Psychology Commons^™

Freesurfer Vs. Manual Tracing: Distinguishing Stable From Cognitively Declining Elders Using Prospectively Measured Hippocampal Volume, Alissa Butts, Kristy A. Nielson, Nathan Hantke, Melissa A. Lancaster, Michael Seidenberg, John L. Woodard, J. Carson Smith, Monica Matthews, Sally Durgerian, Stephen M. Rao

Psychology Faculty Research and Publications

Objective: Alzheimer’s disease (AD) pathology is thought to begin years before symptom onset. Hippocampal volume is sensitive to age-related cognitive decline and conversion from MCI to AD. Measurement of hippocampal volumes has used either automated methods such as FreeSurfer (FS) or manual tracing (MT). We compared the ability of FS and MT in detecting baseline volume differences in cognitively intact older individuals who subsequently showed significant cognitive decline.

Participants and Methods: Seventy-five cognitively intact elders underwent baseline and 18-month follow-up structural MRI scan and neuropsychological testing. Participants were classified as Declining (n=27) or Stable (n=48) based on the baseline to …

Episodic Memory Measures Complement Structural And Functional Mri For Predicting Cognitive Decline In Apolipoprotein E Ε4 Carriers, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, Michael Sugarman, J. Carson Smith, Sally Durgerian, Alissa Butts, Melissa A. Lancaster, Mary K. Foster, Nathan Hantke, Monica Matthews, Stephen M. Rao

Psychology Faculty Research and Publications

Apolipo-protein E (APOE) ?4 allele carriers demonstrate greater risk for cognitive decline and Alzheimer's disease than non-carriers. However, factors associated with risk of decline among APOE ?4 carriers are not well-known. In this longitudinal study, we investigated whether discrete aspects of baseline episodic memory performance and structural (sMRI) and function (fMRI) magnetic resonance imaging were associated with cognitive decline in older APOE ?4 carriers and non-carriers. Seventy-eight healthy older adults underwent cognitive testing at baseline and after 18 months, baseline serum APOE genotyping, manually-traced hippocampal volume measurement from sMRI, and task-activated fMRI. Cognitive decline was defined as a one SD …

Five-Year Changes In Brain Volume And Episodic Memory In Cognitively Intact Elders With And Without An Apolipoprotein Ε4 Allele, Monica A. Matthews, Michael Seidenberg, John L. Woodard, Sally Durgerian, Kristy A. Nielson, J. Carson Smith, Melissa A. Lancaster, Alissa Butts, Nathan Hantke, Stephen M. Rao

Psychology Faculty Research and Publications

The apolipoprotein ε4 allele is a risk factor for Alzheimer's disease. ε4 carriers diagnosed with AD or MCI exhibit an increased rate of atrophy on MRI relative to non-carriers. Few longitudinal studies have examined the rate of atrophy and cognitive change in older ε4 carriers who were cognitively intact at study entry. In this study, structural MRI and episodic memory testing were administered on two occasions separated by 5 years to 45 cognitively intact older adults, ages 65-90 years, divided into two groups: (1) carriers with one or both ε4 alleles (n=24) and (2) demographically-matched non-carriers (n=21). Longitudinal analysis of …

The Contribution Of Blood Serum Biomarkers To The Prediction Of Cognitive Decline By Fmri And Apolipoprotein-E In Healthy Older Adults, Kristy A. Nielson, Michael Sugarman, John L. Woodard, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Stephen M. Rao

Psychology Faculty Research and Publications

Biomarkers are a promising approach to the prediction and early intervention of Alzheimer's disease. We demonstrated that cortical functional MRI (fMRI) activation during a semantic memory task and apolipoprotein-E ?4 allele inheritance (APOE?4) effectively predicted cognitive decline after 18-months in healthy, asymptomatic elders. Hippocampal volume added modest prediction, while AD family history and demographics were ineffective. Previous studies have linked plasma homocysteine (tHcy), vitamin B12 and creatinine values to cognitive functioning, cortical atrophy, hippocampal atrophy and neuropathology, and vascular integrity. Here we incorporated total plasma homocysteine (tHcy), B12 creatinine values into our previous predictive models. Of 78 healthy elders, 27 …

Prediction Of Longitudinal White Matter Change In Healthy Elderly Individuals, Melissa A. Lancaster, Sally Durgerian, Michael Seidenberg, John L. Woodard, Kristy A. Nielson, J. Carson Smith, Monica Matthews, Alissa Butts, Nathan Hantke, Stephen M. Rao

