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2022

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Full-Text Articles in Psychology

The Role Of Mortality Salience And Social Identity In Police Officers And Students Reporting Misconduct, Anna M. Stenkamp Sep 2022

The Role Of Mortality Salience And Social Identity In Police Officers And Students Reporting Misconduct, Anna M. Stenkamp

Dissertations, Theses, and Capstone Projects

Over the past several decades, high-profile police shootings, police brutality, and police misconduct have contributed to a decreased trust in policing in the United States. Beyond the severity and abuse of power, many of these incidents have also revealed that officers have covered up these incidents from the public. The refusal of police officers to both report misconduct or cover it up is well established and known as the “blue wall of silence.” However, no previous studies have examined the psychological processes behind this failure to report fellow officer misconduct. Two psychological theories that may explain this failure are Terror …


Exploring Social And Emotional Functioning In Emerging Adult Survivors Of Adverse Childhood Experiences, Sara Babad Sep 2022

Exploring Social And Emotional Functioning In Emerging Adult Survivors Of Adverse Childhood Experiences, Sara Babad

Dissertations, Theses, and Capstone Projects

As many as two thirds of adults in the United States have experienced adverse childhood experiences (ACEs) and 60% of these individuals have experienced multiple, or cumulative ACEs. ACEs are associated with a range of outcomes, including social, emotional, and cognitive changes, health risk behaviors, psychopathology, worse physical health, and early death. Although some ACEs effects have been well-researched, social and emotional changes have received minimal attention in the literature in general. Research on ACEs effects in emerging adults (ages 18 to 25), an already vulnerable population, is also limited. Furthermore, there is debate in the field as to which …


Unexpected Arousal Suppresses Memory And Metamemory Predictions During Associative Face-Name Recognition Task, Sameer Sabharwal-Siddiqi Sep 2022

Unexpected Arousal Suppresses Memory And Metamemory Predictions During Associative Face-Name Recognition Task, Sameer Sabharwal-Siddiqi

Dissertations, Theses, and Capstone Projects

Successful recognition often depends on probabilistic estimation of memory-signal. Arousal has been shown to offset the influence of heuristic evidence on memory prediction. We conducted three experiments that tested whether arousal also suppresses predictions relevant to memory confidence. Experiments employed associative face-name memory tasks that included retrospective (Experiments 1 and 2) or concurrent (Experiment 3) judgements of confidence. During test, subjects were presented with a masked-affective face on a subset of trials. By timing the masked-affective face to precede a recognition judgement (Experiment 1), we replicated the finding that unexpected arousal offsets the influence of heuristic evidence on expectations of …


Anomalous Self-Experiences And Aberrant Salience In Schizotypy, Victoria Martin Sep 2022

Anomalous Self-Experiences And Aberrant Salience In Schizotypy, Victoria Martin

Dissertations, Theses, and Capstone Projects

Within this investigation, the self-disorder hypothesis of schizophrenia was assessed via an illusory perceptual paradigm. It has been proposed that alteration of basic (minimal) selfhood may underlie cognitive and perceptual disturbances in psychosis (Sass, 2014). Disturbed corporeality (i.e., anomalous experience of one’s body) is an identified component of basic self-disturbance. As it is difficult to empirically capture the spontaneous occurrence of anomalous bodily experiences as they arise, the Pinocchio Illusion (PI) has been employed to capture variations in the plasticity of bodily self-experience (specifically, body boundary plasticity) (Michael & Park, 2016). The PI paradigm provides for the sensations of arm …


Countertransference And The Patient's Experience: Exploring How Engagement With Affect Is Related To Short-Term Psychotherapy Outcomes, Ariel R. Westerman Sep 2022

Countertransference And The Patient's Experience: Exploring How Engagement With Affect Is Related To Short-Term Psychotherapy Outcomes, Ariel R. Westerman

