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Articles 391 - 420 of 744
Full-Text Articles in Psychology
Counseling Attitudes And Stigma Among Polynesian Americans, Timothy B. Smith, G. E. Kawika Allen, Ofa Hafoka
Counseling Attitudes And Stigma Among Polynesian Americans, Timothy B. Smith, G. E. Kawika Allen, Ofa Hafoka
Faculty Publications
There is a paucity of research on the mental health of Pacific Islanders living in the U.S., including those of Polynesian descent. This study examined coping strategies, attitudes towards seeking mental health counseling, public and self-stigma towards seeking professional help, and psychological adjustment among 638 Polynesian Americans. On average, participants held neither favorable nor unfavorable attitudes towards seeking professional psychological help, but Polynesian American men endorsed moderate self-stigma about mental illness and Polynesian American women endorsed high levels of public stigma about mental illness. Women showed relatively more favorable attitudes than men about seeking help from professional mental health providers. …
Psychotherapy Utilization And Presenting Concerns Among Polynesian American College Students, G. E. Kawika Allen, Timothy B. Smith, Jon Cox, Ofa Hafoka, Derek Griner, Mark Beecher
Psychotherapy Utilization And Presenting Concerns Among Polynesian American College Students, G. E. Kawika Allen, Timothy B. Smith, Jon Cox, Ofa Hafoka, Derek Griner, Mark Beecher
Faculty Publications
This study examined psychotherapy utilization, presenting concerns, reported distress levels, and psychotherapy outcomes among Polynesian American students presenting for services at a counseling center at a large inter-mountain university on the mainland U.S. We collected data at intake, during therapy sessions, and at termination for 415 Polynesian American students over a 17-year period. Utilization results indicate no difference, but Polynesian American students were equally likely to utilize counseling services as European American students but were more likely to drop out earlier than European American students. At intake these students presented with shared higher numbers of presenting concerns and greater levels …
Attitudes And Experiences With Older Adults: A Case For Service Learning For Undergraduates, Hardeep Obhi, Erin Woodhead
Attitudes And Experiences With Older Adults: A Case For Service Learning For Undergraduates, Hardeep Obhi, Erin Woodhead
Faculty Publications
The current study examined whether relationship quality with older adults currently and in childhood, as well as experience with older adults, was associated with biases toward older adults and interest in working with older adults as a possible career area. The authors sampled undergraduate students (N = 753, M = 18.97 years, SD = 2.11 years) from a Northern California university. In hierarchical regression analyses, higher perceived quality of relationships with older adult family members, higher perceived social support, and lower perceived conflict from relationships with older adults was significantly associated with positive attitudes toward older adults. Interest in …
Prevention Strategies And Mental Health In Vietnam, Edward Cohen
Prevention Strategies And Mental Health In Vietnam, Edward Cohen
Faculty Publications
This paper addresses the current state of mental health services in Vietnam and provides recommendations for improving the care of people with mental illness. Vietnam’s mental health problems are as prevalent as anywhere else in the world. The country has recently begun an initiative to reform mental health care by improving community-based services for people with serious mental illness. However, mental illness has not been a part of public discourse in Vietnam. There is little recognition of prevalent common mental illnesses (such as depression, anxiety and alcohol abuse) and the care of people with serious mental illnesses relies on either …
Acquisition Of The Cardinal Principle Coincides With Improvement In Approximate Number System Acuity In Preschoolers, Anna Shusterman, Emily Slusser, Justin Halberda, Darko Odic
Acquisition Of The Cardinal Principle Coincides With Improvement In Approximate Number System Acuity In Preschoolers, Anna Shusterman, Emily Slusser, Justin Halberda, Darko Odic
Faculty Publications
