndrome Who Suffer With Prolonged Grief, Brandon Chace Warman Jan 2024

Guideline For Creating A Support Group For Adults With Down Syndrome Who Suffer With Prolonged Grief, Brandon Chace Warman

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Adults with Down syndrome process and express their grief differently from the general population. There are a multitude of support groups and organizations for individuals grieving a loss and experiencing prolonged grief but there are none that exist for people with Down syndrome. This project develops a guideline for creating support groups aimed at adults with Down syndrome who experience prolonged grief. Fifty-one pieces of literature from all over the world were reviewed to formulate recommendations that were graded by seven stakeholders. These recommendations were then used to develop a guideline for creating support groups for this population. Analysis of …


How Team Engagement Improved Positive Behavior Intervention And Support, Colleen Canty Jan 2024

How Team Engagement Improved Positive Behavior Intervention And Support, Colleen Canty

Antioch University Dissertations & Theses

Positive Behavioral Interventions and Supports (PBIS) are a continuum of behavior intervention strategies designed for implementation across the student population. The implementation of PBIS has demonstrated positive academic and behavioral outcomes, as well as safe and favorable school culture in the public education setting (Ockerman et al., 2012; Sugai & Horner, 2009). However, in the alternative school setting, results have not been as favorable. “Alternative school programs have also moved towards adopting PBIS framework, however, outcomes have been less positive. Although alternative programs are often more restrictive and specialized because of the intensified needs of their youth, they share instructional, …


Emotional Intelligence And Its Influence On Burnout From Surface Acting In A Seasonal Service Industry, Jeremy Fishman Jan 2024

Emotional Intelligence And Its Influence On Burnout From Surface Acting In A Seasonal Service Industry, Jeremy Fishman

Dissertations

In the world of customer service, it is commonly believed that the customer is always right, even when they may not be or may be. Roles that carry immediate interaction with the consumer have certain expectations that employees must fulfill, necessitating both surface acting and deep acting; tenets of emotional labor (Diefendorff et al., 2006). Previous research has revealed that relying solely on surface acting can lead to emotional exhaustion and burnout, impacting individuals and even spreading through emotional contagion (Mawritz et al., 2012; Totterdell & Holman, 2003). Leaders turn to emotional intelligence to address these challenges, which can potentially …


The Ethics Of Involuntary Intervention, Landyn Tipton Jan 2024

The Ethics Of Involuntary Intervention, Landyn Tipton

Williams Honors College, Honors Research Projects

This is a deep ethical analysis of the act of non-consensual intervention that discusses the distinction between voluntary and involuntary intervention and explains when it would be considered appropriate and inappropriate to intervene in someone else's life. This paper presents an argument for the right to autonomy, including specific scenarios like consensual types of intervention (psychological therapy), religious intervention (specifically involving LGBTQ conversion therapy), and situations where the person is potentially harming themselves or others. There will also be an interpretation of autonomy and the claim to authority through the lens of Utilitarianism and Kantian ethics.


Examination Of The Differences And Similarities In The Classification Of Multiple Homicide Perpetrators, Lucy M. Papp Jan 2024

Examination Of The Differences And Similarities In The Classification Of Multiple Homicide Perpetrators, Lucy M. Papp

Theses and Dissertations

The applied dissertation compares the lifestyle and behavioral characteristics of mass, serial, and spree murderers. Historically, studies have focused on serial murder according to the perpetrator's typology or indicators at the crime scene. The current topics of research lack a comparison of these classifications. While the classification and described typologies are essential for academic and investigative purposes, understanding the impactful lifestyle factors of these perpetrators may also serve as an essential factor in predictive analysis, victimology, and the motive behind their heinous crimes.

The researcher collected data on the classifications for each type of multiple homicide perpetrator: mass, serial, and …


The Effect Of Mere Presence Of Smartphone On Cognitive Functions: A Four-Level Meta-Analysis, Andree Hartanto, Verity Y. Q. Lua, K. T. A. Sandeeshwara Kasturiratna, Paye Shin Koh, Germaine Y. Q. Tng, Manmeet Kaur, Frosch Y. X. Quek, Jonathan L. Chia, Nadyanna M. Majeed Jan 2024

The Effect Of Mere Presence Of Smartphone On Cognitive Functions: A Four-Level Meta-Analysis, Andree Hartanto, Verity Y. Q. Lua, K. T. A. Sandeeshwara Kasturiratna, Paye Shin Koh, Germaine Y. Q. Tng, Manmeet Kaur, Frosch Y. X. Quek, Jonathan L. Chia, Nadyanna M. Majeed