Dissertations, Theses, and Capstone Projects

Background: Therapist focus on affect in the here-and-now can facilitate a patient’s emotional experience as well as expression of affect, both of which are associated with better outcome over the course of treatment (Diener et al., 2007). A therapist’s use of her own experience of the patient can serve as a signal to intervene in the here-and-now. While “countertransference” was historically seen as an obstacle to a therapist’s neutrality and therefore efficacy (Freud, 1910), shifts in the field toward a two-person psychology model led some to reconsider it as a potential source of clinical data (Winnicott, 1947; Heimann, 1950; Racker, …


An Interdisciplinary Approach To The Epistemic Value Of Moral Ambiguity, Jordan Wylie Sep 2022

An Interdisciplinary Approach To The Epistemic Value Of Moral Ambiguity, Jordan Wylie

Dissertations, Theses, and Capstone Projects

Morality is a critical aspect of life––it influences how we think, design political and legal systems, who we connect with, our norms, and the types of stories we tell. Yet, even with the well documented influence of morality on many aspects of life, exactly what makes moral themes so fascinating remains elusive. This dissertation aims to introduce Moral Worldbuilding as a theory for understanding our epistemic drives toward morally ambiguous and morally bad content.

In Chapter I, we introduce the problem of moral badness, which is not well handled by extant moral literature. To combat this, we offer a new …


Competitive And Facilitative Interactions Between Pavlovian Cues In Human Associative Learning: A Behavioral And Neural Analysis, Fahd Alhazmi Sep 2022

Competitive And Facilitative Interactions Between Pavlovian Cues In Human Associative Learning: A Behavioral And Neural Analysis, Fahd Alhazmi

Dissertations, Theses, and Capstone Projects

Learning to anticipate significant events accurately is a crucial element of survival for all species. The process by which animals acquire this knowledge has been a central question of psychological research. A fundamental assumption of many learning theories is that the predictive value assigned to cues is not simply determined by their probability of reinforcement but rather by their ability to compete with other cues present during learning. The assumption of cue competition has significantly contributed to the development of behavioral and neuroscience research for decades, as it has opened the door to new empirical and theoretical advances on the …


Neuroanatomy In Mild Cognitive Impairment: Relationship To Functional Skills, Treatment Expectancy, And Comorbid Depression, Sara Rushia Sep 2022

Neuroanatomy In Mild Cognitive Impairment: Relationship To Functional Skills, Treatment Expectancy, And Comorbid Depression, Sara Rushia

Dissertations, Theses, and Capstone Projects

Mild cognitive impairment (MCI) is a neurocognitive disorder defined by cognitive decline in older adults. Although MCI has been studied for decades, there remain important areas to be explored in order to adequately characterize aspects of this disorder that provide information valuable for possible interventions and disease progression to dementia, including a better understanding of the neuroanatomical variables relevant to this disorder. Such neuroanatomical variables include cortical thickness, hippocampal volume, and white matter hyperintensities (WMHs). This dissertation consists of three separate studies aimed at addressing gaps in the literature on MCI in relation to brain morphometrics and under-studied characteristics involved …


Lost In Digitization: Physical Products Are Vessels For Social Meaning, Oden H. Groth Sep 2022

Lost In Digitization: Physical Products Are Vessels For Social Meaning, Oden H. Groth

Dissertations, Theses, and Capstone Projects

The explosion in digitization means that consumers increasingly have the opportunity to choose between digital and physical versions of products — for example, between an eBook and a paperback book. However, despite the popularity of digital objects, many people nonetheless prefer physical equivalents. This dissertation explores one reason why this may be the case; namely, that physical versions of objects and products are better vessels for social meaning. In chapter 1, explore the specialness of physical objects, and posit that materiality is critical for holding and embodying significance. In chapter 2, I investigate the effects of product format on perceptions …


The Social Construction Of Premenstrual Dysphoric Disorder (Pmdd), Raya Balabanova Sep 2022

The Social Construction Of Premenstrual Dysphoric Disorder (Pmdd), Raya Balabanova