Human mathematical abilities comprise both learned, symbolic representations of number and unlearned, non-symbolic evolutionarily primitive cognitive systems for representing quantities. However, the mechanisms by which our symbolic (verbal) number system becomes integrated with the non-symbolic (non-verbal) representations of approximate magnitude (supported by the Approximate Number System, or ANS) are not well understood. To explore this connection, forty-six children participated in a 6-month longitudinal study assessing verbal number knowledge and non-verbal numerical acuity. Cross-sectional analyses revealed a strong relationship between verbal number knowledge and ANS acuity. Longitudinal analyses suggested that increases in ANS acuity were most strongly related to the acquisition …
Exploring Differing Experiences Of Homelessness In Hawai‘I: Full Report To Stakeholders Part Ii, Kristen D. Gleason Phd, John P. Barile, Charlene Baker
Exploring Differing Experiences Of Homelessness In Hawai‘I: Full Report To Stakeholders Part Ii, Kristen D. Gleason Phd, John P. Barile, Charlene Baker
Faculty Publications
Because high rates of homelessness have become a growing concern across the U.S., a number of policies, programs, and strategies have been developed to prevent homelessness and to addess the needs of those without a home (Culhane, Park, & Metraux, 2011). As it is unlikely that a one sizefits-all approach to homelessness can be effective, it is important for there to be a wide range of service approaches available to address the issue (Yuan, Vo, & Gleason, 2014). As important is determining how to best target the available services to meet the varied needs of those experiencing homelessness.
Exploring Differing Experiences Of Homelessness In Hawai‘I: Full Report To Stakeholders Part I, Kristen D. Gleason Phd, Charlene Baker, John P. Barile
Exploring Differing Experiences Of Homelessness In Hawai‘I: Full Report To Stakeholders Part I, Kristen D. Gleason Phd, Charlene Baker, John P. Barile
Faculty Publications
In many cities and towns across the U.S., homelessness has arisen as a prominent and difficult problem to address (Quigley, Raphael, & Smolensky, 2001). It has become a public health and humanitarian concern at both the national level and at the state level in Hawai‘i. The recent Homeless Service Utilization Report for Hawai‘i State, which tracks administrative data related to homeless service usage across the state, shows that the number of homeless individuals in Hawai‘i has steadily grown since 2007, with a record 14,954 individuals receiving services in the last fiscal year (Yuan, Vo, Gleason, & Azuma, 2016). Hawai‘i is …
Interdisciplinary Social Action, Leonard A. Jason, Damani Mcclellan, Kristen D. Gleason Phd
Interdisciplinary Social Action, Leonard A. Jason, Damani Mcclellan, Kristen D. Gleason Phd
Faculty Publications
In this article, we will first consider the starting point for change. Social change is more likely to occur when we have a passionate interest in a particular area. Often the beginning of social change occurs when we have a passionate interest in a particular area. Often the beginning of social change occurs with the recognition that something is wrong and unfair. This recognition may take the form of a flash of outrage, but the feeling is clear: this needs to change. We may not even know why we feel this way, but our intuition can steer us in …
Groundhog Oracles And Their Forebears, Daniel S. Capper
Groundhog Oracles And Their Forebears, Daniel S. Capper
Faculty Publications
Groundhog Day animal weather forecasting ceremonies continue to proliferate around the United States despite a lack of public confidence in the oracles. This essay probes religio-historical and original ethnographic perspectives to offer a psychological argument for why these ceremonies exist. Employing Paul Shepard’s notion of a felt loss of sacred, intimate relationships with nonhuman nature, as well as Peter Homans’ concept of the monument that enables mourning, this essay argues that groundhog oracles serve as monuments that allow humans experientially to attempt to heal lost sacred relationships with animals like weather forecasting bears, hedgehogs, and badgers
Cognitive Phenotypes And The Evolution Of Animal Decisions, Tamra C. Mendelson, Courtney L. Fitzpatrick, Mark E. Hauber, Charles H. Pence, Rafael L. Rodríguez, Rebecca J. Safran, Caitlin A. Stern, Jeffrey R. Stevens
Cognitive Phenotypes And The Evolution Of Animal Decisions, Tamra C. Mendelson, Courtney L. Fitzpatrick, Mark E. Hauber, Charles H. Pence, Rafael L. Rodríguez, Rebecca J. Safran, Caitlin A. Stern, Jeffrey R. Stevens
Faculty Publications