Psychology Faculty Research and Publications

Diffusion Tensor Imaging (DTI) studies have shown that significant alteration in white matter (WM) integrity differentiates healthy older adults from persons with Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). Most studies, however, have been cross-sectional and have not related longitudinal DTI changes to cognitive change. Here we report changes in WM integrity and cognition in healthy older adults over an 18-month interval. Sixty-seven cognitively intact elders underwent neuropsychological testing and DTI at baseline to follow-up on the Rey Auditory Verbal Learning Test (recall sum across trials 1-5, delayed recall) and Mattis Dementia Rating Scale-2. Declining participants (N=21) showed a …

Peer Rejection And Friendships In Children With Attention-Deficit/Hyperactivity Disorder: Contributions To Long-Term Outcomes, Sylvie Mrug, Brooke S. G. Molina, Betsy Hoza, Alyson C. Gerdes, Stephen P. Hinshaw, Lily Hechtman, L. Eugene Arnold

Psychology Faculty Research and Publications

Even after evidence-based treatment, Attention- Deficit/Hyperactivity Disorder (ADHD) is associated with poor long-term outcomes. These outcomes may be partly explained by difficulties in peer functioning, which are common among children with ADHD and which do not respond optimally to standard ADHD treatments. We examined whether peer rejection and lack of dyadic friendships experienced by children with ADHD after treatment contribute to long-term emotional and behavioral problems and global impairment, and whether having a reciprocal friend buffers the negative effects of peer rejection. Children with Combined type ADHD (N0300) enrolled in the Multimodal Treatment Study of Children with ADHD (MTA) were …

Discrimination, Acculturation, Acculturative Stress, And Latino Psychological Distress: A Moderated-Mediational Model, Lucas Torres, Mark W. Driscoll, Maria Voell

Psychology Faculty Research and Publications

Prior research has found that perceived discrimination is associated with adverse mental health outcomes among Latinos. However, the process by which this relationship occurs remains an understudied area. The present study investigated the role of acculturative stress in underlying the relationship between perceived discrimination and Latino psychological distress. Also examined was the ability of acculturation to serve as a moderator between perceived discrimination and acculturative stress. Among a sample of Latino adults (N = 669), moderated mediational analyses revealed that acculturative stress mediated the perceived discrimination-psychological distress relationship, and that the link between perceived discrimination and acculturative stress was moderated …

Youth Experiences Of Family Violence And Teen Dating Violence Perpetration: Cognitive And Emotional Mediators, John H. Grych, Ernest N. Jouriles, Renee Mcdonald, Victoria Mueller

Psychology Faculty Research and Publications

This article describes a conceptual model of cognitive and emotional processes proposed to mediate the relation between youth exposure to family violence and teen dating violence perpetration. Explicit beliefs about violence, internal knowledge structures, and executive functioning are hypothesized as cognitive mediators, and their potential influences upon one another are described. Theory and research on the role of emotions and emotional processes in the relation between youths’ exposure to family violence and teen dating violence perpetration are also reviewed. We present an integrated model that highlights how emotions and emotional processes work in tandem with hypothesized cognitive mediators to predict …

Progressive Supranuclear Palsy, James B. Hoelzle

Psychology Faculty Research and Publications

No abstract provided.

Risk Factors For Alzheimer’S Disease And Longitudinal Memory Performance, M. K. Foster, M. Seidenberg, J. Woodard, Kristy A. Nielson, J. Smith, M. Lancaster, M. Matthews, N. Hantke, A. Butts, S. Rao

Psychology Faculty Research and Publications

No abstract provided.

Toward A More Comprehensive Understanding Of Interpersonal Violence: Introduction To The Special Issue On Interconnections Among Different Types Of Violence, Suzanne Swan, John H. Grych

Psychology Faculty Research and Publications

Recent epidemiological work shows that most victims of interpersonal violence have experienced other forms of violence as well. Similarly, perpetrators of one type of violence often engage in aggression in other contexts, and many people report both perpetration and victimization. This special issue presents 8 studies on the leading edge of research investigating the interconnections among different forms of violence, abuse, and maltreatment. They examine links between sexual and physical abuse, intimate partner violence, teen dating violence, community violence, and violent media. Together, they suggest that focusing on the co-occurrence of different types of violence has the potential to advance …