Dissertations, Theses, and Capstone Projects

The creation of psychiatric diagnoses, otherwise known as psychiatric nosology, is a complex endeavor, one involving a great deal of social construction. One diagnosis in particular, premenstrual dysphoric disorder (PMDD), exemplifies the different factors that go into the creation of psychiatric labels. After decades of research, activism, and debates, PMDD was included in the diagnostic and statistical manual (DSM-5), which is widely used by clinicians in the U.S. This thesis aims to describe how the symptoms described by PMDD caught the attention of the medical profession and how PMDD was shaped into the diagnosis it is today. The introduction of …


A Survey Study Of Speech-Language Therapists’ Experiences With Teletherapy At The Onset Of The Covid-19 Crisis, Jason A. Rosas Sep 2022

A Survey Study Of Speech-Language Therapists’ Experiences With Teletherapy At The Onset Of The Covid-19 Crisis, Jason A. Rosas

Dissertations, Theses, and Capstone Projects

The present study aimed to understand how delivering pediatric treatment services via ‘teletherapy’ affected speech-language therapists (SLTs) during the initial outbreak of the COVID-19 pandemic crisis in 2020. SLTs reported on their experiences with the change from in-person to remote service delivery via two national surveys distributed at the start of the pandemic between April 2020 and July 2020. To explain SLTs’ survey responses, this dissertation introduced the Professional Adaptation Model (PA Model). The PA Model facilitated evaluation of the SLTs’ professional environment and the psychological constructs of their professional identity believed to influence the transition to speech-language teletherapy. Specifically, …


Retrieval Practice Promotes Learning Of Turkish As A Foreign Language: A Computer-Assisted Language Learning Study, Maya C. Rose Sep 2022

Retrieval Practice Promotes Learning Of Turkish As A Foreign Language: A Computer-Assisted Language Learning Study, Maya C. Rose

Dissertations, Theses, and Capstone Projects

Adults generally find it difficult to learn a new language, yet exhibit remarkable individual differences in outcomes. Variation in second language (L2) learning is associated with input conditions (Morgan-Short et al., 2010) as well as learners’ aptitude (Dörnyei, 2005). Recent work has demonstrated benefits of retrieval practice in promoting L2 learning of grammatical patterns and vocabulary in both artificial and natural languages (Hopman & MacDonald, 2018; Keppenne et al., 2021). With that said, when retrieval practice is based on oral recall as opposed to a recognition test, it confounds potential benefits of repeated testing (Rowland, 2014) with those associated with …


Cerebrovascular Impairment As A Potential Target For Neuromodulation Therapy In Moderate-Severe Traumatic Brain Injury, Naomi L. Gaggi Sep 2022

Cerebrovascular Impairment As A Potential Target For Neuromodulation Therapy In Moderate-Severe Traumatic Brain Injury, Naomi L. Gaggi

Dissertations, Theses, and Capstone Projects

The main purpose of this dissertation is to characterize noninvasive neuroimaging biomarkers of neurovascular injury in moderate-severe traumatic brain injury (msTBI) as potential treatment targets for neuromodulation therapy. In Chapter 1, I aim to introduce msTBI and two known sequelae of neurovascular damage in msTBI: reduced cerebral blood flow (Ware et al., 2020; Julliene et al., 2016) and altered low frequency fluctuations in blood oxygen level-dependent signal (Zhou et al., 2021; Palacios et al., 2013). Chapter 2 aims to identify the regional pattern of altered resting cerebral blood flow from a cohort of 29 patients with msTBI assessed at 3, …


The Differential Effects Of Acoustic Discriminations On Operant Learning Performance And Neurogenesis In Male And Female Zebra Finches, Kristena L. Newman Sep 2022

The Differential Effects Of Acoustic Discriminations On Operant Learning Performance And Neurogenesis In Male And Female Zebra Finches, Kristena L. Newman