Despite the clear fitness consequences of animal decisions, the science of animal decision making in evolutionary biology is underdeveloped compared with decision science in human psychology. Specifically, the field lacks a conceptual framework that defines and describes the relevant components of a decision, leading to imprecise language and concepts. The ‘judgment and decision-making’ (JDM) framework in human psychology is a powerful tool for framing and understanding human decisions, and we apply it here to components of animal decisions, which we refer to as ‘cognitive phenotypes’. We distinguish multiple cognitive phenotypes in the context of a JDM framework and highlight empirical …
The Maternal Personhood Of Cattle And Plants At A Hindu Center In The United States, Daniel S. Capper
The Maternal Personhood Of Cattle And Plants At A Hindu Center In The United States, Daniel S. Capper
Faculty Publications
Religious experiences with sacred nonhuman natural beings considered to be “persons” remain only vaguely understood. This essay provides a measure of clarification by engendering a dialogue between psychoanalytic self psychology on one side and, on the other, religious experiences of cattle and Tulsi plants as holy mothers at a Hindu cattle sanctuary in the United States. Ethnographic data from the Hindu center uncover experiences of sacred maternal natural beings that are tensive, liminal, and colored with affective themes of nurturance, respect, and intimacy, much like psychoanalytic maternal selfobjects. Devotees protect cattle and ritually venerate plants because these actions facilitate a …
The Unique Influences Of Parental Divorce And Parental Conflict On Emerging Adults In Romantic Relationships, Scott R. Braithwaite, Reed A. Doxey, Krista Dowdle, Frank D. Fincham
The Unique Influences Of Parental Divorce And Parental Conflict On Emerging Adults In Romantic Relationships, Scott R. Braithwaite, Reed A. Doxey, Krista Dowdle, Frank D. Fincham
Faculty Publications
Parental divorce and parental conflict influence children across multiple domains, including risk of divorce in their own marriages. However, parental conflict and divorce, both separately and the interaction between the two, have not often been studied in premarital relationships, especially when considering possible mechanisms mediating these effects. In a large sample of emerging adults (N = 353), we show that when the most plausible mediating mechanisms are simultaneously considered, only relational commitment mediates the influence of parental conflict on outcomes. Parental conflict in the absence of divorce was associated with less commitment and, in turn, less relationship satisfaction and stability …
Family Leadership Through Submission., Beverly J. Sedlacek, David Sedlacek
Family Leadership Through Submission., Beverly J. Sedlacek, David Sedlacek
Faculty Publications
No abstract provided.
Absence Of “Joseph Smith” In The Book Of Mormon: Lack Of The Name Letter Effect In Nephite, Lamanite, And Jaredite Names, Bruce L. Brown, Sharon Black, Brad Wilcox, Wendy Baker Smemoe
Absence Of “Joseph Smith” In The Book Of Mormon: Lack Of The Name Letter Effect In Nephite, Lamanite, And Jaredite Names, Bruce L. Brown, Sharon Black, Brad Wilcox, Wendy Baker Smemoe
Faculty Publications
Although some authors of fiction attempt to hide their real names by publishing their work under pseudonyms, the letters and sounds they consciously or subconsciously select for the names of their characters often reveal the author’s true identity. Since 1985, research has explored the name letter effect—the preference people show for the letters and sounds (especially initial sounds) in their own names. This tendency is evident in the highly personal and introspective literature produced in the United States during Joseph Smith’s lifetime by authors such as Nathaniel Hawthorne, Washington Irving, and Edgar Allan Poe. The purpose of this study was …
An Evaluation Of A Smartphone–Assisted Behavioral Weight Control Intervention For Adolescents: Pilot Study, Chad D. Jensen, Kristina M. Duncombe, Mark A. Lott, Sanita L. Hunsaker, Kara Mcrae Duraccio, Susan J. Woolford
An Evaluation Of A Smartphone–Assisted Behavioral Weight Control Intervention For Adolescents: Pilot Study, Chad D. Jensen, Kristina M. Duncombe, Mark A. Lott, Sanita L. Hunsaker, Kara Mcrae Duraccio, Susan J. Woolford
Faculty Publications
Background: The efficacy of adolescent weight control treatments is modest, and effective treatments are costly and are not widely available. Smartphones may be an effective method for delivering critical components of behavioral weight control treatment including behavioral self-monitoring.