Lifestyle And Genetic Contributions To Cognitive Decline And Hippocampal Structure And Function In Healthy Aging, John L. Woodard, Michael Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Monica A. Matthews, Stephen M. Rao

Psychology Faculty Research and Publications

Background: Engagement in cognitively stimulating activities (CA) and leisure time physical activity (PA) have been associated with maintaining cognitive performance and reducing the likelihood of cognitive decline in older adults. However, neural mechanisms underlying protective effects of these lifestyle behaviors are largely unknown. In the current study, we investigated the effect of self-reported PA and CA on hippocampal volume and semantic processing activation during a fame discrimination task, as measured by functional magnetic resonance imaging (fMRI). We also examined whether possession of the apolipoprotein E (APOE) ?4 allele could moderate the effect of PA or CA on hippocampal structure or …

Behavioral Factors Influencing Health Outcomes In Youth With Type 1 Diabetes, Jessica C. Kichler, Ashley Moss, Astrida S. Kaugars

Psychology Faculty Research and Publications

The Pediatric Self-Management Model provides an overview of how behavioral factors influence children’s chronic medical illnesses. This general framework is used to organize the present review of how self-management behaviors, contextual factors, and processes impact health outcomes for adolescent youth with type 1 diabetes. Adherence has been widely studied in the diabetes literature, and there are consistent findings demonstrating associations between aspects of self-management, adherence, and metabolic control, yet there are still equivocal approaches to adherence assessment methodology (e.g. global versus specific measures). Metabolic control is a hallmark health outcome for youth with type 1 diabetes, but additional outcomes need …

Longitudinal Associations Between Physical Activity, Cognitive Status, And Brain Function In Older Adults At Genetic Risk For Alzheimer’S Disease, J. Carson Smith, Sally Durgerian, John L. Woodard, Kristy A. Nielson, Alissa Butts, Nathan Hantke, Michael Seidenberg, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao

Psychology Faculty Research and Publications

The apolipoproteinE epsilon4 (APOE-?4) allele is associated with cognitive decline in old age and is a risk factor for Alzheimer's disease (AD). Physical activity (P A) is associated with a reduced risk of incident cognitive impairment, particularly among APOE-?4 carriers. We recently reported greater semantic memory related brain activation in cognitively intact physically active (High P A) APOE-?4 carriers compared to physically inactive (Low PA) ?4 carriers and non-carriers (Smith et al., 2011). Here, we compared longitudinal changes in semantic memory-related brain activation in High PA and Low PA APOE-?4 carriers. Thirty-two older ?4 carriers completed neuropsychological testing and a …

Discrimination, Acculturation, Acculturative Stress, And Latino Psychological Distress: A Moderated Mediational Model, Lucas Torres, Mark W. Driscoll, Maria Voell

Psychology Faculty Research and Publications

Prior research has found that perceived discrimination is associated with adverse mental health outcomes among Latinos. However, the process by which this relationship occurs remains an understudied area. The present study investigated the role of acculturative stress in underlying the relationship between perceived discrimination and Latino psychological distress. Also examined was the ability of acculturation to serve as a moderator between perceived discrimination and acculturative stress. Among a sample of Latino adults (N = 669), moderated mediational analyses revealed that acculturative stress mediated the perceived discrimination-psychological distress relationship, and that the link between perceived discrimination and acculturative stress was moderated …

Interactive Gaming Reduces Experimental Pain With Or Without A Head Mounted Display, Nakia S. Gordon, Juniad Merchant, Catherine Zanbaka, Larry F. Hodges, Paula Goolkasian

Psychology Faculty Research and Publications

While virtual reality environments have been shown to reduce pain, the precise mechanism that produces the pain attenuating effect has not been established. It has been suggested that it may be the ability to command attentional resources with the use of head mounted displays (HMDs) or the interactivity of the environment. Two experiments compared participants’ pain ratings to high and low levels of electrical stimulation while engaging in interactive gaming with an HMD. In the first, gaming with the HMD was compared to a positive emotion induction condition; and in the second experiment the HMD was compared to a condition …

Depressive Symptoms And Relational Uncertainty As Predictors Of Reassurance-Seeking And Negative Feedback-Seeking In Conversation, Leanne K. Knobloch, Lynne M. Knobloch-Fedders, C. Emily Durbin