Research Collection School of Social Sciences

As smartphones have become portable and immersive devices that afford social, informational, and recreational conveniences unbounded by physical restrictions, most daily activities have become closely intertwined with the presence of smartphones. This constant presence of smartphones in daily activities, however, may be concerning as some studies have suggested that smartphones—even their mere presence—can be distracting and can impair cognitive outcomes. However, such findings have not been consistently observed. To reconcile mixed findings, the current meta-analysis synthesized 166 effect sizes drawn from 53 samples and 33 studies including 4,368 participants on the effect of mere presence of smartphone on cognitive functions. …


Evaluating The Normative Development And Efficacy Of The Life Functional Module, Kaitlyn A. Hui Jan 2024

Evaluating The Normative Development And Efficacy Of The Life Functional Module, Kaitlyn A. Hui

Graduate Theses/Dissertations

The Life Functional Module (Dixon, 2020) is an all-encompassing assessment and curriculum designed to promote learner’s independence and well-being by teaching daily living, social, leisure, and other functional or meaningful skills. There is a wide variety of curricula that is currently used in applied-behavior analysis services and programming, including the Essentials for Living, Assessment of Functional Living Skills (AFLS), and the Verbal Behavior Milestones Assessment and Placement Program (VB-MAPP). However, there is a lack of research in empirical evidence in regards to the efficacy of these curricula (Ackley et. al, 2019; Padilla et. al, 2023). The first manuscript of this …


Evaluating The Maintenance Of Verbal Relational Operants Following Peak Programming, Jenna Huskey Jan 2024

Evaluating The Maintenance Of Verbal Relational Operants Following Peak Programming, Jenna Huskey

Graduate Theses/Dissertations

The Promoting the Emergence of Advanced Knowledge (PEAK) Relational Training System is an assessment and curriculum tool developed for basic and advanced language skills using behavior analytic approaches (Dixon, 2016). Maintenance describes the retention of performance following the progression of time. In the present study, the purpose was to determine if maintenance was achieved on previously mastered PEAK programs, both in terms of the content and the verbal relational operant (i.e., generalization to new, untrained content). De-identified data were analyzed for five autistic learners (six to fourteen years old) receiving ABA services at a Midwestern clinic. Programs were selected from …


Evaluating The Interdependency Of The Peak Comprehensive Assessment As It Relates To Performance Estimation And Curricular Programming For Autistic Learners, Julia A. Busam Jan 2024

Evaluating The Interdependency Of The Peak Comprehensive Assessment As It Relates To Performance Estimation And Curricular Programming For Autistic Learners, Julia A. Busam

Graduate Theses/Dissertations

Assessments are widely used by behavior analysts throughout the field of Applied Behavior Analysis when determining curriculum and intervention for individuals with autism spectrum disorder (ASD). This thesis combines and discusses two collaborative manuscripts that revolve around the subject of one commonly used ABA assessment and curriculum. The PEAK Relational Training System (PEAK, Dixon 2014-2016) provides a wide-ranging assessment and training program that incorporates Skinnerian verbal operant learning and derived relational responding expressed in contemporary Relational Frame Theories (Hayes et al., 2001). The PEAK Comprehensive Assessment (PEAK-CA; Dixon, 2018) was developed to standardize and streamline assessments from all four PEAK …


A Second Look At Active Shooter Events: Expanding Our Understanding Of Key Factors, Kyle Gamache, Matt Zaitchik, Judith Platania, Cecelia Coslovi, Willem Pontbriand Jan 2024

A Second Look At Active Shooter Events: Expanding Our Understanding Of Key Factors, Kyle Gamache, Matt Zaitchik, Judith Platania, Cecelia Coslovi, Willem Pontbriand

Arts & Sciences Faculty Publications

In the current study, we investigate active shooter events (ASEs) with emphasis on expanding our understanding of key factors involved in these events. The impetus for this study is a 2015 exploration (Gamache et al., 2015) that highlighted common perpetrator and event characteristics in ASEs occurring in the US prior to 2014. Since the 2015 study, mass-shooting events have moved from tragic, isolated incidents, to a phenomenon that is widely discussed in the media and highly politicized. Our goal was to investigate continued trends, if any exist, and to compare our current sample of ASEs to the sample utilized in …


Filipina American Mothers’ Experiences Obtaining Services For Their Children With Autism Spectrum Disorder, Nina Chelle Boling Jan 2024

Filipina American Mothers’ Experiences Obtaining Services For Their Children With Autism Spectrum Disorder, Nina Chelle Boling

University of the Pacific Theses and Dissertations

Autism spectrum disorder (ASD) is a multifaceted developmental condition that manifests in early childhood, affecting various aspects of neurologic, biological, adaptive, social, linguistic, and cognitive functions. A timely and accurate diagnosis of ASD is crucial for effective intervention, promoting personal and social growth, and fostering independent adulthood. However, obtaining this diagnosis can pose challenges, particularly for people of color, who often encounter disparities in healthcare access compared to their White counterparts. This study aims to investigate the experiences of Filipina mothers raising children with ASD, specifically focusing on their journey to access appropriate autism services.