Objective: To examine the efficacy and acceptability of a smartphone assisted adolescent behavioral weight control intervention.
Methods: A total of 16 overweight or obese adolescents (mean age=14.29 years, standard deviation=1.12) received 12 weeks of combined treatment that consisted of weekly in-person group behavioral weight control treatment sessions plus smartphone self-monitoring and daily text messaging. Subsequently they received 12 weeks of electronic-only intervention, …
Sibling Experiences: Living With Young Persons With Autism Spectrum Disorders, Tina Dyches, Beth Ward, Brianna Smith Tanner, Barbara Mandleco, Donna Freeborn
Sibling Experiences: Living With Young Persons With Autism Spectrum Disorders, Tina Dyches, Beth Ward, Brianna Smith Tanner, Barbara Mandleco, Donna Freeborn
Faculty Publications
Like other young people, those with autism spectrum disorder (ASD) have an impact on siblings in both positive and negative ways. Research indicates positive attributes include maturity and responsibility; positive self-concept; less quarrelling and competition; admiration for the person with ASD; and satisfactory sibling relationships. Negative attributes include fear of frightening or violent behavior, decreased sibling intimacy, and social and emotional difficulties. However, most research relies on information from parents/teachers, rather than from siblings. Therefore, this qualitative descriptive study explored experiences of 11 brothers and 11 sisters living with a young person with ASD through audiorecorded semi-structured interviews. Analysis revealed …
No Association Between Current Depression And Latent Toxoplasmosis In Adults, Bruce L. Brown, Shawn D. Gale, Andrew N. Berrett, Lance D. Erickson, Dawson W. Hedges
No Association Between Current Depression And Latent Toxoplasmosis In Adults, Bruce L. Brown, Shawn D. Gale, Andrew N. Berrett, Lance D. Erickson, Dawson W. Hedges
Faculty Publications
Changes in behaviour and cognition have been associated with latent infection from the apicomplexan protozoan Toxoplasma gondii (Nicolle et Manceaux, 1908) in both animal and human studies. Further, neuropsychiatric disorders such as schizophrenia have also been associated with latent toxoplasmosis. Previously, we found no association between T. gondii immunoglobulin G antibody (IgG) seropositivity and depression in human adults between the ages of 20 and 39 years (n = 1 846) in a sample representative of the United States collected by the Centers for Disease Control as part of a National Health and Nutrition Examination Survey (NHANES) from three datasets collected …
Solutions For Wellness: Outcome Review And Analysis Of A Healthy Lifestyle Group, Gary Burlingame, Valerie King, Rebecca Janis
Solutions For Wellness: Outcome Review And Analysis Of A Healthy Lifestyle Group, Gary Burlingame, Valerie King, Rebecca Janis
Faculty Publications
Individuals with serious mental illness (SMI) experience a notably decreased life span due, in part to a metabolic syndrome linked to psychotropic medications commonly prescribed to SMI patients. Eli Lilly’s Solutions for Wellness (SFW) program was designed to address some of the risk factors (e.g., weight, diet, lifestyle) that exacerbate the metabolic syndrome in SMI outpatients. However, there is limited data as to the effectiveness of the SFW program for hospitalized SMI patients. We replicate and compare SFW outcomes from an inpatient SMI population treated at the Utah State Hospital with previous research that tested an abbreviated SFW curriculum of …
Folate And Inflammatory Markers Moderate The Association Between Helicobacter Pylori Exposure And Cognitive Function In Us Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
Folate And Inflammatory Markers Moderate The Association Between Helicobacter Pylori Exposure And Cognitive Function In Us Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
Faculty Publications
Background: Helicobacter pylori(H. pylori) infection is associated with cogni-tive deficits in humans, an association potentially mediated or moderated byfolate concentration or inflammation.Materials and
Methods: We used the National Health and Nutrition Exami-nation Survey (NHANES) datasets to examine whether folate concentrationor inflammation mediates or moderates the relationship betweenH. pyloriand cognitive function. Models were performed using linear, Poisson, andzero-inflated Poisson regression, and we performed separate analyses forgroups aged 20–59 and 60–90 years with sample sizes ranging from 700 to1700.Results:We did not find evidence of mediation in either age group. In the20- to 59-year group, interactions betweenH. pyloriand ferritin (pvaluesranging from .004 to …