Dissertations, Theses, and Capstone Projects

Adult neurogenesis, the creation of new neurons, occurs throughout the lifespan in most organisms. However, though neuronal proliferation occurs daily, most of these neurons do not survive to become incorporated into preexisting neural circuitry and become fully functioning neurons. In the mammalian brain, adult neurogenesis occurs within the hippocampus, a brain region known to be important in learning and memory. In rats, successful acquisition of certain learning tasks increased new neuron numbers when the learning was sufficiently challenging (Curlik and Shors, 2011). It has also been demonstrated that a spatial discrimination task requires new neurons when the discrimination is more …


Relationships Between Sensory Reactivity, Restricted And Repetitive Behaviors, And Autonomic Nervous System Activity In Autistic And Non-Autistic Individuals, Sapir Elimaliah Sep 2022

Relationships Between Sensory Reactivity, Restricted And Repetitive Behaviors, And Autonomic Nervous System Activity In Autistic And Non-Autistic Individuals, Sapir Elimaliah

Dissertations, Theses, and Capstone Projects

The current dissertation includes seven chapters. Chapter 1 includes my professional background and describes the experiences that led me to study restricted and repetitive behaviors. It also briefly describes my personal journey as an international graduate student. Chapter 2 is devoted to the rich literature that this dissertation is based on. The literature review covers both the foundational and most recent findings in the fields of sensory reactivity, restricted and repetitive behaviors, and autonomic activity, as well as the known relationships between these areas in autistic and non-autistic individuals. In Chapter 3, I describe in detail the methodology used in …


Antisocial Behavior And Callous Unemotional Traits In Youth: A Biosocial Approach, Yong Lin Huang Sep 2022

Antisocial Behavior And Callous Unemotional Traits In Youth: A Biosocial Approach, Yong Lin Huang

Dissertations, Theses, and Capstone Projects

Early life presence of antisocial behavior (e.g., aggression/delinquency) and psychopathic/callous-unemotional (CU) traits (lacking empathy/remorse, shallow affect) are precursors to juvenile crime and criminal offending in adulthood. Etiological research on antisocial/CU tendencies has implicated both neurobiological (e.g., alterations in brain function and structure) and environmental (social adversity, prenatal stress) underpinnings. It has been proposed that reward and punishment processing deficits may induce problematic traits and behavior, such that antisocial/CU tendencies may be linked to hypersensitivity to rewards and hyposensitivity to punishment. Studies in this area have generated inconsistent findings and focused primarily on adult and clinical samples, leaving youth and community …


Virtual Reality Supplement To The Peers Social Skills Intervention For Adolescents With Asd, Kevin Ambrose Sep 2022

Virtual Reality Supplement To The Peers Social Skills Intervention For Adolescents With Asd, Kevin Ambrose

Dissertations, Theses, and Capstone Projects

The purpose of this study was to replicate findings of the Program for the Education and Enrichment of Relation Skills (PEERS) parent-assisted social skills training program for a diverse group of adolescents with historical autism spectrum disorder (ASD) diagnoses in an urban locality. Additionally, this study sought to pilot a 3D multi-user virtual environment for adolescent participants and an online learning community for parent coaches; both hypothesized to reinforce the social skills curriculum. A randomized controlled trial of PEERS was completed with 12 adolescents diagnosed with ASD with some participation from their caregivers. Results show that participants who received the …


Linguistic Abstractions In Children’S Very Early Utterances, Qihui Xu Sep 2022

Linguistic Abstractions In Children’S Very Early Utterances, Qihui Xu

Dissertations, Theses, and Capstone Projects

How early do children produce multiword utterances? Do children's early utterances reflect abstract syntactic knowledge or are they the result of data-driven learning? We examine this issue through corpus analysis, computational modeling, and adult simulation experiments. Chapter 1 investigates when children start producing multiword utterances; we use corpora to establish the development of multiword utterances and a probabilistic computational model to account for the quantitative change of early multiword utterances. We find that multiword utterances of different lengths appear early in acquisition and increase together, and the length growth pattern can be viewed as a probabilistic and dynamic process.