As of 2019, there were …


Multiple Exemplar And Mastery Criteria For Stimulus Generalization, Micah Mense Jan 2024

Multiple Exemplar And Mastery Criteria For Stimulus Generalization, Micah Mense

Electronic Theses & Dissertations

This study examines the inclusion of multiple exemplars in mastery criteria and its effect on maintenance and generalization. This study examines early intervention with children aged 3-6 diagnosed with ASD. The utilization of three exemplars in mastery criteria compared to one exemplar lead to greater generalization, but generalization remined low across both conditions.


Internal And Social Sources Shape Judgments About The Mental And Physical Nature Of An Experience, Jacinth Jia Xin Tan, Alexander Karan, Dolores Albarracin Jan 2024

Internal And Social Sources Shape Judgments About The Mental And Physical Nature Of An Experience, Jacinth Jia Xin Tan, Alexander Karan, Dolores Albarracin

Research Collection School of Social Sciences

Although humans are intuitive dualists, little is known about whether they hold lay beliefs about the origins or sources of their intuitive perceptions of what is physical and what is mental. Drawing on theories of the sources of phenomenological experiences, we examined if people hold beliefs about the internal and social origins of judments that their experiences are physical or mental. In Study 1, participants provided physical or mental judgments about a range of personal experiences, and reported relying on both internal (i.e., examining own body and thoughts) and social (i.e., observing others) sources as information for their judgments. To …


The Potential For Competency-Based Teaching Methodologies To Increase Intervention Procedural Fidelity And Reduce Self-Reported Verbal Behavior Associated With Turnover In Behavior Technicians, Dean I. Shearer Jan 2024

The Potential For Competency-Based Teaching Methodologies To Increase Intervention Procedural Fidelity And Reduce Self-Reported Verbal Behavior Associated With Turnover In Behavior Technicians, Dean I. Shearer

Cal Poly Humboldt theses and projects

Within the field of applied behavior analysis, behavior technicians (staff who are supervised by behavioral analysists and provide direct services to clients) experience relatively high rates of turnover. It is possible that improved teaching methodologies which boost the efficacy of these staff may help reduce this turnover by reducing verbal behavior associated with burnout and improve perceptions of training and supervision. We compared intervention procedural fidelity and staff ratings of burnout, supervision, and satisfaction with training following a didactic training, a behavioral skills training, and after a month-long follow up. We found that when mastery criteria were set sufficiently high …


Proteomic Profiles Of Cytokines And Chemokines In Moderate To Severe Depression: Implications For Comorbidities And Biomarker Discovery, Kathleen T. Watson, Jennifer Keller, Caleb M. Spiro, Isaac B. Satz, Samantha V. Goncalves, Heather Pankow, Idit Kosti, Benoit Lehallier, Adolfo Sequeira, William E. Bunney, Natalie L. Rasgon, Alan F. Schatzberg Jan 2024

Proteomic Profiles Of Cytokines And Chemokines In Moderate To Severe Depression: Implications For Comorbidities And Biomarker Discovery, Kathleen T. Watson, Jennifer Keller, Caleb M. Spiro, Isaac B. Satz, Samantha V. Goncalves, Heather Pankow, Idit Kosti, Benoit Lehallier, Adolfo Sequeira, William E. Bunney, Natalie L. Rasgon, Alan F. Schatzberg

Psychology Division Scholarship

Objective: This study assessed the proteomic profiles of cytokines and chemokines in individuals with moderate to severe depression, with or without comorbid medical disorders, compared to healthy controls. Two proteomic multiplex platforms were employed for this purpose. Metods: An immunofluorescent multiplex platform and an aptamer-based method were used to evaluate 32 protein analytes from 153 individuals with moderate to severe major depressive disorder (MDD) and healthy controls (HCs). The study focused on determining the level of agreement between the two platforms and evaluating the ability of individual analytes and principal components (PCs) to differentiate between the MDD and HC groups. …