No Association Between Latent Toxoplasmosis And Multiple Body Measures In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
No Association Between Latent Toxoplasmosis And Multiple Body Measures In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
Faculty Publications
Toxoplasma gondii (Nicolle et Manceaux, 1908) is an intracellular parasite that can cause ongoing latent infection persisting for the duration of a non-definitive host's life. Affecting approximately one-third of the world's population, latent toxoplasmosis has been associated with neuropsychological outcomes and a previous report suggested an association between latent toxoplasmosis and adult height. Given the large number of people with latent toxoplasmosis and its potential associations with human height, we sought to better understand the association between latent toxoplasmosis and human morphology by evaluating seropositivity for T. gondii and multiple body measures reported in the National Health and Nutrition Examination …
What Mediates The Relationship Between Religious Service Attendance And Aspects Of Well-Being?, Scott A. Baldwin, Patrick R. Steffen, Kevin S. Masters
What Mediates The Relationship Between Religious Service Attendance And Aspects Of Well-Being?, Scott A. Baldwin, Patrick R. Steffen, Kevin S. Masters
Faculty Publications
Religious service attendance predicts increased well-being across a number of studies. It is not clear, however, whether this relationship is due to religious factors such as intrinsic religiosity or due to nonreligious factors such as social support or socially desirable responding. The purpose of the present study was to examine the relationship between religious service attendance and well-being while simultaneously examining intrinsic religiosity, social support, and socially desirable responding as potential mediators of the relationship. A sample of 855 participants (71 % female, average age 19.5) completed questionnaires assessing religiosity, social support, socially desirable responding, and well-being. Path models were …
Parent’S Alcoholism Severity And Family Topic Avoidance About Alcohol As Predictors Of Perceived Stigma Among Adult Children Of Alcoholics: Implications For Emotional And Psychological Resilience, Marie Haverfield, Jennifer Theiss
Parent’S Alcoholism Severity And Family Topic Avoidance About Alcohol As Predictors Of Perceived Stigma Among Adult Children Of Alcoholics: Implications For Emotional And Psychological Resilience, Marie Haverfield, Jennifer Theiss
Faculty Publications
Alcoholism is a highly stigmatized condition, with both alcohol-dependent individuals and family members of the afflicted experiencing stigmatization. This study examined the severity of a parent’s alcoholism and family topic avoidance about alcohol as two factors that are associated with family members’ perceptions of stigma. Three dimensions of stigma were considered: discrimination stigma, disclosure stigma, and positive aspect stigma. In addition, this study assessed associations between perceived stigmatization and individuals’ experiences of depressive symptoms, self-esteem, and resilience. Adult children of alcoholics (N = 622) were surveyed about family conditions, perceived stigma, and their emotional and psychological well-being. Regression analyses revealed …
Spatial Estimation: A Non-Bayesian Alternative, Hilary Barth, Ellen Lesser, Jessica Taggart, Emily Slusser
Spatial Estimation: A Non-Bayesian Alternative, Hilary Barth, Ellen Lesser, Jessica Taggart, Emily Slusser
Faculty Publications
A large collection of estimation phenomena (e.g. biases arising when adults or children estimate remembered locations of objects in bounded spaces; Huttenlocher, Newcombe & Sandberg, 1994) are commonly explained in terms of complex Bayesian models. We provide evidence that some of these phenomena may be modeled instead by a simpler non-Bayesian alternative. Undergraduates and 9- to 10-year-olds completed a speeded linear position estimation task. Bias in both groups’ estimates could be explained in terms of a simple psychophysical model of proportion estimation. Moreover, some individual data were not compatible with the requirements of the more complex Bayesian model.