Psychology Faculty Research and Publications

Integrative interpersonal theory implies that relational uncertainty may play a role in the reassurance-seeking and negative feedback-seeking behavior of people with depressive symptoms. We sought to extend the theory by (a) documenting how individuals with depressive symptoms communicate under conditions of relational uncertainty, (b) evaluating actor and partner effects, and (c) utilizing observational measures of reassurance-seeking and negative feedback-seeking. Sixty-nine romantic couples engaged in 50 minutes of conversation rated by independent judges. Multilevel modeling results indicated that the depressive symptoms of actors and partners were the primary predictor of an actor's reassurance-seeking, but an actor's relational uncertainty was the primary …

Ambivalent Sexism And The Expected Distribution Of Power In Romantic Relationships, Teni Davoudian

Master's Theses (2009 -)

The present study examined the associations between ambivalent sexism toward women and power in heterosexual romantic relationships. Specifically, power was measured globally and in specific domains of relationships (e.g., finances, childcare, sexual activities). College students were asked to complete measures assessing their levels of ambivalent sexism and the amount of power that they expected to have in their future, long-term romantic relationships as well as their perceived power in their current romantic relationships. It was predicted that participants would anticipate having more power in various areas of their relationship according to their gender and their levels of ambivalent sexism. Results …

Parents' Influence On Child Social Self-Efficacy And Social Cognition, Denise Marie Gardner

Master's Theses (2009 -)

No abstract provided.

Acculturation, Cultural Values, And Latino Parental Beliefs About The Etiology Of Adhd, Kathryn E. Lawton

Master's Theses (2009 -)

Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most prevalent mental health disorders of childhood, but despite the availability of several evidence-based interventions, Latino children are more likely than non-minority children to have an unmet need for services related to ADHD. Because parental beliefs about the etiology of ADHD likely influence which services are sought, more research is needed to examine this aspect of help-seeking behavior in order to address the unmet need among Latino families. Specifically, research needs to focus on cultural factors that likely influence parental beliefs about the etiology of child behavior problems. Thus, the goal of the …

Effects Of Chronic Variable Stress Across Developmental Stages In Mice, Sheryl Jayne Stevens

Master's Theses (2009 -)

Posttraumatic Stress Disorder (PTSD) is a response to trauma exposure that involves a number of symptoms that can be highly impairing to affected individuals. Only a subset of those exposed to traumatic events will develop the disorder, which is conceptualized as developing via conditional fear. Research into factors predisposing for PTSD is needed. Furthermore, little work has been done to investigate predisposing factors in children more specifically. This research tests the effects of stress exposure on subsequent fear learning, across developmental stages in mice, as a model for PTSD. Juvenile and adult male mice were exposed to chronic variable stress …

Stress-Generation Processes In Latinos: The Roles Of Acculturation, Acculturative Stress, And Intercultural Competence, Mark W. Driscoll

Dissertations (1934 -)

Using a brief longitudinal design, this study examined the role of cultural adaptation processes (acculturation, acculturative stress, and intercultural competence) in predicting depression symptoms among Latinos living in the United States. Based on previous research employing stress generation processes (e.g., Hammen, 2005), it was hypothesized that depression symptoms measured at baseline predicted dependent stressful life events measured at six-month follow-up. It was further hypothesized that depression symptoms measured at baseline predicted dependent stressful life events measured at six-month follow-up indirectly through acculturation, acculturative stress, and intercultural competence, also measured at six-month follow-up. Finally, it was hypothesized that six-month follow-up acculturation, …

Military Mental Health: Problem Recognition, Treatment-Seeking, And Barriers, Laura Bein

Dissertations (1934 -)

Substantial numbers of military troops are serving overseas in military operations and are returning home with elevated reports of psychological symptoms; however, a treatment gap exists between those reporting mental health problems and those receiving appropriate treatment. Stigma has been cited as a potential barrier to treatment-seeking, although few studies distinguish between perceived and public stigma or between stigma for having a mental illness versus that for seeking treatment.