Chapter …


Oxytocin, A Lover And A Fighter: Maternal Trauma Exposure And Mother-Child Coregulation, Patricia M. Pehme Sep 2022

Oxytocin, A Lover And A Fighter: Maternal Trauma Exposure And Mother-Child Coregulation, Patricia M. Pehme

Dissertations, Theses, and Capstone Projects

The placenta is responsible for regulating the fetal growth and environment in preparation for the anticipated external life. To succeed, it continuously adapts and weaves in a variety of neuroendocrine signals from the maternal organism. If a mother was exposed to trauma and her physiology sustained a change in the functioning of the immune, autonomic and/or endocrine systems, the placenta may anticipate different external environments for her children as compared to children of mothers without trauma exposure. This dissertation examined possible underlying mechanisms of psychosocial trauma transmission from one generation to the next via the placental oxytocinergic pathway. Encompassing three …


The Impacts Of Problematic Social Media Use On Youths: Evaluation And Treatment Recommendations, Carianne Archer Sep 2022

The Impacts Of Problematic Social Media Use On Youths: Evaluation And Treatment Recommendations, Carianne Archer

Dissertations

Youths’ frequency and time spent on social media continues to increase over the years parallel to the growing concern of the status of the mental health of youth. This critical literature review project focuses on the impacts that social media use has on youth (ages 8 to 18 years) and what methods of evaluation and treatment are being used clinically, with recommendations provided to clinicians based on the available literature. The questions that guided this review included: What are the impacts of social media on the self-concept and interpersonal functioning of youths?; What clinical presentations are associated with youths who …


Well-Being Science For Teaching And The General Public, William Tov, Derrick Wirtz, Kostadin Kushlev, Robert Biswas-Diener, Ed Diener Sep 2022

Well-Being Science For Teaching And The General Public, William Tov, Derrick Wirtz, Kostadin Kushlev, Robert Biswas-Diener, Ed Diener

Research Collection School of Social Sciences

Research on well-being has exploded in recent years to more than 55,000 relevant publications annually, making it difficult for psychologists—including key communicators such as textbook authors—to stay current with this field. Moreover, well-being is a daily concern among policymakers and members of the general public. Well-being science is relevant to the lives of students—illustrating the diverse methods used in the behavioral sciences, presenting highly replicated findings, and demonstrating the diversity of individuals and cultures. Therefore, in this article, we present eight major findings that teachers and authors should seriously consider in their coverage of this field. These topics include processes …


In Covid-19 Health Messaging, Loss Framing Increases Anxiety With Little-To-No Concomitant Benefits: Experimental Evidence From 84 Countries, Charles A. Dorison, Et. Al., Andree Hartanto Sep 2022

In Covid-19 Health Messaging, Loss Framing Increases Anxiety With Little-To-No Concomitant Benefits: Experimental Evidence From 84 Countries, Charles A. Dorison, Et. Al., Andree Hartanto

Research Collection School of Social Sciences

The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g., “If you do not practice these steps, you can endanger yourself and others”) or potential gains (e.g., “If you practice these steps, you can protect yourself and others”)? Collecting data in 48 languages from 15,929 participants in 84 countries, we experimentally tested the effects of message …


Fundamental Social Motives Measured Across Forty-Two Cultures In Two Waves, C. M. Pick, ..., Norman P. Li Sep 2022

Fundamental Social Motives Measured Across Forty-Two Cultures In Two Waves, C. M. Pick, ..., Norman P. Li