Removing Very Low-Performing Therapists: A Simulation Of Performance-Based Retention In Psychotherapy, Scott A. Baldwin, Zac E. Imel, Elisa Shang, David C. Atkins
Removing Very Low-Performing Therapists: A Simulation Of Performance-Based Retention In Psychotherapy, Scott A. Baldwin, Zac E. Imel, Elisa Shang, David C. Atkins
Faculty Publications
Therapists can impact the likelihood a given patient will benefit from psychotherapy. However, therapists are rarely held accountable for their patients' outcomes. As a result, low performing providers likely continue to practice alongside providers with high response rates. In the current study, we conducted a Monte Carlo simulation to illustrate a thought experiment—what happens to patient outcomes if therapists with the worst outcomes were removed from practice? We drew initial samples of 50 therapists from three simulated populations of 1,000 therapists with a mean patient response rate of 50% and different effect sizes for therapist variability in outcomes. We simulated …
Exploring Human Trafficking In Hawai‘I From The Perspective Of Local Service Providers: Report To Stakeholders, Kristen D. Gleason Phd, Alyssa Carangan, Jared Espinueva, Alma Herrera-Mendoza, Denali Lukacinsky, Andreas Remis
Exploring Human Trafficking In Hawai‘I From The Perspective Of Local Service Providers: Report To Stakeholders, Kristen D. Gleason Phd, Alyssa Carangan, Jared Espinueva, Alma Herrera-Mendoza, Denali Lukacinsky, Andreas Remis
Faculty Publications
Executive Summary
Introduction: Human trafficking is an issue of national importance, but it is also an issue that touches communities at the local level. While progress is being made with regards to better understanding this phenomenon nationally, examining how human trafficking and the policies crafted to address it take shape within the local context is also important. One-size-fits-all approaches to human trafficking are not likely to understand local contextual variation. It is important to understand the local context so that efforts to address human trafficking can be sensitive to the situational needs of different communities. This report seeks to examine …
Collectivistic Coping Strategies For Distress Among Polynesian Americans, G. E. Kawika Allen, Timothy B. Smith
Collectivistic Coping Strategies For Distress Among Polynesian Americans, G. E. Kawika Allen, Timothy B. Smith
Faculty Publications
Previous research has shown that psychological services designed to assist clients in coping with stressful or traumatic events are more effective when aligned with clients’ cultural values, practices, and worldviews. However, limited research is available regarding the preferred coping strategies of Polynesian Americans. In examining collectivistic coping styles and their association with previous distress among 94 Polynesian Americans, we found that participants were highly likely to use family support and religion/spirituality to buffer the initial and residual effects of impairment attributable to distressing events, and private emotional outlets, such as psychotherapy, very infrequently. The use of private emotional outlets was …
Reading And Phonological Skills In Boys With Fragile X Syndrome, Jessica Klusek, Anna W. Hunt, Penny L. Mirrett, Deborah D. Hatton, Stephen R. Hooper, Jane E. Roberts, Donald B. Bailey
Reading And Phonological Skills In Boys With Fragile X Syndrome, Jessica Klusek, Anna W. Hunt, Penny L. Mirrett, Deborah D. Hatton, Stephen R. Hooper, Jane E. Roberts, Donald B. Bailey
Faculty Publications
No abstract provided.