In the present study, Army National Guard soldiers returning from deployment to Iraq were asked to complete questionnaires assessing psychological symptoms, as well as reports of perceived stigma from self and …

Long Term Effects Of Chronic Variable Stress Administered During Different Developmental Stages In Mice, Henry Boeh

Dissertations (1934 -)

A number of studies have suggested that the occurrence of past trauma can increase an individual's chance of developing PTSD from a new traumatic experience later in life. Trauma that occurs during childhood appears to have a particularly strong effect on this risk increase. Furthermore, conditioned fear responses have been shown to incubate over extended periods of time in animal models. To further investigate the role these phenomena play in the development of PTSD, this study exposed juvenile and adult mice to 7 days of chronic variable stress (CVS). One month later, a Pavlovian delay fear conditioning procedure was used …

Influences On Father Involvement: Testing For Unique Contributions Of Religion And Spirituality, Mark Lynn

Dissertations (1934 -)

The role of the father in children's development historically has been neglected. Studies examining family processes were primarily limited to mothers, under the assumption that mothers' influences encapsulated what (little) effects could also be attributed to the father. Although theory and research have begun to address fathers' roles in families in earnest, there is still much work to be done, particularly in regard to understanding the determinants of father involvement. One direction that has received attention from researchers is towards a conceptualization of environmental and contextual influences on fathers' interactions with their families. The goal of this study was to …

The Therapeutic Relationship In Dialectical Behavior Therapy: A Longitudinal Investigation In A Naturalistic Setting, Sara Elizabeth Little

Dissertations (1934 -)

The quality of the therapeutic alliance in psychotherapy has been found to be positively associated with many treatment outcome variables, such as client retention, client satisfaction in treatment, and improvement in symptoms. While some theorists assume that therapeutic alliance is established early in therapy and remains fairly stable across time in treatment, others such as Safran et al. (1990) suggest that the alliance quality fluctuates across time and is likely to be marked by frequent patterns of rupture and repair. In particular, individuals with Borderline Personality Disorder (BPD) have clusters of symptoms and interpersonal styles that are likely to present …

Healing Images: A Historical Outline Of Their Use In Western Medical And Psychotherapeutic Traditions, Anees A. Sheikh

Psychology Faculty Research and Publications

The ancient literature of numerous cultures abounds with accounts of spectacular cures resulting from the imaging process. These accounts are now being corroborated by a growing body of clinical and experimental evidence. The effectiveness of mental imagery in the treatment of a wide variety of problems has been convincingly documented (Sheikh, 1983). This paper outlines the use of imagery in Western medical as well as psychotherapeutic traditions. It concludes with a discussion of the reasons that make imagery an excellent healing agent.

A Naturalistic Study Of The Associations Between Changes In Alcohol Problems, Spiritual Functioning And Psychiatric Symptoms, Melissa L. Miller, Stephen M. Saunders

Psychology Faculty Research and Publications

The study evaluated how spiritual and religious functioning (SRF), alcohol-related problems, and psychiatric symptoms change over the course of treatment and follow-up. Problem drinkers (n = 55, including 39 males and 16 females) in outpatient treatment were administered questionnaires at pretreatment, posttreatment, and follow up, which assessed two aspects of SRF (religious well-being and existential well-being), two aspects of alcohol misuse (severity and consequences), and two aspects of psychiatric symptoms (depression and anxiety). Significant improvements in SRF, psychiatric symptoms and alcohol misuse were observed from pretreatment to follow-up. Although SRF scores were significantly correlated with psychiatric symptoms at all three …

Does Physical Activity Influence Semantic Memory Activation In Amnestic Mild Cognitive Impairment?, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Matthew D. Verber, Sally Durgerian, Piero Antuono, Alissa M. Butts, Nathan C. Hantke, Melissa A. Lancaster, Stephen M. Rao

Psychology Faculty Research and Publications

The effect of physical activity (PA) on functional brain activation for semantic memory in amnestic mild cognitive impairment (aMCI) was examined using event-related functional magnetic resonance imaging during fame discrimination. Significantly greater semantic memory activation occurred in the left caudate of High- versus Low-PA patients, (P=0.03), suggesting PA may enhance memory-related caudate activation in aMCI.

African American Men Facing Homelessness And Co-Occurring Disorders: A Qualitative Investigation Of Multiple Stigmas, Rebecca C. Mayor

Dissertations (1934 -)

Homelessness is a pervasive and problematic phenomenon, and programs designed to assist individuals experiencing homelessness and reduce homelessness face a number of challenges. One such challenge involves difficulty engaging and retaining clientele experiencing homelessness in supportive services (Bhui et al., 2006; Ng & McQuistion, 2004; Padgett et al., 2008). The literature suggests that one explanation for this difficulty may involve the stigmatization experiences that individuals facing homelessness accumulate over time; previous studies have indicated that holding a marginalized position in society may make individuals experiencing homelessness more reluctant to engage in services (because of social rejection fears) and/or more sensitive …