Research Collection School of Social Sciences

How does psychology vary across human societies? The fundamental social motives framework adopts an evolutionary approach to capture the broad range of human social goals within a taxonomy of ancestrally recurring threats and opportunities. These motives—self-protection, disease avoidance, affiliation, status, mate acquisition, mate retention, and kin care—are high in fitness relevance and everyday salience, yet understudied cross-culturally. Here, we gathered data on these motives in 42 countries (N = 15,915) in two cross-sectional waves, including 19 countries (N = 10,907) for which data were gathered in both waves. Wave 1 was collected from mid-2016 through late 2019 (32 countries, N …


Potential And Pitfalls Of Mobile Mental Health Apps In Traditional Treatment: An Umbrella Review, Jerica Koh, Germaine Y. Q. Tng, Andree Hartanto Sep 2022

Potential And Pitfalls Of Mobile Mental Health Apps In Traditional Treatment: An Umbrella Review, Jerica Koh, Germaine Y. Q. Tng, Andree Hartanto

Research Collection School of Social Sciences

While the rapid growth of mobile mental health applications has offered an avenue of support unbridled by physical distance, time, and cost, the digitalization of traditional interventions has also triggered doubts surrounding their effectiveness and safety. Given the need for a more comprehensive and up-to-date understanding of mobile mental health apps in traditional treatment, this umbrella review provides a holistic summary of their key potential and pitfalls. A total of 36 reviews published between 2014 and 2022—including systematic reviews, meta-analyses, scoping reviews, and literature reviews—were identified from the Cochrane library, Medline (via PubMed Central), and Scopus databases. The majority of …


Cultivating Positivity To Achieve A Resilient Society: A Critical Narrative Review From Psychological Perspectives, Andree Hartanto, K. T. A. Sandeeshwara Kasturiratna, Xun Ci Soh Sep 2022

Cultivating Positivity To Achieve A Resilient Society: A Critical Narrative Review From Psychological Perspectives, Andree Hartanto, K. T. A. Sandeeshwara Kasturiratna, Xun Ci Soh

Research Collection School of Social Sciences

With the rapid speed of globalization and technological breakthroughs, current social issues have become more complex than in past decades. As many issues such as pandemics, terrorism, and interracial conflict are realistically unpredictable, the idea of resilience offers an intuitively plausible and attainable strategy to deal with these potential adversities. The current narrative review explores the cultivation of positive emotions and traits as a plausible way to achieve a resilient society. Based on research in the social and industrial organizational psychology literature, we reviewed the role of positive emotions and traits on resilience. Lastly, we highlight important experiences and interventions …


The Effects Of False Heartbeat Feedback On Moral Judgment, Scott Koenig Sep 2022

The Effects Of False Heartbeat Feedback On Moral Judgment, Scott Koenig

Dissertations, Theses, and Capstone Projects

Research on human morality is at a crossroads, with one side claiming that moral judgment is the result of rational inference and the other side claiming that it is the result of emotion-laden intuition. This study investigated whether emotion drives moral judgment by manipulating a core component of the experience of emotion: physiological arousal. The sample consisted of 77 undergraduate students at Brooklyn College (57% women, 43% men; mean age = 20.1). One group of participants was led to believe their heart was beating quickly, and another group slowly, while they read and evaluated a series of text vignettes depicting …


Problematic Social Media Use, Social Comparison, And Defeat: An Intensive Longitudinal Investigation, Natalia Macrynikola Sep 2022

Problematic Social Media Use, Social Comparison, And Defeat: An Intensive Longitudinal Investigation, Natalia Macrynikola

Dissertations, Theses, and Capstone Projects

Self-injurious thoughts and behaviors (SITBs) have steadily risen over the past two decades. The simultaneous dramatic increase in social media use has fueled concerns that using social media may be contributing to suicide risk. Although an emerging body of evidence reveals associations between certain patterns of social media use and SITBs, most research studies have not been designed to assess the temporal order of these variables and have neglected to investigate mechanisms underlying such associations. As a result, whether and how social media use may be conferring suicide risk remains unclear. To address this gap, the present study examined a …