Sertraline Effects On Cerebrospinal Fluid Monoamines And Species-Typical Socioemotional Behavior Of Female Cynomolgus Monkeys, Carol A. Shively, Thomas C. Register, James Dee Higley, Stephanie L. Willard
Sertraline Effects On Cerebrospinal Fluid Monoamines And Species-Typical Socioemotional Behavior Of Female Cynomolgus Monkeys, Carol A. Shively, Thomas C. Register, James Dee Higley, Stephanie L. Willard
Faculty Publications
Rationale—Although widely prescribed, little is known about selective serotonin reuptake inhibitors (SSRIs) effects on social behavior and cerebrospinal fluid (CSF) monoamines in female primates.
Objective—To determine the effects of sertraline on agonistic and affiliative behavior.
Methods—21 adult female cynomolgus monkeys were housed in small, stable social groups, trained to participate in oral dosing, and began a 5-week cumulative dose response study. Serial doses of 0, 5, 10, 15, and 20 mg/kg of sertraline were administered orally for one week each. Behavior was recorded daily during 10-minute observations before and 4 hours after dosing. On the 7th day of dosing, circulating …
Loneliness And Social Isolation As Risk Factors For Mortality: A Meta-Analytic Review, Julianne Holt-Lunstad, Timothy B. Smith, Mark Baker, Tyler Harris, David Stephenson
Loneliness And Social Isolation As Risk Factors For Mortality: A Meta-Analytic Review, Julianne Holt-Lunstad, Timothy B. Smith, Mark Baker, Tyler Harris, David Stephenson
Faculty Publications
Actual and perceived social isolation are both associated with increased risk for early mortality. The objective of this meta-analytic review is to establish the overall and relative magnitude of social isolation and loneliness and examine possible moderators. A literature search of studies (January 1980 to February 2014) was conducted using MEDLINE, CINAHL, PsycINFO, Social Work Abstracts, and Google Scholar. The included studies provide quantitative data on mortality as affected by loneliness, social isolation, or living alone. Across studies that statistically controlled for a variety of possible confounds, the independent random effects weighted average effect sizes for social isolation OR = …
A Sequence Variant In Human Kalrn Impairs Protein Function And Coincides With Reduced Cortical Thickness, Derin J. Cobia, Theron A. Russell, Katherine D. Blizinsky, Michael Cahill, Zhong Xie, Robert A. Sweet, Jubao Duan, Pablo V. Gejman, Lei Wang, John G. Csernansky, Peter Penzes
A Sequence Variant In Human Kalrn Impairs Protein Function And Coincides With Reduced Cortical Thickness, Derin J. Cobia, Theron A. Russell, Katherine D. Blizinsky, Michael Cahill, Zhong Xie, Robert A. Sweet, Jubao Duan, Pablo V. Gejman, Lei Wang, John G. Csernansky, Peter Penzes
Faculty Publications
Dendritic spine pathology is a key feature of several neuropsychiatric disorders. The Rac1 guanine nucleotide exchange factor kalirin-7 is critical for spine morphogenesis on cortical pyramidal neurons. Here we identify a rare coding variant in the KALRN gene region that encodes the catalytic domain, in a schizophrenia patient and his sibling with major depressive disorder. The D1338N substitution significantly diminished the protein's ability catalyze the activation of Rac1. Contrary to wild-type kalirin-7, kalirin-7-D1338N failed to increase spine size and density. Both subjects carrying the polymorphism displayed reduced cortical volume in the superior temporal sulcus (STS), a region implicated in schizophrenia. …