Multimodel Order Independent Component Analysis: A Data-Driven Method For Evaluating Brain Functional Network Connectivity Within And Between Multiple Spatial Scales, Xing Meng, Armin Iraji, Zening Fu, Peter Kochunov, Aysenil Belger, Judith Ford, Sara Mcewen, Daniel H Mathalon, Bryon A Mueller, Godfrey Pearlson, Steven G Potkin, Adrian Preda, Jessica Turner, Theo Van Erp, Jing Sui, Vince D Calhoun Sep 2022

Multimodel Order Independent Component Analysis: A Data-Driven Method For Evaluating Brain Functional Network Connectivity Within And Between Multiple Spatial Scales, Xing Meng, Armin Iraji, Zening Fu, Peter Kochunov, Aysenil Belger, Judith Ford, Sara Mcewen, Daniel H Mathalon, Bryon A Mueller, Godfrey Pearlson, Steven G Potkin, Adrian Preda, Jessica Turner, Theo Van Erp, Jing Sui, Vince D Calhoun

Faculty, Staff and Student Publications

Background:

While functional connectivity is widely studied, there has been little work studying functional connectivity at different spatial scales. Likewise, the relationship of functional connectivity between spatial scales is unknown.

Methods:

We proposed an independent component analysis (ICA)-based approach to capture information at multiple-model orders (component numbers), and to evaluate functional network connectivity (FNC) both within and between model orders. We evaluated the approach by studying group differences in the context of a study of resting-state functional magnetic resonance imaging (rsfMRI) data collected from schizophrenia (SZ) individuals and healthy controls (HC). The predictive ability of FNC at multiple spatial scales …


Epigenetic Grimage Acceleration And Cognitive Impairment In Bipolar Disorder, Camila N C Lima, Robert Suchting, Giselli Scaini, Valeria A Cuellar, Alexandra Del Favero-Campbell, Consuelo Walss-Bass, Jair C Soares, Joao Quevedo, Gabriel R Fries Sep 2022

Epigenetic Grimage Acceleration And Cognitive Impairment In Bipolar Disorder, Camila N C Lima, Robert Suchting, Giselli Scaini, Valeria A Cuellar, Alexandra Del Favero-Campbell, Consuelo Walss-Bass, Jair C Soares, Joao Quevedo, Gabriel R Fries

Faculty, Staff and Student Publications

Bipolar disorder (BD) has been previously associated with clinical signs of premature aging, including accelerated epigenetic aging in blood and brain, and a steeper age-related decline in cognitive function. However, the clinical drivers and cognitive correlates of epigenetic aging in BD are still unknown. We aimed to investigate the relationship between multiple measures of epigenetic aging acceleration with clinical, functioning, and cognitive outcomes in patients with BD and controls. Blood genome-wide DNA methylation levels were measured in BD patients (n = 153) and matched healthy controls (n = 50) with the Infinium MethylationEPIC BeadChip (Illumina). Epigenetic age estimates were calculated …


Revisiting Sex Differences In The Acquisition And Extinction Of Threat Conditioning In Humans, Zhenfu Wen, Jamie Fried, Edward F Pace-Schott, Sara W Lazar, Mohammed R Milad Sep 2022

Revisiting Sex Differences In The Acquisition And Extinction Of Threat Conditioning In Humans, Zhenfu Wen, Jamie Fried, Edward F Pace-Schott, Sara W Lazar, Mohammed R Milad

Faculty, Staff and Student Publications

Findings pertaining to sex differences in the acquisition and extinction of threat conditioning, a paradigm widely used to study emotional homeostasis, remain inconsistent, particularly in humans. This inconsistency is likely due to multiple factors, one of which is sample size. Here, we pooled functional magnetic resonance imaging (fMRI) and skin conductance response (SCR) data from multiple studies in healthy humans to examine sex differences during threat conditioning, extinction learning, and extinction memory recall. We observed increased functional activation in males, relative to females, in multiple parietal and frontal (medial and lateral) cortical regions during acquisition of threat conditioning and extinction …